2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. CDK DYRK
  4. MU1210

MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed).

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MU1210

MU1210 Chemical Structure

CAS No. : 2275601-87-9

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MU1210 Related Antibodies

Top Publications Citing Use of Products

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Description

MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed)[1].

IC50 & Target

CLK1

8 nM (IC50)

CLK2

20 nM (IC50)

CLK4

12 nM (IC50)

HIPK1

187 nM (IC50)

DYRK2

1309 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HT-22 IC50
2.6 μM
Compound: 49; MU1210
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 36876904]
MCF7 IC50
4.6 μM
Compound: MU1210
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CyQuant assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CyQuant assay
[PMID: 33636538]
Molecular Weight

352.39

Formula

C22H16N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1N=CC(C2=NC3=C(C=C2)OC=C3C4=CC=CC(C5=CC=NC=C5)=C4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.5%

SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References
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MU1210 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU12102275601-87-9MU 1210MU-1210CDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasepharmacokinetic characteristicsmicecancerInhibitorinhibitorinhibit

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