2275601-87-9
Chemical Structure
MU1210
- CAS No.: 2275601-87-9
- Formula:C22H16N4O
- Molecular Weight:352.39
IUPAC Name: 5-(1-methyl-1H-pyrazol-4-yl)-3-(4-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine
InChIKey: HEAGNKNMQVIVMM-UHFFFAOYSA-N
SMILES: CN1N=CC(C2=NC3=C(C=C2)OC=C3C4=CC=CC(C5=CC=NC=C5)=C4)=C1
Biological Activity: MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed)[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MU1210 | 99.5% | MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
