PDE10A-IN-4
PDE10A-IN-4 (compound 38) is a compound used to inhibit schizophrenia. As a PDE10A inhibitor, it is less effective than placebo in inhibiting acute schizophrenia and does not show antipsychotic effect.
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- CAS No.: 898563-49-0
- Formule: C25H20N4O
- Masse moléculaire:392.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
1.34 nM
Compound: 3, MP-10
|
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillation counting
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillation counting
|
[PMID: 20450197] |
| Sf9 | IC50 |
0.37 nM
Compound: 9
|
Inhibition of rat recombinant PDE10A transfected in Sf9 cells
Inhibition of rat recombinant PDE10A transfected in Sf9 cells
|
[PMID: 19630403] |
Chemical Information
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CAS No. 898563-49-0
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Masse moléculaire 392.45
-
Formule C25H20N4O
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SMILES
CN(N=C1C2=CC=C(OCC3=NC4=C(C=C3)C=CC=C4)C=C2)C=C1C5=CC=NC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)