MU1700
MU1700, a chemical probe, is an orally active and potent ALK1/2 inhibitor with IC50s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3055312-41-6
- 分子式: C26H22N4O
- 分子量:406.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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ALK2 6 nM (IC50) |
ALK1 13 nM (IC50) |
ALK6 41 nM (IC50) |
MU1700 (0.1-50 μM; 24 h) shows cytotoxic effect at above 2.5 µM in U2OS cells[1].
MU1700 (0-10 μM) inhibits ALK2 catalysed phosphorylation of SMAD1/5/8[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells
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Concentration:0.1-50 μM
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Incubation Time:24 h
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Result:Showed cytotoxic effect above 2.5 µM concentration significantly.
| Dose | 20 mg/kg |
| Bioavailability | 79 % |
| Cl (ml/min/kg) | 30 (IV) |
| T1/2 | 2.5 h |
| Cmax (PO) | 3697 nM |
| Cbrain/Cplasma (4h, 100 mg/kg) | 25 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3055312-41-6
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分子量 406.48
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分子式 C26H22N4O
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SMILES
N1(C2=CC=C(C3=CC(OC=C4C5=C(C=CC=C6)C6=NC=C5)=C4N=C3)C=C2)CCNCC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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