2. TGF-beta/Smad
  3. TGF-β Receptor
  4. MU1700

MU1700 is an orally active and potent ALK1/2 inhibitor with IC50s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability.

For research use only. We do not sell to patients.

MU1700 Chemical Structure

MU1700 Chemical Structure

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MU1700 Related Antibodies

Top Publications Citing Use of Products

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

MU1700 is an orally active and potent ALK1/2 inhibitor with IC50s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability[1].

IC50 & Target[1]

ALK2

6 nM (IC50)

ALK1

13 nM (IC50)

ALK6

41 nM (IC50)

In Vitro

MU1700 (0.1-50 μM; 24 h) shows cytotoxic effect at above 2.5 µM in U2OS cells[1].
MU1700 (0-10 μM) inhibits ALK2 catalysed phosphorylation of SMAD1/5/8[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MU1700 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: U2OS cells
Concentration: 0.1-50 μM
Incubation Time: 24 h
Result: Showed cytotoxic effect above 2.5 µM concentration significantly.
In Vivo

1.19 Pharmacokinetic (PK) Profile in Mice (P.O., 20 mg/kg)[1]

Dose 20 mg/kg
Bioavailability 79 %
Cl (ml/min/kg) 30 (IV)
T1/2 2.5 h
Cmax (PO) 3697 nM
Cbrain/Cplasma (4h, 100 mg/kg) 25

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

406.48

Formula

C26H22N4O
SMILES

N1(C2=CC=C(C3=CC(OC=C4C5=C(C=CC=C6)C6=NC=C5)=C4N=C3)C=C2)CCNCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MU1700 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU1700MU 1700MU-1700TGF-β ReceptorTransforming growth factor beta receptorsoral activitycell membrane permeabilitybrain penetranceU2OS cellInhibitorinhibitorinhibit

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MU1700
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HY-148246
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