HYAL2 - hyaluronidase 2 Gene

Also Known as LUCA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8692

About HYAL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,317,808-50,322,745 (from NCBI)

This gene has 10 transcripts (splice variants), 294 orthologues, 4 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 78.9), lung (RPKM 35.1) and 20 other tissues.

Summary

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to Other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

HYAL2 Products (2)

mRNA	Protein	Name
NM_003773.5	NP_003764.3	hyaluronidase-2 precursor
NM_033158.5	NP_149348.2	hyaluronidase-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	19366691	GOA
enables hyaluronic acid binding	IDA IDA: Inferred from direct assay	12676986	GOA
enables hyaluronoglucuronidase activity	IDA IDA: Inferred from direct assay	21699545	GOA
NOT enables hyalurononglucosaminidase activity	IDA IDA: Inferred from direct assay	11296287	GOA
enables hyalurononglucosaminidase activity	IDA IDA: Inferred from direct assay	9712871	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12676986	GOA
enables receptor signaling protein tyrosine kinase inhibitor activity	IDA IDA: Inferred from direct assay	12676986	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12676986	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	11296287	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cartilage development	IEP IEP: Inferred from expression pattern	11944887	GOA
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	21699545	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	19577615	GOA
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	18390475	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	19366691	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18390475	GOA
involved in fusion of virus membrane with host plasma membrane	IDA IDA: Inferred from direct assay	11296287	GOA
involved in glycosaminoglycan catabolic process	IDA IDA: Inferred from direct assay	9712871	GOA
involved in hyaluronan catabolic process	IDA IDA: Inferred from direct assay	17170110	GOA
involved in monocyte activation	IDA IDA: Inferred from direct assay	19443707	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12676986	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	18725949	GOA
involved in negative regulation of fibroblast migration	IDA IDA: Inferred from direct assay	19577615	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	12676986	GOA
involved in negative regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12676986	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	19443707	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	19443707	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	19443707	GOA
involved in response to antibiotic	IEP IEP: Inferred from expression pattern	11944887	GOA
involved in response to reactive oxygen species	IDA IDA: Inferred from direct assay	20554532	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	11296287	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20554532	GOA
located in cell surface	IDA IDA: Inferred from direct assay	17170110	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17170110	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	16600643	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19366691	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	19366691	GOA
colocalizes with external side of plasma membrane	IDA IDA: Inferred from direct assay	19443707	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11296287	GOA
located in lysosome	IDA IDA: Inferred from direct assay	9712871	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	21740893	GOA
located in microvillus	IDA IDA: Inferred from direct assay	19366691	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16600643	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18390475	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HYAL2 Protein Structure

Glyco_hydro_56

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
hyaluronidase-2	PH-20 homolog

HYAL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HYAL2	Q12891	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	HYAL2	Q12891	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	HYAL2	Q12891	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	HYAL2	Q12891	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	HYAL2	Q12891	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	HYAL2	Q12891	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	HYAL2	Q12891	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	HYAL2	Q12891	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	HYAL2	Q12891	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	HYAL2	Q12891	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	HYAL2	Q12891	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	HYAL2	Q12891	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	HYAL2	Q12891	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	HYAL2	Q12891	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	HYAL2	Q12891	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	HYAL2	Q12891	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HYAL2	Q12891	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	HYAL2	Q12891	PON2	Homo sapiens	Q15165	Anti Tag CoIP	33961781
Intra	HYAL2	Q12891	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
Intra	HYAL2	Q12891	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	HYAL2	Q12891	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	HYAL2	Q12891	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	HYAL2	Q12891	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	HYAL2	Q12891	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	HYAL2	Q12891	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	HYAL2	Q12891	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	HYAL2	Q12891	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	25416956
Intra	HYAL2	Q12891	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	HYAL2	Q12891	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	HYAL2	Q12891	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HYAL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79066	Hyaluronidase 2/HYAL2 Protein, Human (HEK293, His)	Q12891 (M21-G447)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome	Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Deafness Syndrome Hyaluronidase 2 Deficiency
Cor Triatriatum	Triatrial Heart
Mucopolysaccharidosis, Type Ix	Mucopolysaccharidosis Type Ix Hyaluronidase Deficiency MPS9 Mps Ix Mucopolysaccharidosis Ix Mpsix Mucopolysaccharidosis Type 9 Mucopolysaccharidosis 9
Bronchiolo-Alveolar Adenocarcinoma	Bronchioloalveolar Carcinoma Bronchioalveolar Lung Carcinoma Minimally Invasive Lung Adenocarcinoma Carcinoma Bronchioloalveolar Adenocarcinoma, Bronchiolo-Alveolar Bronchioloalveolar Adenocarcinoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2096	Hexapeptide-11		99.77%	Unkown
HY-E70182	Hyaluronidase 2	Inhibitor	/	Unkown
HY-RS06496	HYAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HYAL2	RGD	RGD:620321
Bos taurus	HYAL2	VGNC	VGNC:30011
Mus musculus	HYAL2	MGD	MGI:1196334
Canis familiaris	HYAL2	VGNC	VGNC:41843
Felis catus	HYAL2	VGNC	VGNC:67679
Macaca mulatta	HYAL2	VGNC	VGNC:73548
Others	HYAL2	NCBI