Hyaluronidase 2/HYAL2 Protein, Human (HEK293, His)
Hyaluronidase 2 (HYAL2) protein participates in the hydrolysis of high molecular weight hyaluronic acid, generating intermediate-sized products. Despite low activity, HYAL2 contributes to extracellular matrix dynamics through hyaluronic acid breakdown. Furthermore, it associates with and negatively regulates MST1R, suggesting a potential role in cellular processes mediated by MST1R. Hyaluronidase 2/HYAL2 Protein, Human (HEK293, His) is the recombinant human-derived Hyaluronidase 2/HYAL2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Hyaluronidase 2 (HYAL2) protein participates in the hydrolysis of high molecular weight hyaluronic acid, generating intermediate-sized products. Despite low activity, HYAL2 contributes to extracellular matrix dynamics through hyaluronic acid breakdown. Furthermore, it associates with and negatively regulates MST1R, suggesting a potential role in cellular processes mediated by MST1R. Hyaluronidase 2/HYAL2 Protein, Human (HEK293, His) is the recombinant human-derived Hyaluronidase 2/HYAL2 protein, expressed by HEK293 , with C-His labeled tag.
Background
Hyaluronidase 2 (HYAL2) protein is involved in the hydrolysis of high molecular weight hyaluronic acid, generating intermediate-sized products that are subsequently processed by sperm hyaluronidase to produce small oligosaccharides. Although HYAL2 exhibits very low levels of activity, its role in the breakdown of hyaluronic acid suggests a potential contribution to the modulation of extracellular matrix dynamics. Additionally, HYAL2 associates with and negatively regulates MST1R, indicating a potential regulatory role in cellular processes mediated by MST1R.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
Q12891 (M21-G447)
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Molecular Construction
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N-term
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HYAL2 (M21-G447)
Accession # Q12891 -
His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
HYAL2; Hyaluronidase-2; Hyaluronidase 2; PH-20 Homolog; LUCA2; Hyal-2; Hyaluronoglucosaminidase 2; Hyaluronoglucosaminidase-2; LuCa-2; Hyaluronidase; Lung Carcinoma Protein 2; PH20 Homolog; Lysosomal Hyaluronidase; MCCS
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AA Sequence
MELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAG
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Predicted Molecular Mass
49.2 kDa
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Molecular Weight
Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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