LATS2 - large tumor suppressor kinase 2 Gene

Also Known as KPM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26524

About LATS2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,973,036-21,061,586 (from NCBI)

This gene has 2 transcripts (splice variants), 212 orthologues, 13 paralogues and is associated with 97 phenotypes. Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of Mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to Cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

LATS2 Products (1)

mRNA	Protein	Name
NM_014572.3	NP_055387.2	serine/threonine-protein kinase LATS2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10871863	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16413547	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10871863	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	12853976	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	20412773	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	15131260	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10871863	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12853976	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10871863	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytosol	IDA IDA: Inferred from direct assay	30865227	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10673337	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	12853976	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LATS2 Protein Structure

Pkinase

Pkinase_C

0
200
400
600
800
1000
1088 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase LATS2	LATS (large tumor suppressor, Drosophila) homolog 2

LATS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LATS2	Q9NRM7	MOB1B	Homo sapiens	Q7L9L4	Anti Tag CoIP	19739119
Intra	LATS2	Q9NRM7	MOB1B	Homo sapiens	Q7L9L4	Pull Down	32707033
Intra	LATS2	Q9NRM7	MOB1B	Homo sapiens	Q7L9L4	Pull Down	19739119
Intra	LATS2	Q9NRM7	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	33961781
Intra	LATS2	Q9NRM7	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	19739119
Intra	LATS2	Q9NRM7	SIAH2	Homo sapiens	O43255	Anti Bait CoIP	25438054
Intra	LATS2	Q9NRM7	AJUBA	Homo sapiens	Q96IF1	Anti Tag CoIP	16413547

Cross: Cross-species interaction Intra: Intraspecies interaction

LATS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811305	LATS2 Antibody	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Malignant Peritoneal Mesothelioma	Diffuse Malignant Peritoneal Mesothelioma Primary Malignant Peritoneal Mesothelioma Malignant Mesothelioma Of Peritoneum
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Peritoneal Mesothelioma	Malignant Mesothelioma Of Peritoneum Advanced Malignant Mesothelioma Of Peritoneum Advanced Malignant Peritoneal Mesothelioma Advanced Peritoneal Malignant Mesothelioma
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138489	TRULI	Inhibitor	99.98%	Unkown
HY-147082	GA-017		98.95%	Unkown
HY-W087830	L-p-Boronophenylalanine		99.84%	Unkown
HY-147165	VT02956	Inhibitor	99.58%	Unkown
HY-130504	Propargyl-PEG1-acid		97.0%	Unkown
HY-164254	Cardiomyocyte proliferation promoting agent-1	Inhibitor	99.87%	Unkown
HY-147165A	VT02956 hydrochloride	Inhibitor	/	Unkown
HY-175649	LATS1/2-IN-1	Inhibitor	/	Unkown
HY-RS07537	LAT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07539	LATS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18181	Lats2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21361	Lat2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24655	Lats2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27880	Lat2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LATS2	VGNC	VGNC:82443
Canis familiaris	LATS2	VGNC	VGNC:42599
Rattus norvegicus	LATS2	RGD	RGD:1305906
Macaca mulatta	LATS2	VGNC	VGNC:74239
Mus musculus	LATS2	MGD	MGI:1354386
Bos taurus	LATS2	VGNC	VGNC:30801
Others	LATS2	NCBI