2. Stem Cell/Wnt
  3. Large Tumor Suppressor (LATS) YAP
  4. GA-017

GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.

For research use only. We do not sell to patients.

CAS No. : 2351906-74-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 7 publication(s) in Google Scholar

GA-017 Related Antibodies

Top Publications Citing Use of Products

    GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828.  [Abstract]

    ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) and K-975 for 24 h. Then, qRT-PCR was used to detect the expression of TEAD1 and TEAD4.

    GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828.  [Abstract]

    GA-017 (10 μM) for 24 h. Wound healing assay (scale bar =100 μm) was performed to detect the changes of NCI-H520 cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.

    GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828.  [Abstract]

    GA-017 (10 μM) for 24 h. Transwell assay (scale bar =50 μm) was performed to detect the changes of cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.

    GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828.  [Abstract]

    ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) for 24 h or K-975. Then, qRT-PCR was performed to detect the expression of CSF1.

    GA-017 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Aug 18:S1097-2765(24)00633-6.  [Abstract]

    Caspase-1 (p20) and gasdermin D (cleaved N-term) processing upon NLRP3 inflammasome in BMDM cells with or without the treatment of TRULI and GA-017 (10 μM, 5h) .

    View All YAP Isoform Specific Products:

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    YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].

    IC50 & Target

    Lats1

     

    Lats2

     

    YAP/TAZ

     

    In Vitro

    GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1].
    GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM[1].
    GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    GA-017 Related Antibodies
    Molecular Weight

    343.38

    Formula

    C18H21N3O4
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9122 mL 14.5611 mL 29.1223 mL
    5 mM 0.5824 mL 2.9122 mL 5.8245 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.95%

    SDS (251 KB)

    COA (247 KB) HNMR (272 KB) LCMS (123 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9122 mL 14.5611 mL 29.1223 mL 72.8056 mL
    5 mM 0.5824 mL 2.9122 mL 5.8245 mL 14.5611 mL
    10 mM 0.2912 mL 1.4561 mL 2.9122 mL 7.2806 mL
    15 mM 0.1941 mL 0.9707 mL 1.9415 mL 4.8537 mL
    20 mM 0.1456 mL 0.7281 mL 1.4561 mL 3.6403 mL
    25 mM 0.1165 mL 0.5824 mL 1.1649 mL 2.9122 mL
    30 mM 0.0971 mL 0.4854 mL 0.9707 mL 2.4269 mL
    40 mM 0.0728 mL 0.3640 mL 0.7281 mL 1.8201 mL
    50 mM 0.0582 mL 0.2912 mL 0.5824 mL 1.4561 mL
    60 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2134 mL
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    GA-017 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GA-0172351906-74-4GA017GA 017Large Tumor Suppressor (LATS)YAPLarge Tumor SuppressorYes-associated proteinSKOV3 cellsHUVECsserine/threonine protein kinaseshigh-throughput screeninginhibitorLATSHippo pathwayInhibitorinhibit

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