1. Stem Cell/Wnt
  2. YAP
  3. GA-017

GA-017 

Cat. No.: HY-147082
Handling Instructions

GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.

For research use only. We do not sell to patients.

GA-017 Chemical Structure

GA-017 Chemical Structure

CAS No. : 2351906-74-4

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Description

GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].

IC50 & Target

IC50: 3.92 ± 0.42 nM (LATS2), 4.10 ± 0.79 nM (LATS1)[1]

In Vitro

GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1].
GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM[1].
GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

343.38

Formula

C18H21N3O4

CAS No.
SMILES

O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GA-017
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HY-147082
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