LATS2
Also designated KPM, LATS2 is the paralogue of LATS1 within the NDR branch and the Hippo kinase that most directly restrains YAP/TAZ-driven growth in mammalian cells. Like LATS1 it requires MST1/MST2 phosphorylation and MOB1 association, and it phosphorylates YAP on 14-3-3-binding serines to exclude it from the nucleus. LATS2 additionally engages p53 signalling, being induced by p53 and capable of antagonising MDM2, and it localises to centrosomes where it contributes to mitotic fidelity. The gene lies in a region frequently deleted in cancers, and reduced LATS2 expression correlates with poor prognosis in several tumour types. Recombinant LATS2 is used for Hippo and p53-pathway studies.
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LATS2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
