2351906-74-4
Chemical Structure
GA-017
- CAS No.: 2351906-74-4
- Formula:C18H21N3O4
- Molecular Weight:343.38
IUPAC Name: 1-((3R,10S,14aS)-11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-3-methyl-1,3,4,13,14,14a-hexahydro-2H-pyrazino[1',2':5,6][1,5]oxazocino[4,3,2-de]quinazolin-2-yl)prop-2-en-1-one
InChIKey: FBCPIOAXERAOIA-HKWRFOASSA-N
SMILES: O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
Biological Activity: GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].
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GA-017 | 98.95% | GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids. | ||||||||||||||||||||
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