PKUMDL-WQ-2101
Based on 1 Customer Validation
PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.94%
- No. CAS: 304481-72-9
- Fòrmula: C14H11N3O6
- Peso molecular:317.25
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
IC50: 34.8 μM (PHGDH)[1]
PKUMDL-WQ-2101 (72 hours) shows dose-dependent suppression effects on the cell viability at micromolar concentrations, with good selectivity for PHGDH amplified breast cancer cell lines. The antitumor activities of PKUMDL-WQ-2101 in the two PHGDH amplified breast cancer cell lines (MDA-MB-468 and HCC70) are 7.70 μM and 10.8 μM, respectively[1].
PKUMDL-WQ-2101 (2.5-40 μM; 24 hours) causes cell cycle arrest in MDA-MB-468 cells[1].
PKUMDL-WQ-2101 (37 μM; 24 hours) decreases de novo serine synthesis and metabolism downstream of the serine synthesis pathway, with effects comparable to PHGDH genetic deletion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 cells
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Concentration:2.5 μM, 5.0 μM, 20 μM and 40 μM
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Incubation Time:24 hours
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Result:Caused cell cycle arrest.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.CB17 Scid/J mice injected with MDA-MB-468 cells[1]
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Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:i.p; daily; for 30 days
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Result:Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.
Chemical Information
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No. CAS 304481-72-9
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Appearance Solid
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Peso molecular 317.25
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Fòrmula C14H11N3O6
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(C=C1O)O)N/N=C/C2=CC([N+]([O-])=O)=CC=C2O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 116.67 mg/mL (367.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1521 mL | 15.7604 mL | 31.5209 mL | 78.8022 mL |
| 5 mM | 0.6304 mL | 3.1521 mL | 6.3042 mL | 15.7604 mL | |
| 10 mM | 0.3152 mL | 1.5760 mL | 3.1521 mL | 7.8802 mL | |
| 15 mM | 0.2101 mL | 1.0507 mL | 2.1014 mL | 5.2535 mL | |
| 20 mM | 0.1576 mL | 0.7880 mL | 1.5760 mL | 3.9401 mL | |
| 25 mM | 0.1261 mL | 0.6304 mL | 1.2608 mL | 3.1521 mL | |
| 30 mM | 0.1051 mL | 0.5253 mL | 1.0507 mL | 2.6267 mL | |
| 40 mM | 0.0788 mL | 0.3940 mL | 0.7880 mL | 1.9701 mL | |
| 50 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5760 mL | |
| 60 mM | 0.0525 mL | 0.2627 mL | 0.5253 mL | 1.3134 mL | |
| 80 mM | 0.0394 mL | 0.1970 mL | 0.3940 mL | 0.9850 mL | |
| 100 mM | 0.0315 mL | 0.1576 mL | 0.3152 mL | 0.7880 mL |
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