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BI-4924 

Cat. No.: HY-126254 Purity: 98.48%
Handling Instructions

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h.

For research use only. We do not sell to patients.

BI-4924 Chemical Structure

BI-4924 Chemical Structure

CAS No. : 2244452-09-1

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10 mg USD 950 Ask For Quote & Lead Time
25 mg USD 1650 Ask For Quote & Lead Time
50 mg USD 2650 Ask For Quote & Lead Time

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Description

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1].

IC50 & Target

PHGDH[1]

In Vitro

BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor. BI-4924 shows high selectivity against the majority of other dehydrogenase targets[1].

Molecular Weight

499.36

Formula

C₂₁H₂₀Cl₂N₂O₆S

CAS No.

2244452-09-1

SMILES

O=C(O)CS(=O)(C1=CC=C([[email protected]](NC(C(N2C)=CC3=C2C=C(C)C(Cl)=C3Cl)=O)CO)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (250.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0026 mL 10.0128 mL 20.0256 mL
5 mM 0.4005 mL 2.0026 mL 4.0051 mL
10 mM 0.2003 mL 1.0013 mL 2.0026 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BI-4924BI4924BI 4924OthersInhibitorinhibitorinhibit

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Product Name:
BI-4924
Cat. No.:
HY-126254
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