2244452-09-1
Chemical Structure
BI-4924
- CAS No.: 2244452-09-1
- Formula:C21H20Cl2N2O6S
- Molecular Weight:499.36
IUPAC Name: (S)-2-((4-(1-(4,5-dichloro-1,6-dimethyl-1H-indole-2-carboxamido)-2-hydroxyethyl)phenyl)sulfonyl)acetic acid
InChIKey: CJEJFFCPVBZSIE-OAHLLOKOSA-N
SMILES: O=C(O)CS(=O)(C1=CC=C([C@H](NC(C(N2C)=CC3=C2C=C(C)C(Cl)=C3Cl)=O)CO)C=C1)=O
Biological Activity: BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BI-4924 | 99.55% | BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h. | ||||||||||||||||||||
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Keywords
