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CBR-5884 

Cat. No.: HY-100012 Purity: 98.90%
Handling Instructions

CBR-5884 is a novel and noncompetitive 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with IC50=33 μM).

For research use only. We do not sell to patients.

CBR-5884 Chemical Structure

CBR-5884 Chemical Structure

CAS No. : 681159-27-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 252 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 444 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 792 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CBR-5884 is a novel and noncompetitive 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with IC50=33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines and disrupted the oligomerization state of PHGDH. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH. The identification of a small molecule inhibitor of PHGDH not only enables thorough preclinical evaluation of PHGDH as a target in cancers, but also provides a tool with which to study serine metabolism. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

336.39

Formula

C₁₄H₁₂N₂O₄S₂

CAS No.

681159-27-3

SMILES

O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
CBR-5884
Cat. No.:
HY-100012
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