681159-27-3
Chemical Structure
CBR-5884
- CAS No.: 681159-27-3
- Formula:C14H12N2O4S2
- Molecular Weight:336.39
IUPAC Name: ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
InChIKey: QBVIRPJBDIZKBC-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC
Biological Activity: CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CBR-5884 | 98.73% | CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. | ||||||||||||||||||||
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