Devimistat (Synonyms: CPI-613)

Name: Devimistat
Brand: MedChemExpress
SKU: HY-15453
Rating: 5.0 (23 reviews)

Cat. No.: HY-15453 Purity: 99.57%: Data Sheet
COA

SDS
Handling Instructions
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Devimistat is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells.

For research use only. We do not sell to patients.

CAS No. : 95809-78-2

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of Devimistat:

Devimistat-d₁₀ In-stock

23 Publications Citing Use of MCE Devimistat

In Vivo Efficacy Study

Bio/Physico-chemical Assay

Cell Proliferation/Viability Assay

RT-PCR

: Devimistat purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Sep 26;10(1):315. [Abstract]; Cpi-613 (1 mg/mouse; i.p.). Effects of Cpi-613 in rhFGF21-promoted improvements of Echo parameters EF, FS, CO, LVEDD and LVESD in Fgf21-null mice fasted for 12 hours.

: Devimistat purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693.; CPI-613 (0-100 μM; 24 h). A375 cells treated with OGDH inhibitor (CPI-613), co-cultured with T cells, and stained with crystal violet to measure survival.

: Devimistat purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693.; CPI-613 (0-100 μM; 24 h). Western blot analysis of PD-L1 protein levels in A375 and SK-MEL-28 cells treated with OGDH inhibitor (CPI-613).

: Devimistat purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693.; CPI-613 (75-150 μM; 24 h). mRNA levels of PD-L1 in A375 cells treated with 3-NPA, DMM, or CPI-613.

: Devimistat purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 5:e20444. [Abstract]; NADH level and NADH/NAD⁺ ratio of SH‐SY5Y cells treated with 250 µM CuSO₄ and 4 nM CPI‐613 (CPI) for 18 h.

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Biological Activity
Purity & Documentation
References
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Description

Devimistat is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells^[1].

IC₅₀ & Target

mitochondrial metabolism^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 50 μM Compound: 2	Antiproliferative activity against human A549 cells by CCK8 assay Antiproliferative activity against human A549 cells by CCK8 assay	[PMID: 37939862]
HepG2	IC₅₀	> 50 μM Compound: 2	Antiproliferative activity against human HepG2 cells by CCK8 assay Antiproliferative activity against human HepG2 cells by CCK8 assay	[PMID: 37939862]
K562	IC₅₀	> 50 μM Compound: 2	Antiproliferative activity against human K562 cells by CCK8 assay Antiproliferative activity against human K562 cells by CCK8 assay	[PMID: 37939862]
MCF7	IC₅₀	> 50 μM Compound: 2	Antiproliferative activity against human MCF7 cells by CCK8 assay Antiproliferative activity against human MCF7 cells by CCK8 assay	[PMID: 37939862]
MDA-MB-231	IC₅₀	> 50 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells by CCK8 assay	[PMID: 37939862]
PANC-1	IC₅₀	> 50 μM Compound: 2	Antiproliferative activity against human PANC-1 cells by CCK8 assay Antiproliferative activity against human PANC-1 cells by CCK8 assay	[PMID: 37939862]

In Vitro

Devimistat induces apoptosis of GPM-2 gastric cancer cells. Devimistat targets the altered form of mitochondrial energy metabolism utilized by tumor cells. The change in mitochondrial enzyme activities and cellular redox status induced by devimistat leads to cell death, including apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

388.59

Formula

C₂₂H₂₈O₂S₂

CAS No.

95809-78-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (257.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5734 mL	12.8670 mL	25.7341 mL
5 mM	0.5147 mL	2.5734 mL	5.1468 mL
10 mM	0.2573 mL	1.2867 mL	2.5734 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 4

Add each solvent one by one: 2% DMSO 40% PEG300 5% Tween-80 53% Saline
Solubility: 2 mg/mL (5.15 mM); Suspended solution; Need ultrasonic
Protocol 5

Add each solvent one by one: 2% DMSO 98% (20% SBE-β-CD in Saline)
Solubility: ≥ 2 mg/mL (5.15 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (271 KB) SDS (399 KB)

COA (244 KB) HNMR (188 KB) LCMS (324 KB)

Handling Instructions (2659 KB)

References

[1]. Sakuratani T, et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway. Virchows Arch. 2021;478(3):401-411. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5734 mL	12.8670 mL	25.7341 mL	64.3352 mL
	5 mM	0.5147 mL	2.5734 mL	5.1468 mL	12.8670 mL
	10 mM	0.2573 mL	1.2867 mL	2.5734 mL	6.4335 mL
	15 mM	0.1716 mL	0.8578 mL	1.7156 mL	4.2890 mL
	20 mM	0.1287 mL	0.6434 mL	1.2867 mL	3.2168 mL
	25 mM	0.1029 mL	0.5147 mL	1.0294 mL	2.5734 mL
	30 mM	0.0858 mL	0.4289 mL	0.8578 mL	2.1445 mL
	40 mM	0.0643 mL	0.3217 mL	0.6434 mL	1.6084 mL
	50 mM	0.0515 mL	0.2573 mL	0.5147 mL	1.2867 mL
	60 mM	0.0429 mL	0.2145 mL	0.4289 mL	1.0723 mL
	80 mM	0.0322 mL	0.1608 mL	0.3217 mL	0.8042 mL
	100 mM	0.0257 mL	0.1287 mL	0.2573 mL	0.6434 mL

Devimistat Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Devimistat95809-78-2CPI-613CPI613CPI 613ApoptosisMitochondrial MetabolismmitochondrialipoicacidabrogatesapoptosiscancerInhibitorinhibitorinhibit

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Devimistat (Synonyms: CPI-613)

Customer Review

Other Forms of Devimistat:

Devimistat Related Antibodies

23 Publications Citing Use of MCE Devimistat

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•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

Customer Review

Devimistat Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Devimistat Related Classifications

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