1. Apoptosis
  2. Apoptosis
  3. Devimistat

Devimistat (Synonyms: CPI-613)

Cat. No.: HY-15453 Purity: 99.59%
Handling Instructions

Devimistat (CPI-613) is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.

For research use only. We do not sell to patients.

Devimistat Chemical Structure

Devimistat Chemical Structure

CAS No. : 95809-78-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 78 In-stock
Estimated Time of Arrival: December 31
50 mg USD 168 In-stock
Estimated Time of Arrival: December 31
100 mg USD 216 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Devimistat (CPI-613) is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.

Clinical Trial
Molecular Weight

388.59

Formula

C₂₂H₂₈O₂S₂

CAS No.

95809-78-2

SMILES

O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (257.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5734 mL 12.8670 mL 25.7341 mL
5 mM 0.5147 mL 2.5734 mL 5.1468 mL
10 mM 0.2573 mL 1.2867 mL 2.5734 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

  • 4.

    Add each solvent one by one:  2% DMSO    40% PEG300    5% Tween-80    53% saline

    Solubility: 2 mg/mL (5.15 mM); Suspended solution; Need ultrasonic

  • 5.

    Add each solvent one by one:  2% DMSO    98% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (5.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.59%

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

DevimistatCPI-613CPI613CPI 613ApoptosisInhibitorinhibitorinhibit

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Devimistat
Cat. No.:
HY-15453
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