2-Deoxy-D-glucose
Based on 378 publication(s) in Google Scholar
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 154-17-6
- Formula: C6H12O5
- Molecular Weight:164.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) 2-Deoxy-D-glucose
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- Research Square Preprint. 2021 Dec.
- SSRN. 15 Sep 2021 .
- Biomed Pharmacother. 2021 Oct:142:111652. [Abstract]
- Research Square Preprint. 2021 Feb.
- Biomed Pharmacother. 2020 Jan;121:109521. [Abstract]
- Oncotarget. 2017 Jul 4;8(27):44669-44681. [Abstract]
Customer Validation & Images
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IF
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Cell Proliferation/Viability Assay
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IF
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
Biological Activity
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HSV-1 |
2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner[1]. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 154-17-6
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Appearance Solid
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Molecular Weight 164.16
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Formula C6H12O5
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Color White to off-white
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SMILES
OC1O[C@@H]([C@@H](O)[C@H](O)C1)CO
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Synonyms
2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (378)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Signal Transduct Target Ther
2023 Feb 15;8(1):65. PMID: 36788227
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]
Survival fraction of parental or PSAT1 knockout PLC/PRF/5 cells treated with or without 2.5 mM 2-DG (2-Deoxy-D-glucose).
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Nature
2025 Feb;638(8052):1112-1121. PMID: 39814884
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Nature. 2025 Feb;638(8052):1112-1121. [Abstract]
2-deoxy-d-glucose (10 mM; 16 h) significantly reduces FOXM1 nuclear condensates in FOXM1-GFP stable HeLa cells.
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Cancer Cell
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. [Abstract]2020 Sep 14;38(3):350-365.e7. PMID: 32619406
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2020 Sep 14;38(3):350-365.e7. [Abstract]
IB analysis of C4-2 and 22RV-1 cells treated with 1 mM AICAR or 25 mM 2-DG (2-Deoxy-D-glucose) for 24 h.
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Cell Metab
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies. [Abstract]2022 Dec 6;34(12):1999-2017.e10. PMID: 36395769 -
Cell Metab
2022 Nov 1;34(11):1843-1859.e11. PMID: 36103895 -
Cell Metab
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets. [Abstract]2021 Jan 5;33(1):51-64.e9. PMID: 33181091 -
Cell Res
2021 Mar;31(3):291-311. PMID: 33299139
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Cell Res. 2021 Mar;31(3):291-311. [Abstract]
Immunoblot analysis of anti-PTEN immunoprecipitate and WCL from MCF-7 cells. MCF-7 cells were treated with MMS (0.2 mM, 1 h), or cisplatin (1 μM, 12 h), or cold shock (4 °C for 30 min, then 37 °C for 4 h), or heat shock (45 °C for 30 min, then 37 °C for 4 h), or serum-starved for 4 h, or 2-DG (5 μM, 24 h), or H2O2 (800 μM, 30 min) before harvested.
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Gastroenterology
2024 Jan 24:S0016-5085(24)00064-7. PMID: 38272100
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2024 Jan 24:S0016-5085(24)00064-7. [Abstract]
2-Deoxy-D-glucose (2-DG) (5 mM; 3 days) exhibits toxic effects on normal gastric organoids, leading to their death within 3 days of treatment.
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Cancer Commun (Lond)
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells. [Abstract]2021 Jan;41(1):62-78. PMID: 34236149
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Jan;41(1):62-78. [Abstract]
2-Deoxy-D-glucose (2-DG) (10 μM; 6 h) significantly increases the basal and EGFR activation in SMMC-7721 and HepG2 cells.
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Nat Aging
Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow. [Abstract]2025 May;5(5):831-847. PMID: 40050412 -
Cell Mol Immunol
MAIT cell plasticity generates CD4+ MAIT cells that promote HCC progression via metabolic crosstalk with tumor cells. [Abstract]2026 May;23(5):491-504. PMID: 41974917 -
Cell Mol Immunol
2026 Mar;23(3):284-300. PMID: 41530535 -
Cell Mol Immunol
Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells. [Abstract]2024 Dec;21(12):1474-1490. PMID: 39468304 -
Cell Mol Immunol
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis. [Abstract]2024 Jun;21(6):546-560. PMID: 38641698 -
Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Cell Stem Cell
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation. [Abstract]2025 Apr 3;32(4):581-597.e11. PMID: 39986274 -
Cell Stem Cell
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. [Abstract]2023 Apr 6;30(4):450-459.e9. PMID: 36944335 -
Cell Stem Cell
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis. [Abstract]2022 Jul 7;29(7):1119-1134.e7. PMID: 35803229 -
Nat Cell Biol
2024 Jun;26(6):917-931. PMID: 38714852
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Jun;26(6):917-931. [Abstract]
Representative confocal IF images of IRE1α (red) along with G3BP1 (green) in HeLa cells cultured in glucose-free medium (GD) without (Ctrl) or with 25 mM 2-deoxy-D-glucose (2-DG) for 1 h.
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Cancer Res
Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer. [Abstract]2022 Apr 15;82(8):1503-1517. PMID: 35255118 -
Cancer Res
MTAP Deficiency-Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer. [Abstract]2021 Oct 1;81(19):4964-4980. PMID: 34385182 -
Drug Resist Updat
Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression. [Abstract]2023 Jul:69:100976. PMID: 37210811 -
Bone Res
2024 Aug 28;12(1):49. PMID: 39198395 -
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Nat Microbiol
Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection. [Abstract]2025 Oct;10(10):2521-2536. PMID: 40983701 -
Autophagy
Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment. [Abstract]2026 Jul;22(7):1679-1697. PMID: 41975562 -
Autophagy
Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an alzheimer disease animal model. [Abstract]2024 Dec;20(12):2655-2676. PMID: 39051473 -
Autophagy
Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. [Abstract]2023 Nov;19(11):2982-2996. PMID: 37439113 -
Autophagy
The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy. [Abstract]2019 Jul;15(7):1150-1162. PMID: 30724690 -
Nat Protoc
Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors. [Abstract]2024 May;19(5):1311-1347. PMID: 38307980 -
Nat Commun
INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesis. [Abstract]2026 Mar 15;17(1):4002. PMID: 41833955 -
Nat Commun
Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation. [Abstract]2026 Jan 31;17(1):2227. PMID: 41620436 -
Nat Commun
Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation. [Abstract]2025 Dec 12. PMID: 41387463 -
Nat Commun
Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain. [Abstract]2025 Dec 12;16(1):11314. PMID: 41387431 -
Nat Commun
Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice. [Abstract]2025 Sep 30;16(1):8639. PMID: 41027887 -
Nat Commun
A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. [Abstract]2025 May 7;16(1):4245. PMID: 40335490 -
Nat Commun
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma. [Abstract]2025 Feb 18;16(1):1736. PMID: 39966385 -
Nat Commun
Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy. [Abstract]2024 May 31;15(1):4665. PMID: 38821965 -
Nat Commun
Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS. [Abstract]2022 May 13;13(1):2673. PMID: 35562374 -
Nat Commun
2022 May 12;13(1):2638. PMID: 35551189 -
Nat Commun
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects. [Abstract]2019 Nov 8;10(1):5091. PMID: 31704924 -
ACS Nano
Three-Dimensional Semiconductor Network as Regulators of Energy Metabolism Drives Angiogenesis in Bone Regeneration. [Abstract]2024 Nov 26;18(47):32602-32616. PMID: 39530623
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Nov 26;18(47):32602-32616. [Abstract]
2-Deoxy-D-glucose (2 mM; 4 h) reverses 3D-NTBH-induced angiogenesis in HUVECs by inhibiting glycolysis.
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J Adv Res
High throughput screening identifies sanguinarine chloride as a multi-faceted therapeutic agent for PRCC-TFE3 rRCC by targeting lactylation-driven VEGFB-VEGFR2 signaling and PMN-MDSC infiltration. [Abstract]2026 Apr 7:S2090-1232(26)00291-2. PMID: 41956242 -
J Adv Res
2025 Sep 26:S2090-1232(25)00756-8. PMID: 41016592 -
J Adv Res
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1. [Abstract]2025 Aug 5:S2090-1232(25)00587-9. PMID: 40759348 -
J Adv Res
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis. [Abstract]2025 Jan:67:217-229. PMID: 38219869 -
Cell Discov
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma. [Abstract]2025 Oct 7;11(1):81. PMID: 41057295 -
Sci Immunol
2026 May;11(119):eadz0348. PMID: 42066062 -
Sci Immunol
Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors. [Abstract]2023 Sep 29;8(87):eabq2424. PMID: 37738362 -
Redox Biol
Mitochondrial OXPHOS integrates immunometabolic cascade for bone regeneration via coupled ATP production and ROS homeostasis. [Abstract]2026 Jun 22:95:104272. PMID: 42335846 -
Redox Biol
Mitochondrial superoxide sustains a senescence-like phenotype in PARP- inhibited ovarian cancer cells by stabilizing HIF1α. [Abstract]2026 Jun:93:104158. PMID: 41980461 -
Redox Biol
Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis. [Abstract]2026 Mar 31:93:104139. PMID: 41980459 -
Redox Biol
Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD. [Abstract]2025 Sep:85:103762. PMID: 40644925 -
Redox Biol
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation. [Abstract]2025 Apr:81:103553. PMID: 39970777 -
Redox Biol
Exosome-equipped TNF antisense oligodeoxynucleotide or 2-deoxy-D-glucose ameliorated nonalcoholic steatohepatitis by modulating superoxide dismutase 1 in mice. [Abstract]2025 Jan 3:80:103488. PMID: 39778469 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
Redox Biol
FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue. [Abstract]2023 Nov:67:102877. PMID: 37690164 -
Redox Biol
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]2021 Oct:46:102082. PMID: 34343908 -
Redox Biol
2020 Nov 1;38:101771. PMID: 33189984 -
Gut Microbes
2025 Dec;17(1):2508949. PMID: 40409349 -
Gut Microbes
M28 family peptidase derived from Peribacillus frigoritolerans initiates trained immunity to prevent MRSA via the complosome-phosphatidylcholine axis. [Abstract]2025 Dec;17(1):2484386. PMID: 40159598 -
Gut Microbes
Gut microbiota mediates the inhibition of lymphopoiesis in dietary-restricted mice by suppressing glycolysis. [Abstract]2022 Jan-Dec;14(1):2117509. PMID: 36049025 -
Nucleic Acids Res
A subcellular selective APEX2-based proximity labeling used for identifying mitochondrial G-quadruplex DNA binding proteins. [Abstract]2024 Dec 24:gkae1259. PMID: 39718986 -
Nucleic Acids Res
2023 Oct 13;51(18):9733-9747. PMID: 37638744 -
Theranostics
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis. [Abstract]2024 Jul 8;14(11):4256-4277. PMID: 39113793 -
J Exp Clin Cancer Res
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer. [Abstract]2024 Oct 10;43(1):284. PMID: 39385213 -
J Exp Clin Cancer Res
The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysis. [Abstract]2021 Dec 10;40(1):390. PMID: 34893086 -
Adv Sci (Weinh)
Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells. [Abstract]2026 Apr 22:e22570. PMID: 42018132 -
Adv Sci (Weinh)
Disengaging the Engine: Histone Deacetylases 1 and 2-Mediated Acetylation of Hexokinase-2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage. [Abstract]2026 Mar;13(14):e00194. PMID: 41632031 -
Adv Sci (Weinh)
Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication. [Abstract]2025 Oct 27:e09148. PMID: 41144710 -
Adv Sci (Weinh)
Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate. [Abstract]2025 Oct 13:e09383. PMID: 41082369 -
Adv Sci (Weinh)
LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells. [Abstract]2025 Aug 19:e05666. PMID: 40831212 -
Adv Sci (Weinh)
Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury. [Abstract]2025 Aug 20:e11873. PMID: 40832885 -
Adv Sci (Weinh)
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma. [Abstract]2025 Jun 5:e06529. PMID: 40470706 -
Adv Sci (Weinh)
High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1. [Abstract]2025 Mar 27:e2415530. PMID: 40145796 -
Adv Sci (Weinh)
Hsp90 Promotes Gastric Cancer Cell Metastasis and Stemness by Regulating the Regional Distribution of Glycolysis-Related Metabolic Enzymes in the Cytoplasm. [Abstract]2024 Jun 14:e2310109. PMID: 38874476 -
Adv Sci (Weinh)
Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury. [Abstract]2024 May 20:e2307216. PMID: 38767134 -
Cell Rep Med
Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression. [Abstract]2026 Jun 16;7(6):102833. PMID: 42173096 -
Sci Adv
Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma. [Abstract]2025 May 23;11(21):eadv0558. PMID: 40397754 -
Sci Adv
Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis. [Abstract]2024 Sep 13;10(37):eadi7673. PMID: 39270021 -
Sci Adv
Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation. [Abstract]2022 Feb 25;8(8):eabj2488. PMID: 35196096 -
Cell Death Differ
Targeting ADAR1 lactylation activates innate immune and overcomes chemoresistance in ovarian cancer. [Abstract]2026 May 25. PMID: 42185630 -
Cell Death Differ
Matrix stiffness-induced YEATS2 drives HCC progression via epigenetic activation of the TGFBR2-TAZ-AKT pathway. [Abstract]2026 Mar 3. PMID: 41776086 -
Biomaterials
2025 Dec 18:329:123925. PMID: 41453350 -
Research (Wash D C)
Trabecular-Like Scaffold Dictates Osteogenesis via Fluid Shear Stress-Induced Metabolic Reprogramming through the CAV1-HIF-1α Axis. [Abstract]2026 Jun 16:9:1307. PMID: 42312216 -
Cell Death Dis
2026 Jun 9. PMID: 42265088 -
Cell Death Dis
PEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis. [Abstract]2026 Jun 3. PMID: 42236665 -
Cell Death Dis
De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming. [Abstract]2025 Dec 10;16(1):889. PMID: 41372134 -
Cell Death Dis
Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function. [Abstract]2025 Oct 21;16(1):743. PMID: 41120289 -
Cell Death Dis
NLRP12 decreases TRIM25-mediated HK2 degradation to promote glycolysis and H3K18la in gastric cancer. [Abstract]2025 Aug 13;16(1):615. PMID: 40796546 -
Cell Mol Biol Lett
Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1. [Abstract]2025 May 7;30(1):57. PMID: 40335899 -
Environ Sci Technol
Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models. [Abstract]2025 Apr 3. PMID: 40178189 -
Cell Mol Biol Lett
2025 Mar 31;30(1):38. PMID: 40165083 -
Cell Death Dis
High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy-lysosomal pathway in endometrial cancer. [Abstract]2025 Mar 17;16(1):182. PMID: 40097416 -
Cell Death Dis
Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis. [Abstract]2025 Mar 20;16(1):193. PMID: 40113760 -
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Cell Mol Biol Lett
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. [Abstract]2023 Oct 12;28(1):79. PMID: 37828427 -
Cell Death Dis
Hypoxia-induced ALDH3A1 promotes the proliferation of non-small-cell lung cancer by regulating energy metabolism reprogramming. [Abstract]2023 Sep 20;14(9):617. PMID: 37730658 -
Cell Death Dis
Hypoxia-mediated promotion of glucose metabolism in non-small cell lung cancer correlates with activation of the EZH2/FBXL7/PFKFB4 axis. [Abstract]2023 May 13;14(5):326. PMID: 37179372 -
Cell Death Dis
2022 Mar 11;13(3):229. PMID: 35277475 -
Cell Death Dis
PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure. [Abstract]2021 Nov 16;12(12):1087. PMID: 34789720 -
Cell Death Dis
PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex. [Abstract]2021 Mar 15;12(3):276. PMID: 33723221 -
Cell Mol Biol Lett
Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2. [Abstract]2019 Aug 14:24:52. PMID: 31428167 -
Cancer Lett
Stress-inducible circSCLT1 scaffolds HNRNPA1/CSDE1 to amplify IL1B/NF-κB signaling in TNBC via mRNA stabilization, suppressor degradation, and stress granule shielding. [Abstract]2026 Aug 1:652:218561. PMID: 42092680 -
Cancer Lett
Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition. [Abstract]2026 May 28:646:218425. PMID: 41819525 -
Cancer Lett
Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming. [Abstract]2022 Dec 1:550:215918. PMID: 36150633 -
Cancer Lett
De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer. [Abstract]2022 Nov 28:549:215837. PMID: 35921972 -
J Allergy Clin Immunol
Brg1-imprinted chromatin status controls effector and memory group 2 innate lymphoid cell metabolism to exacerbate allergic lung inflammation. [Abstract]2025 Sep 17:S0091-6749(25)00948-0. PMID: 40972980 -
Int J Biol Sci
IC261, a specific inhibitor of CK1δ/ε, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer. [Abstract]2020 Jan 17;16(5):882-892. PMID: 32071557 -
Cell Commun Signal
HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses. [Abstract]2025 May 9;23(1):219. PMID: 40346557 -
Cell Commun Signal
Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects. [Abstract]2025 Feb 19;23(1):99. PMID: 39972350 -
Cell Commun Signal
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway. [Abstract]2022 Oct 27;20(1):168. PMID: 36303144 -
Cell Commun Signal
Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth. [Abstract]2022 Jul 16;20(1):105. PMID: 35842652 -
Phytomedicine
Modified Fuzheng Yiliu Decoction chemosensitizes colorectal cancer by inhibiting cancer stem cell metabolism and stemness through CAV1/ZNF460/GRP78 signaling. [Abstract]2026 Jul 25:157:158317. PMID: 42177885 -
Phytomedicine
Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization. [Abstract]2024 Jul:129:155675. PMID: 38678954 -
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EBioMedicine
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. [Abstract]2023 Feb:88:104444. PMID: 36709580 -
Mater Today Bio
Nutrient transporter-oriented nanoinhibitor counteracts intracellular metabolic reprogramming for RT-resistant HCC treatment. [Abstract]2025 Feb 25:31:101608. PMID: 40104639 -
Burns Trauma
Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780. [Abstract]2022 Jun 24;10:tkac015. PMID: 35769829 -
J Hazard Mater
Cardiotoxicity of tris(2-chloroethyl) phosphate exposure: Insights into the role of oxygen sensor mediated energy metabolism remodeling. [Abstract]2025 Jan 4:486:137113. PMID: 39787855 -
Cell Death Discov
2025 Nov 7;11(1):509. PMID: 41203613 -
Cell Death Discov
DNMBP-AS1/hsa-miR-30a-5p/PGC1α axis suppresses tumor progression of colorectal cancer by inhibiting PKM2-mediated Warburg effect and enhance anti-PD-1 therapy efficacy. [Abstract]2025 Jul 2;11(1):299. PMID: 40603870 -
Acta Pharmacol Sin
Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma. [Abstract]2021 May;42(5):814-823. PMID: 32855532 -
Cell Death Discov
Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism. [Abstract]2019 Mar 11:5:76. PMID: 30886744 -
NPJ Precis Oncol
TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK. [Abstract]2025 Jun 5;9(1):163. PMID: 40473847 -
J Transl Med
Vitamin D attenuates the progression of pulmonary fibrosis via inhibiting thymidine kinase 1/PFKFB3-driven glycolysis. [Abstract]2026 Apr 22;24(1):571. PMID: 42021376 -
J Transl Med
Lactylation-induced ALKBH5 targets RNF123 to worsen retinal Müller cell activation through PKM2-regulated Glycolysis in diabetic retinopathy. [Abstract]2025 Oct 15;23(1):1105. PMID: 41094513 -
J Transl Med
HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients. [Abstract]2025 Feb 10;23(1):172. PMID: 39930487 -
J Transl Med
FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple-negative breast cancer. [Abstract]2025 Jan 2;23(1):1. PMID: 39748430 -
J Transl Med
Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1. [Abstract]2024 Jan 18;22(1):74. PMID: 38238754 -
J Transl Med
Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent. [Abstract]2023 Oct 26;21(1):754. PMID: 37884960 -
J Transl Med
ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy. [Abstract]2023 Sep 7;21(1):605. PMID: 37679788 -
Proc Natl Acad Sci U S A
2025 Nov 25;122(47):e2518190122. PMID: 41264257 -
Proc Natl Acad Sci U S A
2025 Mar 11;122(10):e2404899122. PMID: 40030031 -
Oncogene
The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity. [Abstract]2024 Oct;43(44):3215-3226. PMID: 39285229 -
Apoptosis
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis. [Abstract]2025 Apr 1. PMID: 40167953 -
Int J Biol Macromol
A dual-pronged glycopeptide hydrogel promotes diabetic wound healing by synchronizing metabolic-angiogenic recoupling. [Abstract]2026 Jun:365:152318. PMID: 42097422 -
Int J Biol Macromol
Lipocalin 2 deficiency attenuates NLRP3 inflammasome activation through glycolysis impairment and MGST1-mediated mitochondrial ROS reduction. [Abstract]2025 Dec;334(Pt 1):149021. PMID: 41260431 -
Int J Mol Med
miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis. [Abstract]2026 Jul;58(1):178. PMID: 42138198 -
Neural Regen Res
2025 Oct 30. PMID: 41169225 -
Neural Regen Res
Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming. [Abstract]2025 Apr 1;20(4):1178-1191. PMID: 38989955 -
J Clin Periodontol
Exosomes Derived From Human Gingival Mesenchymal Stem Cells Induce Metabolic Reprogramming of Inflammatory Macrophages. [Abstract]2025 Aug;52(8):1196-1210. PMID: 40388972 -
Antioxidants (Basel)
2023 Jun 19;12(6):1304. PMID: 37372033 -
Mol Cells
Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells. [Abstract]2019 Sep 30;42(9):628-636. PMID: 31564074 -
Phytother Res
Sarsasapogenin, a principal active component absorbed into blood of total saponins of Anemarrhena, attenuates proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes through downregulating PKM2 inhibited pathological glycolysis. [Abstract]2023 May;37(5):1951-1967. PMID: 36631974 -
Free Radic Biol Med
p67phox/NOX2 inhibits psoriasis by regulating the HIF-1α-glycolysis axis via p53-AMPK in keratinocytes. [Abstract]2025 Sep:237:503-514. PMID: 40516795 -
Free Radic Biol Med
Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway. [Abstract]2025 Jan 27:229:350-363. PMID: 39864757 -
Free Radic Biol Med
Influenza A virus-induced glycolysis facilitates virus replication by activating ROS/HIF-1α pathway. [Abstract]2024 Nov 20:225:910-924. PMID: 39491735 -
Free Radic Biol Med
Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked. [Abstract]2024 Feb 20:212:117-132. PMID: 38151213 -
Free Radic Biol Med
Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum. [Abstract]2020 Feb 1;147:220-230. PMID: 31883976 -
Free Radical Bio Med
Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII. [Abstract]2020 Jan;146:119-129. PMID: 31669347 -
EMBO Mol Med
Glycine decarboxylase advances IgA nephropathy by boosting mesangial cell proliferation through the pyrimidine pathway. [Abstract]2025 Oct 13. PMID: 41083822 -
Cancer Immunol Res
Herpes virus entry mediator costimulation signaling enhances CAR-T cell efficacy against solid tumors through metabolic reprogramming. [Abstract]2023 Apr 3;11(4):515-529. PMID: 36689620 -
Clin Transl Med
Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A. [Abstract]2022 Jan;12(1):e686. PMID: 35090076 -
Br J Cancer
2026 Jun 26. PMID: 42362869 -
Am J Chin Med
Triptolide from Tripterygium wilfordii Suppresses Glycolysis and Induces Cuproptosis via the HK2/DLAT Signaling Pathway in Colorectal Cancer. [Abstract]2026;54(2):661-683. PMID: 41709570 -
Am J Chin Med
Cannabidiol Reprograms Glucose Metabolism in Colorectal Adenocarcinoma by Targeting HIF-1α/LDHA Pathway. [Abstract]2025;53(8):2561-2578. PMID: 41219135 -
Stem Cell Res Ther
H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis. [Abstract]2025 Oct 1;16(1):538. PMID: 41035068 -
ACS Appl Mater Interfaces
Peptide Hydrogels for Renal Carcinoma Therapy via Synergistic Inhibition of Glycolysis and Mitochondrial Metabolism Reprogramming. [Abstract]2025 Jun 25;17(25):36487-36496. PMID: 40518708 -
Stem Cell Res Ther
MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria. [Abstract]2024 May 1;15(1):127. PMID: 38693589 -
Aging Cell
Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target. [Abstract]2026 Mar;25(3):e70434. PMID: 41786630 -
Cell Rep
Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages. [Abstract]2026 Mar 13;45(3):117106. PMID: 41831231 -
Cell Rep
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]2025 Jun 13;44(6):115851. PMID: 40516055 -
Cell Rep
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD. [Abstract]2025 Feb 25;44(3):115350. PMID: 40014451 -
Cell Rep
H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response. [Abstract]2024 Aug 30;43(9):114686. PMID: 39216002 -
Cell Rep
p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP. [Abstract]2023 Nov 14;42(11):113426. PMID: 37967006 -
Cell Rep
Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria. [Abstract]2023 Sep 26;42(9):113147. PMID: 37756158 -
Cell Rep
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. [Abstract]2022 Nov 22;41(8):111707. PMID: 36417875 -
Br J Pharmacol
Ailanthone alleviates septic cardiomyopathy by attenuating MYST histone acetyltransferase 1 (MOF)-mediated H4K16 lactylation-driven inflammation. [Abstract]2026 Aug;183(15):4364-4380. PMID: 42053209 -
Br J Pharmacol
Ginsenoside compound K up-regulates β-subunits of long-chain L-3-hydroxyacyl-CoA (HADHB) to promote fatty acid oxidation recovery and improve the balance of macrophage polarization in mice with ulcerative colitis. [Abstract]2026 Jul;183(13):3633-3650. PMID: 41918496 -
Br J Pharmacol
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells. [Abstract]2023 Jul;180(14):1862-1877. PMID: 36740831 -
Br J Pharmacol
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease. [Abstract]2019 Mar;176(5):711-724. PMID: 30515768 -
Chin Med
Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival. [Abstract]2024 Mar 1;19(1):37. PMID: 38429848 -
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Anal Chem
Streamlined Methods for Profiling Targeted Michael Acceptor Molecules Reveal Natural PTP1B Covalent Inhibitors. [Abstract]2025 Oct 1. PMID: 41035255 -
Anal Chem
2025 May 6;97(17):9192-9201. PMID: 40289315 -
Environ Pollut
Silica-induced innate immune activation drives macrophage pyroptosis and lung inflammation through glycolytic reprogramming. [Abstract]2025 Oct 1:382:126762. PMID: 40614958 -
Cancer Cell Int
Icariin-curcumol inhibits histone H3K18 lactylation and FOXM1 expression to enhance the sensitivity of prostate cancer cells to docetaxel. [Abstract]2025 Nov 25;25(1):423. PMID: 41291725 -
Front Immunol
TCR signaling and cellular metabolism regulate the capacity of murine epidermal γδ T cells to rapidly produce IL-13 but not IFN-γ. [Abstract]2024 Feb 28:15:1361139. PMID: 38482017 -
Front Immunol
The mTORC1 Signaling Support Cellular Metabolism to Dictate Decidual NK Cells Function in Early Pregnancy. [Abstract]2022 Mar 10;13:771732. PMID: 35359988 -
Front Immunol
Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF. [Abstract]2021 May 12:12:639049. PMID: 34054807 -
PLoS Biol
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation. [Abstract]2025 Sep 16;23(9):e3003364. PMID: 40956859 -
PLoS Biol
HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma. [Abstract]2021 Apr 27;19(4):e3001197. PMID: 33905408 -
J Autoimmun
Neutrophil extracellular traps induce trophoblasts pyroptosis via enhancing NLRP3 lactylation in SLE pregnancies. [Abstract]2025 Apr 2:153:103411. PMID: 40179478 -
J Ethnopharmacol
Erjingpill bionic cerebrospinal fluid alleviates LPS-induced inflammatory response in BV2 cells by inhibiting glycolysis via mTOR. [Abstract]2024 May 31:118412. PMID: 38824976 -
Biomater Adv
Matrix stiffness modulates YAP-mediated glycolysis and proliferation in human corneal endothelial cells. [Abstract]2026 Mar:180:214594. PMID: 41218465 -
Ecotoxicol Environ Saf
Glycolytic reprogramming governs crystalline silica-induced pyroptosis and inflammation through promoting lactylation modification. [Abstract]2024 Aug 31:283:116952. PMID: 39217895 -
Ecotoxicol Environ Saf
Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming. [Abstract]2024 Feb:271:115994. PMID: 38262094 -
Ecotoxicol Environ Saf
2-Deoxy-D-glucose ameliorates inflammation and fibrosis in a silicosis mouse model by inhibiting hypoxia-inducible factor-1α in alveolar macrophages. [Abstract]2024 Jan 1:269:115767. PMID: 38039851 -
Ecotoxicol Environ Saf
2022 Sep 1:242:113913. PMID: 35907323 -
Cell Mol Life Sci
Hypoxia drives cervical cancer progression via OCT4/ORAI3-dependent glycolysis and Ca2+ signaling. [Abstract]2025 Nov 6;82(1):390. PMID: 41196424 -
Biochem Pharmacol
2025 Aug 28;242(Pt 2):117289. PMID: 40885322 -
Biochem Pharmacol
Dexmedetomidine alleviates renal ischemia reperfusion injury via suppressing SLC2A1-mediated glycolysis. [Abstract]2025 Jul 12:241:117166. PMID: 40659130 -
Cell Mol Life Sci
Dual phosphorylation of glycogen synthase kinase 3β differentially integrates metabolic programs to determine T cell immunity across vertebrates. [Abstract]2025 May 28;82(1):218. PMID: 40434714 -
Biochem Pharmacol
Dihydroartemisinin breaks the positive feedback loop of YAP1 and GLUT1-mediated aerobic glycolysis to boost the CD8+ effector T cells in hepatocellular carcinoma. [Abstract]2024 May 14:225:116294. PMID: 38754557 -
Biochem Pharmacol
Canagliflozin inhibits p-gp function and early autophagy and improves the sensitivity to the antitumor effect of doxorubicin. [Abstract]2020 May;175:113856. PMID: 32061772 -
Life Sci
Aberrant interferon-γ signaling disrupts trophoblast invasion via IDO1/AHR signaling and metabolic reprogramming associated with recurrent pregnancy loss. [Abstract]2026 Apr 1:390:124256. PMID: 41655779 -
Int Endod J
Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation. [Abstract]2023 Jun;56(6):734-747. PMID: 36938709 -
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J Cell Biol
Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation. [Abstract]2025 Dec 1;224(12):e202501122. PMID: 41147954 -
Oncogenesis
PLEKHA4 is transcriptionally regulated by HOXD9 and regulates glycolytic reprogramming and progression in glioblastoma via activation of the STAT3/SOCS-1 pathway. [Abstract]2025 May 9;14(1):15. PMID: 40346039 -
EMBO Rep
Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis. [Abstract]2024 Mar;25(3):971-990. PMID: 38279020 -
Cells
2-Deoxy-D-glucose Alleviates Cancer Cachexia-Induced Muscle Wasting by Enhancing Ketone Metabolism and Inhibiting the Cori Cycle. [Abstract]2022 Sep 25;11(19):2987. PMID: 36230949 -
Oncogenesis
2022 Apr 11;11(1):15. PMID: 35410460 -
Pharm Biol
α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis. [Abstract]2021 Dec;59(1):11-20. PMID: 33356727 -
Cancer Metab
PFKFB4 promotes M2 polarization of tumor-associated macrophages through aerobic glycolysis-mediated modification of histone H3K18 lactylation in hepatocellular carcinoma. [Abstract]2026 Apr 15;14(1):15. PMID: 41987314 -
Cancer Metab
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells. [Abstract]2026 Apr 2;14(1):13. PMID: 41928364 -
Cancer Metab
Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation. [Abstract]2025 Mar 31;13(1):16. PMID: 40165271 -
Cancer Metab
Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer. [Abstract]2022 Dec 6;10(1):22. PMID: 36474242 -
Commun Biol
Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in piglets. [Abstract]2025 Nov 20;8(1):1626. PMID: 41266595 -
Commun Biol
Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism. [Abstract]2025 Feb 8;8(1):205. PMID: 39922943 -
Cancer Nanotechnol
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Respir Res
Activation of WDHD1 by DNA demethylases promotes MINPP1 transcription and glycolysis in lung adenocarcinoma progression. [Abstract]2025 Nov 25;26(1):330. PMID: 41291744 -
Cell Biol Toxicol
CPT1A mediates succinylation of LDHA at K318 site promoteing metabolic reprogramming in NK/T-cell lymphoma nasal type. [Abstract]2025 Feb 11;41(1):42. PMID: 39934546 -
Respir Res
Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia. [Abstract]2024 Dec 26;25(1):443. PMID: 39725939 -
Respir Res
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3. [Abstract]2024 Jul 30;25(1):291. PMID: 39080660 -
Cell Biol Toxicol
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2. [Abstract]2022 Dec;38(6):1027-1045. PMID: 34510316 -
Int J Mol Sci
Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension. [Abstract]2026 Feb 27;27(5):2255. PMID: 41828479 -
Int Immunopharmacol
Palmatine ameliorates intestinal epithelial barrier injury in ulcerative colitis via targeting enolase 3. [Abstract]2025 Jun 20:162:115110. PMID: 40543101 -
Cell Oncol (Dordr)
UBE2Q2 promotes tumor progression and glycolysis of hepatocellular carcinoma through NF-κB/HIF1α signal pathway. [Abstract]2025 Jun;48(3):637-654. PMID: 39833608 -
Int Immunopharmacol
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα. [Abstract]2024 Dec 9:145:113781. PMID: 39657538 -
Int Immunopharmacol
NMAAP1 regulated macrophage polarizion into M1 type through glycolysis stimulated with BCG. [Abstract]2024 Jan 5:126:111257. PMID: 37988910 -
Int J Mol Sci
Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10. [Abstract]2023 Sep 30;24(19):14808. PMID: 37834257 -
Int J Mol Sci
2023 Jul 13;24(14):11431. PMID: 37511190 -
Int J Mol Sci
Increased Oxidative Phosphorylation Is Required for Stemness Maintenance in Liver Cancer Stem Cells from Hepatocellular Carcinoma Cell Line HCCLM3 Cells. [Abstract]2020 Jul 25;21(15):5276. PMID: 32722385 -
Inflammation
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation. [Abstract]2026 Jan 16;49(1):49. PMID: 41543766 -
J Pathol
Lactate-mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension. [Abstract]2025 Oct 23. PMID: 41128634 -
Immunology
Mechanism of Tumour-Associated Macrophage-Derived Exosomes in Chemo-Sensitivity of Laryngeal Cancer by Regulating Aerobic Glycolysis via WTAP/GLUT-1. [Abstract]2025 Oct 2. PMID: 41038674 -
Arthritis Res Ther
2025 Sep 26;27(1):180. PMID: 41013704 -
Am J Physiol Cell Physiol
Inflammation-induced PFKFB3-mediated glycolysis promoting myometrium contraction through the PI3K-Akt-mTOR pathway in preterm birth mice. [Abstract]2025 Feb 5. PMID: 39907705 -
Am J Physiol Cell Physiol
Hypomethylation-associated ELF3 helps nasopharyngeal carcinoma to escape immune surveillance via MUC16-mediated glycolytic metabolic reprogramming. [Abstract]2024 Oct 1;327(4):C1125-C1142. PMID: 39219440 -
Immunology
Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages. [Abstract]2020 Jun;160(2):183-197. PMID: 32061096 -
Front Cell Dev Biol
2021 Apr 30:9:667435. PMID: 33996822 -
J Nutr Biochem
PRC1 promotes MAFLD progression by regulating glycolysis/lactylation axis and forming a positive feedback loop. [Abstract]2026 Aug:154:110378. PMID: 41967720 -
Chem Biol Interact
Paraquat induces neuroinflammation through glycolytic reprogramming in microglia: evidence from network toxicology analysis and in vitro experiments. [Abstract]2026 Jun 1:432:112037. PMID: 41839307 -
Int Dent J
Pexidartinib Inhibits Macrophage Senescence Through Glycolysis in Periodontitis Microenvironment. [Abstract]2025 Jun 2;75(4):100843. PMID: 40460514 -
J Nutr Biochem
Hepatic Leucine Carboxyl Methyltransferase 1 (LCMT1) contributes to high fat diet-induced glucose intolerance through regulation of glycogen metabolism. [Abstract]2023 Jul:117:109321. PMID: 36963730 -
Chem Biol Interact
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose. [Abstract]2022 Feb 25:354:109843. PMID: 35122754 -
Toxicology
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration. [Abstract]2021 Oct:462:152928. PMID: 34481905 -
Molecules
Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages. [Abstract]2024 Jan 1;29(1):236. PMID: 38202819 -
Mol Med Rep
LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming. [Abstract]2026 May;33(5):141. PMID: 41891951 -
Biochim Biophys Acta Mol Basis Dis
Pharmacological targeting of AMPK to restore glucose and fatty acid metabolism homeostasis attenuates transplanted kidney fibrosis. [Abstract]2024 Sep 13:167510. PMID: 39278511 -
Biochim Biophys Acta Mol Basis Dis
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis. [Abstract]2024 Mar;1870(3):167011. PMID: 38176460 -
Sci Rep
A novel L-shaped ortho-quinone analog and 2-Deoxy-D-Glucose a synergistic approach to inhibit hepatocellular carcinoma cell proliferation. [Abstract]2026 Apr 6;16(1):16498. PMID: 41942736 -
Sci Rep
Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans. [Abstract]2025 Nov 17;15(1):40227. PMID: 41249785 -
Sci Rep
2025 Nov 26;15(1):42171. PMID: 41298629 -
J Mol Cell Cardiol
Beneficial effects of aryl hydrocarbon receptor activation on post-infarction myocardial metabolism, inflammation and fibrosis: implications from multi-omics. [Abstract]2025 Oct 21:209:104-118. PMID: 41130496 -
Sci Rep
Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration. [Abstract]2025 Aug 20;15(1):30552. PMID: 40836054 -
Transl Oncol
KAT5 promotes tumor growth in androgen-independent prostate cancer by facilitating aerobic glycolysis. [Abstract]2025 Jun 7:58:102436. PMID: 40483992 -
Am J Pathol
Lactate Contributes to Remote Ischemic Preconditioning-Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase-Mammalian Target of Rapamycin-Transcription Factor EB-Connexin 43 Axis. [Abstract]2024 Oct;194(10):1857-1878. PMID: 39069170 -
Sci Rep
Controlling glycolysis to generate characteristic volatile organic compounds of lung cancer cells. [Abstract]2024 Jul 17;14(1):16561. PMID: 39020066 -
Exp Neurol
2024 Jan:371:114590. PMID: 37907123 -
Stem Cells
Basic fibroblast growth factor promotes mesenchymal stem cell migration by regulating glycolysis-dependent β-catenin signaling. [Abstract]2023 Jun 15;41(6):628-642. PMID: 36951300 -
Cell Signal
O-GlcNAcylation-mediated glycolytic reprogramming of CD4+ T cells contributes to type H vessel impairment in diabetic osteoporosis. [Abstract]2026 Jun 26:146:112694. PMID: 42361945 -
Cell Signal
PERK-eIF2alpha-mediated translational inhibition of MCL-1 contributes to potential 2-deoxy-D-glucose and BAD mimetic combinatorial cancer therapy. [Abstract]2025 Dec 19:139:112333. PMID: 41423011 -
Virol Sin
Thapsigargin suppresses porcine hemagglutinating encephalomyelitis virus replication by disrupting host energy metabolism. [Abstract]2025 Nov 21:S1995-820X(25)00161-0. PMID: 41276220 -
Cell Signal
NCAPD2 stimulates glycolysis and esophageal cancer metastasis through Wnt5A-dependent Notch activation. [Abstract]2025 Sep 12:136:112120. PMID: 40946944 -
Cell Signal
OTUB1 promotes the progression of acute myeloid leukemia by regulating glycolysis via deubiquitinating c-Myc. [Abstract]2025 Jul:131:111735. PMID: 40081551 -
Cell Signal
Highly expressed VGLL3 in keloid fibroblasts promotes glycolysis and collagen production via the activation of Wnt/β-catenin signaling. [Abstract]2025 Jan 16:127:111604. PMID: 39826675 -
Cell Signal
2023 Sep:109:110747. PMID: 37286120 -
Cell Signal
DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis. [Abstract]2023 May:105:110626. PMID: 36758683 -
iScience
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells. [Abstract]2023 Jul 25;26(8):107464. PMID: 37588169 -
Ann N Y Acad Sci
Tet methylcytosine dioxygenase 1 modulates Porphyromonas gingivalis-triggered pyroptosis by regulating glycolysis in cementoblasts. [Abstract]2023 May;1523(1):119-134. PMID: 36934292
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Ann N Y Acad Sci. 2023 May;1523(1):119-134. [Abstract]
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iScience
Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis. [Abstract]2022 Oct 13;25(11):105353. PMID: 36339254 -
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FASEB J
Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]2026 Mar 31;40(6):e71636. PMID: 41842655 -
FASEB J
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux. [Abstract]2025 Dec 31;39(24):e71369. PMID: 41408993 -
FASEB J
Deubiquitinase OTUD4 Stabilizes SLC5A2 to Promote Pancreatic Cancer Proliferation and Migration Through Enchaining Glycolysis-Mediated Autophagy. [Abstract]2025 Jul 31;39(14):e70880. PMID: 40719816 -
Biochim Biophys Acta Mol Cell Res
Cytoskeletal orchestration of glucose uptake in Sertoli cell to support efferocytosis of apoptotic germ cells. [Abstract]2023 Apr;1870(4):119434. PMID: 36716822 -
Fish Shellfish Immunol
Regulation of Il-2 on the expression of granzyme B- and perforin-like genes and its functional implication in grass carp peripheral blood neutrophils. [Abstract]2022 May;124:472-479. PMID: 35483596 -
Antimicrob Agents Chemother
Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus. [Abstract]2018 Apr 26;62(5). pii: e01659-17. PMID: 29483117 -
J Biol Chem
Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells. [Abstract]2026 May 27:113207. PMID: 42208899 -
Eur J Immunol
Hyperinflammation by Human Macrophages Induced by SARS-CoV-2 Anti-Spike IgG Is Dependent on Glucose and Fatty Acid Metabolism. [Abstract]2025 Dec;55(12):e70087. PMID: 41416928 -
Hum Genomics
2025 Nov 12;19(1):134. PMID: 41225657 -
Eur J Immunol
2025 Oct;55(10):e70068. PMID: 41054024 -
Microbiol Spectr
Attenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1. [Abstract]2025 Oct 7;13(10):e0311624. PMID: 40919783 -
Curr Issues Mol Biol
Comparative Study of Reprogramming Efficiency and Regulatory Mechanisms of Placental- and Fibroblast-Derived Induced Pluripotent Stem Cells (iPSCs) in Mules. [Abstract]2025 Aug 19;47(8):671. PMID: 40864824 -
Curr Issues Mol Biol
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization. [Abstract]2025 Jul 29;47(8):598. PMID: 40864752 -
Cell Stress Chaperones
HSPA12A stimulates "Smurf1-Hif1α-aerobic glycolysis" axis to promote proliferation of renal tubular epithelial cells after hypoxia/reoxygenation injury. [Abstract]2024 Oct;29(5):681-695. PMID: 39349238 -
J Cell Physiol
Mitochondrial and Glucose Metabolic Patterns in Pre-Granulosa Cells and Oocytes and Their Dysfunctions Induce Impaired Primordial Follicle Formation in Mice. [Abstract]2025 Nov;240(11):e70110. PMID: 41251108 -
Naunyn Schmiedebergs Arch Pharmacol
Gastrodin inhibits hexokinase-2 mediated glycolysis to rescue rotenone-damaged PC12 cells. [Abstract]2025 Jun 4. PMID: 40464941 -
J Immunol
Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer. [Abstract]2024 Feb 15;212(4):723-736. PMID: 38197667 -
J Chromatogr A
Targeted profiling of polar metabolites in cancer metabolic reprogramming by hydrophilic interaction liquid chromatography-tandem mass spectrometry. [Abstract]2022 Dec 20:1686:463654. PMID: 36434830 -
Vet Q
Glycolytic reprogramming impairs chondrocyte function in broilers with femoral head necrosis. [Abstract]2025 Dec;45(1):2579940. PMID: 41158005 -
Microb Pathog
T. pallidum achieves immune evasion by blocking autophagic flux in microglia through hexokinase 2. [Abstract]2024 Dec 9:107216. PMID: 39662785 -
Microb Pathog
Regulation of lactate accumulation in bovine mammary epithelial cells by LPS-induced HIF-1α/MCT1 pathway. [Abstract]2024 Dec 24:107261. PMID: 39725042 -
Cell Cycle
SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells. [Abstract]2024 Feb;23(4):435-447. PMID: 38626328 -
Microb Pathog
Acetylation of fructose-bisphosphate aldolase-mediated glycolysis is essential for Bombyx mori nucleopolyhedrovirus infection. [Abstract]2022 Sep:170:105695. PMID: 35921953 -
Mol Pain
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation. [Abstract]2025 May 30:17448069251348778. PMID: 40444883 -
Carcinogenesis
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma. [Abstract]2025 Jan 24:bgaf002. PMID: 39851260 -
Viruses
The Accumulation of Phenyllactic Acid Impairs Host Glutamine Metabolism and Inhibits African Swine Fever Virus Replication: A Novel Target for the Development of Anti-ASFV Drugs. [Abstract]2024 Mar 13;16(3):449. PMID: 38543813 -
J Proteome Res
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification. [Abstract]2023 Dec 1;22(12):3854-3865. PMID: 37955350 -
J Proteome Res
An Integrative Proteome-Based Pharmacologic Characterization and Therapeutic Strategy Exploration of SAHA in Solid Malignancies. [Abstract]2022 Apr 1;21(4):953-964. PMID: 35172096 -
J Bioenerg Biomembr
METTL16-mediated m6A modification of LYRM2 drives breast cancer progression by inducing CD8+ T cell dysfunction via Glycolysis. [Abstract]2026 Mar 18. PMID: 41849076 -
Pathol Res Pract
Serine/arginine-rich splicing factor 1 inhibits ferroptosis and promotes glycolysis in endometrial cancer via activating mTOR and β-catenin. [Abstract]2026 Mar:279:156364. PMID: 41564687 -
J Bioenerg Biomembr
E2F7 transcriptionally upregulates SPC24 to mediate aerobic Glycolysis and facilitate stemness of breast cancer. [Abstract]2025 Jul 15. PMID: 40663204 -
BMC Endocr Disord
The predictive function of miR-122-5p and its action mechanism by regulating PKM2 in metabolic syndrome. [Abstract]2025 Feb 27;25(1):54. PMID: 40011864 -
Mol Immunol
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia. [Abstract]2021 Dec:140:250-266. PMID: 34798593 -
Toxicol Appl Pharmacol
Melanocyte proliferation gene 1 regulated metabolic reprogramming in acute myocardial infarction based on the AMPK/mTOR pathway. [Abstract]2026 Mar 14:511:117797. PMID: 41833858 -
Toxicol Appl Pharmacol
RUNDC3A-AS1 is an adverse prognostic factor for triple-negative breast cancer which mediates the Warburg effect and Adriamycin resistance by targeting miR-224-3p/COL5A2. [Abstract]2026 Feb 27:511:117776. PMID: 41765289 -
J Biochem Mol Toxicol
Transcription Factor Activating Enhancer-Binding Protein 4/Acidic Nuclear Phosphoprotein 32 Family Member E Axis Increases Lactate Production to Promote Triple-Negative Breast Cancer Stemness. [Abstract]2025 Jul;39(7):e70350. PMID: 40557837 -
Toxicol Appl Pharmacol
Vitamin D alleviates silica-induced pulmonary fibrosis partly by inhibiting STAT3/hexokinase 2-mediated fibroblast glycolysis. [Abstract]2025 Oct:503:117456. PMID: 40633737 -
Toxicol Appl Pharmacol
CALML3-AS1 enhances malignancies and stemness of small cell lung cancer cells through interacting with DAXX protein and promoting GLUT4-mediated aerobic glycolysis. [Abstract]22024 Nov 29:495:117177. PMID: 39617259 -
Exp Cell Res
KAT5/8-mediated GPX4 lactylation facilitates ferroptosis and inflammation in diabetic retinopathy. [Abstract]2026 Jan 29;456(2):114915. PMID: 41617054 -
Immun Inflamm Dis
Lipoic Acid Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages. [Abstract]2026 Jan;14(1):e70313. PMID: 41503676 -
Hum Exp Toxicol
Ginsenoside Re suppresses high glucose-induced apoptosis of placental trophoblasts through endoplasmic reticulum stress-related CHOP/GADD153. [Abstract]2025 Jan-Dec:44:9603271241307835. PMID: 39798073 -
Arch Biochem Biophys
ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells. [Abstract]2024 Feb:752:109841. PMID: 38081339 -
J Reprod Immunol
Effect of 2-deoxyglucose-mediated inhibition of glycolysis on migration and invasion of HTR-8/SVneo trophoblast cells. [Abstract]2023 Sep:159:104123. PMID: 37487312 -
J Leukoc Biol
Mitochondrial fusion reduces T cell susceptibility to HIV infection through citrate modulation. [Abstract]2025 Apr 11:qiaf042. PMID: 40211578 -
Digestion
KIF4A Facilitates Oxaliplatin Resistance and Stemness in Colon Cancer by Boosting Glucose Metabolism. [Abstract]2025 Mar 27:1-19. PMID: 40147432 -
Brain Sci
Inhibition of Glycolysis Alleviates Chronic Unpredictable Mild Stress Induced Neuroinflammation and Depression-like Behavior. [Abstract]2024 Oct 30;14(11):1098. PMID: 39595861 -
J Integr Neurosci
2025 Feb 25;24(2):25949. PMID: 40018779 -
Mol Biol Rep
Inhibition of aerobic glycolysis suppresses ferroptosis via activation of the AMPK-FoxO3a pathway in epileptic rats. [Abstract]2026 May 13;53(1):757. PMID: 42126735 -
Biol Reprod
GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion. [Abstract]2024 Apr 11;110(4):739-749. PMID: 38206868 -
Brain Res
Inhibition of glycolysis prevents behavioural changes in mice with MK801-induced SCZ model by alleviating lactate accumulation and lactylation. [Abstract]2023 Aug 1:1812:148409. PMID: 37207839 -
Kaohsiung J Med Sci
Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β-Catenin Pathway. [Abstract]2025 Nov 13:e70123. PMID: 41229334 -
J Appl Toxicol
Cantharidin-induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro. [Abstract]2020 Dec;40(12):1622-1635. PMID: 32638414 -
J Appl Toxicol
The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway. [Abstract]2020 Mar;40(3):388-402. PMID: 31802521 -
J Gene Med
TRIM34-Mediated Ubiquitination and Degradation of HIF-1A Regulates Glycolysis in Endothelial Cells, Inhibits Angiogenesis, and Relieves the Progression of Lung Fibrosis. [Abstract]2025 Aug;27(8):e70032. PMID: 40836270 -
Expert Rev Anticancer Ther
RASGEF1C affects aerobic glycolysis and facilitates lung cancer progression through the PLK1 signaling pathway. [Abstract]2025 Jun 23:1-11. PMID: 40546136 -
Biochim Biophys Acta Gen Subj
DLGAP5-induced glycolysis reprogramming reinforces macrophage M2 polarization to impact BC progression. [Abstract]2026 Sep;1870(9):130969. PMID: 42297309 -
Theriogenology
Lactate metabolism inhibition disrupts goat oocyte meiosis via H3K18la-mediated epigenetic dysregulation. [Abstract]2025 Oct 10:250:117706. PMID: 41086577 -
World J Surg Oncol
2025 Jun 9;23(1):225. PMID: 40490793 -
Discov Oncol
PARP14-mediated glycolysis enhances Tamoxifen resistance in estrogen receptor + breast cancer cells. [Abstract]2025 Jun 17;16(1):1135. PMID: 40526225 -
Vet Microbiol
HDAC4 suppresses porcine epidemic diarrhea virus infection through negatively regulating MEF2A-GLUT1/3 axis- mediated glucose uptake. [Abstract]2025 Apr 11:305:110520. PMID: 40250106 -
Hum Cell
2025 Apr 15;38(3):88. PMID: 40234326 -
Vet Microbiol
Porcine reproductive and respiratory syndrome virus infection manipulates central carbon metabolism. [Abstract]2023 Apr:279:109674. PMID: 36739813 -
Reprod Sci
2023 Mar;30(3):928-951. PMID: 36042151 -
Clin Rheumatol
High glucose-induced mitophagy accelerates premature aging of T cells in patients with rheumatoid arthritis. [Abstract]2025 Nov 20. PMID: 41261244 -
Toxicol In Vitro
2020 Aug;66:104834. PMID: 32200033 -
J Cardiovasc Dev Dis
Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress. [Abstract]2025 Jul 21;12(7):278. PMID: 40710803 -
Biochem Biophys Res Commun
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism. [Abstract]2025 Sep 23:786:152703. PMID: 41027184 -
Biochem Biophys Res Commun
N6-methyladenosine methyltransferase METTL3 facilitates the aerobic glycolysis of non-small cell lung cancer cells by activating the PI3K/AKT/mTOR pathway. [Abstract]2025 Sep 8:778:152337. PMID: 40706246 -
Biochem Biophys Res Commun
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia. [Abstract]2025 Sep 8:778:152379. PMID: 40694902 -
Biochem Biophys Res Commun
SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition. [Abstract]2021 May 7:552:23-29. PMID: 33740661 -
Cell Physiol Biochem
2018;48(6):2318-2336. PMID: 30114709 -
Dev Comp Immunol
HIF-1α-mediated glycolytic reprogramming facilitates decapod iridescent virus 1 pathogenesis in Macrobrachium rosenbergii: Central role of hexokinase in viral metabolic hijacking. [Abstract]2025 Aug:169:105414. PMID: 40659233 -
J Stroke Cerebrovasc Dis
Hydroxysafflor Yellow A promotes angiogenesis of brain microvascular endothelial cells from ischemia/reperfusion injury via glycolysis pathway in vitro. [Abstract]2024 Nov 6:108107. PMID: 39515547 -
Int J Environ Health Res
The ROS/NF-κB/HK2 axis is involved in the arsenic-induced Warburg effect in human L-02 hepatocytes. [Abstract]2024 Jan;34(1):150-165. PMID: 36264688 -
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bioRxiv
MARBL: A Live-Cell Method for Profiling Bioenergetic Heterogeneity by Noncanonical Methionine Labeling of the Cell Surface Proteome. [Abstract]2026 Jun 2:2026.06.01.729353. PMID: 42282597 -
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Heliyon
2024 Sep 20;10(20):e38220. PMID: 39498080 -
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Biomed Pharmacother
Novel therapeutic perspectives for wet age-related macular degeneration: RGD-modified liposomes loaded with 2-deoxy-D-glucose as a promising nanomedicine. [Abstract]2024 Jun:175:116776. PMID: 38788546 -
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Front Med
Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease. [Abstract]2023 Aug;17(4):781-795. PMID: 37266854 -
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Biomed Pharmacother
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer. [Abstract]2023 Mar:159:114301. PMID: 36706634 -
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Biomed Pharmacother
Inhibition of Nrf2-mediated glucose metabolism by brusatol synergistically sensitizes acute myeloid leukemia to Ara-C. [Abstract]2021 Oct:142:111652. PMID: 34112534 -
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Biomed Pharmacother
Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine. [Abstract]2020 Jan;121:109521. PMID: 31689601 -
Oncotarget
BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity. [Abstract]2017 Jul 4;8(27):44669-44681. PMID: 28591720
2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 4;8(27):44669-44681. [Abstract]
Effect of 2-DG treatment on BRSK2 and other components of AKT/mTOR signaling pathway. PANC-1 cells are treated with series concentrations of 2-DG for three hours before analysis.
Solvent & Solubility
H2O : 116.67 mg/mL (710.71 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 130 mg/mL (791.91 mM); Clear solution; Need ultrasonic
Protocol
The effect of 2-DG on cell growth is determined by evaluating the number of adherent cells. Briefly, MCF-7 cells are plated at 3×104 cells per well in flat-bottomed 96-well plates in 100 μL of culture medium under the culture conditions. After 24 hours, cells are fed with fresh medium including 2-Deoxy-D-glucose at doses of 0, 4, 8, or 16 mM. At days 1, 3, and 5 after 2-Deoxy-D-glucose exposure, cells are fixed with 1% glutaraldehyde, replaced with PBS, and stored at 4°C. At the end of an experiment, all of the plates are stained with 0.02% aqueous crystal violet for 30 minutes and rinsed with deionized water. After redissolving the bound crystal violet in 70% ethanol, the absorbance is determined at 590 nm using a SPECTRA MAX PLUS Microplate Spectrophotometer System.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
At 21 days of age, rats are injected with 50 mg 1-methyl-1-nitrosourea per kilogram of body weight (i.p.). Rats are housed two per cage in solid-bottomed polycarbonate cages equipped with a food cup. Six days following carcinogen injection, all rats are randomized into one of three groups, 30 rats per group, and are fed ad libitum AIN-93G diet containing 0.0%, 0.02%, or 0.03% (w/w) 2-Deoxy-D-glucose (2-DG) for 5 weeks. Animal rooms are maintained at 22±1°C with 50% relative humidity and a 12-hour light/12-hour dark cycle. Rats are weighed thrice per week and are palpated for detection of mammary tumors twice per week starting from 19 days postcarcinogen.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65(15):7023-30. [Content Brief]
[2]. Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo. Biol Signals Recept. 2000 Sep-Oct;9(5):267-74. [Content Brief]
[3]. Miwa H, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013 May;29(5):2053-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.0916 mL | 30.4581 mL | 60.9162 mL | 152.2904 mL |
| 5 mM | 1.2183 mL | 6.0916 mL | 12.1832 mL | 30.4581 mL | |
| 10 mM | 0.6092 mL | 3.0458 mL | 6.0916 mL | 15.2290 mL | |
| 15 mM | 0.4061 mL | 2.0305 mL | 4.0611 mL | 10.1527 mL | |
| 20 mM | 0.3046 mL | 1.5229 mL | 3.0458 mL | 7.6145 mL | |
| 25 mM | 0.2437 mL | 1.2183 mL | 2.4366 mL | 6.0916 mL | |
| 30 mM | 0.2031 mL | 1.0153 mL | 2.0305 mL | 5.0763 mL | |
| 40 mM | 0.1523 mL | 0.7615 mL | 1.5229 mL | 3.8073 mL | |
| 50 mM | 0.1218 mL | 0.6092 mL | 1.2183 mL | 3.0458 mL | |
| 60 mM | 0.1015 mL | 0.5076 mL | 1.0153 mL | 2.5382 mL | |
| 80 mM | 0.0761 mL | 0.3807 mL | 0.7615 mL | 1.9036 mL | |
| 100 mM | 0.0609 mL | 0.3046 mL | 0.6092 mL | 1.5229 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Deoxy-D-glucose Related Classifications
HY-13966 Related Classifications
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