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2-Deoxy-D-glucose

(Synonyms: 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose)
390 Cited Publications
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Based on 390 publication(s) in Google Scholar

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.

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  • Pureté : 99.93%
  • CAS No.: 154-17-6
  • Formule: C6H12O5
  • Masse moléculaire:164.16
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 2-Deoxy-D-glucose Chemical Structure
    2-Deoxy-D-glucose Chemical Structure
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
  • Experimental Validation Results for 2-Deoxy-D-glucose
CAS No.: 154-17-6
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  • 2-Deoxy-D-glucose Chemical Structure
    2-Deoxy-D-glucose Chemical Structure
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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Nature. 2025 Feb;638(8052):1112-1121. [Abstract]

    Customer Validation
     2-deoxy-d-glucose (10 mM; 16 h) significantly reduces ​FOXM1 nuclear condensates in FOXM1-GFP stable HeLa cells.

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2024 May;166(5):772-786.e14. [Abstract]

    Customer Validation
     2-Deoxy-D-glucose (2-DG) (5 mM; 3 days) exhibits toxic effects on normal gastric organoids, leading to their death within 3 days of treatment.

  • 1/16

    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Jun;26(6):917-931. [Abstract]

    Customer Validation
     Representative confocal IF images of IRE1α (red) along with G3BP1 (green) in HeLa cells cultured in glucose-free medium (GD) without (Ctrl) or with 25 mM 2-deoxy-D-glucose (2-DG) for 1 h.

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Nov 26;18(47):32602-32616. [Abstract]

    Customer Validation
     2-Deoxy-D-glucose (2 mM; 4 h) reverses 3D-NTBH-induced angiogenesis in HUVECs by inhibiting glycolysis.

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]

    Customer Validation
     Survival fraction of parental or PSAT1 knockout PLC/PRF/5 cells treated with or without 2.5 mM 2-DG (2-Deoxy-D-glucose).

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Ann N Y Acad Sci. 2023 May;1523(1):119-134. [Abstract]

    Customer Validation
     2-Deoxy-D-glucose (2-DG; 200 μM) reduces the protein levels of CASP11, cleaved-CASP11, NLRP3, GSDMD-FL, and GSDMD-NT, accompanied by effective inhibition of the markers involved in glycolysis, in OCCM-30 cells.

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Cell Res. 2021 Mar;31(3):291-311. [Abstract]

    Customer Validation
     Immunoblot analysis of anti-PTEN immunoprecipitate and WCL from MCF-7 cells. MCF-7 cells were treated with MMS (0.2 mM, 1 h), or cisplatin (1 μM, 12 h), or cold shock (4 °C for 30 min, then 37 °C for 4 h), or heat shock (45 °C for 30 min, then 37 °C for 4 h), or serum-starved for 4 h, or 2-DG (5 μM, 24 h), or H2O2 (800 μM, 30 min) before harvested.

  • 1/16

    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Jan;41(1):62-78. [Abstract]

    Customer Validation
     2-Deoxy-D-glucose (2-DG) (10 μM; 6 h) significantly increases the basal and EGFR activation in SMMC-7721 and HepG2 cells.

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2020 Sep 14;38(3):350-365.e7. [Abstract]

    Customer Validation
     IB analysis of C4-2 and 22RV-1 cells treated with 1 mM AICAR or 25 mM 2-DG (2-Deoxy-D-glucose) for 24 h.

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    2-Deoxy-D-glucose purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 4;8(27):44669-44681. [Abstract]

    Customer Validation
     Effect of 2-DG treatment on BRSK2 and other components of AKT/mTOR signaling pathway. PANC-1 cells are treated with series concentrations of 2-DG for three hours before analysis.

  • 2-Deoxy-D-glucose