2. Metabolic Enzyme/Protease Apoptosis
  3. Lactate Dehydrogenase Apoptosis
  4. Oxamic acid sodium

Oxamic acid sodium  (Synonyms: Sodium oxamate)

Cat. No.: HY-W013032A Purity: 99.72%
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Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.

For research use only. We do not sell to patients.

Oxamic acid sodium Chemical Structure

Oxamic acid sodium Chemical Structure

CAS No. : 565-73-1

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Based on 3 publication(s) in Google Scholar

Oxamic acid sodium Related Antibodies

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  • Purity & Documentation

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Description

Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

In Vitro

Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1].
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2].
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2].
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2].
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxamic acid sodium Related Antibodies

Cell Proliferation Assay[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 10 μM
Incubation Time: 24-72 hours
Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively.

Apoptosis Analysis[2]

Cell Line: NPC cells
Concentration: 0, 20, 50 and 100 mM
Incubation Time: 48 hours
Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner.
Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3.

Cell Cycle Analysis[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 0, 20, 50 and 100 mM
Incubation Time: 24 hours
Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.
In Vivo

Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2]
Dosage: 750 mg/kg
Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks
Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.
Molecular Weight

111.03

Formula

C2H2NNaO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Na].O=C(O)C(=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (112.58 mM; Need ultrasonic)

DMSO : 3.23 mg/mL (29.09 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.0066 mL 45.0329 mL 90.0658 mL
5 mM 1.8013 mL 9.0066 mL 18.0132 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  Saline

    Solubility: 100 mg/mL (900.66 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.72%

COA (246 KB) LCMS (84 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 9.0066 mL 45.0329 mL 90.0657 mL 225.1644 mL
5 mM 1.8013 mL 9.0066 mL 18.0131 mL 45.0329 mL
10 mM 0.9007 mL 4.5033 mL 9.0066 mL 22.5164 mL
15 mM 0.6004 mL 3.0022 mL 6.0044 mL 15.0110 mL
20 mM 0.4503 mL 2.2516 mL 4.5033 mL 11.2582 mL
25 mM 0.3603 mL 1.8013 mL 3.6026 mL 9.0066 mL
H2O 30 mM 0.3002 mL 1.5011 mL 3.0022 mL 7.5055 mL
40 mM 0.2252 mL 1.1258 mL 2.2516 mL 5.6291 mL
50 mM 0.1801 mL 0.9007 mL 1.8013 mL 4.5033 mL
60 mM 0.1501 mL 0.7505 mL 1.5011 mL 3.7527 mL
80 mM 0.1126 mL 0.5629 mL 1.1258 mL 2.8146 mL
100 mM 0.0901 mL 0.4503 mL 0.9007 mL 2.2516 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxamic acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxamic acid565-73-1Sodium oxamateLactate DehydrogenaseApoptosisLDHanti-tumor activityanti-proliferative activityinduce apoptosisCNE-1CNE-2A2780SKOV3Inhibitorinhibitorinhibit

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