Oxamic acid sodium
Based on 69 publication(s) in Google Scholar
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 565-73-1
- Formula: C2H2NNaO3
- Molecular Weight:111.03
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Oxamic acid sodium
More- Signal Transduct Target Ther. 2026 Apr 1;11(1):117. [Abstract]
- Nat Commun. 2025 Aug 4;16(1):7165. [Abstract]
- J Adv Res. 2026 Apr 18:S2090-1232(26)00332-2. [Abstract]
- J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]
- Cell Discov. 2025 Oct 7;11(1):81. [Abstract]
- Neuron. 2025 Jul 23;113(14):2280-2296.e8. [Abstract]
- Redox Biol. 2025 Apr:81:103553. [Abstract]
- Redox Biol. 2024 Jun 20:75:103246. [Abstract]
- Theranostics. 2023 Jul 3;13(11):3856-3871. [Abstract]
- Adv Sci (Weinh). 2025 Nov 26:e12002. [Abstract]
- Adv Sci (Weinh). 2025 Aug 11:e01041. [Abstract]
- MedComm (2020). 2025 Aug 29;6(9):e70344. [Abstract]
- Adv Sci (Weinh). 2025 Jun 5:e06529. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(14):e2413121. [Abstract]
- Adv Sci (Weinh). 2024 Jul 9:e2406333. [Abstract]
- Cell Death Differ. 2025 Mar;32(3):530-545. [Abstract]
- Cell Death Dis. 2026 Mar 30;17(1):430. [Abstract]
- Cell Death Dis. 2026 Jan 8;17(1):11. [Abstract]
- Pharmacol Res. 2026 Feb:224:108110. [Abstract]
- Cell Death Dis. 2026 Jan 30;17(1):185. [Abstract]
- Cell Death Dis. 2025 Mar 20;16(1):193. [Abstract]
- J Hazard Mater. 2025 Jun 26:495:139083. [Abstract]
- J Hazard Mater. 2025 Jan 21:488:137310. [Abstract]
- Cell Death Discov. 2026 Mar 19;12(1):146. [Abstract]
- Food Chem. 2025 Sep 12:11:100301. [Abstract]
- J Colloid Interface Sci. 2025 Dec 2:706:139606. [Abstract]
- Int J Mol Med. 2026 Aug;58(2):207. [Abstract]
- Int J Mol Med. 2026 Jul;58(1):178. [Abstract]
- Phytother Res. 2026 Feb;40(2):812-828. [Abstract]
- Free Radic Biol Med. 2024 Nov 20:225:910-924. [Abstract]
- J Anim Sci Biotechnol. 2024 Jun 11;15(1):86. [Abstract]
- Stem Cell Res Ther. 2025 Oct 1;16(1):538. [Abstract]
- Cell Rep. 2026 Apr 27;45(5):117317. [Abstract]
- Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
- Cell Rep. 2024 Aug 30;43(9):114686. [Abstract]
- Br J Pharmacol. 2026 Aug;183(15):4364-4380. [Abstract]
- J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
- Environ Pollut. 2025 Apr 3:373:126200. [Abstract]
- JCI Insight. 2025 Apr 29:e190838. [Abstract]
- J Autoimmun. 2025 Apr 2:153:103411. [Abstract]
- Biochem Pharmacol. 2025 Jun 23:117073. [Abstract]
- Life Sci. 2026 Mar 15:389:124244. [Abstract]
- Food Biosci. 2025 Jun.
- Neurobiol Dis. 2026 Jun 15:224:107397. [Abstract]
- Cancer Immunol Immunother. 2025 Apr 24;74(6):180. [Abstract]
- Biol Direct. 2025 May 26;20(1):64. [Abstract]
- mBio. 2026 Mar 18:e0248925. [Abstract]
- J Nutr Biochem. 2026 Aug:154:110378. [Abstract]
- Toxicology. 2025 Jun:514:154109. [Abstract]
- Tissue Eng Regen Med. 2026 Mar 18. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Dec 18;1872(3):168140. [Abstract]
- Sci Rep. 2025 Nov 26;15(1):42171. [Abstract]
- Exp Neurol. 2026 Feb:396:115553. [Abstract]
- Virol Sin. 2025 Nov 21:S1995-820X(25)00161-0. [Abstract]
- Oncol Res. 2026 Apr 22;34(5):31. [Abstract]
- J Cell Commun Signal. 2025 Jul 25;19(3):e70037. [Abstract]
- Ren Fail. 2026 Dec;48(1):2630507. [Abstract]
- Vet Res. 2025 Apr 30;56(1):94. [Abstract]
- J Proteome Res. 2023 Dec 1;22(12):3854-3865. [Abstract]
- Pathol Res Pract. 2026 Aug:284:156519. [Abstract]
- Mol Immunol. 2025 May 9:183:93-103. [Abstract]
- Exp Cell Res. 2026 Jan 29;456(2):114915. [Abstract]
- Cell Immunol. 2025 Feb 10:409-410:104929. [Abstract]
- World J Surg Oncol. 2026 May 21. [Abstract]
- Curr Microbiol. 2025 Aug 16;82(10):456. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 8:778:152379. [Abstract]
- University of Minnesota. 2025.
- bioRxiv. 2025 Apr 3:2025.04.03.647023. [Abstract]
- Research Square Preprint. 2023 Sep 15.
Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
45.8 mM
Compound: Oxamate sodium
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay
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[PMID: 31129449] |
| MIA PaCa-2 | IC50 |
18.9 mM
Compound: Oxamate sodium
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Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31129449] |
Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1].
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2].
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2].
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2].
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CNE-1 and CNE-2 cells
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Concentration:10 μM
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Incubation Time:24-72 hours
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Result:Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively.
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Cell Line:NPC cells
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Concentration:0, 20, 50 and 100 mM
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Incubation Time:48 hours
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Result:Showed the increasement of early and late apoptotic cells in a dose-dependent manner.
Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3.
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Cell Line:CNE-1 and CNE-2 cells
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Concentration:0, 20, 50 and 100 mM
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Incubation Time:24 hours
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Result:Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Balb/c nude mice injected with CNE-1 cells[2]
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Dosage:750 mg/kg
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Administration:Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks
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Result:Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.
Chemical Information
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CAS No. 565-73-1
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Appearance Solid
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Molecular Weight 111.03
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Formula C2H2NNaO3
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Color White to off-white
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SMILES
[Na].O=C(O)C(=O)N
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Synonyms
Sodium oxamate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (69)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation. [Abstract]2026 Apr 1;11(1):117. PMID: 41922306 -
Nat Commun
Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking. [Abstract]2025 Aug 4;16(1):7165. PMID: 40759894 -
J Adv Res
Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense. [Abstract]2026 Apr 18:S2090-1232(26)00332-2. PMID: 42009104 -
J Adv Res
Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis. [Abstract]2025 May 13:S2090-1232(25)00351-0. PMID: 40373963 -
Cell Discov
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma. [Abstract]2025 Oct 7;11(1):81. PMID: 41057295 -
Neuron
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury. [Abstract]2025 Jul 23;113(14):2280-2296.e8. PMID: 40328251 -
Redox Biol
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation. [Abstract]2025 Apr:81:103553. PMID: 39970777 -
Redox Biol
Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway. [Abstract]2024 Jun 20:75:103246. PMID: 38925041
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246. [Abstract]
Oxamic acid (Ox) (20 mM; 24 h) markedly inhibits the expression of fibrogenic genes (snail1, snail2, and twist1) in AGEs-stimulated mTEC, but no significant effect on quiescent cells.
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246. [Abstract]
Oxamic acid (Ox) (0.75 g/kg; i.p.; once daily for 4 weeks). Immunofluorescent staining of E-cadherin (red), ɑ-SMA (green), and DAPI (blue).
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246. [Abstract]
Oxamic acid (Ox) (20 mM; 24 h) treatment in AGEs-induced mTEC dramatically downregulated the levels of Pan kla and H3K14la.
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Theranostics
Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes. [Abstract]2023 Jul 3;13(11):3856-3871. PMID: 37441587
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 Jul 3;13(11):3856-3871. [Abstract]
Oxamic acid (10 mM) reverses the increase of Klac-HMGB1 levels in H/R-Ko hepatocytes.
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Adv Sci (Weinh)
FSTL1 Orchestrates Metabolic-Epigenetic Crosstalk: Glycolysis-Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis. [Abstract]2025 Nov 26:e12002. PMID: 41293926 -
Adv Sci (Weinh)
Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead-Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.). [Abstract]2025 Aug 11:e01041. PMID: 40788223 -
MedComm (2020)
Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome. [Abstract]2025 Aug 29;6(9):e70344. PMID: 40895187 -
Adv Sci (Weinh)
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma. [Abstract]2025 Jun 5:e06529. PMID: 40470706 -
Adv Sci (Weinh)
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer. [Abstract]2025 Apr;12(14):e2413121. PMID: 39950833 -
Adv Sci (Weinh)
Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. [Abstract]2024 Jul 9:e2406333. PMID: 38981044 -
Cell Death Differ
Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury. [Abstract]2025 Mar;32(3):530-545. PMID: 39496783 -
Cell Death Dis
2026 Mar 30;17(1):430. PMID: 41912489 -
Cell Death Dis
YBX1 orchestrates LDHA-mediated metabolic reprogramming and NF-κB activation to drive clear cell renal cell carcinoma progression. [Abstract]2026 Jan 8;17(1):11. PMID: 41507134 -
Pharmacol Res
YBX1-LDHB axis orchestrates pyruvate production from lactate to promote ICC initiation and development. [Abstract]2026 Feb:224:108110. PMID: 41577157 -
Cell Death Dis
Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression. [Abstract]2026 Jan 30;17(1):185. PMID: 41617670 -
Cell Death Dis
Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis. [Abstract]2025 Mar 20;16(1):193. PMID: 40113760 -
J Hazard Mater
AhR-mediated histone lactylation drives cellular senescence during benzo[a]pyrene-evoked chronic obstructive pulmonary disease. [Abstract]2025 Jun 26:495:139083. PMID: 40609471 -
J Hazard Mater
H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alzheimer-like pathology through mTOR-regulated autophagy and activation of microglia. [Abstract]2025 Jan 21:488:137310. PMID: 39862777
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jan 21:488:137310. [Abstract]
After treating BV-2 cells with 0 or 10 µM oxamate (OX) for 2 h, cells were treated with 0 % or 6 % CSE for 24 h. Representative immunoblot images of NLRP3.
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Cell Death Discov
FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression. [Abstract]2026 Mar 19;12(1):146. PMID: 41857011 -
Food Chem
Metabolic-inhibitor profiling links phenotype and transcriptome of Lachancea thermotolerans to wine fermentation chemistry. [Abstract]2025 Sep 12:11:100301. PMID: 41035854 -
J Colloid Interface Sci
Enhancing solar-driven biological hydrogen production through a copper-based MXene-polypyrrole and Escherichia coli-integrated semiartificial photosynthetic system. [Abstract]2025 Dec 2:706:139606. PMID: 41349200 -
Int J Mol Med
2026 Aug;58(2):207. PMID: 42246181 -
Int J Mol Med
miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis. [Abstract]2026 Jul;58(1):178. PMID: 42138198 -
Phytother Res
Saikosaponin D Regulates HK2-Mediated Glycolytic Lactate Signaling to Alleviate CKD-Induced Renal Fibrosis. [Abstract]2026 Feb;40(2):812-828. PMID: 41508401 -
Free Radic Biol Med
Influenza A virus-induced glycolysis facilitates virus replication by activating ROS/HIF-1α pathway. [Abstract]2024 Nov 20:225:910-924. PMID: 39491735 -
J Anim Sci Biotechnol
The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation. [Abstract]2024 Jun 11;15(1):86. PMID: 38858724 -
Stem Cell Res Ther
H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis. [Abstract]2025 Oct 1;16(1):538. PMID: 41035068 -
Cell Rep
Heat shock protein 90β lactylation acts as a metabolic switch to drive cerebrovascular apoptosis under heat stress. [Abstract]2026 Apr 27;45(5):117317. PMID: 42048184 -
Cell Rep
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy. [Abstract]2025 Apr 9;44(4):115545. PMID: 40215164
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
HT1376 and RT112 cells were treated with or without Oxamic acid (Oxamate) (10 mM; 24 h), then treated with continuous doses of EV for 24 h and harvested for CCK-8 assays to measure the IC50 values of EV.
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
HT1376 and RT112 cells were treated with or without Oxamic acid (Oxamate) (10 mM; 1-5 d) and then collected for the CCK-8 assay.
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
HT1376 cells were treated with or without Oxamic acid (Oxamate) (10 mM) and then collected for colony formation assay.
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
Lactate dehydrogenase inhibitor Oxamic acid (Oxamate) (10 mM; 24 h) reduced lactate production in HT1376 and RT112 cells.
Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
Lactate dehydrogenase inhibitor Oxamic acid (Oxamate) (10 mM; 24 h) reduced total lactylation levels in HT1376 and RT112 cells.
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Cell Rep
H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response. [Abstract]2024 Aug 30;43(9):114686. PMID: 39216002 -
Br J Pharmacol
Ailanthone alleviates septic cardiomyopathy by attenuating MYST histone acetyltransferase 1 (MOF)-mediated H4K16 lactylation-driven inflammation. [Abstract]2026 Aug;183(15):4364-4380. PMID: 42053209 -
J Ginseng Res
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3. [Abstract]2024 May;48(3):298-309. PMID: 38707638 -
Environ Pollut
Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice. [Abstract]2025 Apr 3:373:126200. PMID: 40185193 -
JCI Insight
2025 Apr 29:e190838. PMID: 40299657 -
J Autoimmun
Neutrophil extracellular traps induce trophoblasts pyroptosis via enhancing NLRP3 lactylation in SLE pregnancies. [Abstract]2025 Apr 2:153:103411. PMID: 40179478 -
Biochem Pharmacol
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. [Abstract]2025 Jun 23:117073. PMID: 40562117 -
Life Sci
Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression. [Abstract]2026 Mar 15:389:124244. PMID: 41616844 -
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Neurobiol Dis
Neuronal ACVR1-mediated H3K18 lactylation drives NLRP3 pyroptosis to sustain neuropathic pain via metabolic-epigenetic coupling. [Abstract]2026 Jun 15:224:107397. PMID: 41991084 -
Cancer Immunol Immunother
USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis. [Abstract]2025 Apr 24;74(6):180. PMID: 40274624 -
Biol Direct
LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation. [Abstract]2025 May 26;20(1):64. PMID: 40414964 -
mBio
2026 Mar 18:e0248925. PMID: 41848315 -
J Nutr Biochem
PRC1 promotes MAFLD progression by regulating glycolysis/lactylation axis and forming a positive feedback loop. [Abstract]2026 Aug:154:110378. PMID: 41967720 -
Toxicology
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells. [Abstract]2025 Jun:514:154109. PMID: 40049282 -
Tissue Eng Regen Med
Liraglutide Promoted Osteogenic Differentiation of Dental Pulp Stem Cells via H3K18 Lactylation-Dependent DSPP Activation. [Abstract]2026 Mar 18. PMID: 41849034 -
Biochim Biophys Acta Mol Basis Dis
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis. [Abstract]2025 Dec 18;1872(3):168140. PMID: 41418678 -
Sci Rep
2025 Nov 26;15(1):42171. PMID: 41298629 -
Exp Neurol
2026 Feb:396:115553. PMID: 41238154 -
Virol Sin
Thapsigargin suppresses porcine hemagglutinating encephalomyelitis virus replication by disrupting host energy metabolism. [Abstract]2025 Nov 21:S1995-820X(25)00161-0. PMID: 41276220 -
Oncol Res
Regulation of Histone Emulsification by HPDL via LDHA/LDHB Promotes EC Cell Proliferation. [Abstract]2026 Apr 22;34(5):31. PMID: 42065070 -
J Cell Commun Signal
Cancer-associated fibroblasts-secreted lactate promotes RNA polymerase III subunit G-mediated epithelial-mesenchymal transition in non-small cell lung cancer by increasing m6A modification of zinc finger protein 384. [Abstract]2025 Jul 25;19(3):e70037. PMID: 40717692 -
Ren Fail
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation. [Abstract]2026 Dec;48(1):2630507. PMID: 41808346 -
Vet Res
Neospora caninum hijacks host PFKFB3-driven glycolysis to facilitate intracellular propagation of parasites. [Abstract]2025 Apr 30;56(1):94. PMID: 40307939 -
J Proteome Res
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification. [Abstract]2023 Dec 1;22(12):3854-3865. PMID: 37955350 -
Pathol Res Pract
Lactylation-induced TRIM47 exacerbates cell viability, cell cycle progression, and glycolysis in thyroid cancer by inducing ubiquitin-mediated degradation of FBP1. [Abstract]2026 Aug:284:156519. PMID: 42143948 -
Mol Immunol
Gastric cancer cells shuttle lactate to induce inflammatory CAF-like phenotype and function in bone marrow-derived mesenchymal stem cells. [Abstract]2025 May 9:183:93-103. PMID: 40347782 -
Exp Cell Res
KAT5/8-mediated GPX4 lactylation facilitates ferroptosis and inflammation in diabetic retinopathy. [Abstract]2026 Jan 29;456(2):114915. PMID: 41617054 -
Cell Immunol
The polarization of macrophages participates in the repair after folic acid-induced acute kidney injury. [Abstract]2025 Feb 10:409-410:104929. PMID: 39933418 -
World J Surg Oncol
H3K18 lactylation promotes glycolysis in bladder cancer via inhibiting GNG7 through regulating PI3K-AKT signaling pathway. [Abstract]2026 May 21. PMID: 42163331 -
Curr Microbiol
Shaking Angles Determine Staphylococcus aureus Virulence Via Oxygen-Glucose Metabolic Crosstalk in Vitro. [Abstract]2025 Aug 16;82(10):456. PMID: 40817921 -
Biochem Biophys Res Commun
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia. [Abstract]2025 Sep 8:778:152379. PMID: 40694902 -
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bioRxiv
2025 Apr 3:2025.04.03.647023. PMID: 40236051 -
Solvent & Solubility
H2O : 50 mg/mL (450.33 mM; Need ultrasonic)
DMSO : 3.23 mg/mL (29.09 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: 75 mg/mL (675.49 mM); Suspended solution; Need ultrasonic
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Xiang J, et al. LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells. Aging (Albany NY). 2021 Dec 16;13(24):25920-25930. [Content Brief]
[2]. Zhai X, et al. Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol Rep. 2013 Dec;30(6):2983-91. [Content Brief]
[3]. Muramatsu H, et al. Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells. Oncol Rep. 2019 Jul;42(1):224-230. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 9.0066 mL | 45.0329 mL | 90.0657 mL | 225.1644 mL |
| 5 mM | 1.8013 mL | 9.0066 mL | 18.0131 mL | 45.0329 mL | |
| 10 mM | 0.9007 mL | 4.5033 mL | 9.0066 mL | 22.5164 mL | |
| 15 mM | 0.6004 mL | 3.0022 mL | 6.0044 mL | 15.0110 mL | |
| 20 mM | 0.4503 mL | 2.2516 mL | 4.5033 mL | 11.2582 mL | |
| 25 mM | 0.3603 mL | 1.8013 mL | 3.6026 mL | 9.0066 mL | |
| H2O | 30 mM | 0.3002 mL | 1.5011 mL | 3.0022 mL | 7.5055 mL |
| 40 mM | 0.2252 mL | 1.1258 mL | 2.2516 mL | 5.6291 mL | |
| 50 mM | 0.1801 mL | 0.9007 mL | 1.8013 mL | 4.5033 mL | |
| 60 mM | 0.1501 mL | 0.7505 mL | 1.5011 mL | 3.7527 mL | |
| 80 mM | 0.1126 mL | 0.5629 mL | 1.1258 mL | 2.8146 mL | |
| 100 mM | 0.0901 mL | 0.4503 mL | 0.9007 mL | 2.2516 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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