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Results for "

SKOV3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) ADC Linker (1) Akt (2) Apoptosis (10) CXCR (2) Endogenous Metabolite (1) FAK (1) Fungal (1) FXR (1) Glutaminase (2) Histone Methyltransferase (1) HSP (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Integrin (1) Lactate Dehydrogenase (1) LPL Receptor (1) LXR (1) Microtubule/Tubulin (5) Notch (1) PI3K (1) PKA (2) PKC (2) PROTACs (1) Ribosomal S6 Kinase (RSK) (2) ROCK (2) ROR (1) SGK (2) Src (1) TRP Channel (1) Tyrosinase (2) YAP (1) YB-1 (1)
By Research Areas:	Cancer (42) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

By Targets:

ADC Cytotoxin (1)

ADC Linker (1)

Akt (2)

Apoptosis (10)

CXCR (2)

Endogenous Metabolite (1)

FAK (1)

Fungal (1)

FXR (1)

Glutaminase (2)

Histone Methyltransferase (1)

HSP (1)

Indoleamine 2,3-Dioxygenase (IDO) (2)

Integrin (1)

Lactate Dehydrogenase (1)

LPL Receptor (1)

LXR (1)

Microtubule/Tubulin (5)

Notch (1)

PI3K (1)

PKA (2)

PKC (2)

PROTACs (1)

Ribosomal S6 Kinase (RSK) (2)

ROCK (2)

ROR (1)

SGK (2)

Src (1)

TRP Channel (1)

Tyrosinase (2)

YAP (1)

YB-1 (1)

By Research Areas:

Cancer (42)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-102073

TG53	Glutaminase Integrin FAK Src	Cancer
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research .

HY-N3113

Panaxyne	Others	Cancer
Panaxyne is a polyacetylene, that can be isolated from the roots of cultivated-wild ginseng. Panaxyne shows significant and selective cytotoxicity against SK-OV-3, with an ED₅₀ of 1.40 µM .

HY-146080

Antitumor agent-61	Apoptosis	Cancer
Antitumor agent-61 (Compound 9b), Irinotecan (Ir) derivative, is a potential antitumor agent. Antitumor agent-61 displays potent activity with IC₅₀s of 0.92, 1.39, 1.75, 2.20, 3.05 and 3.23 μM against five human cancer cells SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549 and MG-63, respectively. Antitumor agent-61 induces SK-OV-3 cells apoptosis through mitochondrion pathways .

HY-149717

Antitumor agent-122	Others	Cancer
Antitumor agent-122 (Compound 5j) is an antitumor agent with good efficacy, limited toxicity and low resistance. Antitumor agent-122 has antiproliferative activity for MGC-803 cell, HepG2 cell, SKOV3 cell and T24 cell with IC₅₀ values of 5.23 μM, 3.60 μM, 1.43 μM, 3.03 μM, respectively .

HY-139882

Anticancer agent 16	Others	Cancer
Anticancer agent 16 exhibits good cytotoxic activity against HCT-116, NCI-H460, and SKOV3 cell lines with IC₅₀ 8.55 μΜ, 5.41 μΜ, and 6.4 μΜ, respectively.

HY-144808

Anticancer agent 40	Others	Cancer
Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC₅₀s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively .

HY-N8934

6β-Hydroxytomentosin	Others	Cancer
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines .

HY-N3028

Taccalonolide B	Microtubule/Tubulin	Cancer
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-N6578

3-epi-Isocucurbitacin B	Others	Cancer
3-epi-Isocucurbitacin B (Compound 5) is a cucurbitane triterpene derived from Trichosanthes kirilowii. 3-epi-Isocucurbitacin B shows significant cytotoxicity to human tumor cells A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15 .

HY-116147

Ceranib-2	LPL Receptor Apoptosis	Cancer
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC₅₀ of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .

HY-123898

Cepharadione B	Tyrosinase Endogenous Metabolite	Cancer
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC₅₀ value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells ^[3].

HY-134583

IDO1-IN-7	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer .

HY-144273

IDO1-IN-13	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC₅₀ of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC₅₀= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues .

HY-N1050

Zederone
Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells .

HY-N3179

Norcepharadione B	Others	Others
Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED₅₀s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively .

HY-N1614

1α-Hydroxytorilin	Others	Others
1 α-hydroxytorilin (compound 3) is a sesquiterpenoid. 1 α-hydroxytorilin can be isolated from Torilis japonica. 1α-hydroxytorilin has cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells with ED50 values of 20.52, 18.24, 17.48, 42.54 μg/mL, respectively .

HY-N2416

Taccalonolide A	Microtubule/Tubulin Apoptosis	Cancer
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells ^[3].

HY-N12349

Glucozaluzanin C	Others	Others
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED₅₀ value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Others	Cancer
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-157319

PI3Kα-IN-15	PI3K	Cancer
PI3Kα-IN-15 is a potent PI3Kα inhibitor with an IC₅₀ of 0.15?μM. PI3Kα-IN-15 also has acceptable anti-proliferative activity (inhibits SKOV-3, T47D, NCI-H1975, NCI-H460, and MCF-7 growth with IC₅₀ values of 26.6?μM, 7.9?μM,? 32.1?μM,? 17.7??μM, and 9.4??μM, respectively. PI3Kα-IN-15 can be used for cancer research .

HY-N12589

8-epi-Helenalin	Others	Cancer
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED₅₀ values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .

HY-157574

TRPV6-IN-1

TRP Channel Cancer

TRPV6-IN-1 is a potent and selective TRPV6 inhibitor. TRPV6-IN-1 has anti-proliferative effect and can be used for the research of cancer .

TRPV6-IN-1	TRP Channel	Cancer
TRPV6-IN-1 is a potent and selective TRPV6 inhibitor. TRPV6-IN-1 has anti-proliferative effect and can be used for the research of cancer .

HY-N7028

Withanolide A	Notch Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases ^[3] .

HY-114056

AS115	Others	Cancer
AS115 is a potent and selective KIAA1363 inactivator with IC₅₀ value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues .

HY-N12606

Neodidymelliosides A	Fungal	Infection
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .

HY-151207

Anticancer agent 81	Apoptosis ADC Cytotoxin	Cancer
Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab .

HY-155102

PROTAC TG2 degrader-2	PROTACs Glutaminase	Cancer
PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with K_d > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study .

HY-151986

FOXM1-IN-1	Others	Cancer
FOXM1-IN-1 is a potent FOXM1 inhibitor with an IC₅₀ value of 2.65 µM. FOXM1-IN-1 shows antiproliferative activity. FOXM1-IN-1 decreases the the expression of FOXM1, PLK1, CDC25B protein .

HY-N11010

Eclalbasaponin IV	Others	Cancer
Eclalbasaponin IV is a triterpenoid that can be isolate from the aerial parts of Eclipta prostrata. Eclalbasaponin IV shows antitumor activity in human ovarian cancer cells .

HY-150231

SU056	YB-1	Cancer
SU056 is a YB-1 inhibitor. SU056 induces cell-cycle arrest, apoptosis, and inhibits cell migration in ovarian cancer cells. SU056 interacts with YB-1 and inhibits and its associated downstream proteins and pathways. SU056 can enhance the cytotoxic effects of Paclitaxel (HY-B0015) .

HY-151375

CDK9/10/GSK3β-IN-1	Others	Cancer
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits *HsGSK3β* (IC₅₀=59 nM), HsCDK9/CyclinT (IC₅₀=64 nM), HsCDK5/p25 (IC₅₀=1.093 µM) and HsCDK2/CyclinA (IC₅₀=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines .

HY-13545

ABT-510	Apoptosis	Inflammation/Immunology Cancer
ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) .

HY-W013032A

Oxamic acid sodium 3 Publications Verification Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis ^[3].

HY-13915

NSC348884 2 Publications Verification	Apoptosis	Cancer
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC₅₀s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer .

HY-136121

Tubulin inhibitor 6	Microtubule/Tubulin	Cancer
Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC₅₀ of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC₅₀ of 840 nM .

HY-128890

DOTA-NHS-ester 1 Publications Verification	ADC Linker	Cancer
DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors .

HY-136123

Tubulin inhibitor 8	Microtubule/Tubulin	Cancer
Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC₅₀ of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC₅₀ of 14 nM .

HY-136122

Tubulin inhibitor 7	Microtubule/Tubulin	Cancer
Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC₅₀ of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC₅₀ of 11 nM .

HY-147082

GA-017	YAP	Cancer
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .

HY-P1103A

CTCE-9908 TFA	CXCR	Cancer
CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-P1103

CTCE-9908	CXCR	Cancer
CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-139150

EZH2-IN-4	Histone Methyltransferase	Cancer
EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC₅₀s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity .

HY-157085

BX-2819	HSP	Cancer
BX-2819 is a Hsp90 inhibitor with an IC₅₀ value of 41 nM. BX-2819 inhibits the proliferation of cancer cells. BX-2819 can significantly inhibit the growth of NCI-N87 and HT-29 tumors in nude mice .

HY-10626

T0901317 Maximum Cited Publications 22 Publications Verification	LXR FXR ROR Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
T0901317 is an orally active and highly selective LXR agonist with an EC₅₀ of 20 nM for LXRα . T0901317 activates FXR with an EC₅₀ of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively ^[3]. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Tyrosinase Apoptosis	Infection Inflammation/Immunology Cancer
Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research ^[3].

HY-132302

Hu7691	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 is an orally active, selective Akt inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 inhibits tumor growth and enables decrease of cutaneous toxicity in mice .

HY-132302A

Hu7691 free base	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 free base is an orally active, selective Akt inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice .

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