1. Metabolic Enzyme/Protease
    Autophagy
  2. FXR
    LXR
    Autophagy
  3. T0901317

T0901317 

Cat. No.: HY-10626 Purity: 99.89%
Handling Instructions

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively[1,2]. T0901317 induces its anti-proliferative and cytotoxic effects via an LXR-independent mechanism. T0901317 significantly suppresses cell proliferation and induces programmed cell death in a dose- and time-dependent manner. T0901317 can protect mice from high fat diet-induced obesity and insulin resistance.

For research use only. We do not sell to patients.

T0901317 Chemical Structure

T0901317 Chemical Structure

CAS No. : 293754-55-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 192 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively[1,2]. T0901317 induces its anti-proliferative and cytotoxic effects via an LXR-independent mechanism. T0901317 significantly suppresses cell proliferation and induces programmed cell death in a dose- and time-dependent manner[3]. T0901317 can protect mice from high fat diet-induced obesity and insulin resistance[4].

IC50 & Target

FXR, LXR[1,2]

In Vitro

T0901317 (5-50 μM; 72 hours) significantly inhibits cellular proliferation in all cell lines in a dose-dependent and time-dependent manner[3].
T0901317 (10 μM; 24-72 hours) decreases the percentage of cells in S phase and increases the percentage of cells in the G0/G1 phase, indicating a cell cycle arrest at the G1-S checkpoint. The percentage of cells in G0/G1 phase increases in a time-dependent manner[3].
T0901317 (10-40 μM; 24 hours ) results in a significant increase of cells in early apoptosis[3].
T0901317 (5-40 μM; 48 hours) results in an increase of p21 and p27 protein expression in a dose-dependent manner after 48 hours[3].

Cell Proliferation Assay[3]

Cell Line: A2780, CaOV3 and SKOV3 ovarian cancer cell lines
Concentration: 5, 10, 20, 40 or 50 μM
Incubation Time: 72 hours
Result: Inhibited cellular proliferation in all cell lines in a dose-dependent and time-dependent manner.

Cell Cycle Analysis[3]

Cell Line: A2780, CaOV3 and SKOV3 cells
Concentration: 10 μM
Incubation Time: 24, 48 or 72 hours
Result: Decreased the percentage of cells in S phase and increased the percentage of cells in the G0/G1 phase.

Apoptosis Analysis[3]

Cell Line: CaOV3 cells
Concentration: 10 to 40 μM
Incubation Time: 24 hours
Result: Resulted in a significant increase of cells in early apoptosis.

Western Blot Analysis[3]

Cell Line: CaOV3 cells
Concentration: 5 to 40 μM
Incubation Time: 48 hours
Result: Resulted in an increase of p21 and p27 protein expression in a dose-dependent manner.
In Vivo

T0901317 (i.p.; 50 mg/kg; twice weekly for 7 days) significantly slowes down the weight gain of C57/BL6 mice[4] .

Animal Model: Male C57BL/6 mice[4]
Dosage: 50 mg/kg
Administration: I.p.; twice weekly; for 7 days
Result: Slowed down the weight gain of C57/BL6 mice.
Molecular Weight

481.33

Formula

C₁₇H₁₂F₉NO₃S

CAS No.

293754-55-9

SMILES

OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (207.76 mM)

Methanol : ≥ 100 mg/mL (207.76 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0776 mL 10.3879 mL 20.7758 mL
5 mM 0.4155 mL 2.0776 mL 4.1552 mL
10 mM 0.2078 mL 1.0388 mL 2.0776 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.89%

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