1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin inhibitor 7

Tubulin inhibitor 7 

Cat. No.: HY-136122
Handling Instructions

Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM.

For research use only. We do not sell to patients.

Tubulin inhibitor 7 Chemical Structure

Tubulin inhibitor 7 Chemical Structure

CAS No. : 1309925-41-4

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Description

Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].

IC50 & Target

IC50: 0.52 μM (tubulin polymerization)[1]

In Vitro

Tubulin inhibitor 7 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1].
Tubulin inhibitor 7 shows excellent antiproliferative potencies with IC50s of 40, 24, 16, 6, 29, and 16 nM for NCIH460, SKOV3, BT549, 451LU, SW480, and DLD-1 tumor cell lines, recpectively[1].

Molecular Weight

358.35

Formula

C₂₁H₁₄N₂O₄

CAS No.

1309925-41-4

SMILES

N#CC1=CC=C2N(C(C3=CC=C(OC)C(O)=C3)=O)C4=C(C=CC=C4)OC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Tubulin inhibitor 7Tubulin inhibitor7Tubulin inhibitor-7Microtubule/TubulinAntiproliferativetubulincellcycleK562NCIH460SKOV3BT549451LUSW480COLO-205DLD-1Inhibitorinhibitorinhibit

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Tubulin inhibitor 7
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