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Cat. No.: HY-136122

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Tubulin inhibitor 7

Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC₅₀ of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC₅₀ of 11 nM.

For research use only. We do not sell to patients.

CAS No.: 1309925-41-4
Formula: C₂₁H₁₄N₂O₄
Molecular Weight:358.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tubulin inhibitor 7 Chemical Structure

CAS No.: 1309925-41-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC50: 0.52 μM (tubulin polymerization)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
5637	GI₅₀	0.0019 μM Compound: 33c	Antiproliferative activity against human 5637 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human 5637 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
A-375	GI₅₀	0.0027 μM Compound: 33c	Antiproliferative activity against human A375 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human A375 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
ASPC1	GI₅₀	>10 μM Compound: 33c	Antiproliferative activity against human AsPC1 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human AsPC1 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
BT-549	IC₅₀	0.016 μM Compound: 33c	Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
BXPC-3	GI₅₀	2.2494 μM Compound: 33c	Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
COLO 205	GI₅₀	4.2556 μM Compound: 33c	Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
COLO-678	GI₅₀	0.0623 μM Compound: 33c	Antiproliferative activity against human COLO-678 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human COLO-678 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
DLD-1	IC₅₀	0.016 μM Compound: 33c	Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
HT-1080	GI₅₀	0.0026 μM Compound: 33c	Antiproliferative activity against human HT1080 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human HT1080 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
HT-29	GI₅₀	5.6032 μM Compound: 33c	Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
IGROV-1	GI₅₀	0.0633 μM Compound: 33c	Antiproliferative activity against human IGROV1 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human IGROV1 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
K562	IC₅₀	0.011 μM Compound: 33c	Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis	[PMID: 21563750]
MDA-MB-436	GI₅₀	1.1309 μM Compound: 33c	Antiproliferative activity against human MDA-MB-436 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human MDA-MB-436 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
MG-63	GI₅₀	0.0018 μM Compound: 33c	Antiproliferative activity against human MG63 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human MG63 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
MIA PaCa-2	GI₅₀	8.4137 μM Compound: 33c	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
NCI-H460	IC₅₀	0.04 μM Compound: 33c	Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
PBMC	GI₅₀	>10 μM Compound: 33c	Antiproliferative activity against human resting PBMC after 72 hrs by sulforhodamine staining method Antiproliferative activity against human resting PBMC after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
RD	GI₅₀	0.002 μM Compound: 33c	Antiproliferative activity against human RD cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human RD cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-MEL-28	GI₅₀	0.002 μM Compound: 33c	Antiproliferative activity against human SK-MEL-28 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human SK-MEL-28 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-N-AS	GI₅₀	0.0018 μM Compound: 33c	Antiproliferative activity against human SK-N-AS cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human SK-N-AS cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-N-SH	GI₅₀	0.0018 μM Compound: 33c	Antiproliferative activity against human SK-N-SH cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human SK-N-SH cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-OV-3	IC₅₀	0.024 μM Compound: 33c	Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
SW480	IC₅₀	0.029 μM Compound: 33c	Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay	[PMID: 21563750]

In Vitro

Tubulin inhibitor 7 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms^[1].
Tubulin inhibitor 7 shows excellent antiproliferative potencies with IC₅₀s of 40, 24, 16, 6, 29, and 16 nM for NCIH460, SKOV3, BT549, 451LU, SW480, and DLD-1 tumor cell lines, recpectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1309925-41-4
Molecular Weight 358.35
Formula C₂₁H₁₄N₂O₄
SMILES

N#CC1=CC=C2N(C(C3=CC=C(OC)C(O)=C3)=O)C4=C(C=CC=C4)OC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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