1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. IDO1-IN-7

IDO1-IN-7 

Cat. No.: HY-134583
Handling Instructions

IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.

For research use only. We do not sell to patients.

IDO1-IN-7 Chemical Structure

IDO1-IN-7 Chemical Structure

CAS No. : 2351199-98-7

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Description

IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer[1].

IC50 & Target

IC50: 6.1 nM (IDO1, SKOV3 cells)[1]

In Vitro

IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC50of 330 nM[1].
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity[1].
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC50=14,000 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IDO1-IN-7 (10 mg/kg; p.o.) shows Cmax=10.0 µM, AUC0-8 h=27.1 µM*h, t1/2=1.4 h in mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: Cmax (10.0 µM), AUC0-8 h (27.1 µM*h), t1/2 (1.4 h)
Molecular Weight

427.86

Formula

C₂₂H₁₉ClFN₃O₃

CAS No.

2351199-98-7

SMILES

FC1=CC2=C(C=C1)N=CC=C2[[email protected]@H](CC3)[[email protected]@H](O)CN3C(C(NC4=CC=C(Cl)C=C4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IDO1-IN-7Indoleamine 2,3-Dioxygenase (IDO)indoleamine-2,3-dioxygenase-1IDO1checkpointimmunomodulatinganti-tumorInhibitorinhibitorinhibit

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