IDO1-IN-7 

IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer^[1].

IC50: 6.1 nM (IDO1, SKOV3 cells)^[1]

IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC₅₀of 330 nM^[1].
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity^[1].
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC₅₀=14,000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1-IN-7 (10 mg/kg; p.o.) shows C_max=10.0 µM, AUC_{0-8 h}=27.1 µM*h, t_1/2=1.4 h in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

427.86

C₂₂H₁₉ClFN₃O₃

2351199-98-7

FC1=CC2=C(C=C1)N=CC=C2[C@@H](CC3)[C@@H](O)CN3C(C(NC4=CC=C(Cl)C=C4)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Christoph Steeneck, et al. Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors. Bioorg Med Chem Lett. 2020 Dec 15;33:127744.  [Content Brief]