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Cat. No.: HY-134583

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IDO1-IN-7

IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2351199-98-7
Formula: C₂₂H₁₉ClFN₃O₃
Molecular Weight:427.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

IDO1-IN-7 Chemical Structure

CAS No.: 2351199-98-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC50: 6.1 nM (IDO1, SKOV3 cells)^[1]

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

In Vitro

IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC₅₀of 330 nM^[1].
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity^[1].
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC₅₀=14,000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

IDO1-IN-7 (10 mg/kg; p.o.) shows C_max=10.0 µM, AUC_{0-8 h}=27.1 µM*h, t_1/2=1.4 h in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse^[1]
Dosage:

10 mg/kg (Pharmacokinetic Analysis)
Administration:

Oral administration
Result:

C_max (10.0 µM), AUC_{0-8 h} (27.1 µM*h), t_1/2 (1.4 h)

Chemical Information

CAS No. 2351199-98-7
Molecular Weight 427.86
Formula C₂₂H₁₉ClFN₃O₃
SMILES

FC1=CC2=C(C=C1)N=CC=C2[C@@H](CC3)[C@@H](O)CN3C(C(NC4=CC=C(Cl)C=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christoph Steeneck, et al. Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors. Bioorg Med Chem Lett. 2020 Dec 15;33:127744. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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