Piperaceae
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- Piper nigrum Linn. (32)
- Piper crocatum Ruiz & Pav. (16)
- Piper kadsura (Choisy) Ohwi (14)
- Piper longum Linn. (14)
- Piper methysticum G.Forst. (8)
- Piper aduncum L. (6)
- Piper retrofractum Vahl (5)
- Piper wightii Miq. (4)
- Piper betle L. (3)
- Piper cubeba L.f. (3)
- Piper methysticum G.Forst. (3)
- Piper sarmentosum Roxb. (3)
- Piper tuberculatum jacq. (3)
- Piper elongatum VAHL (2)
- Piper hancei Maxim. (2)
- Peperomia blanda (Jacq.) Kunth (1)
- Peperomia obtusifolia (L.) A. Dietr. (1)
- Piper aduncum (1)
- Piper attenuatum Buch.-Ham. ex Miq. (1)
- Piper boehmeriifolium (Miq.) Wall. ex C. DC. (1)
- Piper capense (1)
- Piper fimbriulatum C.DC. (1)
- Piper flaviflorum C. DC. (1)
- Piper guineense Schumach. & Thonn. (1)
- Piper hongkongense C. de Candolle (1)
- Piper kadsura (1)
- Piper lenticellosum C.DC. (1)
- Piper mikanianum (Kunth) Steud. (1)
- Piper obliquum Ruiz & Pav. (1)
- Piper pleiocarpum Chang ex Tseng (1)
- Piper sanctum (Miq.) Schltdl. ex C.DC. (1)
- Piper schmidtii Hook.f. (1)
- Piper taiwanense Lin & Lu (1)
- Piper umbellatum L. (1)
- Piper puberulilimbum C. DC. (1)
- Formula: C17H19NO5
- Molecular Weight: 317.34
Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.
- Formula: C17H19NO3
- Molecular Weight: 285.34
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
- Formula: C10H12O2
- Molecular Weight: 164.20
Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.
- Formula: C18H19NO4
- Molecular Weight: 313.35
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research.
- Formula: C8H6O4
- Molecular Weight: 166.13
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities.
- Formula: C15H25NO
- Molecular Weight: 235.37
(2E,4Z-Decadienoyl)piperidine is a herbicide found in the fruits of Piper longum L..
- Formula: C19H18O7
- Molecular Weight: 358.34
5-Hydroxy-3′,4′,7,8-tetramethoxyflavone is a flavone found in the whole plant of Peperomia sui. 5-Hydroxy-3′,4′,7,8-tetramethoxyflavone shows no activity against cancer cell lines in vitro.
- Formula: C17H23NO3
- Molecular Weight: 289.37
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs<、b>, and an activator of the PI3K/Akt/mTOR<、b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke.
- Formula: C17H16O5
- Molecular Weight: 300.31
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway. Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer.
- Formula: C10H12O
- Molecular Weight: 148.20
Butyrophenone (1-Phenylbutan-1-one) is a dopamine receptor (DA Receptor) antagonist and can be used in research on mental disorders.
- Formula: C10H8O4
- Molecular Weight: 192.17
3,4-Methylenedioxycinnamic acid is an inhibitor of the 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. 3,4-Methylenedioxycinnamic acid exhibits the Km value for the substrate ferulic acid of 4CL is 8.4 μM.3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid. 3,4-Methylenedioxycinnamic acid demonstrates larvicidal activity.
- Formula: C14H14O3
- Molecular Weight: 230.26
(+)-Kavain, a main kavalactone that can be extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.
- Formula: C17H19NO3
- Molecular Weight: 285.34
Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
- Formula: C5H7NO
- Molecular Weight: 97.12
5,6-Dihydropyridin-2(1H)-one (1,5,6-Trihydropyridin-2-one) is a Sesquiterpenoids product that can be isolated from the leaves of Alpinia intermedia.
- Formula: C21H24O5
- Molecular Weight: 356.41
Kadsurenone is a lignan with specific antagonistic activity against platelet-activating factor. Kadsurenone can be derived from the stem of Piper kadsura.
- Formula: C16H14O2
- Molecular Weight: 238.28
- Formula: C14H20O6
- Molecular Weight: 284.31
β-Phenylethyl β-D-glucoside (Phenylethyl β-D-glucopyranoside) (Compound 7), a phenolic compounds, is an antifungal agent. β-Phenylethyl β-D-glucoside can be isolated from the leaves of Piper crocatum. β-Phenylethyl β-D-glucoside has antifungal activity against Candida albicans. β-Phenylethyl β-D-glucoside can be used for fungal infections research.
