94-62-2
94-62-2
Chemical Structure
Piperine
Synonym(s): Bioperine; 1-Piperoylpiperidine
- CAS No.: 94-62-2
- Formula:C17H19NO3
- Molecular Weight:285.34
IUPAC Name: (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
InChIKey: MXXWOMGUGJBKIW-YPCIICBESA-N
SMILES: O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2
Biological Activity: Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Piperine | 98.99% | Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL. | ||||||||||||||||||||
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Piperine (Standard) | 98.55% | Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL. | ||||||||||||||||||||
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Piperin-d10 | Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL. | |||||||||||||||||||||
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hMAO-B/MB-COMT-IN-1 | 98.04% | hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD). | ||||||||||||||||||||
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Isochavicine | 93.21% | Isochavicine is a TRPV1 and TRPA1 activator with EC50 values of 3.4 µM and 71.1 µM, respectively. Isochavicine is an alkaloid that can be isolated from Piper longum L. Isochavicine inhibits the growth of cress and barnyardgrass. Isochavicine can be used in research on leishmaniasis. | ||||||||||||||||||||
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Z-Antiepilepsirine | Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC50 value of 27 µM for W2 strain of Plasmodium falciparum. | |||||||||||||||||||||
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Piperanine | Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum. | |||||||||||||||||||||
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Piperundecalidine | Piperundecalidine is an amide alkaloids that can be purified from Piper longum L. Piperundecalidine shows various biological properties, such as anti-inammatory, analgesic, anti-amoebic, anti-depressant, hepatoprotective,etc.. | |||||||||||||||||||||
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Dehydropipernonaline | 99.94% | Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC508.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity . | ||||||||||||||||||||
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(2E,4Z,8E)-Dehydropipernonaline | (2E,4Z,8E)-Dehydropipernonaline is a natural product that can be found in Biba. | |||||||||||||||||||||
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Piperettine | Piperettine is the active substance in pepper. | |||||||||||||||||||||
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Piperdardine | Piperdardine is a natural alkaloid. | |||||||||||||||||||||
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(E/Z)-Piperine | 98.91% | (E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease. | ||||||||||||||||||||
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References
- [1]. Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [Content Brief]
- [2]. Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [Content Brief]
- [3]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [Content Brief]
