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Art. -Nr.: HY-N0144B

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Isochavicine

Name: Isochavicine
Brand: MedChemExpress
SKU: HY-N0144B
Price: 510.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Isochavicine is a TRPV1 and TRPA1 activator with EC₅₀ values of 3.4 µM and 71.1 µM, respectively. Isochavicine is an alkaloid that can be isolated from Piper longum L. Isochavicine inhibits the growth of cress and barnyardgrass. Isochavicine can be used in research on leishmaniasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 93.21%
CAS. Nr.: 30511-77-4
Formel: C₁₇H₁₉NO₃
Molecular Weight:285.34

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Isochavicine Chemical Structure

CAS. Nr.: 30511-77-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

TRPV1

3.4 μM (EC₅₀)

TRPA1

71.1 μM (EC₅₀)

Alle TRP Channel Isoform-spezifische Produkte anzeigen :

In Vitro

Isochavicine activates human TRPV1 in TRPV1-expressing HEK293T cells with an EC₅₀ of 3.4 µM^[1].
Isochavicine activates human TRPA1 in TRPA1-expressing HEK T-REx cells with an EC₅₀ of 71.1 µM^[1].
Isochavicine (compound 6) reduces the germination rate of cress and barnyardgrass and delays their germination^[2].
Isochavicine (48 h) inhibits the growth of watercress seedlings, with I₅₀ values of 11 µM and 18 µM for shoots and roots, respectively, and inhibits the growth of barnyardgrass seedlings, with I₅₀ values of 758 µM and 153 µM for shoots and roots, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 30511-77-4
Appearance Solid
Molecular Weight 285.34
Formel C₁₇H₁₉NO₃
Color Light yellow to yellow
SMILES

O=C(N1CCCCC1)/C=C/C=C\C2=CC=C(OCO3)C3=C2
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Okumura Y, et al. Activation of TRPV1 and TRPA1 by black pepper components. Bioscience, biotechnology, and biochemistry. 2010;74(5):1068-72.

[2]. Suwitchayanon P, et al. Phytotoxic property of Piper retrofractum fruit extracts and compounds against the germination and seedling growth of weeds. Acta Physiologiae Plantarum. 2019 Mar;41(3):33.

[3]. Kozukue N, et al. Kinetics of light-induced cis-trans isomerization of four piperines and their levels in ground black peppers as determined by HPLC and LC/MS. Journal of agricultural and food chemistry. 2007 Aug 22;55(17):7131-9.

[4]. Tsuboi S, et al. A facile synthesis of 3,4-dienamides by the reaction of propargyl alcohols with cyclic amide acetals and their stereoselective rearrangement to 2(E),4(Z)-dienamides promoted with alumina. Total synthesis of isochavicine. J Org Chem. 1984 Apr;49(7):1204-1208.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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Isochavicine

Alle TRP Channel Isoform-spezifische Produkte anzeigen

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IC50 & Target

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Chemical Information

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