495-85-2
495-85-2
Chemical Structure
Methylsticin
- CAS No.: 495-85-2
- Formula:C15H14O5
- Molecular Weight:274.27
IUPAC Name: (R,E)-6-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
InChIKey: GTEXBOVBADJOQH-FWEMWIAWSA-N
SMILES: O=C1C=C(OC)C[C@H](/C=C/C2=CC=C(OCO3)C3=C2)O1
Biological Activity: Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methylsticin | 99.82% | Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity. | ||||||||||||||||||||
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Methylsticin (Standard) | ≥98% | Methylsticin (Standard) is the analytical standard of Methylsticin. This product is intended for research and analytical applications. Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity. | ||||||||||||||||||||
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Stiripentol (Standard) | ≥98% | Stiripentol (Standard) is the analytical standard of Stiripentol (HY-103392). This product is intended for research and analytical applications. Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively. | ||||||||||||||||||||
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Piperic acid | 99.43% | Piperic acid is a natural antioxidant and antibacterial agent. Piperic acid can be used in food preservation and human health. | ||||||||||||||||||||
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(+)-Kavain (Standard) | ≥98% | (+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied. | ||||||||||||||||||||
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Dihydrokavain (Standard) | ≥98% | Dihydrokavain (Standard) (7,8-Dihydrokawain (Standard)) is the analytical standard of Dihydrokavain (HY-N0920). This product is intended for research and analytical applications. Dihydrokavain is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects. | ||||||||||||||||||||
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Dihydromethysticin | 99.71% | Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma. | ||||||||||||||||||||
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Methysticin | Methysticin is a major kavalactone in kava extract to induce CYP1A1. | |||||||||||||||||||||
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Futoamide | Futoamide is an active compound. Futoamide can be isolated from Piper futokadzura SIEB. et ZUCC. | |||||||||||||||||||||
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Retrofractamide A | Retrofractamide A is an amide constituent that can be isolated from the fruit of Piper chaba. Retrofractamide A promotes adipogenesis in 3T3-L1 cells. | |||||||||||||||||||||
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Methyl piperate | Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC503.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC5027.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to research mental disorders . | |||||||||||||||||||||
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Kavain (Standard) | ≥98% | Kavain (Standard) is the analytical standard of Kavain. This product is intended for research and analytical applications. Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor. | ||||||||||||||||||||
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