1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. 4'-Methoxychalcone

4'-Methoxychalcone 

Cat. No.: HY-128400 Purity: 99.44%
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4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.

For research use only. We do not sell to patients.

4'-Methoxychalcone Chemical Structure

4'-Methoxychalcone Chemical Structure

CAS No. : 959-23-9

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Based on 1 publication(s) in Google Scholar

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Description

4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].

IC50 & Target

PPARγ[1]

In Vitro

4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4[1].
4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells[1].
4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days
Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte.

Western Blot Analysis[1]

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 8 days
Result: Increased PPARγ expression in adipocyte.
Molecular Weight

238.28

Formula

C16H14O2

CAS No.
SMILES

O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (209.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1967 mL 20.9837 mL 41.9674 mL
5 mM 0.8393 mL 4.1967 mL 8.3935 mL
10 mM 0.4197 mL 2.0984 mL 4.1967 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
4'-Methoxychalcone
Cat. No.:
HY-128400
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