1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. 4'-Methoxychalcone

4'-Methoxychalcone 

Cat. No.: HY-128400
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4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.

For research use only. We do not sell to patients.

4'-Methoxychalcone Chemical Structure

4'-Methoxychalcone Chemical Structure

CAS No. : 959-23-9

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Description

4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].

IC50 & Target

PPARγ[1]

In Vitro

4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4[1].
4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells[1].
4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected[1].

RT-PCR[1]

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days
Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte.

Western Blot Analysis[1]

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 8 days
Result: Increased PPARγ expression in adipocyte.
Molecular Weight

238.28

Formula

C₁₆H₁₄O₂

CAS No.

959-23-9

SMILES

O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

4'-MethoxychalconePARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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4'-Methoxychalcone
Cat. No.:
HY-128400
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