2. Apoptosis
  3. Apoptosis
  4. NSC348884

NSC348884 

Cat. No.: HY-13915 Purity: ≥98.0%
COA Handling Instructions

NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer.

For research use only. We do not sell to patients.

NSC348884 Chemical Structure

NSC348884 Chemical Structure

CAS No. : 81624-55-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 100 In-stock
Solution
10 mM * 1 mL in DMSO USD 100 In-stock
Solid
5 mg USD 72 In-stock
10 mg USD 127 In-stock
25 mg USD 253 In-stock
50 mg USD 418 In-stock
100 mg USD 605 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

NSC348884 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer[1].

IC50 & Target

IC50: 4 μM (LNCaP cells), 1.7 μM (Granta cells)[1]
In Vitro

NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation[1].
NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells[1].
NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin[1].
NSC348884 (1-5 μM; 24 h) induces cell apoptosis[1].
NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC348884 Related Antibodies

Cell Viability Assay[1]

Cell Line: LNCaP and Granta cell lines
Concentration: 0.01-100 μM
Incubation Time: 4 days
Result: Inhibited LNCaP cells and Granta cell lines with IC50s of 4 and 1.7 μM, respectively.

Apoptosis Analysis[1]

Cell Line: LNCaP cell line
Concentration: 1-5 μM
Incubation Time: 24 h
Result: Induced apoptosis in LNCaP cell line.

Western Blot Analysis[1]

Cell Line: LNCaP cell line
Concentration: 0-5 μM
Incubation Time: 0-24 h
Result: Dose-dependently increased both p53 protein level and phosphorylation on Ser15, and increased the concentration of p21.

Western Blot Analysis[2]

Cell Line: SKOV3, ES2 and MOSEC/Luc cell lines
Concentration: 0, 2.5 and 5 μM
Incubation Time: 48 h
Result: Increased PD-L1 expression in ovarian cancer cells.
In Vivo

NSC348884 (50 μg; i.p. once) reduces tumor growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6J mice with MOSEC/Luc cells injection[2]
Dosage: 50 μg
Administration: Intraperitoneal injection; 50 μg once
Result: Reduced tumorigenesis, but not completely inhibited.
Molecular Weight

636.79

Appearance

Solid

Formula

C38H40N10
CAS No.
SMILES

CC1=CC=C2N=C(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)NC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (53.39 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5704 mL 7.8519 mL 15.7038 mL
5 mM 0.3141 mL 1.5704 mL 3.1408 mL
10 mM 0.1570 mL 0.7852 mL 1.5704 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (3.93 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (3.93 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (3.93 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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NSC348884 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

NSC34888481624-55-7NSC 348884NSC-348884Apoptosissmall molecularp53apoptosisdoxorubicincancerLNCaPlymphomaSKOV3ES2MOSEC/Luc cellInhibitorinhibitorinhibit

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