Tubulin inhibitor 8
Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM.
For research use only. We do not sell to patients.
- CAS No.: 1309925-39-0
- Formula: C21H14N2O3
- Molecular Weight:342.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.73 μM (tubulin polymerization)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | GI50 |
>10 μM
Compound: 33b
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Antiproliferative activity against human AsPC1 cells after 72 hrs by sulforhodamine staining method
Antiproliferative activity against human AsPC1 cells after 72 hrs by sulforhodamine staining method
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[PMID: 21563750] |
| BT-549 | IC50 |
0.008 μM
Compound: 33b
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Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay
Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay
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[PMID: 21563750] |
| COLO 205 | IC50 |
0.006 μM
Compound: 33b
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Antiproliferative activity against human COLO205 cells after 48 hrs by alamar blue assay
Antiproliferative activity against human COLO205 cells after 48 hrs by alamar blue assay
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[PMID: 21563750] |
| DLD-1 | IC50 |
0.009 μM
Compound: 33b
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Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay
Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay
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[PMID: 21563750] |
| K562 | IC50 |
0.014 μM
Compound: 33b
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Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis
Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis
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[PMID: 21563750] |
| NCI-H460 | IC50 |
0.015 μM
Compound: 33b
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Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay
Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay
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[PMID: 21563750] |
| PBMC | GI50 |
>10 μM
Compound: 33b
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Antiproliferative activity against human resting PBMC after 72 hrs by sulforhodamine staining method
Antiproliferative activity against human resting PBMC after 72 hrs by sulforhodamine staining method
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[PMID: 21563750] |
| SK-OV-3 | IC50 |
0.006 μM
Compound: 33b
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Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay
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[PMID: 21563750] |
| SW480 | IC50 |
0.008 μM
Compound: 33b
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Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay
Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay
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[PMID: 21563750] |
Tubulin inhibitor 8 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1].
Tubulin inhibitor 8 shows excellent antiproliferative potencies with IC50s of 15, 6, 8, 2, 8, 6, and 9 nM for NCIH460, SKOV3, BT549, 451LU, SW480, COLO-205, and DLD-1 tumor cell lines, recpectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1309925-39-0
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Molecular Weight 342.35
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Formula C21H14N2O3
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SMILES
N#CC1=CC=C2N(C(C3=CC=C(OC)C=C3)=O)C4=C(C=CC=C4)OC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin inhibitor 8 Related Classifications
HY-136123 Related Classifications
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