Tubulin inhibitor 6
Based on 1 Customer Validation
Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM.
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 105925-39-1
- Formula: C20H14ClNO2S
- Molecular Weight:367.85
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-16569
Colchicine
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HY-13520
Nocodazole
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HY-16569R
Colchicine (Standard)
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HY-13674
Maytansine
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HY-N0282
Demecolcine
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HY-13520R
Nocodazole (Standard)
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HY-N2146
Combretastatin A4
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HY-N0282R
Demecolcine (Standard)
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HY-10222
Ixabepilone
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HY-12098
Verubulin hydrochloride
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HY-13270
ABT-751
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HY-16569B
Colchicine,suitable for plant cell culture
Biological Activity
IC50: 0.87 μM (tubulin polymerization)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
0.84 μM
Compound: 14b
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Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis
Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis
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[PMID: 21563750] |
Tubulin inhibitor 6 displays submicromolar antiproliferative activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 105925-39-1
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Appearance Solid
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Molecular Weight 367.85
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Formula C20H14ClNO2S
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Color White to off-white
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SMILES
O=C(N1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13)C4=CC=C(OC)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (169.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7185 mL | 13.5925 mL | 27.1850 mL | 67.9625 mL |
| 5 mM | 0.5437 mL | 2.7185 mL | 5.4370 mL | 13.5925 mL | |
| 10 mM | 0.2718 mL | 1.3592 mL | 2.7185 mL | 6.7962 mL | |
| 15 mM | 0.1812 mL | 0.9062 mL | 1.8123 mL | 4.5308 mL | |
| 20 mM | 0.1359 mL | 0.6796 mL | 1.3592 mL | 3.3981 mL | |
| 25 mM | 0.1087 mL | 0.5437 mL | 1.0874 mL | 2.7185 mL | |
| 30 mM | 0.0906 mL | 0.4531 mL | 0.9062 mL | 2.2654 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6991 mL | |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL | 1.3592 mL | |
| 60 mM | 0.0453 mL | 0.2265 mL | 0.4531 mL | 1.1327 mL | |
| 80 mM | 0.0340 mL | 0.1699 mL | 0.3398 mL | 0.8495 mL | |
| 100 mM | 0.0272 mL | 0.1359 mL | 0.2718 mL | 0.6796 mL |
Tubulin inhibitor 6 Related Classifications
HY-136121 Related Classifications
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