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Signaling Pathway

Ixabepilone

HY-10222

(Azaepothilone B; BMS 247550; BMS 247550-1)

Ixabepilone

Ixabepilone Chemical Structure

Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $279 In-stock
5 mg $250 In-stock
10 mg $440 In-stock
50 mg $1500 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €273 In-stock
5 mg €245 In-stock
10 mg €431 In-stock
50 mg €1470 In-stock
100 mg Get quote
200 mg Get quote

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Inquiry Information
Product name: Ixabepilone
Cat. No.: HY-10222

Ixabepilone Data Sheet

  • View current batch:

    Purity: 95.11%

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    DataSheet

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    MSDS

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    COA

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    NMR

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    LCMS

Related Compound Libraries

Biological Activity of Ixabepilone

Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.
IC50 Value:
Target: Microtubule/Tubulin
in vitro: BMS-247550 (EpoB), a novel epothilone B analogue, induces cell cycle arrest at the G(2)-M phase transition and subsequent apoptotic cell death of MDA-MB-468 (468) cells.
in vivo: Ixabepilone, on a once every 21-day schedule, is modestly active against metastatic gastric cancer previously treated with a taxane. The days 1-5 every 21 days schedule had a more favorable safety profile but no activity. The results of this study suggest that once every 21-day ixabepilone schedule should be pursued further in untreated gastric or gastroesophageal adenocarcinoma patients. Ixabepilone has demonstrated activity in patients with chemotherapy-naive metastatic HRPC. Major toxicities were neutropenia and neuropathy. Further testing to define its activity relative to standard therapy is warranted.

Chemical Information

M.Wt 506.7 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₇H₄₂N₂O₅S
CAS No 219989-84-1
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.9736 mL 9.8678 mL 19.7355 mL
5 mM 0.3947 mL 1.9736 mL 3.9471 mL
10 mM 0.1974 mL 0.9868 mL 1.9736 mL

Clinical Information of Ixabepilone

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Ixabepilone Bristol-Myers Squibb Co Metastatic breast cancer 30-SEP-03 31-MAR-08 Phase 3 05-NOV-12
Sarah Cannon Research Institute Breast tumor 31-JAN-09 31-JAN-16 Phase 3 12-JUL-13
Bristol-Myers Squibb Co Endometrioid carcinoma 31-AUG-09 31-DEC-13 Phase 3 29-AUG-13
Federation Nationale des Centres de Lutte Contre le Cancer Breast tumor 30-SEP-07 Phase 3 24-JUL-12
Cancer and Leukemia Group B Metastatic breast cancer 31-OCT-08 31-DEC-13 Phase 3 05-AUG-13

References on Ixabepilone

Inhibitor Kit

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