Cat. No.: HY-N2146

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Combretastatin A4

(Synonyms: CRC 87-09)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

For research use only. We do not sell to patients.

Purity: 99.81%
CAS No.: 117048-59-6
Formula: C₁₈H₂₀O₅
Molecular Weight:316.35

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Combretastatin A4 Chemical Structure

CAS No.: 117048-59-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
- In Vivo
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Bioz

Biological Activity

Description

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

IC₅₀ & Target^[1]

α-Tubulin

β-Tubulin

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	IC₅₀	3.6 nM Compound: combretastatin A4	Antiproliferative activity against human 1A9 cells Antiproliferative activity against human 1A9 cells	[PMID: 18411048]
518A2	IC₅₀	18 nM Compound: CA4	Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay	[PMID: 20731355]
518A2	IC₅₀	1.8 nM Compound: CA-4	Growth inhibition of human 518A2 cells after 72 hrs by MTT assay Growth inhibition of human 518A2 cells after 72 hrs by MTT assay	[PMID: 27116710]
518A2	IC₅₀	0.02 μM Compound: CA4	Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 31958738]
786-0	GI₅₀	0.1 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human 786-0 cells after 48 hrs by SRB assay Growth inhibition of human 786-0 cells after 48 hrs by SRB assay	[PMID: 22982122]
786-0	GI₅₀	0.1 μM Compound: CA4, NSC 613729	Growth inhibition of human 786-0 cells after 48 hrs by SRB assay Growth inhibition of human 786-0 cells after 48 hrs by SRB assay	[PMID: 24387982]
786-0	GI₅₀	100 nM Compound: CA4	Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
786-0	GI₅₀	0.1 μM Compound: CA4; NSC 613729	Cytotoxicity against human 786-0 cells by SRB assay Cytotoxicity against human 786-0 cells by SRB assay	[PMID: 26257861]
A10	IC₅₀	23 nM Compound: 2, CSA4	Growth inhibition of rat A10 cells Growth inhibition of rat A10 cells	[PMID: 19601594]
A10	EC₅₀	0.007 μM Compound: 1, CA-4	Antiproliferative activity against rat A10 cells assessed as microtubule depolymerization after 18 to 24 hrs by indirect immunofluorescence technique Antiproliferative activity against rat A10 cells assessed as microtubule depolymerization after 18 to 24 hrs by indirect immunofluorescence technique	[PMID: 19894742]
A10	EC₅₀	<0.025 μM Compound: CA-4	Inhibition of tubulin in rat A10 cells assessed as induction of cellular microtubule disassembly after 18 hrs by indirect immunofluorescence technique Inhibition of tubulin in rat A10 cells assessed as induction of cellular microtubule disassembly after 18 hrs by indirect immunofluorescence technique	[PMID: 20006519]
A10	IC₅₀	1.2 μM Compound: CA4	Inhibition of bovine brain tubulin assembly in A-10 cells Inhibition of bovine brain tubulin assembly in A-10 cells	[PMID: 21786793]
A10	IC₅₀	1 nM Compound: 2, CSA4	Growth inhibition of rat A10 cells after 48 hrs by MTT assay Growth inhibition of rat A10 cells after 48 hrs by MTT assay	[PMID: 22044164]
A10	EC₅₀	13 nM Compound: CA-4	Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by indirect immunofluorescence assay Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by indirect immunofluorescence assay	[PMID: 23332369]
A10	EC₅₀	7 nM Compound: CA-4	Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay	[PMID: 23895532]
A10	EC₅₀	9.8 nM Compound: CA-4	Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay	[PMID: 25882519]
A10	EC₅₀	9.8 nM Compound: CA-4	Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence method Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence method	[PMID: 30098869]
A10	EC₅₀	<0.025 μM Compound: 1	Inhibition of tubulin polymerization in rat A10 cells assessed as microtubule loss Inhibition of tubulin polymerization in rat A10 cells assessed as microtubule loss	10.1039/C0MD00119H
A2780	IC₅₀	1.66 nM Compound: CA-4	Antiproliferative activity against doxorubicin-resistant human A2780-dx cells Antiproliferative activity against doxorubicin-resistant human A2780-dx cells	[PMID: 16722633]
A2780	IC₅₀	2.19 nM Compound: CA-4	Antiproliferative activity against human A2780 cells Antiproliferative activity against human A2780 cells	[PMID: 16722633]
A2780	IC₅₀	1.9 nM Compound: 2, CA4	Antiproliferative activity against human A2780 cells after 5 days by MTT assay Antiproliferative activity against human A2780 cells after 5 days by MTT assay	[PMID: 19837594]
A2780	IC₅₀	2.84 μM Compound: CA-4	Antiproliferative activity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 26974371]
A2780	IC₅₀	2.95 μM Compound: CA-4	Antiproliferative activity against cisplatin resistant human A2780 cells assessed as cell viability after 48 hrs by MTT assay Antiproliferative activity against cisplatin resistant human A2780 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 26974371]
A2780	IC₅₀	0.009 μM Compound: CA-4	Cytotoxicity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 27149641]
A2780	IC₅₀	0.016 μM Compound: CA-4	Antiproliferative activity against human A2780 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells measured after 48 hrs by MTT assay	[PMID: 27721152]
A2780	IC₅₀	0.006 μM Compound: CA-4	Growth inhibition of human A2780 cells Growth inhibition of human A2780 cells	[PMID: 27805821]
A2780	IC₅₀	12 nM Compound: CA-4	Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay	[PMID: 28792756]
A2780	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human A2780 cells by MTT assay Antiproliferative activity against human A2780 cells by MTT assay	[PMID: 29126741]
A2780	IC₅₀	0.006 μM Compound: 1; CA-4	Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay	[PMID: 29306206]
A2780	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
A2780	IC₅₀	12 nM Compound: CA-4	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
A2780	IC₅₀	72.753 μM Compound: CA-4	Antiproliferative activity against paclitaxel-resistant human A2780 cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against paclitaxel-resistant human A2780 cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
A2780	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33581556]
A2780	IC₅₀	2.5 nM Compound: CA-4	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33618157]
A2780	IC₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34649064]
A2780	IC₅₀	0.004 μM Compound: 1; CA-4	Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay	[PMID: 35065411]
A2780	IC₅₀	0.004 μM Compound: Combretastatin A-4	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 35567964]
A2780	IC₅₀	0.003 μM Compound: 6; CA-4	Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
A2780	IC₅₀	2.155 nM Compound: CA-4	Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
A-375	IC₅₀	2.1 nM Compound: 4, CA4	Antiproliferative activity against human A375 after 48 hrs by spectrophotometry Antiproliferative activity against human A375 after 48 hrs by spectrophotometry	[PMID: 21774499]
A-375	IC₅₀	0.21 μM Compound: 2a, CA-4	Cytotoxicity against human A375 cells after 48 hrs by MTT assay Cytotoxicity against human A375 cells after 48 hrs by MTT assay	[PMID: 22543234]
A-375	IC₅₀	0.21 μM Compound: Combretastatin-A4	Cytotoxicity against human A375 cells after 48 hrs by MTT assay Cytotoxicity against human A375 cells after 48 hrs by MTT assay	[PMID: 27487568]
A-375	IC₅₀	0.21 μM Compound: Combretastatin A-4	Cytotoxicity against human A375 cells after 48 hrs by MTT assay Cytotoxicity against human A375 cells after 48 hrs by MTT assay	[PMID: 30108703]
A-375	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human A-375 cells Antiproliferative activity against human A-375 cells	[PMID: 34655985]
A-431	EC₅₀	0.0035 μM Compound: CA4	Cell cycle arrest in A431 cells by accumulation at G2/M phase cell Cell cycle arrest in A431 cells by accumulation at G2/M phase cell	[PMID: 16198562]
A-431	EC₅₀	0.0035 μM Compound: CA4	Cell cycle arrest in A431 cells by accumulation at G2/M phase Cell cycle arrest in A431 cells by accumulation at G2/M phase	[PMID: 16377187]
A-431	IC₅₀	188 nM Compound: 4, CA4	Antiproliferative activity against human A431 after 48 hrs by spectrophotometry Antiproliferative activity against human A431 after 48 hrs by spectrophotometry	[PMID: 21774499]
A-431	IC₅₀	0.25 μM Compound: 1a; CA-4	Cytotoxicity against human A431 cells after 48 hrs by MTT assay Cytotoxicity against human A431 cells after 48 hrs by MTT assay	[PMID: 29291446]
A498	GI₅₀	0.61 μM Compound: CA-4	In vitro cytotoxic activity was tested against human renal cancer (A498) cell line In vitro cytotoxic activity was tested against human renal cancer (A498) cell line	[PMID: 12729640]
A498	GI₅₀	50.1 nM Compound: 1, CA-4	Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
A498	GI₅₀	0.006 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human A498 cells after 48 hrs by SRB assay Growth inhibition of human A498 cells after 48 hrs by SRB assay	[PMID: 22982122]
A498	GI₅₀	0.006 μM Compound: CA4, NSC 613729	Growth inhibition of human A498 cells after 48 hrs by SRB assay Growth inhibition of human A498 cells after 48 hrs by SRB assay	[PMID: 24387982]
A498	GI₅₀	6.11 nM Compound: CA4	Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
A498	GI₅₀	0.006 μM Compound: CA4; NSC 613729	Cytotoxicity against human A498 cells by SRB assay Cytotoxicity against human A498 cells by SRB assay	[PMID: 26257861]
A498	GI₅₀	0.006 μM Compound: CA-4	Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
A549	IC₅₀	2.1 nM Compound: combretastatin A-4 (CA-4)	Concentration which produces 50% inhibition of growth of human lung carcinoma cell line A549 Concentration which produces 50% inhibition of growth of human lung carcinoma cell line A549	[PMID: 11714613]
A549	IC₅₀	117 nM Compound: CA4 (Combretastatin)	Concentration required for the 50% inhibition of human lung caner (A549) cell line growth Concentration required for the 50% inhibition of human lung caner (A549) cell line growth	[PMID: 15293996]
A549	ED₅₀	3.2 μM Compound: 2	Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line. Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line.	[PMID: 1613753]
A549	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 17434303]
A549	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human A549 cells after 72 hrs by XTT method Cytotoxicity against human A549 cells after 72 hrs by XTT method	[PMID: 18502133]
A549	ED₅₀	uM μM Compound: 1a	Cytotoxic concentration required to inhibit 50% cell growth in A-549 lung carcinoma cell lines Cytotoxic concentration required to inhibit 50% cell growth in A-549 lung carcinoma cell lines	[PMID: 1875350]
A549	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 18790642]
A549	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 19647439]
A549	IC₅₀	0.42 μM Compound: CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 19665898]
A549	IC₅₀	7.8 nM Compound: 2, CA4	Antiproliferative activity against human A549 cells after 5 days by MTT assay Antiproliferative activity against human A549 cells after 5 days by MTT assay	[PMID: 19837594]
A549	IC₅₀	0.003 μM Compound: II, CA-4	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 19939521]
A549	IC₅₀	180 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 20420439]
A549	IC₅₀	0.09 μg/mL Compound: 1, CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 21440448]
A549	IC₅₀	180 nM Compound: 1, CA-4	Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
A549	GI₅₀	1200 nM Compound: 1, CA-4	Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
A549	IC₅₀	>10 μM Compound: 2, CSA4	Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22044164]
A549	IC₅₀	180 nM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22136312]
A549	IC₅₀	0.55 μg/mL Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22261027]
A549	IC₅₀	0.53 μg/mL Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22503741]
A549	IC₅₀	0.09 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22512906]
A549	IC₅₀	0.11 μM Compound: 2a, CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22543234]
A549	IC₅₀	180 nM Compound: 1, CA-4	Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 22578111]
A549	IC₅₀	5.3 nM Compound: 2, CA-4	Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay	[PMID: 22727370]
A549	GI₅₀	0.015 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human A549 cells after 48 hrs by SRB assay Growth inhibition of human A549 cells after 48 hrs by SRB assay	[PMID: 22982122]
A549	IC₅₀	180 nM Compound: CA-4, 1a, 1	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 23117171]
A549	IC₅₀	>10000 nM Compound: 2	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23214452]
A549	IC₅₀	5.6 nM Compound: CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23356786]
A549	IC₅₀	3.64 nM Compound: 1, CA-4	Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay	[PMID: 23360369]
A549	IC₅₀	180 nM Compound: 1, CA-4	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 23445496]
A549	IC₅₀	0.28 μM Compound: 2	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23809851]
A549	GI₅₀	0.016 μM Compound: CA4, NSC 613729	Growth inhibition of human A549 cells after 48 hrs by SRB assay Growth inhibition of human A549 cells after 48 hrs by SRB assay	[PMID: 24387982]
A549	GI₅₀	16.11 nM Compound: CA4	Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
A549	IC₅₀	0.0038 μM Compound: CA-4	Cytotoxicity against human A549 cells after 72 hrs by resazurin based fluorescence assay Cytotoxicity against human A549 cells after 72 hrs by resazurin based fluorescence assay	[PMID: 24669888]
A549	IC₅₀	7.9 nM Compound: 1, CA-4	Growth inhibition of human A549 cells after 48 hrs by SRB assay Growth inhibition of human A549 cells after 48 hrs by SRB assay	[PMID: 24900453]
A549	IC₅₀	0.1 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 24909678]
A549	IC₅₀	0.46 μg/mL Compound: 2, CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 24916028]
A549	IC₅₀	180 nM Compound: 1a, CA-4	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 25025853]
A549	IC₅₀	2.79 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 24 to 48 hrs by CKK8 assay Antiproliferative activity against human A549 cells after 24 to 48 hrs by CKK8 assay	[PMID: 25105922]
A549	IC₅₀	0.052 μM Compound: CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25192811]
A549	IC₅₀	0.008 μM Compound: CA4	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 25462279]
A549	IC₅₀	0.46 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 25703297]
A549	IC₅₀	180 nM Compound: 1a, CA-4	Antiproliferative activity against human A549 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human A549 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
A549	IC₅₀	0.28 μM Compound: CA-4	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 25817588]
A549	IC₅₀	0.14 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 25828827]
A549	GI₅₀	2.8 μM Compound: CA-4	Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay	[PMID: 26070164]
A549	GI₅₀	0.0841 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition by SRB assay	[PMID: 26242242]
A549	GI₅₀	0.016 μM Compound: CA4; NSC 613729	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 26257861]
A549	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
A549	IC₅₀	0.051 μM Compound: 1; CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 26970659]
A549	GI₅₀	0.016 μM Compound: CA-4	Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
A549	IC₅₀	0.005 μM Compound: CA-4	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 27149641]
A549	IC₅₀	0.014 μM Compound: CA-4	Cytotoxicity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 27149641]
A549	IC₅₀	49.05 μM Compound: 3; CA-4	Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay	[PMID: 27172319]
A549	IC₅₀	3.01 μM Compound: CA-4	Antiproliferative activity against CA-4-resistant human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against CA-4-resistant human A549 cells measured after 72 hrs by MTT assay	[PMID: 27187864]
A549	IC₅₀	0.11 μM Compound: Combretastatin-A4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 27487568]
A549	GI₅₀	0.06 μM Compound: 2; CA4	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 27515320]
A549	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 27721152]
A549	IC₅₀	0.009 μM Compound: 1; CA-4	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 27994764]
A549	IC₅₀	0.058 μM Compound: 2A; CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28034647]
A549	IC₅₀	0.01 μM Compound: CA4	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 28174064]
A549	IC₅₀	0.43 μM Compound: CA-4	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 28622907]
A549	IC₅₀	5.3 μM Compound: CA 4	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 28684120]
A549	IC₅₀	9.29 μM Compound: CA-4; B	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28774575]
A549	IC₅₀	4 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28792756]
A549	GI₅₀	0.056 μM Compound: Combretastatin	Antiproliferative activity against human A549 cells after 48 hrs by SRB cell proliferation assay Antiproliferative activity against human A549 cells after 48 hrs by SRB cell proliferation assay	[PMID: 29089233]
A549	IC₅₀	180 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by resazurin-based fluorescence assay Antiproliferative activity against human A549 cells after 72 hrs by resazurin-based fluorescence assay	[PMID: 29202409]
A549	IC₅₀	1.15 μM Compound: 1; CA-4	Antiproliferative activity against human A549 cells after 24 hrs by SRB assay Antiproliferative activity against human A549 cells after 24 hrs by SRB assay	[PMID: 29268127]
A549	IC₅₀	>20 μM Compound: 1a; CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 29291446]
A549	IC₅₀	0.45 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 29407949]
A549	IC₅₀	130 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 2 days by MTT assay Antiproliferative activity against human A549 cells after 2 days by MTT assay	[PMID: 29432949]
A549	IC₅₀	0.004 μM Compound: CA4	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 29509413]
A549	IC₅₀	94.3 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 30006162]
A549	GI₅₀	0.31 μM Compound: CA-4	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 30041136]
A549	IC₅₀	0.11 μM Compound: Combretastatin A-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 30108703]
A549	IC₅₀	6.45 μM Compound: Combretastatin	Antiproliferative activity in human A549 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay Antiproliferative activity in human A549 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay	[PMID: 30108756]
A549	IC₅₀	5.99 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
A549	IC₅₀	0.037 μM Compound: CA-4; 2	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30176537]
A549	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by XTT assay Antiproliferative activity against human A549 cells after 72 hrs by XTT assay	[PMID: 30216850]
A549	IC₅₀	0.016 μM Compound: 2; CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30245397]
A549	IC₅₀	0.13 μM Compound: CA-4	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 30502686]
A549	IC₅₀	200 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTS assay Antiproliferative activity against human A549 cells after 72 hrs by MTS assay	[PMID: 30525602]
A549	IC₅₀	0.009 μM Compound: 1; CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30530194]
A549	IC₅₀	0.16 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 30606674]
A549	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30633509]
A549	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
A549	IC₅₀	200 nM Compound: 7; CA-4	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
A549	IC₅₀	4.422 nM Compound: CA-4	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTS assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTS assay	[PMID: 31541870]
A549	IC₅₀	7 nM Compound: CA-4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 31610375]
A549	IC₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 31787361]
A549	IC₅₀	0.57 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 31830637]
A549	GI₅₀	0.167 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
A549	GI₅₀	5.5 nM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 31938468]
A549	IC₅₀	0.47 μM Compound: CA-4	Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 31954880]
A549	IC₅₀	0.23 μM Compound: CA-4	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
A549	GI₅₀	0.0047 μM Compound: 42; CA4	Cytotoxicity against human A549 cells incubated for 52 hrs in oxic condition by sulforhodamine B assay Cytotoxicity against human A549 cells incubated for 52 hrs in oxic condition by sulforhodamine B assay	[PMID: 32196334]
A549	GI₅₀	0.0061 μM Compound: 42; CA4	Cytotoxicity against human A549 cells incubated for 4 hrs in anoxic condition followed by oxic exposure for 48 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells incubated for 4 hrs in anoxic condition followed by oxic exposure for 48 hrs by sulforhodamine B assay	[PMID: 32196334]
A549	IC₅₀	0.021 μM Compound: CA-4	Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 32717486]
A549	GI₅₀	0.82 μM Compound: CA-4	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 32832031]
A549	IC₅₀	2.78 μM Compound: Combretastatin A-4	Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
A549	IC₅₀	0.05 μM Compound: CA-4	Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay	[PMID: 33010448]
A549	IC₅₀	0.021 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
A549	IC₅₀	130.384 μM Compound: CA-4	Antiproliferative activity against cisplatin resistant human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against cisplatin resistant human A549 cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
A549	IC₅₀	200 nM Compound: 1; CA-4	Antiproliferative activity against human A549 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human A549 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
A549	GI₅₀	4.8 nM Compound: CA-4	Antiproliferation activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferation activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33201714]
A549	IC₅₀	0.058 μM Compound: 1; CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 33421913]
A549	IC₅₀	0.18 μM Compound: CA-4;1a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 33550186]
A549	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33581556]
A549	IC₅₀	0.021 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
A549	IC₅₀	0.015 μM Compound: CA-4	Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
A549	IC₅₀	0.6 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 34311158]
A549	IC₅₀	0.005 μM Compound: 8; CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by SRB assay	[PMID: 34454126]
A549	IC₅₀	0.008 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34649064]
A549	GI₅₀	5.5 nM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 34917259]
A549	IC₅₀	0.006 μM Compound: 1; CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 35065411]
A549	IC₅₀	0.046 μM Compound: CA-4	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
A549	IC₅₀	0.04 μM Compound: CA4	Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 35551039]
A549	IC₅₀	0.004 μM Compound: Combretastatin A-4	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 35567964]
A549	IC₅₀	0.0075 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 35635956]
A549	IC₅₀	200 nM Compound: CA4	Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
A549	IC₅₀	0.00254 μM Compound: CA4	Cytotoxicity against human A549 cells assessed as cell growth inhibition Cytotoxicity against human A549 cells assessed as cell growth inhibition	[PMID: 35964428]
A549	IC₅₀	0.035 μM Compound: CA4	Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35964428]
A549	IC₅₀	2.83 μM Compound: CA-4	Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
A549	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 36162214]
A549	IC₅₀	0.39 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
A549	IC₅₀	0.027 μM Compound: 2; CA-4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36334455]
A549	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth Antiproliferative activity against human A549 cells assessed as inhibition of cell growth	[PMID: 36828299]
A549	IC₅₀	0.021 μM Compound: 1; CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37172475]
A549	IC₅₀	0.002 μM Compound: 6; CA-4	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
A549	IC₅₀	43 nM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell growth by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
A549	IC₅₀	0.011 μM Compound: CA-4; Cpd II	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37883897]
A549	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay	[PMID: 37890199]
A549	IC₅₀	10 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 38107170]
A549	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human A549 cells incubated for 72 hrs Antiproliferative activity against human A549 cells incubated for 72 hrs	[PMID: 38171146]
A549	IC₅₀	0.28 μM Compound: CA-4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38280356]
A549	IC₅₀	0.014 μM Compound: CA-4	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38452727]
A549	IC₅₀	0.01 μM Compound: CA-4	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
A549	IC₅₀	0.11 μM Compound: CA-4; 1	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38806101]
A549	IC₅₀	0.04 μM Compound: CA4	Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 38889607]
A549	IC₅₀	2.57 nM Compound: CA-4	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
A549	IC₅₀	0.55 μM Compound: 1, CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	10.1039/C2MD20085F
A549	IC₅₀	12.52 μM Compound: CA-4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	10.1039/C3MD00372H
A549	GI₅₀	0.018 μM Compound: CA-4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	10.1039/C5MD00139K
A549	IC₅₀	0.012 μM Compound: 2; CA-4	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00150A
A549/CDDP	IC₅₀	0.017 μM Compound: CA4	Growth inhibition of human A549/CDDP cells after 48 hrs by MTT assay Growth inhibition of human A549/CDDP cells after 48 hrs by MTT assay	[PMID: 29509413]
A549/TR	IC₅₀	0.175 μM Compound: 1; CA-4	Antiproliferative activity against human taxol-resistant A549/TR cells after 72 hrs by MTT assay Antiproliferative activity against human taxol-resistant A549/TR cells after 72 hrs by MTT assay	[PMID: 30530194]
A549/TR	IC₅₀	0.076 μM Compound: CA-4; Cpd II	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37883897]
ACHN	IC₅₀	1.6 nM Compound: CA4	Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay	[PMID: 17286393]
ACHN	IC₅₀	0.17 μM Compound: 2a, CA-4	Cytotoxicity against human ACHN cells after 48 hrs by MTT assay Cytotoxicity against human ACHN cells after 48 hrs by MTT assay	[PMID: 22543234]
ACHN	GI₅₀	0.006 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human ACHN cells after 48 hrs by SRB assay Growth inhibition of human ACHN cells after 48 hrs by SRB assay	[PMID: 22982122]
ACHN	GI₅₀	0.006 μM Compound: CA4, NSC 613729	Growth inhibition of human ACHN cells after 48 hrs by SRB assay Growth inhibition of human ACHN cells after 48 hrs by SRB assay	[PMID: 24387982]
ACHN	GI₅₀	6.14 nM Compound: CA4	Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
ACHN	IC₅₀	0.005 μM Compound: CA-4	Cytotoxicity against human ACHN cells after 48 hrs by MTT assay Cytotoxicity against human ACHN cells after 48 hrs by MTT assay	[PMID: 25192811]
ACHN	GI₅₀	0.006 μM Compound: CA4; NSC 613729	Cytotoxicity against human ACHN cells by SRB assay Cytotoxicity against human ACHN cells by SRB assay	[PMID: 26257861]
AGS	IC₅₀	0.04 μM Compound: 1, CA-4	Cytotoxicity against human AGS cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human AGS cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23566762]
AGS	IC₅₀	0.064 μM Compound: CA-4	Cytotoxicity against human AGS cells after 48 hrs by MTT assay Cytotoxicity against human AGS cells after 48 hrs by MTT assay	[PMID: 24238904]
AGS	IC₅₀	0.074 μM Compound: CA-4	Cytotoxicity against human AGS cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human AGS cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
AU565	IC₅₀	4.4 nM Compound: 4, CA4	Antiproliferative activity against human AU565 after 48 hrs by spectrophotometry Antiproliferative activity against human AU565 after 48 hrs by spectrophotometry	[PMID: 21774499]
B16	IC₅₀	1 nM Compound: combretastatin A-4 (CA-4)	Concentration which produces 50% inhibition of growth of murine melanoma B16 cell line Concentration which produces 50% inhibition of growth of murine melanoma B16 cell line	[PMID: 11714613]
B16	IC₅₀	0.003 μM Compound: 1, CA-4	Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay	[PMID: 18226429]
B16	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test	[PMID: 18583138]
B16	IC₅₀	0.005 μM Compound: CA4	Cytotoxicity against mouse B16 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against mouse B16 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 21112130]
B16	IC₅₀	0.002 μM Compound: 2, CA-4	Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay	[PMID: 21524832]
B16	IC₅₀	0.003 μM Compound: 1, CA4	Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 22647220]
B16	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay	[PMID: 23369686]
B16	IC₅₀	56 μM Compound: CA-4	Cytotoxicity against mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33479639]
B16	IC₅₀	0.0046 μM Compound: 1	Cytotoxicity against mouse B16 cells Cytotoxicity against mouse B16 cells	10.1039/C0MD00119H
B16-F10	IC₅₀	0.4 μg/mL Compound: 1, CA-4	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 21440448]
B16-F10	IC₅₀	0.4 μg/mL Compound: 2, CA-4	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay	[PMID: 21783370]
B16-F10	IC₅₀	0.75 μg/mL Compound: CA-4	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 22192936]
B16-F10	IC₅₀	0.42 μg/mL Compound: 2, CA-4	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 24916028]
B16-F10	IC₅₀	0.42 μM Compound: CA-4	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 25703297]
B16-F10	IC₅₀	0.05 μM Compound: CA-4	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 33280898]
B16-F10	IC₅₀	0.014 μM Compound: CA-4	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
B16-F10	IC₅₀	0.007 μM Compound: 6; CA-4	Antiproliferative activity against mouse B16-F10 cells incubated for 72 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
B16-F10	IC₅₀	82 nM Compound: CA-4	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell growth by SRB assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
Bel-7402	IC₅₀	10 nM Compound: 1	Antiproliferative activity against human Bel7402 cells after 72 hrs Antiproliferative activity against human Bel7402 cells after 72 hrs	[PMID: 17034133]
Bel-7402	IC₅₀	10 nM Compound: 5, CA4	Antiproliferative activity against human Bel-7402 cells Antiproliferative activity against human Bel-7402 cells	[PMID: 17197178]
Bel-7402	IC₅₀	10 nM Compound: CA-4	Antiproliferative activity against human Bel7402 cells Antiproliferative activity against human Bel7402 cells	[PMID: 17482458]
Bel-7402	IC₅₀	0.01 μM Compound: CA-4, combretastatin A-4	Antiproliferative activity against human Bel7402 cells Antiproliferative activity against human Bel7402 cells	[PMID: 17977727]
Bel-7402	IC₅₀	1.72 μM Compound: CA-4	Anticancer activity against human Bel7402 cells after 72 hrs Anticancer activity against human Bel7402 cells after 72 hrs	[PMID: 19713108]
Bel-7402	IC₅₀	1.718 μM Compound: CA4	Cytotoxicity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
Bel-7402	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against human Bel7402 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human Bel7402 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 27149641]
Bel-7402	IC₅₀	0.013 μM Compound: CA-4	Antiproliferative activity against human Bel7402 cells measured after 48 hrs by MTT assay Antiproliferative activity against human Bel7402 cells measured after 48 hrs by MTT assay	[PMID: 27721152]
Bel-7402	IC₅₀	0.02 μM Compound: 1; CA-4	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
Bel-7402	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 30530194]
Bel-7402	IC₅₀	0.084 μM Compound: CA-4	Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
Bel-7402	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
Bel-7402	IC₅₀	0.058 μM Compound: 1; CA-4	Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
Bel-7402	GI₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human Bel7402 cells after 48 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 48 hrs by MTT assay	10.1039/C5MD00139K
BeWo	IC₅₀	12.74 μM Compound: CA-4	Cytotoxicity against human Bewo cells after 48 hrs by MTT assay Cytotoxicity against human Bewo cells after 48 hrs by MTT assay	10.1039/C3MD00372H
BJ	IC₅₀	28.6 nM Compound: 7; CA-4	Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
BMEC	IC₅₀	0.0037 μM Compound: CA-4	Antiproliferative activity against bovine BMEC Antiproliferative activity against bovine BMEC	[PMID: 16722633]
BMEC	IC₅₀	3.7 nM Compound: 1, CA-4	Cytotoxicity against BMEC by sulforhodamine B test Cytotoxicity against BMEC by sulforhodamine B test	[PMID: 18783207]
BT-474	IC₅₀	3.9 nM Compound: 3	Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
BT-549	IC₅₀	3.5 nM Compound: 4, CA4	Antiproliferative activity against human BT549 after 48 hrs by spectrophotometry Antiproliferative activity against human BT549 after 48 hrs by spectrophotometry	[PMID: 21774499]
BT-549	GI₅₀	10 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human BT549 cells after 48 hrs by SRB assay Growth inhibition of human BT549 cells after 48 hrs by SRB assay	[PMID: 22982122]
BT-549	IC₅₀	1.71 nM Compound: CA-4	Cytotoxicity against human BT549 cells after 72 hrs by MTT assay Cytotoxicity against human BT549 cells after 72 hrs by MTT assay	[PMID: 30472600]
BXPC-3	GI₅₀	3.9 μg/mL Compound: 1c	Compound was evaluated against Human cell line pancreas BXPC-3 Compound was evaluated against Human cell line pancreas BXPC-3	[PMID: 10212132]
BXPC-3	GI₅₀	0.39 μg/mL Compound: 3b	Evaluated for growth inhibition (anticancer activity) of human pancreas-a BXPC-3 cell line. Evaluated for growth inhibition (anticancer activity) of human pancreas-a BXPC-3 cell line.	[PMID: 10893310]
BXPC-3	GI₅₀	0.39 μg/mL Compound: 2a	Cell growth inhibition against pancreatic BXPC-3 cells, 50% reduction in the net protein increase Cell growth inhibition against pancreatic BXPC-3 cells, 50% reduction in the net protein increase	[PMID: 12036362]
BXPC-3	GI₅₀	>0.1 μg/mL Compound: 1a (Combretastatin A-4)	Growth inhibition against human pancreas carcinoma cell line (BxPC-3) Growth inhibition against human pancreas carcinoma cell line (BxPC-3)	[PMID: 15943482]
BXPC-3	GI₅₀	0.39 μg/mL Compound: 1a, CA4	Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
BXPC-3	GI₅₀	0.39 μM Compound: CA4, combretastatin A4	Cytotoxicity against human BXPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BXPC3 cells after 48 hrs by SRB assay	[PMID: 18303849]
BXPC-3	GI₅₀	0.39 μg/mL Compound: 3, CA4	Antitumor activity against human BxPC3 cells by sulforhodamine B assay Antitumor activity against human BxPC3 cells by sulforhodamine B assay	[PMID: 19228038]
BXPC-3	GI₅₀	0.39 μg/mL Compound: Z-1b	Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 19709889]
BXPC-3	GI₅₀	0.39 μg/mL Compound: 2a	Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 19719153]
BXPC-3	GI₅₀	0.39 μg/mL Compound: 1a, CA4	Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
BXPC-3	IC₅₀	<50 nM Compound: CA-4	Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
CA46	IC₅₀	6 nM Compound: CA-4	Antiproliferative activity against human CA46 cells Antiproliferative activity against human CA46 cells	[PMID: 22247790]
CA46	IC₅₀	20 nM Compound: combretastatin A-4	Cytotoxicity against human CA46 cells Cytotoxicity against human CA46 cells	[PMID: 23747810]
CA46	IC₅₀	20 nM Compound: CA-4	Antiproliferative activity against human CA46 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human CA46 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25050880]
CAKI-1	GI₅₀	0.025 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human Caki1 cells after 48 hrs by SRB assay Growth inhibition of human Caki1 cells after 48 hrs by SRB assay	[PMID: 22982122]
CAKI-1	GI₅₀	0.026 μM Compound: CA4, NSC 613729	Growth inhibition of human CAKI-1 cells after 48 hrs by SRB assay Growth inhibition of human CAKI-1 cells after 48 hrs by SRB assay	[PMID: 24387982]
CAKI-1	GI₅₀	25.94 nM Compound: CA4	Growth inhibition of human CAKI-1 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human CAKI-1 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
CAKI-1	GI₅₀	0.026 μM Compound: CA4; NSC 613729	Cytotoxicity against human CAKI-1 cells by SRB assay Cytotoxicity against human CAKI-1 cells by SRB assay	[PMID: 26257861]
CAKI-1	GI₅₀	0.025 μM Compound: CA-4	Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
CAL-27	IC₅₀	3.01 nM Compound: CA-4	Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35576703]
Calu-1	IC₅₀	2.78 μM Compound: Combretastatin A-4	Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
Calu-6	IC₅₀	0.94 nM Compound: 4, CA4	Antiproliferative activity against human Calu6 after 48 hrs by spectrophotometry Antiproliferative activity against human Calu6 after 48 hrs by spectrophotometry	[PMID: 21774499]
Cancer cell lines	IC₅₀	30 nM Compound: combretastatin A-4	Cell growth inhibition against HR, human gastric cancer cells using MTS assay Cell growth inhibition against HR, human gastric cancer cells using MTS assay	[PMID: 12036364]
Cancer cell lines	IC₅₀	8520 nM Compound: combretastatin A-4	Cell growth inhibition against NUGC3 human stomach cancer cells using MTS assay Cell growth inhibition against NUGC3 human stomach cancer cells using MTS assay	[PMID: 12036364]
CAPAN-1	IC₅₀	0.84 μM Compound: COMB	Cytotoxicity against human Capan1 cells after 48 hrs by XTT assay Cytotoxicity against human Capan1 cells after 48 hrs by XTT assay	[PMID: 30017114]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1	Concentration required to inhibit human T-lymphoblast CEM cell line proliferation Concentration required to inhibit human T-lymphoblast CEM cell line proliferation	[PMID: 16005627]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1, CA-4	Antiproliferative activity against human CEM cells Antiproliferative activity against human CEM cells	[PMID: 17034150]
CCRF-CEM	IC₅₀	1.9 nM Compound: 5, CA4	Cytotoxicity against human CEM cells Cytotoxicity against human CEM cells	[PMID: 17197178]
CCRF-CEM	IC₅₀	1.9 nM Compound: CA-4, 1	Antiproliferative effect against human CEM cells after 3 days Antiproliferative effect against human CEM cells after 3 days	[PMID: 17419607]
CCRF-CEM	IC₅₀	1.9 nM Compound: CA-4	Antiproliferative activity against human CEM cells Antiproliferative activity against human CEM cells	[PMID: 17482458]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1, combretastatin A-4	Antiproliferative activity against human CEM cells Antiproliferative activity against human CEM cells	[PMID: 18260616]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1, CA-4	Antiproliferative activity against human CEM cells Antiproliferative activity against human CEM cells	[PMID: 18725179]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1, CA-4	Antiproliferative activity against human CEM cells after 2 days Antiproliferative activity against human CEM cells after 2 days	[PMID: 18755591]
CCRF-CEM	IC₅₀	12 nM Compound: 1, CA-4	Antiproliferative activity against human CEM cells after 2 days by coulter counter method Antiproliferative activity against human CEM cells after 2 days by coulter counter method	[PMID: 19663386]
CCRF-CEM	IC₅₀	0.002 μM Compound: CA-4	Anticancer activity against human CCRF-CEM cells after 72 hrs Anticancer activity against human CCRF-CEM cells after 72 hrs	[PMID: 19713108]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1, CA4	Cytotoxicity against human CEM cells after 2 days Cytotoxicity against human CEM cells after 2 days	[PMID: 19736015]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1, CA-4	Antiproliferative activity against human CEM cells after 2 days by coulter counting Antiproliferative activity against human CEM cells after 2 days by coulter counting	[PMID: 20579891]
CCRF-CEM	IC₅₀	0.002 μM Compound: 1, CA-4	Antiproliferative activity against human CEM cells after 2 days by coulter counter analysis Antiproliferative activity against human CEM cells after 2 days by coulter counter analysis	[PMID: 22027100]
CCRF-CEM	IC₅₀	>100 μM Compound: 2, CA-4	Cytotoxicity against human CEM cells by alamar blue assay Cytotoxicity against human CEM cells by alamar blue assay	[PMID: 22137934]
CCRF-CEM	IC₅₀	0.001 μM Compound: CA-4	Cytotoxicity against human CEM cells after 72 hrs by MTT assay Cytotoxicity against human CEM cells after 72 hrs by MTT assay	[PMID: 22676247]
CCRF-CEM	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay	[PMID: 22982122]
CCRF-CEM	IC₅₀	0.0016 μM Compound: CA4	Cytotoxicity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
CCRF-CEM	IC₅₀	1.9 nM Compound: 1a, CA-4	Cytotoxicity against human CEM/0 cells assessed as growth inhibition after 48 hrs by coulter counting analysis Cytotoxicity against human CEM/0 cells assessed as growth inhibition after 48 hrs by coulter counting analysis	[PMID: 24164557]
CCRF-CEM	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay	[PMID: 24387982]
CCRF-CEM	GI₅₀	2.62 nM Compound: CA4	Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
CCRF-CEM	IC₅₀	12 nM Compound: 1a, CA-4	Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay	[PMID: 25025853]
CCRF-CEM	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human CCRF-CEM cells by SRB assay Cytotoxicity against human CCRF-CEM cells by SRB assay	[PMID: 26257861]
CCRF-CEM	IC₅₀	2 nM Compound: 1; CA-4	Antiproliferative activity against human CEM cells after 3 days by Coulter counter method Antiproliferative activity against human CEM cells after 3 days by Coulter counter method	[PMID: 29220790]
CCRF-CEM	IC₅₀	0.708 nM Compound: 7; CA-4	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
CCRF-CEM	IC₅₀	0.002 μM Compound: CA-4;1a	Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 33550186]
CEM-DNR	IC₅₀	319 nM Compound: 7; CA-4	Cytotoxicity against human CEM/DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human CEM/DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
COLO 205	IC₅₀	2756 nM Compound: combretastatin A-4	Cell growth inhibition against colo 205 human colon cancer cells using tetrazolium dye reduction (MTS) assay Cell growth inhibition against colo 205 human colon cancer cells using tetrazolium dye reduction (MTS) assay	[PMID: 12036364]
COLO 205	GI₅₀	0.1 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human COLO205 cells after 48 hrs by SRB assay Growth inhibition of human COLO205 cells after 48 hrs by SRB assay	[PMID: 22982122]
COLO 205	GI₅₀	0.1 μM Compound: CA4, NSC 613729	Growth inhibition of human COLO205 cells after 48 hrs by SRB assay Growth inhibition of human COLO205 cells after 48 hrs by SRB assay	[PMID: 24387982]
COLO 205	GI₅₀	100 nM Compound: CA4	Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
COLO 205	GI₅₀	0.1 μM Compound: CA4; NSC 613729	Cytotoxicity against human COLO205 cells by SRB assay Cytotoxicity against human COLO205 cells by SRB assay	[PMID: 26257861]
COLO 205	GI₅₀	0.221 μM Compound: CA-4	Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
COLO 205	GI₅₀	0.025 μM Compound: 1; CA-4	Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
COLO 205	IC₅₀	0.001 μM Compound: CA-4	Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31174062]
COLO 205	IC₅₀	0.001 μM Compound: CA-4	Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability by MTT assay	[PMID: 31362922]
Colon 26	IC₅₀	0.44 μM Compound: CA-4	Antiproliferative activity against mouse Colon 26 cells measured after 72 hrs by MTT assay Antiproliferative activity against mouse Colon 26 cells measured after 72 hrs by MTT assay	[PMID: 27187864]
Colon 26	IC₅₀	18 nM Compound: Combrestatin A-4	Growth inhibition of colon 26 adenocarcinoma cells by 50 %. Growth inhibition of colon 26 adenocarcinoma cells by 50 %.	[PMID: 9685242]
Colon 26	IC₅₀	8.7 nM Compound: 2	Cytotoxic activity was determined against Colon 26 adenocarcinoma cells Cytotoxic activity was determined against Colon 26 adenocarcinoma cells	[PMID: 9873736]
CPT30 cell line	IC₅₀	6.9 nM Compound: CA-4	Inhibitory concentration against camptothecin (CPT) resistant cell line using tetrazolium dye reduction assay (MTT) Inhibitory concentration against camptothecin (CPT) resistant cell line using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
CT26	IC₅₀	45.1 nM Compound: CA-4	Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK8 assay Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK8 assay	[PMID: 30006162]
Daoy	IC₅₀	12.3 nM Compound: 1a; CA-4	Antiproliferative activity against human Daoy cells assessed as inhibition of cell growth Antiproliferative activity against human Daoy cells assessed as inhibition of cell growth	[PMID: 32417696]
DLD-1	IC₅₀	36 nM Compound: combretastatin A-4	Cell growth inhibition against DLD-1 human colon cancer cells using MTS assay Cell growth inhibition against DLD-1 human colon cancer cells using MTS assay	[PMID: 12036364]
DLD-1	IC₅₀	3.3 nM Compound: 1, CA-4	Growth inhibition of human DLD1 cells after 48 hrs by SRB assay Growth inhibition of human DLD1 cells after 48 hrs by SRB assay	[PMID: 24900453]
DMS-79	IC₅₀	124 nM Compound: 1	Antiproliferative activity against human DMS79 cells after 72 hrs Antiproliferative activity against human DMS79 cells after 72 hrs	[PMID: 17034133]
DU-145	GI₅₀	7.6 μg/mL Compound: 1c	Compound was evaluated against Human cell line prostate DU-145 Compound was evaluated against Human cell line prostate DU-145	[PMID: 10212132]
DU-145	GI₅₀	0.0008 μg/mL Compound: 3b	Evaluated for growth inhibition (anticancer activity) of Human prostate cancer DU-145 cell line Evaluated for growth inhibition (anticancer activity) of Human prostate cancer DU-145 cell line	[PMID: 10893310]
DU-145	GI₅₀	0.0008 μg/mL Compound: 2a	Cell growth inhibition of prostate DU-145 cells, expressed as 50% reduction in the net protein increase Cell growth inhibition of prostate DU-145 cells, expressed as 50% reduction in the net protein increase	[PMID: 12036362]
DU-145	IC₅₀	32 nM Compound: combretastatin A-4	Cell growth inhibition against DU-145 human prostate cancer cells using MTS assay Cell growth inhibition against DU-145 human prostate cancer cells using MTS assay	[PMID: 12036364]
DU-145	GI₅₀	0.00076 μg/mL Compound: 1a (Combretastatin A-4)	Growth inhibition against human prostate cell line (DU-145) Growth inhibition against human prostate cell line (DU-145)	[PMID: 15943482]
DU-145	GI₅₀	0.0008 μg/mL Compound: 1a, CA4	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
DU-145	IC₅₀	9.3 nM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs Antiproliferative activity against human DU145 cells after 72 hrs	[PMID: 17034133]
DU-145	IC₅₀	9.3 nM Compound: 5, CA4	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17197178]
DU-145	IC₅₀	57 μg/mL Compound: 1'	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 17373779]
DU-145	IC₅₀	9.3 nM Compound: CA-4	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17482458]
DU-145	IC₅₀	0.009 μM Compound: CA-4, combretastatin A-4	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17977727]
DU-145	GI₅₀	0.0008 μM Compound: CA4, combretastatin A4	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 18303849]
DU-145	GI₅₀	0.0008 μg/mL Compound: CA4	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 18710804]
DU-145	GI₅₀	0.002 μM Compound: CA4	Growth inhibition of human DU145 after 48 hrs by SRB assay Growth inhibition of human DU145 after 48 hrs by SRB assay	[PMID: 18722127]
DU-145	GI₅₀	0.0008 μg/mL Compound: 3, CA4	Antitumor activity against human DU145 cells by sulforhodamine B assay Antitumor activity against human DU145 cells by sulforhodamine B assay	[PMID: 19228038]
DU-145	GI₅₀	8 x 10^-4 μg/mL Compound: Z-1b	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 19709889]
DU-145	GI₅₀	0.0008 μg/mL Compound: 2a	Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 19719153]
DU-145	GI₅₀	2 nM Compound: CA4	Anticancer activity against human DU145 cells after 24 hrs by SRB assay Anticancer activity against human DU145 cells after 24 hrs by SRB assay	[PMID: 19733085]
DU-145	GI₅₀	0.001 μM Compound: 1, CA4	Cytotoxicity against human DU145 cells by SRB assay Cytotoxicity against human DU145 cells by SRB assay	[PMID: 20496923]
DU-145	IC₅₀	4 nM Compound: 4, CA4	Antiproliferative activity against human DU145 after 48 hrs by spectrophotometry Antiproliferative activity against human DU145 after 48 hrs by spectrophotometry	[PMID: 21774499]
DU-145	GI₅₀	2.5 nM Compound: 1, CA-4	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
DU-145	GI₅₀	0.0008 μg/mL Compound: 1a, CA4	Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
DU-145	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 22982122]
DU-145	GI₅₀	0.00054 μM Compound: CA4	Growth inhibition of human DU145 cells by sulforhodamine B assay Growth inhibition of human DU145 cells by sulforhodamine B assay	[PMID: 23772309]
DU-145	GI₅₀	0.00484 μM Compound: CA4	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 23993969]
DU-145	GI₅₀	0.00054 μM Compound: 2, CA4	Cytotoxicity against human DU145 cells by SRB assay Cytotoxicity against human DU145 cells by SRB assay	[PMID: 24016002]
DU-145	GI₅₀	0.00327 μM Compound: CA4, CA4P	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 24183586]
DU-145	GI₅₀	6.02 nM Compound: CA4	Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26852340]
DU-145	IC₅₀	0.007 μM Compound: 1; CA-4	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 26970659]
DU-145	GI₅₀	0.046 μM Compound: 1; CA-4	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
DU-145	GI₅₀	0.07 μM Compound: 2; CA4	Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 27515320]
DU-145	IC₅₀	0.069 μM Compound: 2A; CA-4	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 28034647]
DU-145	IC₅₀	0.28 μM Compound: CA-4; B	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 28774575]
DU-145	GI₅₀	0.27 μM Compound: CA-4	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 29227648]
DU-145	GI₅₀	0.00327 μM Compound: CA4	Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay	[PMID: 31059248]
DU-145	GI₅₀	0.00602 μM Compound: CA4	Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 31534659]
DU-145	IC₅₀	0.12 μM Compound: 2a; CA-4	Cytotoxicity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay	10.1039/C5MD00155B
EA.hy 926	IC₅₀	11 nM Compound: CA-4	Growth inhibition of human EAhy926 cells after 72 hrs by MTT assay Growth inhibition of human EAhy926 cells after 72 hrs by MTT assay	[PMID: 27116710]
EA.hy 926	IC₅₀	0.17 μM Compound: CA-4	Growth inhibition of human EAhy926 cells measured after 72 hrs by MTT assay Growth inhibition of human EAhy926 cells measured after 72 hrs by MTT assay	[PMID: 27187864]
EA.hy 926	IC₅₀	0.01 μM Compound: CA4	Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 31958738]
EA.hy 926	IC₅₀	0.011 μM Compound: 13; CA-4	Antiproliferative activity against human EA.hy 926 cells assessed as cell growth inhibition Antiproliferative activity against human EA.hy 926 cells assessed as cell growth inhibition	[PMID: 34101463]
ECa-109 cell line	IC₅₀	4.5 μM Compound: CA-4	Cytotoxicity against human ECA109 cells after 48 hrs by MTT assay Cytotoxicity against human ECA109 cells after 48 hrs by MTT assay	[PMID: 19665898]
ECV-304	IC₅₀	<1 μg/mL Compound: 1'	Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay	[PMID: 17373779]
EKVX	GI₅₀	0.079 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human EKVX cells after 48 hrs by SRB assay Growth inhibition of human EKVX cells after 48 hrs by SRB assay	[PMID: 22982122]
EKVX	GI₅₀	0.086 μM Compound: CA4, NSC 613729	Growth inhibition of human EKVX cells after 48 hrs by SRB assay Growth inhibition of human EKVX cells after 48 hrs by SRB assay	[PMID: 24387982]
EKVX	GI₅₀	85.7 nM Compound: CA4	Growth inhibition of human EKVX cells after 48 hrs by sulforhodamine B assay Growth inhibition of human EKVX cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
EMT6	IC₅₀	495 nM Compound: CA-4	Antiproliferative activity against drug resistant mouse EMT6/AR1 cells incubated for 24 hrs by sulforhodamine B assay Antiproliferative activity against drug resistant mouse EMT6/AR1 cells incubated for 24 hrs by sulforhodamine B assay	[PMID: 26938120]
Epithelial cell	IC₅₀	10 mM Compound: 2a	Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay	[PMID: 21080725]
FaDu	GI₅₀	6.5 μg/mL Compound: 1c	Compound was evaluated against Human cell line pharynx FADU Compound was evaluated against Human cell line pharynx FADU	[PMID: 10212132]
FaDu	GI₅₀	0.0007 μg/mL Compound: 1b	Cytotoxicity against human FaDu cells Cytotoxicity against human FaDu cells	[PMID: 10924176]
FaDu	GI₅₀	0.00065 μg/mL Compound: 1a (Combretastatin A-4)	Growth inhibition against human pharynx FADU cell line Growth inhibition against human pharynx FADU cell line	[PMID: 15943482]
FaDu	IC₅₀	1.9 nM Compound: 1	Antiproliferative activity against human CEM cells after 72 hrs Antiproliferative activity against human CEM cells after 72 hrs	[PMID: 17034133]
FaDu	IC₅₀	5.05 nM Compound: CA-4	Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35576703]
Farage	IC₅₀	0.7 nM Compound: CA-4	Antiproliferative activity against human Farage cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human Farage cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay	[PMID: 36502578]
Fibroblast	IC₅₀	>100 μM Compound: 2, CA-4	Cytotoxicity against human fibroblast cells by alamar blue assay Cytotoxicity against human fibroblast cells by alamar blue assay	[PMID: 22137934]
Fibroblast	IC₅₀	5.48 μM Compound: CA-4	Growth inhibition of primary chicken fibroblasts after 48 hrs by MTT assay Growth inhibition of primary chicken fibroblasts after 48 hrs by MTT assay	[PMID: 27116710]
FM3A	IC₅₀	42 nM Compound: 1	Concentration required to inhibit murine mammary carcinoma FM3A cell line proliferation Concentration required to inhibit murine mammary carcinoma FM3A cell line proliferation	[PMID: 16005627]
FM3A	IC₅₀	42 nM Compound: 1, CA-4	Antiproliferative activity against mouse FM3A cells Antiproliferative activity against mouse FM3A cells	[PMID: 17034150]
FM3A	IC₅₀	42 nM Compound: CA-4, 1	Antiproliferative effect against mouse FM3A cells after 2 days Antiproliferative effect against mouse FM3A cells after 2 days	[PMID: 17419607]
FM3A	IC₅₀	42 nM Compound: 1, combretastatin A-4	Antiproliferative activity against mouse FM3A cells Antiproliferative activity against mouse FM3A cells	[PMID: 18260616]
FM3A	IC₅₀	42 nM Compound: 1, CA-4	Antiproliferative activity against mouse FM3A cells Antiproliferative activity against mouse FM3A cells	[PMID: 18725179]
FM3A	IC₅₀	42 nM Compound: 1, CA-4	Antiproliferative activity against mouse FM3A cells after 2 days Antiproliferative activity against mouse FM3A cells after 2 days	[PMID: 18755591]
FM3A	IC₅₀	42 nM Compound: 1, CA-4	Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method	[PMID: 19663386]
FM3A	IC₅₀	42 nM Compound: 1, CA4	Cytotoxicity against mouse FM3A0 cells after 2 days Cytotoxicity against mouse FM3A0 cells after 2 days	[PMID: 19736015]
FM3A	IC₅₀	42 nM Compound: 1, CA-4	Antiproliferative activity against mouse FM3A cells after 2 days by coulter counting Antiproliferative activity against mouse FM3A cells after 2 days by coulter counting	[PMID: 20579891]
FM3A	IC₅₀	0.042 μM Compound: 1, CA-4	Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter analysis Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter analysis	[PMID: 22027100]
FM3A	IC₅₀	42 nM Compound: 1; CA-4	Antiproliferative activity against mouse FM3A cells after 2 days by Coulter counter method Antiproliferative activity against mouse FM3A cells after 2 days by Coulter counter method	[PMID: 29220790]
H22	IC₅₀	0.008 μM Compound: CA-4; 1	Antiproliferative activity against human H22 cells after 72 hrs by MTT assay Antiproliferative activity against human H22 cells after 72 hrs by MTT assay	[PMID: 30344902]
H22	IC₅₀	0.015 μM Compound: 1; CA-4	Antiproliferative activity against mouse H22 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against mouse H22 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
H69AR	IC₅₀	2.5 nM Compound: CA4	Antiproliferative activity against drug resistant H69AR cell line expressing MRP1 by Alamar Blue assay Antiproliferative activity against drug resistant H69AR cell line expressing MRP1 by Alamar Blue assay	[PMID: 17286393]
HA22T cell line	IC₅₀	2708 nM Compound: combretastatin A-4	Cell growth inhibition against HA22T human liver cancer cells using MTS assay Cell growth inhibition against HA22T human liver cancer cells using MTS assay	[PMID: 12036364]
HaCaT	IC₅₀	1 nM Compound: cis CA-4	Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay	[PMID: 23063401]
HaCaT	IC₅₀	0.06 μM Compound: CA-4	Antiproliferative activity against human HaCaT cells measured after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells measured after 72 hrs by MTT assay	[PMID: 27187864]
HaCaT	IC₅₀	0.19 μM Compound: 1a; CA-4	Cytotoxicity against human HaCaT cells after 48 hrs by MTT assay Cytotoxicity against human HaCaT cells after 48 hrs by MTT assay	[PMID: 29291446]
HaCaT	IC₅₀	0.0014 μM Compound: CA-4	Antiproliferative activity against human HaCaT cells after 72 hrs by SRB assay Antiproliferative activity against human HaCaT cells after 72 hrs by SRB assay	[PMID: 30201525]
HaCaT	IC₅₀	0.0034 μM Compound: CA-4	Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay	[PMID: 34837817]
HaCaT	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against human HaCaT cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human HaCaT cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
HBL-100	IC₅₀	0.003 μM Compound: 2, CA-4	Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay	[PMID: 18805012]
HBL-100	IC₅₀	3 nM Compound: CA-4	Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay	[PMID: 21488686]
HCC 2998	GI₅₀	0.063 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay	[PMID: 22982122]
HCC 2998	GI₅₀	0.063 μM Compound: CA4, NSC 613729	Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay	[PMID: 24387982]
HCC 2998	GI₅₀	63.4 nM Compound: CA4	Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HCC 2998	GI₅₀	0.063 μM Compound: CA4; NSC 613729	Cytotoxicity against human HCC2998 cells by SRB assay Cytotoxicity against human HCC2998 cells by SRB assay	[PMID: 26257861]
HCC827	IC₅₀	2.25 nM Compound: CA-4	Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
HCT-116	IC₅₀	0.9 nM Compound: combretastatin A-4 (CA-4)	Concentration which produces 50% inhibition of growth of human colon tumor HCT 116 Concentration which produces 50% inhibition of growth of human colon tumor HCT 116	[PMID: 11714613]
HCT-116	IC₅₀	1.9 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 16722633]
HCT-116	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 17174089]
HCT-116	IC₅₀	0.35 nM Compound: CA-4	Cytotoxicity against HCT116 cell line Cytotoxicity against HCT116 cell line	[PMID: 17249649]
HCT-116	IC₅₀	1.8 nM Compound: CA-4, combretastatin A-4	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 18477509]
HCT-116	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19211248]
HCT-116	IC₅₀	2.3 nM Compound: CA-4	Cytotoxicity against human HCT116 cells after 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs	[PMID: 19530698]
HCT-116	IC₅₀	0.006 μM Compound: CA-4	Anticancer activity against human HCT116 cells after 72 hrs Anticancer activity against human HCT116 cells after 72 hrs	[PMID: 19713108]
HCT-116	IC₅₀	2 nM Compound: CA-4	Cytotoxicity against human HCT116 cells after 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs	[PMID: 20627378]
HCT-116	IC₅₀	2 x 10^-9 M Compound: CA-4	Cytotoxicity against human HCT116 cells after 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs	[PMID: 20627378]
HCT-116	IC₅₀	0.001 μM Compound: CA4	Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 21112130]
HCT-116	IC₅₀	0.00074 μM Compound: CA4	Cytotoxicity against human HCT116 cells assessed as reduction of [3H]thymidine incorporation after 72 hrs by scintillation counting Cytotoxicity against human HCT116 cells assessed as reduction of [3H]thymidine incorporation after 72 hrs by scintillation counting	[PMID: 21955454]
HCT-116	GI₅₀	2 nM Compound: CA-4	Cytotoxicity against human HCT116 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis Cytotoxicity against human HCT116 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis	[PMID: 22449653]
HCT-116	IC₅₀	0.001 μM Compound: CA-4	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 22676247]
HCT-116	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human HCT116 cells after 48 hrs by SRB assay Growth inhibition of human HCT116 cells after 48 hrs by SRB assay	[PMID: 22982122]
HCT-116	IC₅₀	5 nM Compound: 2	Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
HCT-116	GI₅₀	2 nM Compound: 1a, CA-4	Growth inhibition of human HCT116 cells after 72 hrs by Victor microtiter plate fluorimeter analysis Growth inhibition of human HCT116 cells after 72 hrs by Victor microtiter plate fluorimeter analysis	[PMID: 23353744]
HCT-116	IC₅₀	0.006 μM Compound: CA4	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
HCT-116	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human HCT116 cells after 48 hrs by SRB assay Growth inhibition of human HCT116 cells after 48 hrs by SRB assay	[PMID: 24387982]
HCT-116	GI₅₀	3.28 nM Compound: CA4	Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HCT-116	GI₅₀	2 nM Compound: CA-4	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis	[PMID: 24681982]
HCT-116	IC₅₀	0.004 μM Compound: CA4	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 25462279]
HCT-116	GI₅₀	2.1 nM Compound: CA-4	Cytotoxicity against human HCT116 cells after 72 hrs by CellTitre-Blue assay Cytotoxicity against human HCT116 cells after 72 hrs by CellTitre-Blue assay	[PMID: 25528337]
HCT-116	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human HCT116 cells by SRB assay Cytotoxicity against human HCT116 cells by SRB assay	[PMID: 26257861]
HCT-116	GI₅₀	0.003 μM Compound: CA-4	Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
HCT-116	IC₅₀	2.6 nM Compound: CA-4	Growth inhibition of human HCT116 cells expressing wild type p53 after 72 hrs by MTT assay Growth inhibition of human HCT116 cells expressing wild type p53 after 72 hrs by MTT assay	[PMID: 27116710]
HCT-116	IC₅₀	3.4 nM Compound: CA-4	Growth inhibition of p53 null human HCT116 cells after 72 hrs by MTT assay Growth inhibition of p53 null human HCT116 cells after 72 hrs by MTT assay	[PMID: 27116710]
HCT-116	GI₅₀	2 nM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27707624]
HCT-116	IC₅₀	6.1 μM Compound: CA-4	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 27810596]
HCT-116	IC₅₀	6.1 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28410492]
HCT-116	IC₅₀	9.12 μM Compound: CA-4; B	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28774575]
HCT-116	IC₅₀	7 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28792756]
HCT-116	IC₅₀	0.006 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells by MTT assay Antiproliferative activity against human HCT116 cells by MTT assay	[PMID: 29126741]
HCT-116	IC₅₀	2.3 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells after 72 hrs by resazurin-based fluorescence assay Antiproliferative activity against human HCT116 cells after 72 hrs by resazurin-based fluorescence assay	[PMID: 29202409]
HCT-116	IC₅₀	9 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
HCT-116	IC₅₀	6.1 μM Compound: CA-4	Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay	[PMID: 30448234]
HCT-116	IC₅₀	2.2 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 30525602]
HCT-116	IC₅₀	0.001 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31174062]
HCT-116	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
HCT-116	IC₅₀	0.001 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability by MTT assay	[PMID: 31362922]
HCT-116	IC₅₀	0.0794 nM Compound: 7; CA-4	Cytotoxicity against p53 deficient human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against p53 deficient human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
HCT-116	IC₅₀	0.547 nM Compound: 7; CA-4	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
HCT-116	IC₅₀	0.232 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTS assay Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTS assay	[PMID: 31541870]
HCT-116	IC₅₀	212 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 31610375]
HCT-116	IC₅₀	0.93 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 31830637]
HCT-116	GI₅₀	0.006 μM Compound: CA-4	Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HCT-116	IC₅₀	0.002 μM Compound: CA4	Cytotoxicity against human HCT-116 p53 mutant cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against human HCT-116 p53 mutant cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 31958738]
HCT-116	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against wild type human HCT-116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against wild type human HCT-116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 31958738]
HCT-116	IC₅₀	0.11 μM Compound: CA-4	Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HCT-116	IC₅₀	0.01 μM Compound: 2; CA-4	Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32912434]
HCT-116	IC₅₀	2.6 nM Compound: 1; CA-4	Antiproliferative activity against human HCT116 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human HCT116 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
HCT-116	GI₅₀	2.4 nM Compound: CA-4	Antiproliferation activity against human HCT116 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferation activity against human HCT116 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33201714]
HCT-116	IC₅₀	0.029 μM Compound: 1; CA-4	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 33421913]
HCT-116	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33581556]
HCT-116	IC₅₀	6.1 μM Compound: CA-4	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
HCT-116	IC₅₀	0.008 μM Compound: CA-4	Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
HCT-116	IC₅₀	0.0047 μM Compound: 6a; CA-4	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
HCT-116	IC₅₀	0.008 μM Compound: 1; CA-4	Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay	[PMID: 35065411]
HCT-116	IC₅₀	1.1 μM Compound: 1; CA-4	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HCT-116	IC₅₀	0.004 μM Compound: Combretastatin A-4	Cytotoxicity against human HCT-116 cells Cytotoxicity against human HCT-116 cells	[PMID: 35567964]
HCT-116	IC₅₀	0.0011 μM Compound: CA-4	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 35635956]
HCT-116	GI₅₀	2.4 nM Compound: CA4	Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
HCT-116	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35834904]
HCT-116	IC₅₀	6.1 μM Compound: 2; CA-4	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36334455]
HCT-116	IC₅₀	6.8 nM Compound: CA-4	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
HCT-116	IC₅₀	2.32 μM Compound: CA-4	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HCT-116	IC₅₀	15.76 nM Compound: CA-4	Antiproliferative activity against human HCT116 cells assessed as inhibition of proliferation measured after 24 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells assessed as inhibition of proliferation measured after 24 hrs by CCK-8 assay	[PMID: 37301075]
HCT-116	IC₅₀	0.007 μM Compound: CA-4	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
HCT-116	IC₅₀	4.77 μM Compound: CA-4; 1	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38806101]
HCT-116	IC₅₀	0.008 μM Compound: CA-4; 1a	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 38901104]
HCT-15	IC₅₀	1.7 nM Compound: CA-4	Concentration required to inhibit proliferation of multidrug resistant Human colon carcinoma HCT-15 cell line Concentration required to inhibit proliferation of multidrug resistant Human colon carcinoma HCT-15 cell line	[PMID: 11294380]
HCT-15	IC₅₀	1.7 nM Compound: Combretastatin A4	Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15 Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15	[PMID: 11814821]
HCT-15	IC₅₀	1.7 nM Compound: CA-4	Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth	[PMID: 11931625]
HCT-15	GI₅₀	<0.01 μM Compound: 1, NSC-613729	Cytotoxicity against MDR HCT15 cells Cytotoxicity against MDR HCT15 cells	[PMID: 16950621]
HCT-15	IC₅₀	2.5 nM Compound: CA4	Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay	[PMID: 17286393]
HCT-15	GI₅₀	<0.01 μM Compound: 1, CA-4	Growth inhibition of human HCT15 cells after 3 days by crystal violet staining Growth inhibition of human HCT15 cells after 3 days by crystal violet staining	[PMID: 19954252]
HCT-15	IC₅₀	0.001 μM Compound: CA4	Antiproliferative activity against human HCT15 cells after 72 hrs by MTS assay Antiproliferative activity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 21112130]
HCT-15	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human HCT15 cells after 48 hrs by SRB assay Growth inhibition of human HCT15 cells after 48 hrs by SRB assay	[PMID: 22982122]
HCT-15	IC₅₀	3 nM Compound: 2	Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
HCT-15	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human HCT15 cells after 48 hrs by SRB assay Growth inhibition of human HCT15 cells after 48 hrs by SRB assay	[PMID: 24387982]
HCT-15	GI₅₀	3.66 nM Compound: CA4	Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HCT-15	IC₅₀	39 nM Compound: 2, CSA4	Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay	[PMID: 25025991]
HCT-15	GI₅₀	0.004 μM Compound: CA4; NSC 613729	Cytotoxicity against human HCT15 cells by SRB assay Cytotoxicity against human HCT15 cells by SRB assay	[PMID: 26257861]
HCT-15	GI₅₀	0.004 μM Compound: CA-4	Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
HCT-15	IC₅₀	8.87 μM Compound: CA-4; B	Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay	[PMID: 28774575]
HCT-15	IC₅₀	3.2 nM Compound: CA-4	Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
HCT-8	IC₅₀	0.0017 μM Compound: CA-4	Cytotoxicity against human HCT8 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 27149641]
HCT-8	IC₅₀	0.015 μM Compound: CA-4; 1	Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 30344902]
HCT-8	IC₅₀	0.015 μM Compound: CA-4	Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 30525584]
HCT-8	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 30530194]
HCT-8	IC₅₀	0.01 μM Compound: 1; CA-4	Antiproliferative activity against human HCT8 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30981112]
HCT-8	IC₅₀	0.027 μM Compound: 1; CA-4	Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HCT-8	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
HCT-8	IC₅₀	0.087 μM Compound: 1; CA-4	Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
HCT-8	IC₅₀	0.023 μM Compound: CA-4	Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34649064]
HEK293	IC₅₀	5.7 μg/mL Compound: 1'	Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay	[PMID: 17373779]
HEK293	IC₅₀	25 μM Compound: 1a, CoA4	Cytotoxicity against HEK293 cells assessed as growth inhibition after 3 days by MTT assay Cytotoxicity against HEK293 cells assessed as growth inhibition after 3 days by MTT assay	[PMID: 24145138]
HEK293	IC₅₀	25 μM Compound: CoA4	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 25240870]
HEK293	IC₅₀	1.73 μM Compound: 1; CA-4	Antiproliferative activity against HEK293 cells after 24 hrs by SRB assay Antiproliferative activity against HEK293 cells after 24 hrs by SRB assay	[PMID: 29268127]
HEK293	IC₅₀	25000 nM Compound: CA-4	Antiproliferative activity against HEK293 cells after 2 days by MTT assay Antiproliferative activity against HEK293 cells after 2 days by MTT assay	[PMID: 29432949]
HEK293	IC₅₀	25 μM Compound: CA-4	Antiproliferative activity against HEK293 cells by MTT assay Antiproliferative activity against HEK293 cells by MTT assay	[PMID: 30502686]
HEK293	IC₅₀	0.01 μM Compound: 12	Cytotoxicity against HEK293 cells after 68 hrs by MTT assay Cytotoxicity against HEK293 cells after 68 hrs by MTT assay	[PMID: 32243160]
HEK293	IC₅₀	45.69 μM Compound: CA-4	Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay	[PMID: 32717486]
HEK293	IC₅₀	45.69 μM Compound: CA-4	Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 48 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
HEK293	IC₅₀	11 μM Compound: CA-4	Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 33280898]
HEK293	IC₅₀	45.69 μM Compound: CA-4	Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
HEK293	IC₅₀	45.69 μM Compound: 1; CA-4	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HEK293	IC₅₀	45.69 μM Compound: 2; CA-4	Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36334455]
HEK293	IC₅₀	45.69 μM Compound: 1; CA-4	Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37172475]
HEK293	IC₅₀	48.05 μM Compound: CA-4; 1	Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38806101]
HEK-293T	CC₅₀	>300 μM Compound: CA-4	Cytotoxicity against HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30041136]
HEK-293T	CC₅₀	162.35 μM Compound: CA-4	Cytotoxicity against HEK293T cells after 24 hrs by MTT assay Cytotoxicity against HEK293T cells after 24 hrs by MTT assay	[PMID: 30606674]
HEK-293T	CC₅₀	1.44 μM Compound: CA-4	Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HEK-293T	IC₅₀	>80 μM Compound: CA-4	Antiproliferative activity against human HEK293T cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HEK293T cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HEK-293T	IC₅₀	9 μM Compound: CA-4	Inhibition of tubulin polymerization in HEK293T cell lysate after 15 mins by spectrophotometry Inhibition of tubulin polymerization in HEK293T cell lysate after 15 mins by spectrophotometry	10.1039/C3MD00357D
HeLa	IC₅₀	2.75 nM Compound: CA-4	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 17127061]
HeLa	IC₅₀	0.3 nM Compound: CA-4	Cytotoxicity against HeLa cell line Cytotoxicity against HeLa cell line	[PMID: 17249649]
HeLa	IC₅₀	2.7 nM Compound: CA4	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 17286393]
HeLa	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 17434303]
HeLa	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human HeLa cells after 72 hrs by XTT method Cytotoxicity against human HeLa cells after 72 hrs by XTT method	[PMID: 18502133]
HeLa	IC₅₀	2.7 μM Compound: CA-4	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 18790642]
HeLa	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 19647439]
HeLa	IC₅₀	1.9 nM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells after 2 days by coulter counter method Antiproliferative activity against human HeLa cells after 2 days by coulter counter method	[PMID: 19663386]
HeLa	IC₅₀	1.9 nM Compound: 1, CA4	Cytotoxicity against human HeLa cells after 2 days Cytotoxicity against human HeLa cells after 2 days	[PMID: 19736015]
HeLa	IC₅₀	0.00051 μM Compound: 1, CA4	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19879758]
HeLa	IC₅₀	0.0029 μM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 19894742]
HeLa	IC₅₀	0.0033 μM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay	[PMID: 19894742]
HeLa	IC₅₀	1.1 μM Compound: 1, CA-4	Relative resistance, ratio of IC50 for human HeLa cells expressing wild type beta3 tubulin to IC50 for human HeLa cells Relative resistance, ratio of IC50 for human HeLa cells expressing wild type beta3 tubulin to IC50 for human HeLa cells	[PMID: 19894742]
HeLa	IC₅₀	0.003 μM Compound: II, CA-4	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 19939521]
HeLa	IC₅₀	0.002 μM Compound: CA-4, 1a	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 20338766]
HeLa	IC₅₀	4 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 20420439]
HeLa	IC₅₀	1.9 nM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells after 2 days by coulter counting Antiproliferative activity against human HeLa cells after 2 days by coulter counting	[PMID: 20579891]
HeLa	IC₅₀	4 nM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
HeLa	IC₅₀	1.7 nM Compound: 1, CA-4	Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21696175]
HeLa	IC₅₀	4.02 nM Compound: CA4	Antiproliferative activity against beta3-tubulin overexpressing human HeLa cells Antiproliferative activity against beta3-tubulin overexpressing human HeLa cells	[PMID: 21786793]
HeLa	IC₅₀	4.09 nM Compound: CA4	Antiproliferative activity against human HeLa cells Antiproliferative activity against human HeLa cells	[PMID: 21786793]
HeLa	IC₅₀	0.002 μM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells after 2 days by coulter counter analysis Antiproliferative activity against human HeLa cells after 2 days by coulter counter analysis	[PMID: 22027100]
HeLa	IC₅₀	0.2 μM Compound: 2, CSA4	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22044164]
HeLa	IC₅₀	4 nM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 22136312]
HeLa	IC₅₀	4 nM Compound: 1, CA-4	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 22578111]
HeLa	IC₅₀	2.2 nM Compound: 2, CA-4	Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay	[PMID: 22727370]
HeLa	IC₅₀	4 nM Compound: CA-4, 1a, 1	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 23117171]
HeLa	IC₅₀	20 nM Compound: 2	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23214452]
HeLa	IC₅₀	4.7 nM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23332369]
HeLa	IC₅₀	5.2 nM Compound: CA-4	Inhibition of beta-3 tubulin (unknown origin) transfected in human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay Inhibition of beta-3 tubulin (unknown origin) transfected in human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23332369]
HeLa	IC₅₀	2.1 nM Compound: CA-4	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 23356786]
HeLa	IC₅₀	4 nM Compound: 1, CA-4	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 23445496]
HeLa	IC₅₀	0.004 μM Compound: 2	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23809851]
HeLa	IC₅₀	4.7 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 23895532]
HeLa	IC₅₀	5.7 nM Compound: CA-4	Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay	[PMID: 23895532]
HeLa	IC₅₀	4 nM Compound: CA-4	Cytotoxicity against human HeLa cells expressing beta3-tubulin containing alanine residue at 227 after 72 hrs by MTS assay Cytotoxicity against human HeLa cells expressing beta3-tubulin containing alanine residue at 227 after 72 hrs by MTS assay	[PMID: 24087857]
HeLa	IC₅₀	4.1 nM Compound: CA-4	Cytotoxicity against human HeLa cells after 72 hrs by MTS assay Cytotoxicity against human HeLa cells after 72 hrs by MTS assay	[PMID: 24087857]
HeLa	IC₅₀	1.9 nM Compound: 1a, CA-4	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by coulter counting analysis Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by coulter counting analysis	[PMID: 24164557]
HeLa	IC₅₀	0.0009 μM Compound: CA-4	Cytotoxicity against human HeLa cells after 72 hrs by resazurin based fluorescence assay Cytotoxicity against human HeLa cells after 72 hrs by resazurin based fluorescence assay	[PMID: 24669888]
HeLa	IC₅₀	1.8 nM Compound: CA	Growth inhibition of wild type human HeLa cells after 96 hrs incubation by sulforhodamine B technique Growth inhibition of wild type human HeLa cells after 96 hrs incubation by sulforhodamine B technique	[PMID: 24900865]
HeLa	IC₅₀	2.5 nM Compound: CA	Growth inhibition of human HeLa cells overexpressing beta-3 after 96 hrs incubation by sulforhodamine B technique Growth inhibition of human HeLa cells overexpressing beta-3 after 96 hrs incubation by sulforhodamine B technique	[PMID: 24900865]
HeLa	IC₅₀	4 nM Compound: 1a, CA-4	Growth inhibition of human HeLa cells after 72 hrs by MTT assay Growth inhibition of human HeLa cells after 72 hrs by MTT assay	[PMID: 25025853]
HeLa	IC₅₀	1.44 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 24 to 48 hrs by CKK8 assay Antiproliferative activity against human HeLa cells after 24 to 48 hrs by CKK8 assay	[PMID: 25105922]
HeLa	IC₅₀	0.018 μM Compound: CA-4	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25192811]
HeLa	IC₅₀	0.003 μM Compound: CA4	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 25462279]
HeLa	IC₅₀	4 nM Compound: 1a, CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human HeLa cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
HeLa	IC₅₀	5.6 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 25882519]
HeLa	IC₅₀	5.7 nM Compound: CA-4	Antiproliferative activity against human HeLa cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay	[PMID: 25882519]
HeLa	IC₅₀	0.003 μM Compound: Combretastatin A-4	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay	[PMID: 26092446]
HeLa	EC₅₀	9 nM Compound: CA-4	Inhibition of Tubulin polymerization in human HeLa cells assessed as decrease in dynamic tyrosinated microtubules after 2 hrs by microplate reader analysis Inhibition of Tubulin polymerization in human HeLa cells assessed as decrease in dynamic tyrosinated microtubules after 2 hrs by microplate reader analysis	[PMID: 26602281]
HeLa	IC₅₀	25 nM Compound: CA-4	Antiproliferative activity against human HeLa cells incubated for 24 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by sulforhodamine B assay	[PMID: 26938120]
HeLa	IC₅₀	0.012 μM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 27149641]
HeLa	GI₅₀	0.008 μM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
HeLa	IC₅₀	0.0093 μM Compound: 3; CA-4	Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 27213719]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against multidrug resistant human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay Antiproliferative activity against multidrug resistant human HeLa cells expressing wild type beta3 tubulin after 48 hrs by SRB assay	[PMID: 27213719]
HeLa	GI₅₀	0.06 μM Compound: 2; CA4	Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 27515320]
HeLa	IC₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay	[PMID: 27721152]
HeLa	IC₅₀	0.01 μM Compound: CA-4	Growth inhibition of human HeLa cells Growth inhibition of human HeLa cells	[PMID: 27805821]
HeLa	IC₅₀	1.8 μM Compound: CA	Growth inhibition of human HeLa cells measured after 96 hrs by sulforhodamine B assay Growth inhibition of human HeLa cells measured after 96 hrs by sulforhodamine B assay	[PMID: 27894589]
HeLa	IC₅₀	2.5 μM Compound: CA	Growth inhibition of human HeLa cells over expressing beta3-tubulin measured after 96 hrs by sulforhodamine B assay Growth inhibition of human HeLa cells over expressing beta3-tubulin measured after 96 hrs by sulforhodamine B assay	[PMID: 27894589]
HeLa	IC₅₀	0.005 μM Compound: 2A; CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 28034647]
HeLa	IC₅₀	0.23 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 28410492]
HeLa	IC₅₀	5.8 μM Compound: CA 4	Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 28684120]
HeLa	IC₅₀	3.8 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 28792756]
HeLa	IC₅₀	0.53 μM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 28803799]
HeLa	GI₅₀	0.084 μM Compound: Combretastatin	Antiproliferative activity against human HeLa cells after 48 hrs by SRB cell proliferation assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB cell proliferation assay	[PMID: 29089233]
HeLa	IC₅₀	0.007 μM Compound: CA-4	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 29126741]
HeLa	IC₅₀	0.013 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 29172084]
HeLa	IC₅₀	2 nM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method	[PMID: 29220790]
HeLa	IC₅₀	1.43 μM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells after 24 hrs by SRB assay Antiproliferative activity against human HeLa cells after 24 hrs by SRB assay	[PMID: 29268127]
HeLa	IC₅₀	0.11 μM Compound: 1a; CA-4	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29291446]
HeLa	IC₅₀	0.01 μM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29306206]
HeLa	IC₅₀	2100 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 2 days by MTT assay Antiproliferative activity against human HeLa cells after 2 days by MTT assay	[PMID: 29432949]
HeLa	IC₅₀	4.7 nM Compound: CA-4	Antiproliferative activity against human HeLa cells by SRB assay Antiproliferative activity against human HeLa cells by SRB assay	[PMID: 29655610]
HeLa	IC₅₀	5.7 nM Compound: CA-4	Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin by SRB assay Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin by SRB assay	[PMID: 29655610]
HeLa	IC₅₀	14.2 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 30006162]
HeLa	GI₅₀	0.092 μM Compound: CA-4	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 30041136]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells after 72 hrs by sulforhodamine B assay	[PMID: 30098869]
HeLa	IC₅₀	5.36 μM Compound: Combretastatin	Antiproliferative activity in human HeLa cells assessed as reduction in cell number incubated for 48 hrs by SRB assay Antiproliferative activity in human HeLa cells assessed as reduction in cell number incubated for 48 hrs by SRB assay	[PMID: 30108756]
HeLa	IC₅₀	11.33 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
HeLa	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by XTT assay Antiproliferative activity against human HeLa cells after 72 hrs by XTT assay	[PMID: 30216850]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 30297118]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HeLa cells expressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay	[PMID: 30297118]
HeLa	IC₅₀	0.007 μM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell growth after 48 hrs by MTT assay	[PMID: 30448234]
HeLa	IC₅₀	2.1 μM Compound: CA-4	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 30502686]
HeLa	IC₅₀	0.24 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay	[PMID: 30606674]
HeLa	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30633509]
HeLa	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
HeLa	IC₅₀	4 nM Compound: 1a; CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 31400707]
HeLa	CC₅₀	0.428 nM Compound: CA4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay	[PMID: 31413794]
HeLa	IC₅₀	1.347 nM Compound: CA-4	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTS assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTS assay	[PMID: 31541870]
HeLa	IC₅₀	9.2 nM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
HeLa	IC₅₀	0.21 μM Compound: CA-4	Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 31954880]
HeLa	IC₅₀	0.003 μM Compound: 1; CA4	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 32063430]
HeLa	IC₅₀	10 nM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
HeLa	IC₅₀	4 nM Compound: 1a; CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth	[PMID: 32417696]
HeLa	IC₅₀	0.0047 μM Compound: CA-4	Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay	[PMID: 32717486]
HeLa	IC₅₀	0.007 μM Compound: 2; CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32912434]
HeLa	IC₅₀	2.78 μM Compound: Combretastatin A-4	Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
HeLa	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
HeLa	IC₅₀	0.06 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 33280898]
HeLa	IC₅₀	4.7 nM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as decrease in cell growth measured after 48 hrs by SRB method Antiproliferative activity against human HeLa cells assessed as decrease in cell growth measured after 48 hrs by SRB method	[PMID: 33310545]
HeLa	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by XTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by XTT assay	[PMID: 33328100]
HeLa	IC₅₀	0.005 μM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 33421913]
HeLa	IC₅₀	0.004 μM Compound: CA-4;1a	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 33550186]
HeLa	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33581556]
HeLa	IC₅₀	4.7 nM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay	[PMID: 33636303]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
HeLa	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
HeLa	IC₅₀	0.004 μM Compound: CA-4	Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
HeLa	IC₅₀	0.009 μM Compound: 8; CA-4	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by SRB assay	[PMID: 34454126]
HeLa	IC₅₀	0.023 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HeLa	IC₅₀	0.0029 μM Compound: 6a; CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
HeLa	IC₅₀	0.016 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34649064]
HeLa	IC₅₀	0.0042 μM Compound: 2; CA-4	Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay	[PMID: 35339837]
HeLa	IC₅₀	0.0042 μM Compound: 2; CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay	[PMID: 35339837]
HeLa	IC₅₀	0.005 μM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HeLa	IC₅₀	0.007 μM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HeLa	IC₅₀	0.004 μM Compound: Combretastatin A-4	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 35567964]
HeLa	IC₅₀	0.0014 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 35635956]
HeLa	IC₅₀	0.4 μM Compound: CA4	Cytotoxicity against human HeLa cells assessed as cell growth inhibition Cytotoxicity against human HeLa cells assessed as cell growth inhibition	[PMID: 35964428]
HeLa	IC₅₀	0.013 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 36162214]
HeLa	IC₅₀	5 μM Compound: 2; CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36334455]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against human HeLa cells overexpressing betaIII-tubulin assessed as inhibition of cell growth by SRB assay Antiproliferative activity against human HeLa cells overexpressing betaIII-tubulin assessed as inhibition of cell growth by SRB assay	[PMID: 36889150]
HeLa	IC₅₀	3.3 nM Compound: CA-4	Antiproliferative activity against wild type human HeLa cells assessed as inhibition of cell growth by SRB assay Antiproliferative activity against wild type human HeLa cells assessed as inhibition of cell growth by SRB assay	[PMID: 36889150]
HeLa	IC₅₀	0.63 μM Compound: CA-4	Antiproliferative activity against human HeLa cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HeLa	IC₅₀	0.043 μM Compound: 1; CA-4	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37172475]
HeLa	IC₅₀	24 nM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth by SRB assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
HeLa	IC₅₀	0.21 μM Compound: CA-4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability Cytotoxicity against human HeLa cells assessed as reduction in cell viability	[PMID: 38107170]
HeLa	IC₅₀	0.009 μM Compound: CA-4	Antiproliferative activity against human HeLa cells incubated for 72 hrs Antiproliferative activity against human HeLa cells incubated for 72 hrs	[PMID: 38171146]
HeLa	IC₅₀	0.09 μM Compound: CA-4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38280356]
HeLa	IC₅₀	0.08 μM Compound: CA-4; 1	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay	[PMID: 38806101]
HeLa	EC₅₀	1.4 nM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTS assay Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTS assay	10.1039/C0MD00095G
HeLa	IC₅₀	14.83 μM Compound: CA-4	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	10.1039/C3MD00372H
HeLa	GI₅₀	0.0028 μM Compound: CA-4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	10.1039/C5MD00139K
HeLa	IC₅₀	0.15 μM Compound: 2a; CA-4	Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay	10.1039/C5MD00155B
HEp-2	IC₅₀	5 μg/mL Compound: 1'	Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay	[PMID: 17373779]
HEp-2	IC₅₀	0.0052 μM Compound: CA-4, 1a	Cytotoxicity against human cisplatin-resistant Hep2 cells after 72 hrs by MTT assay Cytotoxicity against human cisplatin-resistant Hep2 cells after 72 hrs by MTT assay	[PMID: 20338766]
HEp-2	IC₅₀	0.0055 μM Compound: CA-4, 1a	Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay	[PMID: 20338766]
Hepatocyte	CC₅₀	178.32 μM Compound: CA-4	Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay	[PMID: 30606674]
HepG2	IC₅₀	0.14 nM Compound: CA-4	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 17127061]
HepG2	EC₅₀	<0.03 μM Compound: CA-4	Cell cycle arrest in human HepG2 cells assessed as increase in G2/M phase cells after 20 hrs by flow cytometry using propidium iodide staining Cell cycle arrest in human HepG2 cells assessed as increase in G2/M phase cells after 20 hrs by flow cytometry using propidium iodide staining	[PMID: 19713108]
HepG2	IC₅₀	0.006 μM Compound: CA-4	Anticancer activity against human HepG2 cells after 72 hrs Anticancer activity against human HepG2 cells after 72 hrs	[PMID: 19713108]
HepG2	IC₅₀	0.19 μg/mL Compound: 1, CA-4	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 21440448]
HepG2	IC₅₀	0.54 μg/mL Compound: CA-4	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22192936]
HepG2	IC₅₀	0.19 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22512906]
HepG2	IC₅₀	0.006 μM Compound: CA4	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
HepG2	IC₅₀	0.16 μM Compound: CA-4	Antiproliferative activity against mouse HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against mouse HepG2 cells after 48 hrs by MTT assay	[PMID: 24909678]
HepG2	IC₅₀	0.008 μM Compound: CA-4	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 25192811]
HepG2	IC₅₀	0.17 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 25828827]
HepG2	GI₅₀	7.4 μM Compound: CA-4	Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay	[PMID: 26070164]
HepG2	IC₅₀	0.023 μM Compound: 1; CA-4	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 26970659]
HepG2	IC₅₀	0.0021 μM Compound: 3; CA-4	Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
HepG2	IC₅₀	0.11 μM Compound: CA-4	Growth inhibition of human HepG2 cells measured after 72 hrs by MTT assay Growth inhibition of human HepG2 cells measured after 72 hrs by MTT assay	[PMID: 27187864]
HepG2	GI₅₀	0.08 μM Compound: 2; CA4	Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay	[PMID: 27515320]
HepG2	IC₅₀	5.29 μM Compound: CA-4	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 27810596]
HepG2	IC₅₀	0.002 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.009 μM Compound: 2A; CA-4	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28034647]
HepG2	IC₅₀	4.3 μM Compound: CA 4	Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay	[PMID: 28684120]
HepG2	IC₅₀	3.9 nM Compound: CA-4	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28792756]
HepG2	IC₅₀	2.41 μM Compound: CA-4	Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 29031074]
HepG2	IC₅₀	0.19 μM Compound: CA4	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 29396364]
HepG2	IC₅₀	0.009 μM Compound: CA4	Growth inhibition of human HepG2 cells after 48 hrs by MTT assay Growth inhibition of human HepG2 cells after 48 hrs by MTT assay	[PMID: 29509413]
HepG2	GI₅₀	0.17 μM Compound: CA-4	Growth inhibition of human HepG2 cells after 48 hrs by MTT assay Growth inhibition of human HepG2 cells after 48 hrs by MTT assay	[PMID: 30041136]
HepG2	IC₅₀	16.04 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
HepG2	IC₅₀	0.012 μM Compound: CA-4; 2	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30176537]
HepG2	IC₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30525584]
HepG2	IC₅₀	0.009 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30530194]
HepG2	IC₅₀	0.33 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 30606674]
HepG2	IC₅₀	0.012 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30981112]
HepG2	IC₅₀	2.41 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 31536891]
HepG2	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31610375]
HepG2	IC₅₀	0.39 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 31830637]
HepG2	GI₅₀	0.002 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HepG2	IC₅₀	0.27 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HepG2	IC₅₀	0.002 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
HepG2	IC₅₀	0.031 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HepG2	IC₅₀	0.006 μM Compound: 2; CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32912434]
HepG2	IC₅₀	3.45 μM Compound: Combretastatin A-4	Antiproliferative activity against human HepG2 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
HepG2	IC₅₀	0.009 μM Compound: CA-4	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay	[PMID: 33010448]
HepG2	GI₅₀	6.1 nM Compound: CA-4	Antiproliferation activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferation activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33201714]
HepG2	IC₅₀	0.59 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 33280898]
HepG2	IC₅₀	0.28 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 33421913]
HepG2	IC₅₀	0.01 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
HepG2	IC₅₀	5.29 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
HepG2	IC₅₀	0.007 μM Compound: 8; CA-4	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay	[PMID: 34454126]
HepG2	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HepG2	IC₅₀	0.0029 μM Compound: 6a; CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
HepG2	IC₅₀	7.32 μM Compound: 133	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34826681]
HepG2	IC₅₀	5.25 μM Compound: 1; CA-4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HepG2	IC₅₀	0.09 μM Compound: CA4	Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 35551039]
HepG2	IC₅₀	0.01285 μM Compound: CA4	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition Cytotoxicity against human HepG2 cells assessed as cell growth inhibition	[PMID: 35964428]
HepG2	IC₅₀	2.39 μM Compound: CA4	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35964428]
HepG2	IC₅₀	0.008 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 36162214]
HepG2	IC₅₀	0.41 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
HepG2	IC₅₀	0.007 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth	[PMID: 36828299]
HepG2	IC₅₀	1.36 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HepG2	IC₅₀	2.9 nM Compound: CA-4	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 37804769]
HepG2	IC₅₀	0.033 μM Compound: CA-4; Cpd II	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37883897]
HepG2	IC₅₀	0.007 μM Compound: CA-4	Antiproliferative activity against human HepG2 cells incubated for 72 hrs Antiproliferative activity against human HepG2 cells incubated for 72 hrs	[PMID: 38171146]
HFL1	IC₅₀	0.082 μM Compound: 6; CA-4	Antiproliferative activity against human HFL1 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HFL1 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
HFL1	IC₅₀	0.091 μM Compound: CA-4; Cpd II	Antiproliferative activity against human HFL1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HFL1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37883897]
HK-2	IC₅₀	116 μM Compound: 2; CA-4	Cytotoxicity against HK-2 cells assessed as reduction in cell growth measured after 24 hrs by microplate reader analysis Cytotoxicity against HK-2 cells assessed as reduction in cell growth measured after 24 hrs by microplate reader analysis	[PMID: 35339837]
HL-60	IC₅₀	1.9 nM Compound: CA-4	Antiproliferative activity against human HL60 cells Antiproliferative activity against human HL60 cells	[PMID: 17174089]
HL-60	IC₅₀	0.032 μM Compound: CA4	Cytotoxicity against human HL60 cells after 72 hrs by XTT method Cytotoxicity against human HL60 cells after 72 hrs by XTT method	[PMID: 18502133]
HL-60	IC₅₀	0.002 μM Compound: CA4	Cytotoxicity against human HL60 cells after 72 hrs by XTT assay Cytotoxicity against human HL60 cells after 72 hrs by XTT assay	[PMID: 19647439]
HL-60	IC₅₀	0.002 μM Compound: II, CA-4	Cytotoxicity against human HL60 cells after 72 hrs by XTT assay Cytotoxicity against human HL60 cells after 72 hrs by XTT assay	[PMID: 19939521]
HL-60	IC₅₀	1 nM Compound: CA-4	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 20420439]
HL-60	IC₅₀	4 nM Compound: CA-4	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 20690624]
HL-60	IC₅₀	0.1 nM Compound: CA4	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 20731355]
HL-60	IC₅₀	1 nM Compound: 1, CA-4	Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
HL-60	GI₅₀	31.6 nM Compound: 1, CA-4	Cytotoxicity against human HL60 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HL60 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
HL-60	IC₅₀	1 nM Compound: 1	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 22136312]
HL-60	IC₅₀	1 nM Compound: 1, CA-4	Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 22578111]
HL-60	IC₅₀	1 nM Compound: CA-4, 1a, 1	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23117171]
HL-60	IC₅₀	1 nM Compound: 1, CA-4	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23445496]
HL-60	IC₅₀	1 nM Compound: 1a, CA-4	Antiproliferative activity against human HL60 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human HL60 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
HL-60	IC₅₀	0.013 μM Compound: Combretastatin A-4	Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay	[PMID: 26092446]
HL-60	IC₅₀	0.0019 μM Compound: 2; CA-4	Antiproliferative activity against combretastatin A-4 resistant human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay Antiproliferative activity against combretastatin A-4 resistant human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay	[PMID: 28254699]
HL-60	IC₅₀	0.56 μM Compound: CA-4	Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 29031074]
HL-60	IC₅₀	4000 nM Compound: CA-4	Antiproliferative activity against human HL60 cells after 2 days by MTT assay Antiproliferative activity against human HL60 cells after 2 days by MTT assay	[PMID: 29432949]
HL-60	IC₅₀	0.013 μM Compound: CA-4	Antiproliferative activity against human HL60 cells after 72 hrs by XTT assay Antiproliferative activity against human HL60 cells after 72 hrs by XTT assay	[PMID: 30216850]
HL-60	IC₅₀	4 μM Compound: CA-4	Antiproliferative activity against human HL60 cells by MTT assay Antiproliferative activity against human HL60 cells by MTT assay	[PMID: 30502686]
HL-60	IC₅₀	1 nM Compound: 1a; CA-4	Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 31400707]
HL-60	IC₅₀	0.56 μM Compound: CA-4	Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 31536891]
HL-60	IC₅₀	0.251 nM Compound: CA-4	Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTS assay Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTS assay	[PMID: 31541870]
HL-60	IC₅₀	1 nM Compound: 1a; CA-4	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth	[PMID: 32417696]
HL-60	IC₅₀	13 nM Compound: CA-4	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth after 72 hrs by XTT assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth after 72 hrs by XTT assay	[PMID: 33328100]
HL-60	IC₅₀	0.001 μM Compound: CA-4;1a	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 33550186]
HL-60	IC₅₀	0.0013 μM Compound: CA-4	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 35635956]
HL-60	IC₅₀	<0.03 μM Compound: CA-4	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	10.1039/C3MD00372H
HL-60(TB)	GI₅₀	0.002 μM Compound: CA4, NSC 613729	Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay	[PMID: 24387982]
HL-60(TB)	GI₅₀	2.16 nM Compound: CA4	Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HL-60(TB)	GI₅₀	0.002 μM Compound: CA4; NSC 613729	Cytotoxicity against human HL-60(TB) cells by SRB assay Cytotoxicity against human HL-60(TB) cells by SRB assay	[PMID: 26257861]
HL-60(TB)	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
HMEC-1	IC₅₀	3.5 nM Compound: CA-4	Antiproliferative activity against human HMEC1 cells Antiproliferative activity against human HMEC1 cells	[PMID: 17174089]
HMEC-1	IC₅₀	3400 nM Compound: CA-4	Antiproliferative activity against HMEC1 cells after 2 days by MTT assay Antiproliferative activity against HMEC1 cells after 2 days by MTT assay	[PMID: 29432949]
HMEC-1	IC₅₀	3.4 μM Compound: CA-4	Antiproliferative activity against HMEC1 cells by MTT assay Antiproliferative activity against HMEC1 cells by MTT assay	[PMID: 30502686]
HMEC-1	IC₅₀	6.42 nM Compound: CA-4	Anti-proliferative activity against human HMEC-1 cells measured after 48 hrs Anti-proliferative activity against human HMEC-1 cells measured after 48 hrs	[PMID: 38781920]
HN-6	IC₅₀	4.43 nM Compound: CA-4	Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35576703]
HONE1 cell line	IC₅₀	4 nM Compound: combretastatin A-4	Cell growth inhibition against Hone-1 human NPC cancer cells using MTS assay Cell growth inhibition against Hone-1 human NPC cancer cells using MTS assay	[PMID: 12036364]
HONE1 cell line	IC₅₀	6.5 nM Compound: CA-4	Inhibitory concentration against human NPC cancer cell line using tetrazolium dye reduction assay (MTT) Inhibitory concentration against human NPC cancer cell line using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
HOP-62	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human HOP62 cells after 48 hrs by SRB assay Growth inhibition of human HOP62 cells after 48 hrs by SRB assay	[PMID: 22982122]
HOP-62	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human HOP62 cells after 48 hrs by SRB assay Growth inhibition of human HOP62 cells after 48 hrs by SRB assay	[PMID: 24387982]
HOP-62	GI₅₀	2.65 nM Compound: CA4	Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HOP-62	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human HOP62 cells by SRB assay Cytotoxicity against human HOP62 cells by SRB assay	[PMID: 26257861]
HOP-62	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
HOP-62	GI₅₀	0.15 μM Compound: 1; CA-4	Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
HOP-92	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human HOP92 cells after 48 hrs by SRB assay Growth inhibition of human HOP92 cells after 48 hrs by SRB assay	[PMID: 22982122]
HOP-92	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human HOP92 cells after 48 hrs by SRB assay Growth inhibition of human HOP92 cells after 48 hrs by SRB assay	[PMID: 24387982]
HOP-92	GI₅₀	2.73 nM Compound: CA4	Growth inhibition of human HOP92 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP92 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HOP-92	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human HOP92 cells by SRB assay Cytotoxicity against human HOP92 cells by SRB assay	[PMID: 26257861]
Hs-578T	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human Hs578T cells after 48 hrs by SRB assay Growth inhibition of human Hs578T cells after 48 hrs by SRB assay	[PMID: 22982122]
Hs-578T	IC₅₀	1.36 nM Compound: CA-4	Cytotoxicity against human Hs578T cells after 72 hrs by MTT assay Cytotoxicity against human Hs578T cells after 72 hrs by MTT assay	[PMID: 30472600]
HT-1080	IC₅₀	0.0076 μM Compound: 1a, CA-4	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 25233100]
HT-1080	IC₅₀	0.008 μM Compound: 1a, CA-4	Cytotoxicity against human HT1080 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25529737]
HT-1080	IC₅₀	1.8 nM Compound: CA-4	Antiproliferative activity against human HT1080 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT1080 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26069928]
HT-1080	IC₅₀	0.07 μM Compound: CA4	Cytotoxicity against human HT1080 cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human HT1080 cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
HT-1080	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay	[PMID: 27428395]
HT-1080	IC₅₀	0.009 μM Compound: 1; CA-4	Cytotoxicity against human HT1080 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HT1080 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 27994764]
HT-1080	IC₅₀	0.016 μM Compound: 2; CA-4	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 30245397]
HT-1080	IC₅₀	0.051 μM Compound: 1; CA-4	Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells measured after 72 hrs by MTT assay	[PMID: 30901597]
HT-1080	IC₅₀	0.016 μM Compound: CA-4	Antiproliferative activity against human HT-1080 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HT-1080 cells measured after 72 hrs by MTT assay	[PMID: 31787361]
HT-1080	IC₅₀	2.2 nM Compound: CA-4	Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay	[PMID: 33472119]
HT-1080	IC₅₀	0.0026 μM Compound: CA-4	Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay	[PMID: 34837817]
HT-1080	IC₅₀	1.3 nM Compound: CA-4	Antiproliferative activity against human HT-1080 cells transfected with empty vector assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-1080 cells transfected with empty vector assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 36780426]
HT-1080	IC₅₀	2.1 nM Compound: CA-4	Antiproliferative activity against human HT-1080 cells expressing CYP1A1 assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-1080 cells expressing CYP1A1 assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 36780426]
HT-1080	IC₅₀	6 nM Compound: CA-4	Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 36780426]
HT-1080	IC₅₀	0.011 μM Compound: 1a; CA-4	Anti-proliferative activity against human HT1080 cells after 72 hrs by MTT assay Anti-proliferative activity against human HT1080 cells after 72 hrs by MTT assay	10.1039/C5MD00028A
HT-1080	IC₅₀	0.016 μM Compound: 2; CA-4	Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00150A
HT-22	CC₅₀	13.9 μM Compound: CA-4	Cytotoxicity against mouse HT22 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse HT22 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32832031]
HT-22	CC₅₀	14.5 μM Compound: CA-4	Cytotoxicity against mouse HT-22 cells measured after 48 hrs by MTT assay Cytotoxicity against mouse HT-22 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
HT-29	IC₅₀	260 nM Compound: CA-4	In vitro cytotoxic activity against human HT-29 cell line of colorectal carcinoma In vitro cytotoxic activity against human HT-29 cell line of colorectal carcinoma	[PMID: 15139768]
HT-29	ED₅₀	1 μM Compound: 2	Cytotoxicity against human HT-29 colon cell line. Cytotoxicity against human HT-29 colon cell line.	[PMID: 1613753]
HT-29	IC₅₀	54 nM Compound: 4	Antiproliferative activity against human HT29 cell line by methylene blue dye assay Antiproliferative activity against human HT29 cell line by methylene blue dye assay	[PMID: 17034147]
HT-29	IC₅₀	>1000 nM Compound: CA4	Cytotoxicity against human HT29 cells Cytotoxicity against human HT29 cells	[PMID: 17286393]
HT-29	GI₅₀	0.089 μM Compound: CA-4	Growth inhibition of human HT29 cells Growth inhibition of human HT29 cells	[PMID: 17291753]
HT-29	IC₅₀	5 μg/mL Compound: 1'	Cytotoxicity against human HT29 cells after 72 hrs by MTT assay Cytotoxicity against human HT29 cells after 72 hrs by MTT assay	[PMID: 17373779]
HT-29	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against human HT29 cells Cytotoxicity against human HT29 cells	[PMID: 17434303]
HT-29	IC₅₀	118 nM Compound: 1, combretastatin A-4, CA-4	Cytotoxic activity against human HT29 cells after 72 hrs by sulforhodamine B test Cytotoxic activity against human HT29 cells after 72 hrs by sulforhodamine B test	[PMID: 18396857]
HT-29	IC₅₀	0.002 μM Compound: CA4	Cytotoxicity against human HT29 cells after 72 hrs by XTT method Cytotoxicity against human HT29 cells after 72 hrs by XTT method	[PMID: 18502133]
HT-29	ED₅₀	uM μM Compound: 1a	Cytotoxic concentration required to inhibit 50% cell growth in HT-29 colon adenocarcinoma cell lines Cytotoxic concentration required to inhibit 50% cell growth in HT-29 colon adenocarcinoma cell lines	[PMID: 1875350]
HT-29	IC₅₀	118 nM Compound: 1, CA-4	Cytotoxicity against human HT29 cells by sulforhodamine B test Cytotoxicity against human HT29 cells by sulforhodamine B test	[PMID: 18783207]
HT-29	IC₅₀	0.032 μM Compound: CA-4	Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay	[PMID: 18790642]
HT-29	IC₅₀	0.032 μM Compound: CA4	Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay	[PMID: 19647439]
HT-29	IC₅₀	0.032 μM Compound: II, CA-4	Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay	[PMID: 19939521]
HT-29	IC₅₀	835 nM Compound: 1a, CA4	Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
HT-29	IC₅₀	3600 nM Compound: CA4	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 20731355]
HT-29	IC₅₀	0.013 μM Compound: CA4	Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 21112130]
HT-29	IC₅₀	61 nM Compound: 1, CA-4	Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
HT-29	IC₅₀	94 nM Compound: 1, CA4	Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay	[PMID: 21641700]
HT-29	IC₅₀	3100 nM Compound: 1, CA-4	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
HT-29	IC₅₀	61 nM Compound: 2, CA-4	Antiproliferative activity against human HT-29 cells after 48 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 48 hrs by SRB assay	[PMID: 21920638]
HT-29	GI₅₀	631 nM Compound: 1, CA-4	Cytotoxicity against human HT29 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HT29 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
HT-29	IC₅₀	3.1 μM Compound: 1, CA-4	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 22027100]
HT-29	IC₅₀	>10 μM Compound: 2, CSA4	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22044164]
HT-29	IC₅₀	94 nM Compound: 2, CA4	Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay	[PMID: 22060033]
HT-29	IC₅₀	3100 nM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 22136312]
HT-29	IC₅₀	0.4 μM Compound: 2, CA-4	Cytotoxicity against human HT-29 cells by alamar blue assay Cytotoxicity against human HT-29 cells by alamar blue assay	[PMID: 22137934]
HT-29	IC₅₀	0.93 μM Compound: 2a, CA-4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 22543234]
HT-29	IC₅₀	3100 nM Compound: 1, CA-4	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 22578111]
HT-29	IC₅₀	12000 nM Compound: 2, CA-4	Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay	[PMID: 22727370]
HT-29	GI₅₀	0.1 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human HT-29 cells after 48 hrs by SRB assay Growth inhibition of human HT-29 cells after 48 hrs by SRB assay	[PMID: 22982122]
HT-29	IC₅₀	3100 nM Compound: CA-4, 1a, 1	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 23117171]
HT-29	IC₅₀	130 nM Compound: 2	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23214452]
HT-29	IC₅₀	3100 nM Compound: 1, CA-4	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 23445496]
HT-29	IC₅₀	0.18 μM Compound: 1, CA-4	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23566762]
HT-29	IC₅₀	1 μM Compound: CA-4	Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 23810282]
HT-29	IC₅₀	270 nM Compound: CA-4	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
HT-29	IC₅₀	4.2 μM Compound: 1a, CoA4	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 3 days by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 3 days by MTT assay	[PMID: 24145138]
HT-29	IC₅₀	1.58 μM Compound: CA-4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 24238904]
HT-29	GI₅₀	0.1 μM Compound: CA4, NSC 613729	Growth inhibition of human HT-29 cells after 48 hrs by SRB assay Growth inhibition of human HT-29 cells after 48 hrs by SRB assay	[PMID: 24387982]
HT-29	GI₅₀	100 nM Compound: CA4	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
HT-29	IC₅₀	87.2 nM Compound: 1, CA4	Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay	[PMID: 24657567]
HT-29	IC₅₀	538 nM Compound: 1, CA-4	Growth inhibition of combretastatin-resistant human HT-29 cells after 48 hrs by SRB assay Growth inhibition of combretastatin-resistant human HT-29 cells after 48 hrs by SRB assay	[PMID: 24900453]
HT-29	IC₅₀	3100 nM Compound: 1a, CA-4	Growth inhibition of human HT-29 cells after 72 hrs by MTT assay Growth inhibition of human HT-29 cells after 72 hrs by MTT assay	[PMID: 25025853]
HT-29	IC₅₀	4.2 μM Compound: CoA4	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 25240870]
HT-29	IC₅₀	0.001 μM Compound: CA-4	Growth inhibition of human HT-29 cells by MTT assay Growth inhibition of human HT-29 cells by MTT assay	[PMID: 25689111]
HT-29	IC₅₀	3100 nM Compound: 1a, CA-4	Antiproliferative activity against human HT-29 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human HT-29 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
HT-29	IC₅₀	560 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26069928]
HT-29	IC₅₀	0.03 μM Compound: Combretastatin A-4	Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay	[PMID: 26092446]
HT-29	GI₅₀	0.1 μM Compound: CA4; NSC 613729	Cytotoxicity against human HT-29 cells by SRB assay Cytotoxicity against human HT-29 cells by SRB assay	[PMID: 26257861]
HT-29	IC₅₀	0.42 μM Compound: CA4	Cytotoxicity against human HT-29 cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human HT-29 cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
HT-29	IC₅₀	0.049 μM Compound: 1; CA-4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 26970659]
HT-29	GI₅₀	0.118 μM Compound: CA-4	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
HT-29	GI₅₀	0.26 μM Compound: CA-4	Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by SRB assay	[PMID: 27040661]
HT-29	IC₅₀	>5000 nM Compound: CA-4	Growth inhibition of combretastatin A-4 resistant human HT-29 cells after 72 hrs by MTT assay Growth inhibition of combretastatin A-4 resistant human HT-29 cells after 72 hrs by MTT assay	[PMID: 27116710]
HT-29	IC₅₀	2.61 μM Compound: CA-4	Antiproliferative activity against CA-4-resistant human HT-29 cells measured after 72 hrs by MTT assay Antiproliferative activity against CA-4-resistant human HT-29 cells measured after 72 hrs by MTT assay	[PMID: 27187864]
HT-29	IC₅₀	0.93 μM Compound: Combretastatin-A4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 27487568]
HT-29	IC₅₀	1.96 μM Compound: CA-4	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 27810596]
HT-29	IC₅₀	4.165 μM Compound: 2; CA-4	Antiproliferative activity against combretastatin A-4 resistant human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against combretastatin A-4 resistant human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 28254699]
HT-29	IC₅₀	0.05 μM Compound: CA-4	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 28622907]
HT-29	IC₅₀	0.06 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 29407949]
HT-29	IC₅₀	4200 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells after 2 days by MTT assay Antiproliferative activity against human HT-29 cells after 2 days by MTT assay	[PMID: 29432949]
HT-29	IC₅₀	0.93 μM Compound: Combretastatin A-4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 30108703]
HT-29	IC₅₀	0.72 μM Compound: CA4	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30108866]
HT-29	IC₅₀	0.032 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells after 72 hrs by XTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by XTT assay	[PMID: 30216850]
HT-29	IC₅₀	1.96 μM Compound: CA-4	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 48 hrs by MTT assay	[PMID: 30448234]
HT-29	IC₅₀	4.2 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells by MTT assay Antiproliferative activity against human HT-29 cells by MTT assay	[PMID: 30502686]
HT-29	IC₅₀	>8000 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 30525602]
HT-29	IC₅₀	3.1 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 30633509]
HT-29	IC₅₀	3100 nM Compound: 1a; CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 31400707]
HT-29	IC₅₀	30.5 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
HT-29	IC₅₀	4.165 μM Compound: CA-4; D-613729	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31954879]
HT-29	IC₅₀	0.31 μM Compound: CA-4	Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HT-29	IC₅₀	3100 nM Compound: 1a; CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth	[PMID: 32417696]
HT-29	GI₅₀	0.2 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay	[PMID: 32832031]
HT-29	IC₅₀	1.963 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
HT-29	IC₅₀	>8000 nM Compound: 1; CA-4	Antiproliferative activity against human HT-29 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human HT-29 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
HT-29	IC₅₀	305 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by XTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by XTT assay	[PMID: 33328100]
HT-29	IC₅₀	5.1 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay	[PMID: 33472119]
HT-29	IC₅₀	3.1 μM Compound: CA-4;1a	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 33550186]
HT-29	IC₅₀	1.96 μM Compound: CA-4	Antiproliferative activity against human HT29 cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HT29 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
HT-29	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells Antiproliferative activity against human HT-29 cells	[PMID: 34655985]
HT-29	IC₅₀	>1 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay	[PMID: 34837817]
HT-29	IC₅₀	1.96 μM Compound: 1; CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HT-29	IC₅₀	0.43 μM Compound: CA-4	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HT-29	IC₅₀	>10000 nM Compound: CA4	Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
HT-29	IC₅₀	0.42 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
HT-29	IC₅₀	0.49 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
HT-29	IC₅₀	390.8 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
HT-29	IC₅₀	6 nM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 36780426]
HT-29	IC₅₀	1.18 μM Compound: 1; CA-4	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37172475]
HT-29	IC₅₀	0.13 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth	[PMID: 38107170]
HT-29	IC₅₀	0.38 μM Compound: CA-4	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38280356]
HT-29	IC₅₀	1.65 μM Compound: CA-4; 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38806101]
Huh-7	IC₅₀	430 nM Compound: CA-4	Antiproliferative activity against human HuH7 cells incubated for 24 hrs by sulforhodamine B assay Antiproliferative activity against human HuH7 cells incubated for 24 hrs by sulforhodamine B assay	[PMID: 26938120]
Huh-7	CC₅₀	1.05 nM Compound: CA4	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay	[PMID: 31413794]
Huh-7	CC₅₀	38.3 μM Compound: CA4	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 24 hrs by cell titer blue assay Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 24 hrs by cell titer blue assay	[PMID: 31413794]
Huh-7	IC₅₀	4 nM Compound: CA-4	Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
Huh-7	IC₅₀	0.009 μM Compound: CA-4	Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay	[PMID: 37890199]
HuTu80	IC₅₀	1.37 nM Compound: CA-4	Antiproliferative activity in human HuTu 80 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity in human HuTu 80 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 22329561]
HUVEC	IC₅₀	1.5 nM Compound: CA-4	Antiproliferative activity against human HUVEC Antiproliferative activity against human HUVEC	[PMID: 16722633]
HUVEC	IC₅₀	2.5 nM Compound: CA-4, combretastatin A-4	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 18477509]
HUVEC	IC₅₀	5 nM Compound: 2, CSA4	Growth inhibition of HUVEC Growth inhibition of HUVEC	[PMID: 19601594]
HUVEC	IC₅₀	0.005 μM Compound: 1, CA-4	Cytotoxicity against HUVEC after 72 hrs by crystal violet staining Cytotoxicity against HUVEC after 72 hrs by crystal violet staining	[PMID: 19954252]
HUVEC	IC₅₀	0.01 μM Compound: 1, CA-4	Vascular disrupting activity in HUVEC assessed as change in cell morphology with detachment form substrate after 1 hr by crystal violet staining-based inverted light microscopy Vascular disrupting activity in HUVEC assessed as change in cell morphology with detachment form substrate after 1 hr by crystal violet staining-based inverted light microscopy	[PMID: 19954252]
HUVEC	IC₅₀	0.4 μM Compound: 1, CA-4	Cytotoxicity against HUVEC after 1 hr by crystal violet staining Cytotoxicity against HUVEC after 1 hr by crystal violet staining	[PMID: 19954252]
HUVEC	IC₅₀	3.6 nM Compound: 4, CA4	Antiproliferative activity against HUVEC grown in presence of growth factors after 48 hrs by spectrophotometry Antiproliferative activity against HUVEC grown in presence of growth factors after 48 hrs by spectrophotometry	[PMID: 21774499]
HUVEC	IC₅₀	3.9 nM Compound: 4, CA4	Antiproliferative activity against HUVEC grown in absence of growth factors after 48 hrs by spectrophotometry Antiproliferative activity against HUVEC grown in absence of growth factors after 48 hrs by spectrophotometry	[PMID: 21774499]
HUVEC	IC₅₀	1 nM Compound: 2, CSA4	Growth inhibition of HUVEC cells after 48 hrs by MTT assay Growth inhibition of HUVEC cells after 48 hrs by MTT assay	[PMID: 22044164]
HUVEC	IC₅₀	2.4 nM Compound: CA-4	Cytotoxicity against HUVEC after 48 hrs using resazurin by microplate fluorometer analysis Cytotoxicity against HUVEC after 48 hrs using resazurin by microplate fluorometer analysis	[PMID: 22185476]
HUVEC	IC₅₀	2.2 nM Compound: 1, CA-4, combretastatin	Antivascular activity against HUVEC cells assessed as cell growth inhibition measured every 30 mins for 21 hrs by xCELLigence assay Antivascular activity against HUVEC cells assessed as cell growth inhibition measured every 30 mins for 21 hrs by xCELLigence assay	[PMID: 22304851]
HUVEC	IC₅₀	3.34 nM Compound: 1, CA-4	Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay	[PMID: 23360369]
HUVEC	IC₅₀	8.9 nM Compound: 1, CA-4	Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay	[PMID: 23360369]
HUVEC	IC₅₀	0.005 μM Compound: Combretastatin A-4, IODWF	Cytotoxicity against HUVEC assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against HUVEC assessed as cell viability after 48 hrs by MTT assay	[PMID: 24012378]
HUVEC	IC₅₀	2.5 nM Compound: 3	Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
HUVEC	IC₅₀	2.2 nM Compound: 1, CA-4	Antivascular activity against HUVEC after 24 hrs by xCELLigence assays Antivascular activity against HUVEC after 24 hrs by xCELLigence assays	[PMID: 24900453]
HUVEC	IC₅₀	1.7 nM Compound: CA-4	Antiproliferative activity against HUVEC after 72 hrs by MTS assay Antiproliferative activity against HUVEC after 72 hrs by MTS assay	[PMID: 30525602]
HUVEC	IC₅₀	4.17 nM Compound: 7; CA-4	Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
HUVEC	IC₅₀	>100000 nM Compound: CA-4	Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
HUVEC	IC₅₀	0.98 μM Compound: CA-4	Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 31954880]
HUVEC	IC₅₀	1.56 μM Compound: CA-4	Antiproliferative activity against HUVEC cells Antiproliferative activity against HUVEC cells	[PMID: 34655985]
HUVEC	EC₅₀	0.9 nM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Antivascular activity in growth factor-induced HUVEC after 45 hrs xCELLigence analysis Antivascular activity in growth factor-induced HUVEC after 45 hrs xCELLigence analysis	10.1039/C0MD00095G
HUVEC	EC₅₀	1.9 nM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Antivascular activity in growth factor-induced HUVEC after 24 hrs xCELLigence analysis Antivascular activity in growth factor-induced HUVEC after 24 hrs xCELLigence analysis	10.1039/C0MD00095G
HUVEC	EC₅₀	3.2 nM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Antiproliferative activity against growth factor-induced HUVEC assessed as growth inhibition after 48 hrs by MTS assay Antiproliferative activity against growth factor-induced HUVEC assessed as growth inhibition after 48 hrs by MTS assay	10.1039/C0MD00095G
IGROV-1	IC₅₀	10.3 nM Compound: CA-4	Antiproliferative activity against human IGROV1 cells Antiproliferative activity against human IGROV1 cells	[PMID: 16722633]
IGROV-1	GI₅₀	0.015 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay	[PMID: 22982122]
IGROV-1	GI₅₀	0.015 μM Compound: CA4, NSC 613729	Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay	[PMID: 24387982]
IGROV-1	GI₅₀	14.56 nM Compound: CA4	Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
IGROV-1	GI₅₀	0.015 μM Compound: CA4; NSC 613729	Cytotoxicity against human IGROV1 cells by SRB assay Cytotoxicity against human IGROV1 cells by SRB assay	[PMID: 26257861]
IMR-32	IC₅₀	5.72 μM Compound: Combretastatin	Antiproliferative activity in human IMR32 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay Antiproliferative activity in human IMR32 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay	[PMID: 30108756]
Ishikawa	IC₅₀	20.1 μM Compound: CA-4	Cytotoxicity against human Ishikawa cells after 48 hrs by MTT assay Cytotoxicity against human Ishikawa cells after 48 hrs by MTT assay	10.1039/C3MD00372H
Jurkat	IC₅₀	5 nM Compound: CA-4	Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 20420439]
Jurkat	IC₅₀	5 nM Compound: 1, CA-4	Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
Jurkat	IC₅₀	5 nM Compound: 1	Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 22136312]
Jurkat	IC₅₀	5 nM Compound: 1, CA-4	Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 22578111]
Jurkat	IC₅₀	5 nM Compound: CA-4, 1a, 1	Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 23117171]
Jurkat	IC₅₀	5 nM Compound: 1, CA-4	Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 23445496]
Jurkat	IC₅₀	5 nM Compound: 1a, CA-4	Growth inhibition of human Jurkat cells after 72 hrs by MTT assay Growth inhibition of human Jurkat cells after 72 hrs by MTT assay	[PMID: 25025853]
Jurkat	IC₅₀	5 nM Compound: 1a, CA-4	Antiproliferative activity against human Jurkat cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human Jurkat cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
Jurkat	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 30633509]
Jurkat	IC₅₀	0.8 nM Compound: 1a; CA-4	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth	[PMID: 32417696]
Jurkat E6.1	IC₅₀	0.00608 μM Compound: 3, CA4	Anticancer activity against human Jurkat E6-1 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay Anticancer activity against human Jurkat E6-1 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay	[PMID: 25466200]
K562	IC₅₀	0.02 μM Compound: 3 (Combretastatin A-4)	In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth	[PMID: 12852768]
K562	IC₅₀	3.6 nM Compound: 1, CA-4	Antiproliferative activity against human K562 cell line Antiproliferative activity against human K562 cell line	[PMID: 16789746]
K562	IC₅₀	0.01 μM Compound: 1, CA-4	Cytotoxicity against human K562 cells after 5 days by MTT assay Cytotoxicity against human K562 cells after 5 days by MTT assay	[PMID: 18396050]
K562	IC₅₀	3.6 nM Compound: CA-4, combretastatin A-4	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 18477509]
K562	IC₅₀	3.6 nM Compound: CA-4	Cytotoxicity against human K562 cells after 72 hrs Cytotoxicity against human K562 cells after 72 hrs	[PMID: 19530698]
K562	IC₅₀	0.046 μM Compound: CA-4	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 19665898]
K562	IC₅₀	1.4 nM Compound: 2, CA4	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 19837594]
K562	IC₅₀	3.2 μM Compound: 2, CA4	Antiproliferative activity against human K562 cells after 5 days by MTT assay Antiproliferative activity against human K562 cells after 5 days by MTT assay	[PMID: 19837594]
K562	IC₅₀	5 nM Compound: CA-4	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 20420439]
K562	IC₅₀	0.01 μM Compound: 1, CA-4	Cytotoxicity against human K562 cells after 5 days by MTT assay Cytotoxicity against human K562 cells after 5 days by MTT assay	[PMID: 20708408]
K562	IC₅₀	1.5 μM Compound: CA-4	Inhibition of tubulin polymerization in human K562 cells by fluorometric analysis Inhibition of tubulin polymerization in human K562 cells by fluorometric analysis	[PMID: 21342735]
K562	IC₅₀	5 nM Compound: 1, CA-4	Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
K562	GI₅₀	4 nM Compound: CA-4	Cytotoxicity against human K562 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis Cytotoxicity against human K562 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis	[PMID: 22449653]
K562	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human K562 cells after 48 hrs by SRB assay Growth inhibition of human K562 cells after 48 hrs by SRB assay	[PMID: 22982122]
K562	IC₅₀	2.3 nM Compound: 1, CA-4	Antiproliferative activity against human K562 cells by MTT assay Antiproliferative activity against human K562 cells by MTT assay	[PMID: 23010271]
K562	IC₅₀	4.8 nM Compound: CA-4	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 23356786]
K562	GI₅₀	0.002 μM Compound: CA4, NSC 613729	Growth inhibition of human K562 cells after 48 hrs by SRB assay Growth inhibition of human K562 cells after 48 hrs by SRB assay	[PMID: 24387982]
K562	GI₅₀	2.36 nM Compound: CA4	Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
K562	GI₅₀	4.3 nM Compound: CA-4	Cytotoxicity against human K562 cells after 72 hrs by CellTitre-Blue assay Cytotoxicity against human K562 cells after 72 hrs by CellTitre-Blue assay	[PMID: 25528337]
K562	GI₅₀	0.002 μM Compound: CA4; NSC 613729	Cytotoxicity against human K562 cells by SRB assay Cytotoxicity against human K562 cells by SRB assay	[PMID: 26257861]
K562	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
K562	GI₅₀	0.031 μM Compound: 1; CA-4	Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
K562	IC₅₀	<0.1 μM Compound: CA-4	Growth inhibition of human K562 cells measured after 72 hrs by MTT assay Growth inhibition of human K562 cells measured after 72 hrs by MTT assay	[PMID: 27187864]
K562	IC₅₀	0.003 μM Compound: Combretastatin A-4	Antiproliferative activity against human K562 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay Antiproliferative activity against human K562 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay	[PMID: 27212068]
K562	GI₅₀	4 nM Compound: 1	Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27707624]
K562	IC₅₀	1 μM Compound: 6	Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay	[PMID: 28143677]
K562	IC₅₀	0.013 μM Compound: CA-4	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 29172084]
K562	IC₅₀	6 nM Compound: CA-4	Antiproliferative activity against human K562 cells after 72 hrs by resazurin-based fluorescence assay Antiproliferative activity against human K562 cells after 72 hrs by resazurin-based fluorescence assay	[PMID: 29202409]
K562	IC₅₀	0.021 μM Compound: CA-4; 2	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30176537]
K562	IC₅₀	0.015 μM Compound: CA-4; 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30344902]
K562	IC₅₀	0.011 μM Compound: CA-4	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30525584]
K562	IC₅₀	5 nM Compound: CA-4	Antiproliferative activity against human K562 cells after 72 hrs by MTS assay Antiproliferative activity against human K562 cells after 72 hrs by MTS assay	[PMID: 30525602]
K562	IC₅₀	0.007 μM Compound: 1; CA-4	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30530194]
K562	IC₅₀	4 nM Compound: CA-4	Cytotoxicity against human K562 cells after 48 hrs by SRB assay Cytotoxicity against human K562 cells after 48 hrs by SRB assay	[PMID: 30784885]
K562	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30981112]
K562	IC₅₀	0.0282 nM Compound: 7; CA-4	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
K562	IC₅₀	0.61 μM Compound: CA-4	Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
K562	IC₅₀	6.15 μM Compound: CA-4	Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
K562	IC₅₀	0.009 μM Compound: 1; CA-4	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
K562	IC₅₀	0.001 μM Compound: CA4	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 33038545]
K562	IC₅₀	5.5 nM Compound: 1; CA-4	Antiproliferative activity against human K562 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human K562 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
K562	IC₅₀	610 nM Compound: 1; CA-4	Antiproliferative activity against human K562 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition by MTT assay	[PMID: 33636303]
K562	IC₅₀	0.007 μM Compound: 1; CA-4	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
K562	IC₅₀	25 nM Compound: CA4	Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
K562	IC₅₀	5.5 nM Compound: CA4	Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
K562	IC₅₀	0.005 μM Compound: CA-4	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 35926141]
K562	IC₅₀	11.2 nM Compound: CA-4	Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
K562	IC₅₀	0.007 μM Compound: 6; CA-4	Antiproliferative activity against human K562 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
K562	IC₅₀	0.004 μM Compound: CA-4; Cpd II	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37883897]
K562	EC₅₀	0.001 μM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	10.1039/C0MD00095G
K562/VCR	IC₅₀	0.057 μM Compound: 1; CA-4	Antiproliferative activity against human VCR-resistant K562/VCR cells after 72 hrs by MTT assay Antiproliferative activity against human VCR-resistant K562/VCR cells after 72 hrs by MTT assay	[PMID: 30530194]
K562/VCR	IC₅₀	0.057 μM Compound: 1; CA-4	Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
K-562R	IC₅₀	23 nM Compound: CA-4	Antiproliferative activity against human K562R cells after 72 hrs by resazurin-based fluorescence assay Antiproliferative activity against human K562R cells after 72 hrs by resazurin-based fluorescence assay	[PMID: 29202409]
K-562R	IC₅₀	25 nM Compound: CA-4	Antiproliferative activity against human K562R cells after 72 hrs by MTS assay Antiproliferative activity against human K562R cells after 72 hrs by MTS assay	[PMID: 30525602]
K-562R	IC₅₀	25 nM Compound: 1; CA-4	Antiproliferative activity against human K562R cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human K562R cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
KARPAS-422	IC₅₀	0.58 nM Compound: CA-4	Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay	[PMID: 36502578]
KB	IC₅₀	6.2 nM Compound: CA-4	Inhibitory concentration against human oral cancer cell line (KB) using tetrazolium dye reduction assay (MTT) Inhibitory concentration against human oral cancer cell line (KB) using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
KB	IC₅₀	7 nM Compound: CA-4	Inhibitory concentration against taxol resistant cell line (KBs5) at a concentration of 50 nM using tetrazolium dye reduction assay (MTT) Inhibitory concentration against taxol resistant cell line (KBs5) at a concentration of 50 nM using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
KB	IC₅₀	7.3 nM Compound: CA-4	Inhibitory concentration against camptothecin (CPT) resistant cell line (KB-100) using tetrazolium dye reduction assay (MTT) Inhibitory concentration against camptothecin (CPT) resistant cell line (KB-100) using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
KB	IC₅₀	7.9 nM Compound: CA-4	Inhibitory concentration against VP16 resistant cell line (KB-7D) using tetrazolium dye reduction assay (MTT) Inhibitory concentration against VP16 resistant cell line (KB-7D) using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
KB	IC₅₀	9.5 nM Compound: CA-4	Inhibitory concentration against vincristine-resistant cell line (KB-Vin 10) using tetrazolium dye reduction assay (MTT) Inhibitory concentration against vincristine-resistant cell line (KB-Vin 10) using tetrazolium dye reduction assay (MTT)	[PMID: 12467626]
KB	IC₅₀	2.1 nM Compound: CA-4	In vitro cytotoxic activity against human KB cell line of epidermoid carcinoma In vitro cytotoxic activity against human KB cell line of epidermoid carcinoma	[PMID: 15139768]
KB	IC₅₀	1.5 nM Compound: 4	Antiproliferative activity against human KB cell line by methylene blue dye assay Antiproliferative activity against human KB cell line by methylene blue dye assay	[PMID: 17034147]
KB	IC₅₀	<1 μg/mL Compound: 1'	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 17373779]
KB	IC₅₀	2.2 nM Compound: 1, CA4	Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay	[PMID: 18588280]
KB	IC₅₀	2.4 nM Compound: 1a, CA4	Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
KB	IC₅₀	2 nM Compound: 1, CA4	Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay	[PMID: 21641700]
KB	IC₅₀	2 nM Compound: 2, CA4	Growth inhibition of human KB cells after 72 hrs by methylene blue assay Growth inhibition of human KB cells after 72 hrs by methylene blue assay	[PMID: 22060033]
KB	IC₅₀	6 nM Compound: CA-4	Cytotoxicity against vincristine-resistant human KB cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against vincristine-resistant human KB cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
KB	IC₅₀	8 nM Compound: CA-4	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
KB	IC₅₀	2.5 nM Compound: 1, CA4	Cytotoxicity against human KB cells after 72 hrs by methylene blue assay Cytotoxicity against human KB cells after 72 hrs by methylene blue assay	[PMID: 24657567]
KB	IC₅₀	0.013 μM Compound: 1a, CA-4	Antiproliferative activity against human KB cells after 72 hrs by MTT assay Antiproliferative activity against human KB cells after 72 hrs by MTT assay	[PMID: 25233100]
KB	IC₅₀	0.013 μM Compound: 1a, CA-4	Cytotoxicity against human KB cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human KB cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25529737]
KB	IC₅₀	2.5 nM Compound: 1, CA4	Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay	[PMID: 26160020]
KB	GI₅₀	0.0036 μM Compound: CA-4	Antiproliferative activity against human KB cells assessed as cell growth inhibition by SRB assay Antiproliferative activity against human KB cells assessed as cell growth inhibition by SRB assay	[PMID: 26242242]
KB	IC₅₀	0.007 μM Compound: CA-4	Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay	[PMID: 27428395]
KB	IC₅₀	0.012 μM Compound: CA-4; 1	Antiproliferative activity against human KB cells after 72 hrs by MTT assay Antiproliferative activity against human KB cells after 72 hrs by MTT assay	[PMID: 30344902]
KB	IC₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human KB cells after 72 hrs by MTT assay Antiproliferative activity against human KB cells after 72 hrs by MTT assay	[PMID: 30525584]
KB	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human KB cells after 72 hrs by MTT assay Antiproliferative activity against human KB cells after 72 hrs by MTT assay	[PMID: 30530194]
KB	IC₅₀	0.25 μM Compound: 1; CA-4	Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay Antiproliferative activity against human KB cells measured after 72 hrs by MTT assay	[PMID: 30901597]
KB	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30981112]
KB	GI₅₀	3.6 nM Compound: CA-4	Antiproliferative activity against human KB cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 31938468]
KB	GI₅₀	3.6 nM Compound: CA-4	Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 34917259]
KB	IC₅₀	0.016 μM Compound: 1a; CA-4	Anti-proliferative activity against human KB cells after 72 hrs by MTT assay Anti-proliferative activity against human KB cells after 72 hrs by MTT assay	10.1039/C5MD00028A
KB 3-1	IC₅₀	0.78 nM Compound: CA-4	Cytotoxicity against KB-3-1 cell line Cytotoxicity against KB-3-1 cell line	[PMID: 17249649]
KB 3-1	IC₅₀	0.01 μM Compound: 12	Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay	[PMID: 32243160]
KB-V1	IC₅₀	0.64 nM Compound: CA-4	Cytotoxicity against P-glycoprotein-overexpressing KB-V1 cell line Cytotoxicity against P-glycoprotein-overexpressing KB-V1 cell line	[PMID: 17249649]
KB-V1	IC₅₀	0.4 nM Compound: CA4	Cytotoxicity against human vinblastine-resistant KBV1 cells after 72 hrs by MTT assay Cytotoxicity against human vinblastine-resistant KBV1 cells after 72 hrs by MTT assay	[PMID: 20731355]
KB-V1	IC₅₀	0.004 μM Compound: CA4	Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 31958738]
KM12	GI₅₀	0.005 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human KM12 cells after 48 hrs by SRB assay Growth inhibition of human KM12 cells after 48 hrs by SRB assay	[PMID: 22982122]
KM12	GI₅₀	0.005 μM Compound: CA4, NSC 613729	Growth inhibition of human KM12 cells after 48 hrs by SRB assay Growth inhibition of human KM12 cells after 48 hrs by SRB assay	[PMID: 24387982]
KM12	GI₅₀	4.99 nM Compound: CA4	Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
KM12	GI₅₀	0.005 μM Compound: CA4; NSC 613729	Cytotoxicity against human KM12 cells by SRB assay Cytotoxicity against human KM12 cells by SRB assay	[PMID: 26257861]
KM-20L2	GI₅₀	6.1 μg/mL Compound: 1c	Compound was evaluated against Human cell line colon KM20L2 Compound was evaluated against Human cell line colon KM20L2	[PMID: 10212132]
KM-20L2	GI₅₀	0.34 μg/mL Compound: 3b	Evaluated for growth inhibition (anticancer activity) of Human colon KM20L2 cancer cell line Evaluated for growth inhibition (anticancer activity) of Human colon KM20L2 cancer cell line	[PMID: 10893310]
KM-20L2	GI₅₀	0.34 μg/mL Compound: 2a	Cell growth inhibition of colon KM20L2 cells, expressed as 50% reduction in the net protein increase Cell growth inhibition of colon KM20L2 cells, expressed as 50% reduction in the net protein increase	[PMID: 12036362]
KM-20L2	GI₅₀	0.061 μg/mL Compound: 1a, CA4	Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
KM-20L2	GI₅₀	0.34 μM Compound: CA4, combretastatin A4	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 18303849]
KM-20L2	GI₅₀	0.34 μg/mL Compound: 3, CA4	Antitumor activity against human KM20L2 cells by sulforhodamine B assay Antitumor activity against human KM20L2 cells by sulforhodamine B assay	[PMID: 19228038]
KM-20L2	GI₅₀	0.34 μg/mL Compound: Z-1b	Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay	[PMID: 19709889]
KM-20L2	GI₅₀	0.34 μg/mL Compound: 2a	Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay	[PMID: 19719153]
KM-20L2	GI₅₀	0.061 μg/mL Compound: 1a, CA4	Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
KYSE-150 cell line	IC₅₀	0.6 μM Compound: 1; CA4	Antiproliferative activity against human KYSE-150 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human KYSE-150 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 32063430]
KYSE-30	IC₅₀	0.171 μM Compound: CA-4; 1a	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 38901104]
KYSE-450	IC₅₀	0.012 μM Compound: CA-4	Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35834904]
L02	IC₅₀	0.095 μM Compound: CA-4; 1	Cytotoxicity against human LO2 cells after 72 hrs by MTT assay Cytotoxicity against human LO2 cells after 72 hrs by MTT assay	[PMID: 30344902]
L02	IC₅₀	0.095 μM Compound: CA-4	Cytotoxicity against human LO2 cells after 72 hrs by MTT assay Cytotoxicity against human LO2 cells after 72 hrs by MTT assay	[PMID: 30525584]
L02	IC₅₀	0.046 μM Compound: 1; CA-4	Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay	[PMID: 30530194]
L02	IC₅₀	0.095 μM Compound: 1; CA-4	Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30981112]
L02	IC₅₀	1.71 μM Compound: CA-4	Cytotoxicity against human LO2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 31830637]
L02	CC₅₀	0.36 μM Compound: CA-4	Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
L02	IC₅₀	4.23 μM Compound: Combretastatin A-4	Cytotoxicity against human L02 cells Cytotoxicity against human L02 cells	[PMID: 32992133]
L02	GI₅₀	332.6 nM Compound: CA-4	Cytotoxicity against human L02 cells assessed as assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33201714]
L02	IC₅₀	0.046 μM Compound: 1; CA-4	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
L02	IC₅₀	0.0103 μM Compound: CA-4	Antiproliferative activity against human L-O2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human L-O2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34428056]
L02	IC₅₀	0.18 μM Compound: CA4	Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay	[PMID: 35551039]
L02	IC₅₀	3.27 μM Compound: CA-4	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
L02	IC₅₀	3.2 μM Compound: CA-4	Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38280356]
L1210	ED₅₀	7 nM Compound: 1b	Cytotoxicity against mouse L1210 cells Cytotoxicity against mouse L1210 cells	[PMID: 10924176]
L1210	IC₅₀	2.8 nM Compound: 1	Concentration required to inhibit murine leukemia L1210 cell line proliferation Concentration required to inhibit murine leukemia L1210 cell line proliferation	[PMID: 16005627]
L1210	IC₅₀	8.3 nM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cell line Antiproliferative activity against mouse L1210 cell line	[PMID: 16789746]
L1210	IC₅₀	2.8 nM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cells Antiproliferative activity against mouse L1210 cells	[PMID: 17034150]
L1210	IC₅₀	0.002 μM Compound: 1, CA-4	Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay	[PMID: 18226429]
L1210	IC₅₀	2.8 nM Compound: 1, combretastatin A-4	Antiproliferative activity against mouse L1210 cells Antiproliferative activity against mouse L1210 cells	[PMID: 18260616]
L1210	IC₅₀	2.8 nM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cells Antiproliferative activity against mouse L1210 cells	[PMID: 18725179]
L1210	IC₅₀	2.8 nM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cells after 2 days Antiproliferative activity against mouse L1210 cells after 2 days	[PMID: 18755591]
L1210	IC₅₀	2.8 nM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method	[PMID: 19663386]
L1210	IC₅₀	2.8 nM Compound: 1, CA4	Cytotoxicity against mouse L1210 cells after 2 days Cytotoxicity against mouse L1210 cells after 2 days	[PMID: 19736015]
L1210	IC₅₀	2.3 nM Compound: 2, CA4	Antiproliferative activity against mouse L1210 cells after 5 days by MTT assay Antiproliferative activity against mouse L1210 cells after 5 days by MTT assay	[PMID: 19837594]
L1210	IC₅₀	2.8 nM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cells after 2 days by coulter counting Antiproliferative activity against mouse L1210 cells after 2 days by coulter counting	[PMID: 20579891]
L1210	IC₅₀	0.003 μM Compound: 2, CA-4	Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay	[PMID: 21524832]
L1210	IC₅₀	0.003 μM Compound: 1, CA-4	Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter analysis Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter analysis	[PMID: 22027100]
L1210	IC₅₀	2.8 nM Compound: 1a, CA-4	Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counting analysis Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counting analysis	[PMID: 24164557]
L1210	IC₅₀	3 nM Compound: 1; CA-4	Antiproliferative activity against mouse L1210 cells after 2 days by Coulter counter method Antiproliferative activity against mouse L1210 cells after 2 days by Coulter counter method	[PMID: 29220790]
L132	IC₅₀	<1 μg/mL Compound: 1'	Cytotoxicity against human L132 cells after 72 hrs by MTT assay Cytotoxicity against human L132 cells after 72 hrs by MTT assay	[PMID: 17373779]
L929	IC₅₀	0.82 μM Compound: 2; CA-4	Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay	[PMID: 30245397]
L929	IC₅₀	117 nM Compound: CA-4	Cytotoxicity against mouse L929 cells assessed as reduction in cell growth by SRB assay Cytotoxicity against mouse L929 cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
LoVo	IC₅₀	2.9 nM Compound: 4, CA4	Antiproliferative activity against human LoVo after 48 hrs by spectrophotometry Antiproliferative activity against human LoVo after 48 hrs by spectrophotometry	[PMID: 21774499]
LoVo	IC₅₀	0.017 μM Compound: CA-4	Antiproliferative activity against human LoVo cells measured after 48 hrs by MTT assay Antiproliferative activity against human LoVo cells measured after 48 hrs by MTT assay	[PMID: 27721152]
LoVo	IC₅₀	2.4 nM Compound: CA-4	Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay	[PMID: 28792756]
LOX IMVI	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay	[PMID: 22982122]
LOX IMVI	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay	[PMID: 24387982]
LOX IMVI	GI₅₀	3.25 nM Compound: CA4	Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
LOX IMVI	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human LOXIMVI cells by SRB assay Cytotoxicity against human LOXIMVI cells by SRB assay	[PMID: 26257861]
M14	GI₅₀	0.0001 μM Compound: CA-4	In vitro cytotoxic activity was tested against human melanoma cancer (M14) cell line In vitro cytotoxic activity was tested against human melanoma cancer (M14) cell line	[PMID: 12729640]
M14	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human M14 cells after 48 hrs by SRB assay Growth inhibition of human M14 cells after 48 hrs by SRB assay	[PMID: 22982122]
M14	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human M14 cells after 48 hrs by SRB assay Growth inhibition of human M14 cells after 48 hrs by SRB assay	[PMID: 24387982]
M14	GI₅₀	2.78 nM Compound: CA4	Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
M14	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human M14 cells by SRB assay Cytotoxicity against human M14 cells by SRB assay	[PMID: 26257861]
M21	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human M21 cells Growth inhibition of human M21 cells	[PMID: 17291753]
M21	IC₅₀	4.3 nM Compound: 1, CA-4	Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
M21	IC₅₀	4.3 nM Compound: 2, CA-4	Antiproliferative activity against human M21 cells after 48 hrs by SRB assay Antiproliferative activity against human M21 cells after 48 hrs by SRB assay	[PMID: 21920638]
M21	IC₅₀	1.6 nM Compound: CA-4	Antiproliferative activity against human M21 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human M21 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26069928]
M21	IC₅₀	2.2 nM Compound: CA-4	Antiproliferative activity against human M21 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay Antiproliferative activity against human M21 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay	[PMID: 33472119]
M21	IC₅₀	0.0019 μM Compound: CA-4	Antiproliferative activity against human M21 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay Antiproliferative activity against human M21 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay	[PMID: 34837817]
M21	IC₅₀	0.4 nM Compound: CA-4	Antiproliferative activity against human M21 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human M21 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 36780426]
Malme-3M	GI₅₀	0.019 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay	[PMID: 22982122]
Malme-3M	GI₅₀	0.02 μM Compound: CA4, NSC 613729	Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay	[PMID: 24387982]
Malme-3M	GI₅₀	19.5 nM Compound: CA4	Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
Maver1	IC₅₀	4.6 nM Compound: CA-4	Antiproliferative activity against human MAVER-1 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human MAVER-1 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay	[PMID: 36502578]
MC-38	IC₅₀	0.08 μM Compound: CA-4	Antiproliferative activity against mouse MC38 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Antiproliferative activity against mouse MC38 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 33280898]
MCF-10A	IC₅₀	1.17 μM Compound: CA-4	Antiproliferative activity against human MCF10A cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF10A cells measured after 72 hrs by MTT assay	[PMID: 27187864]
MCF-10A	GI₅₀	<1 x 10^-6 μM Compound: CA-4	Growth inhibition of human MCF10A cells after 72 hrs by MTT assay Growth inhibition of human MCF10A cells after 72 hrs by MTT assay	[PMID: 28284864]
MCF-10A	IC₅₀	0.0016 μM Compound: 1	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 96 hrs by MTT assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 96 hrs by MTT assay	[PMID: 30935796]
MCF-10A	IC₅₀	0.099 μM Compound: CA-4	Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34428056]
MCF7	IC₅₀	11 nM Compound: 1	Cytotoxicity was determined by inhibition of cell growth of MCF-7 human breast carcinoma cell Cytotoxicity was determined by inhibition of cell growth of MCF-7 human breast carcinoma cell	[PMID: 11527727]
MCF7	IC₅₀	2.7 nM Compound: combretastatin A-4 (CA-4)	Concentration which produces 50% inhibition of growth of human breast tumor MCF-7 cell line Concentration which produces 50% inhibition of growth of human breast tumor MCF-7 cell line	[PMID: 11714613]
MCF7	IC₅₀	25 nM Compound: combretastatin A-4	Cell growth inhibition against MCF-7 human breast cancer cells using MTS assay Cell growth inhibition against MCF-7 human breast cancer cells using MTS assay	[PMID: 12036364]
MCF7	IC₅₀	11 nM Compound: CA4	Inhibitory concentration to inhibit the growth of MCF-7 human breast carcinoma cells. Inhibitory concentration to inhibit the growth of MCF-7 human breast carcinoma cells.	[PMID: 12036378]
MCF7	IC₅₀	2.1 μM Compound: 2a	Inhibitory activity against tubulin (1.0 mg/mL) assembly was determined Inhibitory activity against tubulin (1.0 mg/mL) assembly was determined	[PMID: 12570374]
MCF7	IC₅₀	8 nM Compound: CA4 (Combretastatin)	Concentration required for the 50% inhibition of human breast cancer (MCF-7) cell line growth Concentration required for the 50% inhibition of human breast cancer (MCF-7) cell line growth	[PMID: 15293996]
MCF7	IC₅₀	17 nM Compound: 6, combretastatin A-4	Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs	[PMID: 15566282]
MCF7	IC₅₀	11 nM Compound: 2g	Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method	[PMID: 16124759]
MCF7	ED₅₀	5.6 μM Compound: 2	Cytotoxicity against human MCF-7 breast cancer cell line. Cytotoxicity against human MCF-7 breast cancer cell line.	[PMID: 1613753]
MCF7	IC₅₀	2 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 16722633]
MCF7	IC₅₀	12 nM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs	[PMID: 17034133]
MCF7	IC₅₀	12 nM Compound: 5, CA4	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17197178]
MCF7	GI₅₀	0.003 μM Compound: CA-4	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 17291753]
MCF7	GI₅₀	0.026 μM Compound: CA4	Growth inhibition of MCF7 cells after 48 hrs Growth inhibition of MCF7 cells after 48 hrs	[PMID: 17360188]
MCF7	IC₅₀	12 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17482458]
MCF7	IC₅₀	17 nM Compound: 2a, CAS4	Growth inhibition of human MCF7 cells after 48 hrs Growth inhibition of human MCF7 cells after 48 hrs	[PMID: 17497841]
MCF7	IC₅₀	0.012 μM Compound: CA-4, combretastatin A-4	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17977727]
MCF7	ED₅₀	uM μM Compound: 1a	Cytotoxic concentration required to inhibit 50% cell growth in MCF-7 breast carcinoma cell lines Cytotoxic concentration required to inhibit 50% cell growth in MCF-7 breast carcinoma cell lines	[PMID: 1875350]
MCF7	IC₅₀	2.5 nM Compound: 2, CSA4	Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 19601594]
MCF7	IC₅₀	0.03 μM Compound: CA-4	Anticancer activity against human MCF7 cells after 72 hrs Anticancer activity against human MCF7 cells after 72 hrs	[PMID: 19713108]
MCF7	IC₅₀	0.0024 μM Compound: 1, CA4	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 19879758]
MCF7	IC₅₀	0.032 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 24 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 24 hrs by SRB assay	[PMID: 20006519]
MCF7	IC₅₀	370 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 20420439]
MCF7	IC₅₀	0.013 μM Compound: CSA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20493717]
MCF7	IC₅₀	0.0031 μM Compound: 2, CA-4	Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs by MTT assay	[PMID: 20933304]
MCF7	IC₅₀	0.013 μM Compound: CSA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21036623]
MCF7	IC₅₀	0.0052 μM Compound: 2a	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21080725]
MCF7	IC₅₀	1.5 μM Compound: CA-4	Inhibition of tubulin polymerization in human MCF7 cells by fluorometric analysis Inhibition of tubulin polymerization in human MCF7 cells by fluorometric analysis	[PMID: 21342735]
MCF7	IC₅₀	5.6 nM Compound: 1, CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
MCF7	IC₅₀	370 nM Compound: 1, CA-4	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 21663319]
MCF7	IC₅₀	11 nM Compound: 4, CA4	Antiproliferative activity against human MCF7 cells assessed after 48 hrs by spectrophotometry Antiproliferative activity against human MCF7 cells assessed after 48 hrs by spectrophotometry	[PMID: 21774499]
MCF7	IC₅₀	0.005 μM Compound: 4, CA-4	Antiproliferative activity against ER expressing human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against ER expressing human MCF7 cells after 72 hrs by MTT assay	[PMID: 21840628]
MCF7	IC₅₀	5.6 nM Compound: 2, CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 21920638]
MCF7	GI₅₀	39.8 nM Compound: 1, CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
MCF7	IC₅₀	13 nM Compound: 2, CSA4	Growth inhibition of human MCF7 cells after 96 hrs Growth inhibition of human MCF7 cells after 96 hrs	[PMID: 22044164]
MCF7	IC₅₀	370 nM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 22136312]
MCF7	IC₅₀	48.9 μM Compound: 2, CA-4	Cytotoxicity against human MCF7 cells by alamar blue assay Cytotoxicity against human MCF7 cells by alamar blue assay	[PMID: 22137934]
MCF7	IC₅₀	0.48 μg/mL Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22192936]
MCF7	IC₅₀	0.41 μg/mL Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22261027]
MCF7	IC₅₀	1.11 nM Compound: CA-4	Antiproliferative activity in human MCF7 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity in human MCF7 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 22329561]
MCF7	IC₅₀	0.43 μg/mL Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22503741]
MCF7	IC₅₀	0.41 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22512906]
MCF7	IC₅₀	0.18 μM Compound: 2a, CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22543234]
MCF7	IC₅₀	370 nM Compound: 1, CA-4	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 22578111]
MCF7	GI₅₀	0.005 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 22982122]
MCF7	IC₅₀	370 nM Compound: CA-4, 1a, 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23117171]
MCF7	IC₅₀	13 nM Compound: 2	Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay	[PMID: 23214452]
MCF7	IC₅₀	370 nM Compound: 1, CA-4	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23445496]
MCF7	IC₅₀	5 nM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 23454513]
MCF7	IC₅₀	0.4 μM Compound: 1, CA-4	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23566762]
MCF7	IC₅₀	9 nM Compound: CA4	Darktoxicity against human MCF7 cells incubated for 24 hrs followed by 30 mins incubation in dark measured after 3 days by MTT assay Darktoxicity against human MCF7 cells incubated for 24 hrs followed by 30 mins incubation in dark measured after 3 days by MTT assay	[PMID: 23631389]
MCF7	IC₅₀	0.029 μM Compound: CA4	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
MCF7	IC₅₀	0.098 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23809851]
MCF7	IC₅₀	0.006 μM Compound: CA-4	Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay	[PMID: 23810282]
MCF7	IC₅₀	220 nM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
MCF7	IC₅₀	0.0025 μM Compound: Combretastatin A-4, IODWF	Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24012378]
MCF7	IC₅₀	0.004 μM Compound: 1, CA-4	Cytotoxicity against human MCF7 cells after 3 days Cytotoxicity against human MCF7 cells after 3 days	[PMID: 24139940]
MCF7	IC₅₀	1 μM Compound: 1a, CoA4	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 3 days by MTT assay	[PMID: 24145138]
MCF7	IC₅₀	0.67 μM Compound: CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24238904]
MCF7	IC₅₀	3 nM Compound: 1, CA-4	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 24900453]
MCF7	IC₅₀	0.31 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24909678]
MCF7	IC₅₀	0.21 μg/mL Compound: 2, CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24916028]
MCF7	IC₅₀	370 nM Compound: 1a, CA-4	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 25025853]
MCF7	IC₅₀	13 nM Compound: 2, CSA4	Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy	[PMID: 25025991]
MCF7	IC₅₀	0.072 μM Compound: CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 25192811]
MCF7	IC₅₀	1 μM Compound: CoA4	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 25240870]
MCF7	IC₅₀	0.21 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 25703297]
MCF7	IC₅₀	370 nM Compound: 1a, CA-4	Antiproliferative activity against human MCF7 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human MCF7 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
MCF7	IC₅₀	0.31 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 25828827]
MCF7	IC₅₀	2.1 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26069928]
MCF7	GI₅₀	9.4 μM Compound: CA-4	Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay	[PMID: 26070164]
MCF7	IC₅₀	13 nM Compound: 2, CSA4	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26132075]
MCF7	IC₅₀	0.042 μM Compound: CA4	Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
MCF7	IC₅₀	0.0039 μM Compound: 2; CA-4	Antiproliferative activity against human MCF7 cells assessed as cell viability pre-incubated for 24 hrs with CO2 followed by compound addition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell viability pre-incubated for 24 hrs with CO2 followed by compound addition after 72 hrs by MTT assay	[PMID: 26680364]
MCF7	IC₅₀	18 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by sulforhodamine B assay	[PMID: 26938120]
MCF7	IC₅₀	0.046 μM Compound: 1; CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 26970659]
MCF7	IC₅₀	1.23 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 26974371]
MCF7	GI₅₀	0.018 μM Compound: CA-4	Growth inhibition of human MCF7 cells after 3 days by MTT assay Growth inhibition of human MCF7 cells after 3 days by MTT assay	[PMID: 27031215]
MCF7	GI₅₀	0.025 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by SRB assay	[PMID: 27040661]
MCF7	IC₅₀	0.013 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 27149641]
MCF7	GI₅₀	0.033 μM Compound: 1; CA-4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
MCF7	IC₅₀	0.0125 μM Compound: 3; CA-4	Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
MCF7	IC₅₀	0.18 μM Compound: Combretastatin-A4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 27487568]
MCF7	IC₅₀	0.029 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay	[PMID: 27721152]
MCF7	IC₅₀	0.005 μM Compound: 1; CA-4	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MCF7	IC₅₀	2.5 μM Compound: CA-4	Inhibition of tubulin polymerization in human MCF7 cells assessed as suppression of protein assembly after 15 mins by spectrophotometric analysis Inhibition of tubulin polymerization in human MCF7 cells assessed as suppression of protein assembly after 15 mins by spectrophotometric analysis	[PMID: 27994737]
MCF7	IC₅₀	0.043 μM Compound: 2A; CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28034647]
MCF7	IC₅₀	0.0035 μM Compound: 2; CA-4	Antiproliferative activity against combretastatin A-4 resistant human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay Antiproliferative activity against combretastatin A-4 resistant human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay	[PMID: 28254699]
MCF7	IC₅₀	0.041 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28410492]
MCF7	IC₅₀	13 nM Compound: CSA4	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay	[PMID: 28523104]
MCF7	IC₅₀	4.2 μM Compound: CA 4	Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 28684120]
MCF7	IC₅₀	14 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28792756]
MCF7	IC₅₀	0.12 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 28803046]
MCF7	IC₅₀	8 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 72 hrs by resazurin-based fluorescence assay Antiproliferative activity against human MCF7 cells after 72 hrs by resazurin-based fluorescence assay	[PMID: 29202409]
MCF7	IC₅₀	0.17 μM Compound: 1a; CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29291446]
MCF7	IC₅₀	69.6 μM Compound: CA4	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29396364]
MCF7	IC₅₀	1000 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 2 days by MTT assay Antiproliferative activity against human MCF7 cells after 2 days by MTT assay	[PMID: 29432949]
MCF7	IC₅₀	5 nM Compound: CSA4	Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay	[PMID: 29730191]
MCF7	IC₅₀	39.1 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay	[PMID: 30006162]
MCF7	GI₅₀	0.14 μM Compound: CA-4	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 30041136]
MCF7	IC₅₀	0.18 μM Compound: Combretastatin A-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30108703]
MCF7	IC₅₀	4.63 μM Compound: Combretastatin	Antiproliferative activity in human MCF7 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay Antiproliferative activity in human MCF7 cells assessed as reduction in cell number incubated for 48 hrs by SRB assay	[PMID: 30108756]
MCF7	IC₅₀	0.67 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
MCF7	IC₅₀	0.0021 μM Compound: CA-4	Antiproliferative activity against CYP1A1 expressing human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against CYP1A1 expressing human MCF7 cells after 72 hrs by SRB assay	[PMID: 30201525]
MCF7	IC₅₀	0.2 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTS/PMS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS/PMS assay	[PMID: 30230828]
MCF7	IC₅₀	0.041 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 48 hrs by MTT assay	[PMID: 30448234]
MCF7	IC₅₀	3 nM Compound: CA-4	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30472600]
MCF7	IC₅₀	1 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 30502686]
MCF7	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 30606674]
MCF7	IC₅₀	0.002 μM Compound: 1	Antiproliferative activity against ER positive human MCF7 cells expressing low level of CYP assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against ER positive human MCF7 cells expressing low level of CYP assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 30935796]
MCF7	IC₅₀	0.002 μM Compound: 1	Antiproliferative activity against TCCD-induced ER positive human MCF7 cells expressing CYP1A1 assessed as reduction in cell viability after 96 hrs by MTT assay Antiproliferative activity against TCCD-induced ER positive human MCF7 cells expressing CYP1A1 assessed as reduction in cell viability after 96 hrs by MTT assay	[PMID: 30935796]
MCF7	IC₅₀	370 nM Compound: 1a; CA-4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 31400707]
MCF7	IC₅₀	0.37 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 31536891]
MCF7	IC₅₀	1.04 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTS assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTS assay	[PMID: 31541870]
MCF7	GI₅₀	84 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 31938468]
MCF7	IC₅₀	0.004 μM Compound: CA-4; D-613729	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31954879]
MCF7	IC₅₀	0.25 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
MCF7	IC₅₀	0.49 μM Compound: CA-4	Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
MCF7	IC₅₀	0.041 μM Compound: 1; CA4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 32063430]
MCF7	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
MCF7	IC₅₀	0.09 μM Compound: 12	Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay	[PMID: 32243160]
MCF7	IC₅₀	0.032 μM Compound: Combretastatin A-4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 32302879]
MCF7	IC₅₀	0.17 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay	[PMID: 32717486]
MCF7	IC₅₀	0.01 μM Compound: CA4	Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 32731188]
MCF7	IC₅₀	3.45 μM Compound: Combretastatin A-4	Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
MCF7	IC₅₀	0.04 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay	[PMID: 33010448]
MCF7	IC₅₀	0.041 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 33022479]
MCF7	IC₅₀	8 nM Compound: 1; CA-4	Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
MCF7	IC₅₀	0.034 μM Compound: 1; CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 33421913]
MCF7	IC₅₀	1.9 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay	[PMID: 33472119]
MCF7	IC₅₀	170 nM Compound: 1; CA-4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by MTT assay	[PMID: 33636303]
MCF7	IC₅₀	0.01 μM Compound: CA-4	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
MCF7	IC₅₀	0.42 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 34311158]
MCF7	IC₅₀	0.0031 μM Compound: CA-4	Antiproliferative activity against human MCF7/ADR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7/ADR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34428056]
MCF7	IC₅₀	0.0048 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34428056]
MCF7	IC₅₀	0.011 μM Compound: 8; CA-4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by SRB assay	[PMID: 34454126]
MCF7	IC₅₀	0.019 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
MCF7	IC₅₀	0.14 μM Compound: 6a; CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
MCF7	IC₅₀	0.029 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34649064]
MCF7	IC₅₀	4.85 μM Compound: 133	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34826681]
MCF7	GI₅₀	84 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 34917259]
MCF7	IC₅₀	0.009 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MCF7	IC₅₀	0.12 μM Compound: CA4	Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay	[PMID: 35551039]
MCF7	IC₅₀	172 nM Compound: CA4	Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
MCF7	IC₅₀	0.014 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 36162214]
MCF7	IC₅₀	0.018 μM Compound: CA-4	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition Cytotoxicity against human MCF7 cells assessed as cell growth inhibition	[PMID: 36242921]
MCF7	IC₅₀	0.46 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
MCF7	IC₅₀	5.9 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
MCF7	IC₅₀	9 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells expressing CYP1A1 assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells expressing CYP1A1 assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay	[PMID: 36780426]
MCF7	IC₅₀	0.071 μM Compound: 6; CA-4	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
MCF7	IC₅₀	24 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
MCF7	IC₅₀	15 μM Compound: CSA4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay	[PMID: 37902628]
MCF7	GI₅₀	9 nM Compound: CA4	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 37984295]
MCF7	IC₅₀	0.011 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells incubated for 72 hrs Antiproliferative activity against human MCF7 cells incubated for 72 hrs	[PMID: 38171146]
MCF7	IC₅₀	0.21 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38280356]
MCF7	IC₅₀	0.031 μM Compound: CA-4	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 38452727]
MCF7	IC₅₀	3.9 nM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
MCF7	IC₅₀	32.69 nM Compound: CA-4	Antiproliferation activity against human MCF7 cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human MCF7 cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
MCF7	IC₅₀	0.008 μM Compound: Combretastatin A-4	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 38911170]
MCF7	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MCF7	IC₅₀	0.032 μM Compound: 1	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	10.1039/C0MD00119H
MCF7	IC₅₀	25.51 μM Compound: CA-4	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	10.1039/C3MD00372H
MCF7	IC₅₀	0.134 μM Compound: 2a; CA-4	Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay	10.1039/C5MD00155B
MCF7-DOX	IC₅₀	2.3 nM Compound: CA-4	Antiproliferative activity against doxorubicin-resistant human MCF7-dx cells Antiproliferative activity against doxorubicin-resistant human MCF7-dx cells	[PMID: 16722633]
MCF-A	GI₅₀	0.09 μM Compound: CA-4	In vitro cytotoxic activity tested against human breast cancer MCF/ADR cell line In vitro cytotoxic activity tested against human breast cancer MCF/ADR cell line	[PMID: 12729640]
MDA-MB-231	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human MDA-MB-231 cells Growth inhibition of human MDA-MB-231 cells	[PMID: 17291753]
MDA-MB-231	IC₅₀	6 nM Compound: 1, CA-4	Cytotoxicity against human MDA-MB-231 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter Cytotoxicity against human MDA-MB-231 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter	[PMID: 18396050]
MDA-MB-231	IC₅₀	3 nM Compound: CA-4, combretastatin A-4	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 18477509]
MDA-MB-231	IC₅₀	4 nM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay	[PMID: 19117761]
MDA-MB-231	IC₅₀	3 nM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells after 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs	[PMID: 19530698]
MDA-MB-231	IC₅₀	0.043 μM Compound: 2, CA-4	Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 20933304]
MDA-MB-231	IC₅₀	0.043 μM Compound: 2a	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 21080725]
MDA-MB-231	IC₅₀	3.2 nM Compound: 4, CA4	Antiproliferative activity against human MDA-MB-231 after 48 hrs by spectrophotometry Antiproliferative activity against human MDA-MB-231 after 48 hrs by spectrophotometry	[PMID: 21774499]
MDA-MB-231	IC₅₀	0.043 μM Compound: 4, CA-4	Antiproliferative activity against ER-independent human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against ER-independent human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 21840628]
MDA-MB-231	GI₅₀	3 nM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis Cytotoxicity against human MDA-MB-231 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis	[PMID: 22449653]
MDA-MB-231	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 22982122]
MDA-MB-231	IC₅₀	0.0028 μM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by resazurin based fluorescence assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by resazurin based fluorescence assay	[PMID: 24669888]
MDA-MB-231	GI₅₀	3.2 nM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTitre-Blue assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTitre-Blue assay	[PMID: 25528337]
MDA-MB-231	IC₅₀	331 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by sulforhodamine B assay	[PMID: 26938120]
MDA-MB-231	IC₅₀	0.03 μM Compound: Combretastatin A-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell proliferation after 3 days by 3H-thymidine incorporation assay	[PMID: 27212068]
MDA-MB-231	IC₅₀	0.008 μM Compound: CA-4	Growth inhibition of human MDA-MB-231 cells Growth inhibition of human MDA-MB-231 cells	[PMID: 27805821]
MDA-MB-231	IC₅₀	270 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28410492]
MDA-MB-231	IC₅₀	4.1 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28792756]
MDA-MB-231	IC₅₀	0.17 μM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 28803046]
MDA-MB-231	GI₅₀	0.046 μM Compound: Combretastatin	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB cell proliferation assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB cell proliferation assay	[PMID: 29089233]
MDA-MB-231	IC₅₀	0.002 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells by MTT assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay	[PMID: 29126741]
MDA-MB-231	GI₅₀	0.045 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29227648]
MDA-MB-231	IC₅₀	0.92 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SRB assay	[PMID: 29268127]
MDA-MB-231	IC₅₀	0.56 μM Compound: 1a; CA-4	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29291446]
MDA-MB-231	IC₅₀	0.008 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29306206]
MDA-MB-231	IC₅₀	3.4 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells by SRB assay Antiproliferative activity against human MDA-MB-231 cells by SRB assay	[PMID: 29655610]
MDA-MB-231	IC₅₀	0.0045 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CCK8 assay	[PMID: 30006162]
MDA-MB-231	IC₅₀	0.0024 μM Compound: CA-4	Antiproliferative activity against CYP1A1 deficient human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against CYP1A1 deficient human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 30201525]
MDA-MB-231	IC₅₀	0.015 μM Compound: CA-4; 1	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30344902]
MDA-MB-231	IC₅₀	3.17 nM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30472600]
MDA-MB-231	IC₅₀	0.015 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30525584]
MDA-MB-231	IC₅₀	0.011 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30530194]
MDA-MB-231	IC₅₀	0.01 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30981112]
MDA-MB-231	IC₅₀	4.5 nM Compound: 1a; CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 31400707]
MDA-MB-231	IC₅₀	13.5 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
MDA-MB-231	GI₅₀	8.2 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 31938468]
MDA-MB-231	IC₅₀	0.09 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
MDA-MB-231	IC₅₀	0.017 μM Compound: 1; CA4	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 32063430]
MDA-MB-231	IC₅₀	8 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
MDA-MB-231	IC₅₀	0.015 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33676300]
MDA-MB-231	GI₅₀	8.2 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 34917259]
MDA-MB-231	IC₅₀	0.012 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 35065411]
MDA-MB-231	IC₅₀	0.013 μM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MDA-MB-231	IC₅₀	3 nM Compound: CA4	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
MDA-MB-231	IC₅₀	0.0033 μM Compound: CA4	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition	[PMID: 35964428]
MDA-MB-231	IC₅₀	2.13 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
MDA-MB-231	IC₅₀	0.077 μM Compound: 1; CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37172475]
MDA-MB-231	IC₅₀	0.029 μM Compound: 6; CA-4	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 37269670]
MDA-MB-231	IC₅₀	100 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
MDA-MB-231	IC₅₀	0.02 μM Compound: CA-4; Cpd II	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37883897]
MDA-MB-231	GI₅₀	3.5 nM Compound: CA4	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 37984295]
MDA-MB-231	IC₅₀	0.11 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38280356]
MDA-MB-231	IC₅₀	0.008 μM Compound: CA-4	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 38452727]
MDA-MB-231	IC₅₀	5 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
MDA-MB-231	IC₅₀	0.1 μM Compound: 1, CA-4	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	10.1039/C2MD20085F
MDA-MB-231	GI₅₀	0.021 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	10.1039/C5MD00139K
MDA-MB-435	IC₅₀	0.003 μM Compound: 1, CA-4	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay	[PMID: 19894742]
MDA-MB-435	EC₅₀	13 nM Compound: CA4	Inhibition of microtubule polymerization in human MDA-MB-435 cells Inhibition of microtubule polymerization in human MDA-MB-435 cells	[PMID: 21786793]
MDA-MB-435	IC₅₀	3.4 nM Compound: CA4	Antiproliferative activity against human MDA-MB-435 cells by SRB assay Antiproliferative activity against human MDA-MB-435 cells by SRB assay	[PMID: 21786793]
MDA-MB-435	GI₅₀	31.6 nM Compound: 1, CA-4	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
MDA-MB-435	IC₅₀	0.001 μM Compound: CA-4	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 22676247]
MDA-MB-435	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human MDA-MB-435 cells after 48 hrs by SRB assay Growth inhibition of human MDA-MB-435 cells after 48 hrs by SRB assay	[PMID: 22982122]
MDA-MB-435	IC₅₀	3.4 nM Compound: CA-4	Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23332369]
MDA-MB-435	IC₅₀	5 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 25882519]
MDA-MB-435	GI₅₀	0.003 μM Compound: CA-4	Growth inhibition of human MDA-MB-435 cells after 72 hrs by MTT assay Growth inhibition of human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 27031215]
MDA-MB-435	EC₅₀	4.4 nM Compound: CA-4	Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27213719]
MDA-MB-435	GI₅₀	3 nM Compound: 1	Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27707624]
MDA-MB-435	IC₅₀	4.4 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by sulforhodamine B assay	[PMID: 30098869]
MDA-MB-435	IC₅₀	4.4 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 30297118]
MDA-MB-435	IC₅₀	3.4 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cell line assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-435 cell line assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay	[PMID: 33310545]
MDA-MB-435	IC₅₀	4.4 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
MDA-MB-435	IC₅₀	4.4 μM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cells Antiproliferative activity against human MDA-MB-435 cells	[PMID: 33705908]
MDA-MB-435	IC₅₀	4.4 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth by SRB assay Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth by SRB assay	[PMID: 36889150]
MDA-MB-468	IC₅₀	3.1 nM Compound: 1, CA-4	Antiproliferative activity against human MDA-MB-468 cells expressing NQO1 by MTT assay Antiproliferative activity against human MDA-MB-468 cells expressing NQO1 by MTT assay	[PMID: 23010271]
MDA-MB-468	IC₅₀	1.1 nM Compound: 3	Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
MDA-MB-468	IC₅₀	1.55 nM Compound: CA-4	Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTT assay	[PMID: 30472600]
MDA-MB-468	IC₅₀	0.003 μM Compound: 1	Antiproliferative activity against ER negative human MDA-MB-468 cells expressing CYP1A1 and CYP1B1 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against ER negative human MDA-MB-468 cells expressing CYP1A1 and CYP1B1 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 30935796]
MDA-MB-468	IC₅₀	6.5 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
MDA-MB-468	IC₅₀	16 nM Compound: CA4	Phototoxicity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 24 hrs followed by LED illumination by MTT assay Phototoxicity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 24 hrs followed by LED illumination by MTT assay	[PMID: 35964428]
MDA-MB-468	IC₅₀	1.8 nM Compound: CA-4	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
MES-SA	IC₅₀	13 nM Compound: CA4 (Combretastatin)	Concentration required for the 50% inhibition of human uterine cancer (MESSA) cell line growth Concentration required for the 50% inhibition of human uterine cancer (MESSA) cell line growth	[PMID: 15293996]
MES-SA	IC₅₀	1.6 nM Compound: CA4	Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay	[PMID: 17286393]
MES-SA	IC₅₀	2.7 nM Compound: 2	Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
MES-SA	IC₅₀	2.7 nM Compound: 2, CSA4	Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay	[PMID: 25025991]
MES-SA	IC₅₀	2.7 nM Compound: 2, CSA4	Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	[PMID: 26132075]
MES-SA	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay	[PMID: 26602281]
MES-SA/Dx5	IC₅₀	4 nM Compound: combretastatin A-4	Cell growth inhibition against,MES-SA/DX5 human uterine cancer cells using MTS assay Cell growth inhibition against,MES-SA/DX5 human uterine cancer cells using MTS assay	[PMID: 12036364]
MES-SA/Dx5	IC₅₀	5 nM Compound: combretastatin A-4	Cell growth inhibition against MES-SA human uterine cancer cells using MTS assay Cell growth inhibition against MES-SA human uterine cancer cells using MTS assay	[PMID: 12036364]
MES-SA/Dx5	IC₅₀	1.4 nM Compound: CA4	Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay	[PMID: 17286393]
MES-SA/Dx5	IC₅₀	2.6 nM Compound: 2	Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
MES-SA/Dx5	IC₅₀	2.6 nM Compound: 2, CSA4	Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay	[PMID: 25025991]
MES-SA/Dx5	IC₅₀	2.6 nM Compound: 2, CSA4	Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	[PMID: 26132075]
MES-SA/Dx5	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay	[PMID: 33618157]
MeWo	IC₅₀	4 nM Compound: CA-4	Antiproliferative activity against human MeWo cells Antiproliferative activity against human MeWo cells	[PMID: 16722633]
MGC-803	IC₅₀	8.9 nM Compound: CA-4	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay	[PMID: 28792756]
MGC-803	IC₅₀	1.76 μM Compound: CA-4	Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
MGC-803	IC₅₀	0.002 μM Compound: 8; CA-4	Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay	[PMID: 34454126]
MGC-803	IC₅₀	0.006 μM Compound: 6a; CA-4	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
MGC-803	IC₅₀	0.008 μM Compound: CA-4	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35834904]
MGC-803	IC₅₀	0.02058 μM Compound: CA4	Cytotoxicity against human MGC-803 cells assessed as cell growth inhibition Cytotoxicity against human MGC-803 cells assessed as cell growth inhibition	[PMID: 35964428]
MGC-803	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 36162214]
MGC-803	IC₅₀	0.53 μM Compound: CA-4	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
MGC-803	IC₅₀	0.002 μM Compound: CA-4	Antiproliferative activity against human MGC-803 cells incubated for 72 hrs Antiproliferative activity against human MGC-803 cells incubated for 72 hrs	[PMID: 38171146]
MGC-803	IC₅₀	0.003 μM Compound: CA-4; 1a	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 38901104]
MHCC97H	IC₅₀	0.008 μM Compound: CA-4	Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34649064]
MIA PaCa-2	IC₅₀	<1 μg/mL Compound: 1'	Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay	[PMID: 17373779]
MIA PaCa-2	IC₅₀	8 nM Compound: CA-4	Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay	[PMID: 19117761]
MIA PaCa-2	IC₅₀	0.0072 μM Compound: CA-4, 1a	Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 20338766]
MIA PaCa-2	IC₅₀	0.003 μM Compound: 1; CA-4	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MIA PaCa-2	IC₅₀	8 nM Compound: 1; CA-4	Antiproliferative activity against human MiaPaca2 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay Antiproliferative activity against human MiaPaca2 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay	[PMID: 33038796]
MIA PaCa-2	IC₅₀	2.1 nM Compound: CA-4	Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33618157]
MIA PaCa-2	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human MIA PaCa-2 cells Antiproliferative activity against human MIA PaCa-2 cells	[PMID: 34655985]
MIA PaCa-2	IC₅₀	8 nM Compound: CA4	Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
MIA PaCa-2	IC₅₀	0.087 μM Compound: 2a; CA-4	Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by SRB assay Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by SRB assay	10.1039/C5MD00155B
MKN-45	IC₅₀	82 nM Compound: CA4 (Combretastatin)	Concentration required for the 50% inhibition of human stomach cancer (MKN45) cell line growth Concentration required for the 50% inhibition of human stomach cancer (MKN45) cell line growth	[PMID: 15293996]
MKN-45	IC₅₀	52 nM Compound: 4	Antiproliferative activity against human MKN45 cell line by methylene blue dye assay Antiproliferative activity against human MKN45 cell line by methylene blue dye assay	[PMID: 17034147]
MKN-45	IC₅₀	5.6 nM Compound: 1, CA4	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 18588280]
MKN-45	IC₅₀	4.9 nM Compound: 1a, CA4	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
MKN-45	IC₅₀	4.8 nM Compound: 1, CA4	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 21641700]
MKN-45	IC₅₀	4.8 nM Compound: 2, CA4	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 22060033]
MKN-45	IC₅₀	3.2 nM Compound: 1, CA4	Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 24657567]
MKN-45	IC₅₀	3.2 nM Compound: 1, CA4	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 26160020]
MKN-45	IC₅₀	0.11 μM Compound: CA-4	Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay	[PMID: 28622907]
MKN-45	IC₅₀	0.21 μM Compound: CA-4	Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay	[PMID: 29407949]
MKN-45	IC₅₀	0.0081 μM Compound: 6a; CA-4	Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
MLM	ED₅₀	4.3 μM Compound: 2	Cytotoxicity against human MLM melanoma cell line. Cytotoxicity against human MLM melanoma cell line.	[PMID: 1613753]
MLM	ED₅₀	uM μM Compound: 1a	Cytotoxic concentration required to inhibit 50% cell growth in MLM melanoma cell lines Cytotoxic concentration required to inhibit 50% cell growth in MLM melanoma cell lines	[PMID: 1875350]
MOLT-3	IC₅₀	9.3 nM Compound: 1	Antiproliferative activity against human Molt3 cells after 72 hrs Antiproliferative activity against human Molt3 cells after 72 hrs	[PMID: 17034133]
MOLT-3	IC₅₀	9.3 nM Compound: 5, CA4	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17197178]
MOLT-3	IC₅₀	9.3 nM Compound: CA-4	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17482458]
MOLT-3	IC₅₀	0.09 μM Compound: CA-4, combretastatin A-4	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17977727]
MOLT-4	IC₅₀	16 nM Compound: 1	Concentration required to inhibit human T-lymphoblast Molt4/C8 cell line proliferation Concentration required to inhibit human T-lymphoblast Molt4/C8 cell line proliferation	[PMID: 16005627]
MOLT-4	IC₅₀	1.6 nM Compound: 1, CA-4	Antiproliferative activity against human Molt4/C8 cells Antiproliferative activity against human Molt4/C8 cells	[PMID: 17034150]
MOLT-4	IC₅₀	1.6 nM Compound: CA-4, 1	Antiproliferative effect against human Molt4/C8 cells after 3 days Antiproliferative effect against human Molt4/C8 cells after 3 days	[PMID: 17419607]
MOLT-4	IC₅₀	1.6 nM Compound: 1, combretastatin A-4	Antiproliferative activity against human Molt4/C8 cells Antiproliferative activity against human Molt4/C8 cells	[PMID: 18260616]
MOLT-4	IC₅₀	1.6 nM Compound: 1, CA-4	Antiproliferative activity against human Molt4/C8 cells Antiproliferative activity against human Molt4/C8 cells	[PMID: 18725179]
MOLT-4	IC₅₀	16 nM Compound: 1, CA-4	Antiproliferative activity against human Molt4/C8 cells after 2 days Antiproliferative activity against human Molt4/C8 cells after 2 days	[PMID: 18755591]
MOLT-4	IC₅₀	16 nM Compound: 1, CA-4	Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method	[PMID: 19663386]
MOLT-4	IC₅₀	16 nM Compound: 1, CA4	Cytotoxicity against human Molt4/C8 cells after 2 days Cytotoxicity against human Molt4/C8 cells after 2 days	[PMID: 19736015]
MOLT-4	IC₅₀	16 nM Compound: 1, CA-4	Antiproliferative activity against human Molt4/C8 cells after 2 days by coulter counting Antiproliferative activity against human Molt4/C8 cells after 2 days by coulter counting	[PMID: 20579891]
MOLT-4	IC₅₀	0.016 μM Compound: 1, CA-4	Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter analysis Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter analysis	[PMID: 22027100]
MOLT-4	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay	[PMID: 22982122]
MOLT-4	IC₅₀	16 nM Compound: 1a, CA-4	Cytotoxicity against human Molt4/C8 cells assessed as growth inhibition after 48 hrs by coulter counting analysis Cytotoxicity against human Molt4/C8 cells assessed as growth inhibition after 48 hrs by coulter counting analysis	[PMID: 24164557]
MOLT-4	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay	[PMID: 24387982]
MOLT-4	GI₅₀	3.27 nM Compound: CA4	Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
MOLT-4	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human MOLT4 cells by SRB assay Cytotoxicity against human MOLT4 cells by SRB assay	[PMID: 26257861]
MRC5	IC₅₀	2.8 nM Compound: 1, CA-4	Growth inhibition of human MRC5 cells after 48 hrs by SRB assay Growth inhibition of human MRC5 cells after 48 hrs by SRB assay	[PMID: 24900453]
MV4-11	IC₅₀	0.00627 μM Compound: 3, CA4	Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay	[PMID: 25466200]
MX1	IC₅₀	52 nM Compound: CA-4	Cytotoxicity against human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
MX1	IC₅₀	71 nM Compound: CA-4	Cytotoxicity against taxol-resistant human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against taxol-resistant human MX1 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23981529]
NCI/ADR-RES	EC₅₀	0.0015 μM Compound: CA4	Cell cycle arrest in NCI/ADR (MDR) cells by accumulation at G2/M phase Cell cycle arrest in NCI/ADR (MDR) cells by accumulation at G2/M phase	[PMID: 16377187]
NCI/ADR-RES	IC₅₀	1.3 nM Compound: 2, CSA4	Growth inhibition of doxorubicin-resistant human NCI-ADR-RES cells overexpressing P-glycoprotein after 96 hrs Growth inhibition of doxorubicin-resistant human NCI-ADR-RES cells overexpressing P-glycoprotein after 96 hrs	[PMID: 22044164]
NCI/ADR-RES	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human NCI/ADR-RES cells after 48 hrs by SRB assay Growth inhibition of human NCI/ADR-RES cells after 48 hrs by SRB assay	[PMID: 22982122]
NCI/ADR-RES	IC₅₀	1.3 nM Compound: 2	Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay	[PMID: 23214452]
NCI/ADR-RES	GI₅₀	1 nM Compound: CA4	Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
NCI/ADR-RES	EC₅₀	5000 nM Compound: C A-4	Cytotoxicity against human NCI-ADR-RES cells assessed as inhibition of cell proliferation by SRB assay Cytotoxicity against human NCI-ADR-RES cells assessed as inhibition of cell proliferation by SRB assay	[PMID: 24801610]
NCI/ADR-RES	IC₅₀	1.3 nM Compound: 2, CSA4	Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy	[PMID: 25025991]
NCI/ADR-RES	IC₅₀	1.8 nM Compound: 2, CSA4	Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26132075]
NCI/ADR-RES	IC₅₀	1.3 μM Compound: CA	Growth inhibition of human NCI/ADR-RES cells over expressing Pgp measured after 96 hrs by sulforhodamine B assay Growth inhibition of human NCI/ADR-RES cells over expressing Pgp measured after 96 hrs by sulforhodamine B assay	[PMID: 27894589]
NCI/ADR-RES	IC₅₀	3.5 nM Compound: CSA4	Growth inhibition of human NCI/ADR-RES cells after 96 hrs by trypan blue exclusion assay Growth inhibition of human NCI/ADR-RES cells after 96 hrs by trypan blue exclusion assay	[PMID: 29730191]
NCI/ADR-RES	IC₅₀	1.8 nM Compound: CA-4	Antiproliferative activity against human NCI/ADR-RES cells overexpressing Pgp Antiproliferative activity against human NCI/ADR-RES cells overexpressing Pgp	[PMID: 33705908]
NCI/ADR-RES	IC₅₀	12.47 nM Compound: CA-4	Antiproliferation activity against human MCF7/ADR cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human MCF7/ADR cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
NCI-H1299	IC₅₀	5 nM Compound: CA-4, combretastatin A-4	Cytotoxicity against human H1299 cells Cytotoxicity against human H1299 cells	[PMID: 18477509]
NCI-H1299	IC₅₀	5 nM Compound: CA-4	Cytotoxicity against human H1299 cells after 72 hrs Cytotoxicity against human H1299 cells after 72 hrs	[PMID: 19530698]
NCI-H1299	GI₅₀	5 nM Compound: CA-4	Cytotoxicity against human H1299 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis Cytotoxicity against human H1299 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis	[PMID: 22449653]
NCI-H1299	IC₅₀	0.0062 μM Compound: 2	Cytotoxicity against human H1299 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human H1299 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23809851]
NCI-H1299	GI₅₀	5.1 nM Compound: CA-4	Cytotoxicity against human H1299 cells after 72 hrs by CellTitre-Blue assay Cytotoxicity against human H1299 cells after 72 hrs by CellTitre-Blue assay	[PMID: 25528337]
NCI-H1299	IC₅₀	>100 μM Compound: CA-4	Antiproliferative activity against human NCI-H1299 cells measured after 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
NCI-H1437	IC₅₀	0.03 μM Compound: CA-4	Antiproliferative activity against human NCI-H1437 cells measured after 48 hrs by MTT assay Antiproliferative activity against human NCI-H1437 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
NCI-H226	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay	[PMID: 22982122]
NCI-H226	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay	[PMID: 24387982]
NCI-H226	GI₅₀	3.81 nM Compound: CA4	Growth inhibition of human NCI-H226 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H226 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
NCI-H23	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay	[PMID: 22982122]
NCI-H23	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay	[PMID: 24387982]
NCI-H23	GI₅₀	3.42 nM Compound: CA4	Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
NCI-H23	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human NCI-H23 cells by SRB assay Cytotoxicity against human NCI-H23 cells by SRB assay	[PMID: 26257861]
NCI-H322M	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay	[PMID: 22982122]
NCI-H322M	GI₅₀	0.007 μM Compound: CA4, NSC 613729	Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay	[PMID: 24387982]
NCI-H322M	GI₅₀	7.45 nM Compound: CA4	Growth inhibition of human NCI-H322M cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H322M cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
NCI-H460	GI₅₀	5.6 μg/mL Compound: 1c	Compound was evaluated against Human cell line lung-NSC NCI-H460 Compound was evaluated against Human cell line lung-NSC NCI-H460	[PMID: 10212132]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: 3b	Evaluated for growth inhibition (anticancer activity) of Human lung-NSC cancer NCI-H460 cell line Evaluated for growth inhibition (anticancer activity) of Human lung-NSC cancer NCI-H460 cell line	[PMID: 10893310]
NCI-H460	IC₅₀	3 nM Compound: CA-4	Concentration required to inhibit proliferation of Human lung carcinoma NCI-H460 cell line Concentration required to inhibit proliferation of Human lung carcinoma NCI-H460 cell line	[PMID: 11294380]
NCI-H460	IC₅₀	3 nM Compound: Combretastatin A4	Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460 Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460	[PMID: 11814821]
NCI-H460	IC₅₀	3 nM Compound: CA-4	Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth	[PMID: 11931625]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: 2a	Cell growth inhibition of lung-NSC NCI-H460 cells, expressed as 50% reduction in the net protein increase Cell growth inhibition of lung-NSC NCI-H460 cells, expressed as 50% reduction in the net protein increase	[PMID: 12036362]
NCI-H460	GI₅₀	0.00056 μg/mL Compound: 1a (Combretastatin A-4)	Growth inhibition against human lung-NSC NCI-H460 cell line Growth inhibition against human lung-NSC NCI-H460 cell line	[PMID: 15943482]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: 1a, CA4	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
NCI-H460	IC₅₀	1.24 nM Compound: CA-4	Antiproliferative activity against human H460 cells Antiproliferative activity against human H460 cells	[PMID: 16722633]
NCI-H460	GI₅₀	<0.01 μM Compound: 1, NSC-613729	Cytotoxicity against NCI-H460 cells Cytotoxicity against NCI-H460 cells	[PMID: 16950621]
NCI-H460	IC₅₀	1.9 nM Compound: 4	Antiproliferative activity against human H460 cell line by methylene blue dye assay Antiproliferative activity against human H460 cell line by methylene blue dye assay	[PMID: 17034147]
NCI-H460	IC₅₀	10 nM Compound: CA4	Inhibition of proliferation of human H460 cells Inhibition of proliferation of human H460 cells	[PMID: 17286393]
NCI-H460	GI₅₀	0.0006 μM Compound: CA4, combretastatin A4	Cytotoxicity against human NCIH460 cells after 48 hrs by SRB assay Cytotoxicity against human NCIH460 cells after 48 hrs by SRB assay	[PMID: 18303849]
NCI-H460	IC₅₀	1.24 nM Compound: 1, combretastatin A-4, CA-4	Cytotoxic activity against human NCI-H460 cells after 72 hrs by sulforhodamine B test Cytotoxic activity against human NCI-H460 cells after 72 hrs by sulforhodamine B test	[PMID: 18396857]
NCI-H460	IC₅₀	2.8 nM Compound: 1, CA4	Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 18588280]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: CA4	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 18710804]
NCI-H460	GI₅₀	0.002 μM Compound: CA4	Growth inhibition of human NCI-H460 after 48 hrs by SRB assay Growth inhibition of human NCI-H460 after 48 hrs by SRB assay	[PMID: 18722127]
NCI-H460	IC₅₀	1.2 nM Compound: 1, CA-4	Cytotoxicity against human H460 cells by sulforhodamine B test Cytotoxicity against human H460 cells by sulforhodamine B test	[PMID: 18783207]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: 3, CA4	Antitumor activity against human NCI-H460 cells by sulforhodamine B assay Antitumor activity against human NCI-H460 cells by sulforhodamine B assay	[PMID: 19228038]
NCI-H460	GI₅₀	6 x 10^-4 μg/mL Compound: Z-1b	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 19709889]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: 2a	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 19719153]
NCI-H460	GI₅₀	<0.01 μM Compound: 1, CA-4	Growth inhibition of human NCI-H460 cells after 3 days by crystal violet staining Growth inhibition of human NCI-H460 cells after 3 days by crystal violet staining	[PMID: 19954252]
NCI-H460	IC₅₀	2.6 nM Compound: 1a, CA4	Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
NCI-H460	IC₅₀	2.3 nM Compound: 1, CA4	Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay	[PMID: 21641700]
NCI-H460	IC₅₀	4.4 μM Compound: 2, CA-4	Cytotoxicity against human NCI-H460 cells by alamar blue assay Cytotoxicity against human NCI-H460 cells by alamar blue assay	[PMID: 22137934]
NCI-H460	GI₅₀	0.0006 μg/mL Compound: 1a, CA4	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
NCI-H460	GI₅₀	0.007 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 22982122]
NCI-H460	GI₅₀	0.0028 μM Compound: CA4	Growth inhibition of human NCI-H460 cells by sulforhodamine B assay Growth inhibition of human NCI-H460 cells by sulforhodamine B assay	[PMID: 23772309]
NCI-H460	GI₅₀	0.00449 μM Compound: CA4	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 23993969]
NCI-H460	GI₅₀	0.0028 μM Compound: 2, CA4	Cytotoxicity against human NCI-H460 cells by SRB assay Cytotoxicity against human NCI-H460 cells by SRB assay	[PMID: 24016002]
NCI-H460	GI₅₀	0.00223 μM Compound: CA4, CA4P	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 24183586]
NCI-H460	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 24387982]
NCI-H460	GI₅₀	3.11 nM Compound: CA4	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
NCI-H460	GI₅₀	5 nM Compound: CA4	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26852340]
NCI-H460	IC₅₀	35.81 μM Compound: 3; CA-4	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay	[PMID: 27172319]
NCI-H460	IC₅₀	0.08 μM Compound: CA-4	Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 28622907]
NCI-H460	IC₅₀	0.048 μM Compound: CA-4; B	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 28774575]
NCI-H460	IC₅₀	0.08 μM Compound: CA-4	Antiproliferative activity against human H460 cells after 72 hrs by MTT assay Antiproliferative activity against human H460 cells after 72 hrs by MTT assay	[PMID: 29407949]
NCI-H460	GI₅₀	0.00223 μM Compound: CA4	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay	[PMID: 31059248]
NCI-H460	GI₅₀	0.005 μM Compound: CA4	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 31534659]
NCI-H460	IC₅₀	0.01 μM Compound: 12	Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay	[PMID: 32243160]
NCI-H460	IC₅₀	0.076 μM Compound: CA-4	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 34311158]
NCI-H460	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human NCI-H460 cells Antiproliferative activity against human NCI-H460 cells	[PMID: 34655985]
NCI-H520	GI₅₀	0.007 μM Compound: CA-4	In vitro cytotoxic activity tested against human lung cancer (H-522) cell line In vitro cytotoxic activity tested against human lung cancer (H-522) cell line	[PMID: 12729640]
NCI-H522	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay	[PMID: 22982122]
NCI-H522	GI₅₀	0.002 μM Compound: CA4, NSC 613729	Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay	[PMID: 24387982]
NCI-H522	GI₅₀	2.18 nM Compound: CA4	Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
NCI-H522	GI₅₀	0.002 μM Compound: CA4; NSC 613729	Cytotoxicity against human NCI-H522 cells by SRB assay Cytotoxicity against human NCI-H522 cells by SRB assay	[PMID: 26257861]
NCI-H522	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
NCI-H69	IC₅₀	1.7 nM Compound: CA4	Antiproliferative activity against drug sensitive NCI-H69 cell line by Alamar Blue assay Antiproliferative activity against drug sensitive NCI-H69 cell line by Alamar Blue assay	[PMID: 17286393]
NCI-N87	IC₅₀	2.5 nM Compound: 3	Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
NCI-N87	IC₅₀	11 nM Compound: CA4	Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
NCM460	IC₅₀	>20 μM Compound: 3, CA4	Cytotoxicity against human NCM460 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay Cytotoxicity against human NCM460 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay	[PMID: 25466200]
NCM460	IC₅₀	12 μM Compound: CA-4	Cytotoxicity against human NCM460 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Cytotoxicity against human NCM460 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 33280898]
NCM460	CC₅₀	2.3 μM Compound: CA-4	Cytotoxicity against human NCM460 cells measured after 48 hrs by MTT assay Cytotoxicity against human NCM460 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
NCM460	IC₅₀	0.011 μM Compound: CA-4	Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
NIH3T3	IC₅₀	0.02 μM Compound: 1, CA-4	Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23566762]
NIH3T3	IC₅₀	0.097 μM Compound: CA-4	Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay	[PMID: 24238904]
NUGC-3	IC₅₀	>10000 nM Compound: CA4 (Combretastatin)	Concentration required for the 50% inhibition of human stomach cancer (NUGC3) cell line growth Concentration required for the 50% inhibition of human stomach cancer (NUGC3) cell line growth	[PMID: 15293996]
OVCAR	IC₅₀	3.3 nM Compound: 1, CA-4	Cytotoxicity against human OVCAR cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter Cytotoxicity against human OVCAR cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter	[PMID: 18396050]
OVCAR-3	GI₅₀	<1 μg/mL Compound: 1c	Compound was evaluated against Human cell line ovarian OVCAR-3 Compound was evaluated against Human cell line ovarian OVCAR-3	[PMID: 10212132]
OVCAR-3	GI₅₀	39.8 nM Compound: 1, CA-4	Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
OVCAR-3	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay	[PMID: 22982122]
OVCAR-3	GI₅₀	0.002 μM Compound: CA4, NSC 613729	Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay	[PMID: 24387982]
OVCAR-3	GI₅₀	2.1 nM Compound: CA4	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
OVCAR-3	GI₅₀	0.002 μM Compound: CA4; NSC 613729	Cytotoxicity against human OVCAR3 cells by SRB assay Cytotoxicity against human OVCAR3 cells by SRB assay	[PMID: 26257861]
OVCAR-3	GI₅₀	0.002 μM Compound: CA-4	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
OVCAR-3	EC₅₀	3.45 nM Compound: CA4	Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by WST8 assay Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by WST8 assay	[PMID: 28197314]
OVCAR-4	GI₅₀	0.015 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay	[PMID: 22982122]
OVCAR-4	GI₅₀	0.014 μM Compound: CA4, NSC 613729	Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay	[PMID: 24387982]
OVCAR-4	GI₅₀	14.42 nM Compound: CA4	Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
OVCAR-4	GI₅₀	0.014 μM Compound: CA4; NSC 613729	Cytotoxicity against human OVCAR4 cells by SRB assay Cytotoxicity against human OVCAR4 cells by SRB assay	[PMID: 26257861]
OVCAR-5	GI₅₀	0.1 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay	[PMID: 22982122]
OVCAR-5	GI₅₀	0.1 μM Compound: CA4, NSC 613729	Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay	[PMID: 24387982]
OVCAR-5	GI₅₀	100 nM Compound: CA4	Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
OVCAR-8	IC₅₀	1.3 nM Compound: 2, CSA4	Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs	[PMID: 22044164]
OVCAR-8	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay	[PMID: 22982122]
OVCAR-8	IC₅₀	1.3 nM Compound: 2	Cytotoxicity against human OVCAR8 cells assessed as growth inhibition by trypan blue exclusion assay Cytotoxicity against human OVCAR8 cells assessed as growth inhibition by trypan blue exclusion assay	[PMID: 23214452]
OVCAR-8	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay	[PMID: 24387982]
OVCAR-8	GI₅₀	2.99 nM Compound: CA4	Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
OVCAR-8	EC₅₀	5.5 nM Compound: C A-4	Cytotoxicity against human OVCAR8 cells assessed as inhibition of cell proliferation by SRB assay Cytotoxicity against human OVCAR8 cells assessed as inhibition of cell proliferation by SRB assay	[PMID: 24801610]
OVCAR-8	IC₅₀	1.3 nM Compound: 2, CSA4	Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy	[PMID: 25025991]
OVCAR-8	IC₅₀	2.8 nM Compound: 2, CSA4	Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26132075]
OVCAR-8	IC₅₀	1.3 μM Compound: CA	Growth inhibition of human OVCAR8 cells measured after 96 hrs by sulforhodamine B assay Growth inhibition of human OVCAR8 cells measured after 96 hrs by sulforhodamine B assay	[PMID: 27894589]
OVCAR-8	IC₅₀	4 nM Compound: CSA4	Growth inhibition of human OVCAR8 cells after 96 hrs by trypan blue exclusion assay Growth inhibition of human OVCAR8 cells after 96 hrs by trypan blue exclusion assay	[PMID: 29730191]
OVCAR-8	IC₅₀	1.8 nM Compound: CA-4	Antiproliferative activity against human OVCAR-8 cells Antiproliferative activity against human OVCAR-8 cells	[PMID: 33705908]
P388	ED₅₀	2.7 μg/mL Compound: 1c	Compound was evaluated against P388 mouse Leukemia cell line Compound was evaluated against P388 mouse Leukemia cell line	[PMID: 10212132]
P388	GI₅₀	0.0003 μg/mL Compound: 3b	Evaluated for growth inhibition (anticancer activity) of Murine P388 lymphocytic leukemia cell line Evaluated for growth inhibition (anticancer activity) of Murine P388 lymphocytic leukemia cell line	[PMID: 10893310]
P388	ED₅₀	0.0003 μg/mL Compound: 1b	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 10924176]
P388	IC₅₀	0.16 μM Compound: 1b	Concentration required for 50% inhibition of P388 murine leukemia cell growth in MTT assay Concentration required for 50% inhibition of P388 murine leukemia cell growth in MTT assay	[PMID: 11140732]
P388	ED₅₀	0.0003 μg/mL Compound: 2a	Evaluated for cell growth inhibition of the mouse leukemia P388 cells in 10% horse serum/Fisher media Evaluated for cell growth inhibition of the mouse leukemia P388 cells in 10% horse serum/Fisher media	[PMID: 12036362]
P388	ED₅₀	0.0026 μg/mL Compound: 1a (Combretastatin A-4)	Effective dose against murine P388 leukemia cell line Effective dose against murine P388 leukemia cell line	[PMID: 15943482]
P388	ED₅₀	0.0003 μg/mL Compound: 1a, CA4	Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
P388	ED₅₀	0.0009 μg/mL Compound: 3, CA4	In vivo antitumor activity against mouse P388 cells In vivo antitumor activity against mouse P388 cells	[PMID: 19228038]
P388	ED₅₀	3 x 10^-2 μg/mL Compound: Z-1b	Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay	[PMID: 19709889]
P388	IC₅₀	3.1 nM Compound: 2, CA4	Antiproliferative activity against mouse P388 cells after 5 days by MTT assay Antiproliferative activity against mouse P388 cells after 5 days by MTT assay	[PMID: 19837594]
P388	ED₅₀	3.4 x 10^-3 μg/mL Compound: 3d	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 20161135]
P388	ED₅₀	0.0003 μg/mL Compound: 1a, CA4	Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis	[PMID: 22324723]
P388	GI₅₀	0.32 x 10^-8 M Compound: 2a	In vitro inhibitory activity against P388 lymphocytic leukemia cell line In vitro inhibitory activity against P388 lymphocytic leukemia cell line	[PMID: 7752190]
P388	IC₅₀	0.0026 μM Compound: Combrestatin A4	Cytotoxicity against mouse P388 cells assessed as growth inhibition after 5 days by MTT assay Cytotoxicity against mouse P388 cells assessed as growth inhibition after 5 days by MTT assay	10.1039/C2MD20199B
PA-1	IC₅₀	<1 μg/mL Compound: 1'	Cytotoxicity against human PA1 cells after 72 hrs by MTT assay Cytotoxicity against human PA1 cells after 72 hrs by MTT assay	[PMID: 17373779]
PANC-1	IC₅₀	0.16 μM Compound: COMB	Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay	[PMID: 30017114]
PANC-1	IC₅₀	0.18 μM Compound: CA-4	Antiproliferative activity against human PANC-1 cells Antiproliferative activity against human PANC-1 cells	[PMID: 34655985]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	<10 nM Compound: Combretastatin A-4	Growth inhibition of human Panel NCI-60 (60 carcinoma cell lines) Growth inhibition of human Panel NCI-60 (60 carcinoma cell lines)	[PMID: 32485531]
PBL	IC₅₀	>10 μM Compound: CA-4	Cytotoxicity against human PBL cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human PBL cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 29202409]
PBL	IC₅₀	0.1 μM Compound: CA-4	Cytotoxicity against human PBL cells assessed as reduction in cell proliferation after 72 hrs by MTT assay Cytotoxicity against human PBL cells assessed as reduction in cell proliferation after 72 hrs by MTT assay	[PMID: 29202409]
PBMC	IC₅₀	0.011 μM Compound: CA4	Inhibition of LPS-induced TNFalpha production in human PBMC preincubated 1 hr prior to LPS stimulation measured after 18 to 20 hrs by ELISA Inhibition of LPS-induced TNFalpha production in human PBMC preincubated 1 hr prior to LPS stimulation measured after 18 to 20 hrs by ELISA	[PMID: 21955454]
PC-3	IC₅₀	2.7 nM Compound: combretastatin A-4 (CA-4)	Concentration which produces 50% inhibition of growth of prostate tumor cell line PC-3 Concentration which produces 50% inhibition of growth of prostate tumor cell line PC-3	[PMID: 11714613]
PC-3	IC₅₀	2.8 nM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs	[PMID: 17034133]
PC-3	IC₅₀	2.8 nM Compound: 5, CA4	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17197178]
PC-3	IC₅₀	3.2 nM Compound: CA4	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 17286393]
PC-3	IC₅₀	2.8 nM Compound: CA-4	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17482458]
PC-3	IC₅₀	0.003 μM Compound: CA-4, combretastatin A-4	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17977727]
PC-3	IC₅₀	5.4 μM Compound: CA-4	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 19665898]
PC-3	IC₅₀	0.4 μM Compound: 2, CSA4	Antiproliferative activity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22044164]
PC-3	GI₅₀	0.001 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human PC3 cells after 48 hrs by SRB assay Growth inhibition of human PC3 cells after 48 hrs by SRB assay	[PMID: 22982122]
PC-3	IC₅₀	1 μM Compound: CA-4	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 23810282]
PC-3	IC₅₀	2.9 nM Compound: 1, CA-4	Growth inhibition of human PC3 cells after 48 hrs by SRB assay Growth inhibition of human PC3 cells after 48 hrs by SRB assay	[PMID: 24900453]
PC-3	GI₅₀	0.001 μM Compound: CA-4	Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
PC-3	IC₅₀	0.0034 μM Compound: 3; CA-4	Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
PC-3	IC₅₀	0.026 μM Compound: CA-4	Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay	[PMID: 27721152]
PC-3	IC₅₀	22.03 μM Compound: CA-4	Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 27810596]
PC-3	IC₅₀	3.53 μM Compound: CA-4; B	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 28774575]
PC-3	IC₅₀	0.007 μM Compound: CA-4	Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 28803799]
PC-3	IC₅₀	0.4 μM Compound: CA-4	Anticancer activity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Anticancer activity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 31954880]
PC-3	IC₅₀	0.06 μM Compound: CA-4	Cytotoxicity against human PC-3 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38093696]
PC-3	IC₅₀	0.003 μM Compound: CA-4	Cytotoxicity against human PC-3 cells incubated for 72 hrs by MTT assay Cytotoxicity against human PC-3 cells incubated for 72 hrs by MTT assay	[PMID: 38452727]
PC-3	GI₅₀	0.014 μM Compound: CA-4	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	10.1039/C5MD00139K
Platelet	IC₅₀	75.17 μg Compound: 10, combretastin A-4	Inhibition of adenosine diphosphate-induced platelet aggregation in human platelet-rich plasma Inhibition of adenosine diphosphate-induced platelet aggregation in human platelet-rich plasma	[PMID: 9392877]
Platelet	IC₅₀	97.7 μg Compound: 10, combretastin A-4	Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma	[PMID: 9392877]
PrEC	IC₅₀	0.08 μM Compound: CA-4	Cytotoxicity against human PrEC cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human PrEC cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38093696]
RKO	IC₅₀	9.8 nM Compound: CA-4	Antiproliferative activity against human RKO cells after 48 hrs by MTT assay Antiproliferative activity against human RKO cells after 48 hrs by MTT assay	[PMID: 28792756]
RKO	IC₅₀	0.78 μM Compound: CA-4	Antiproliferative activity against human RKO cells measured after 48 hrs by MTT assay Antiproliferative activity against human RKO cells measured after 48 hrs by MTT assay	[PMID: 36150341]
RL	IC₅₀	1.4 nM Compound: CA-4	Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33618157]
RPMI-8226	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay	[PMID: 22982122]
RPMI-8226	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay	[PMID: 24387982]
RPMI-8226	GI₅₀	3.42 nM Compound: CA4	Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
RPMI-8226	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human RPMI8226 cells by SRB assay Cytotoxicity against human RPMI8226 cells by SRB assay	[PMID: 26257861]
RS4-11	IC₅₀	0.8 nM Compound: 1a, CA-4	Antiproliferative activity against human RS4:11 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test Antiproliferative activity against human RS4:11 cells after 72 hrs by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test	[PMID: 25785605]
RS4-11	IC₅₀	0.001 μM Compound: CA-4	Antiproliferative activity against human RS4:11 cells after 72 hrs by MTT assay Antiproliferative activity against human RS4:11 cells after 72 hrs by MTT assay	[PMID: 30633509]
RT-112	IC₅₀	0.0216 μM Compound: CA-4, 1a	Cytotoxicity against human RT112 cells after 72 hrs by MTT assay Cytotoxicity against human RT112 cells after 72 hrs by MTT assay	[PMID: 20338766]
RXF 393	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human RXF393 cells after 48 hrs by SRB assay Growth inhibition of human RXF393 cells after 48 hrs by SRB assay	[PMID: 22982122]
RXF 393	GI₅₀	0.002 μM Compound: CA4, NSC 613729	Growth inhibition of human RXF393 cells after 48 hrs by SRB assay Growth inhibition of human RXF393 cells after 48 hrs by SRB assay	[PMID: 24387982]
RXF 393	GI₅₀	2.37 nM Compound: CA4	Growth inhibition of human RXF393 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human RXF393 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SAOS-2	IC₅₀	0.0114 μM Compound: 3, CA4	Anticancer activity against human Saos2 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay Anticancer activity against human Saos2 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay	[PMID: 25466200]
SEM	IC₅₀	5 nM Compound: 1, CA-4	Cytotoxicity against human SEM cells after 72 hrs by MTT assay Cytotoxicity against human SEM cells after 72 hrs by MTT assay	[PMID: 23445496]
SEM	IC₅₀	5 nM Compound: 1a, CA-4	Growth inhibition of human SEM cells after 72 hrs by MTT assay Growth inhibition of human SEM cells after 72 hrs by MTT assay	[PMID: 25025853]
SEM	IC₅₀	5.1 nM Compound: 1a; CA-4	Antiproliferative activity against human SEM cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human SEM cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 31400707]
SEM	IC₅₀	5 nM Compound: 1a; CA-4	Antiproliferative activity against human SEM cells assessed as inhibition of cell growth Antiproliferative activity against human SEM cells assessed as inhibition of cell growth	[PMID: 32417696]
SEM	IC₅₀	0.005 μM Compound: CA-4;1a	Antiproliferative activity against human SEM cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human SEM cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 33550186]
SF-188	IC₅₀	0.021 μM Compound: CA4	Cytotoxicity against human SF188 cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human SF188 cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
SF-268	GI₅₀	>0.001 μg/mL Compound: 2a	Cell growth inhibition of central nervous system (CNS) SF-268 cells, expressed as 50% reduction in the net protein increase Cell growth inhibition of central nervous system (CNS) SF-268 cells, expressed as 50% reduction in the net protein increase	[PMID: 12036362]
SF-268	GI₅₀	<0.001 μg/mL Compound: 1a, CA4	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
SF-268	GI₅₀	>1 x 10^-2 μg/mL Compound: Z-1b	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 19709889]
SF-268	GI₅₀	>0.01 μg/mL Compound: 2a	Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 19719153]
SF-268	GI₅₀	<0.001 μg/mL Compound: 1a, CA4	Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
SF-268	GI₅₀	0.006 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 22982122]
SF-268	GI₅₀	0.006 μM Compound: CA4, NSC 613729	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 24387982]
SF-268	GI₅₀	5.7 nM Compound: CA4	Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SF-268	GI₅₀	0.006 μM Compound: CA4; NSC 613729	Cytotoxicity against human SF268 cells by SRB assay Cytotoxicity against human SF268 cells by SRB assay	[PMID: 26257861]
SF-295	GI₅₀	<1 μg/mL Compound: 1c	Compound was evaluated against Human cell line CNS SF-295 Compound was evaluated against Human cell line CNS SF-295	[PMID: 10212132]
SF-295	GI₅₀	>0.001 μg/mL Compound: 3b	Evaluated for growth inhibition (anticancer activity) of Human CNS cancer SF-295 cell line Evaluated for growth inhibition (anticancer activity) of Human CNS cancer SF-295 cell line	[PMID: 10893310]
SF-295	GI₅₀	63.1 nM Compound: 1, CA-4	Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 21920767]
SF-295	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SF295 cells after 48 hrs by SRB assay Growth inhibition of human SF295 cells after 48 hrs by SRB assay	[PMID: 22982122]
SF-295	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human SF295 cells after 48 hrs by SRB assay Growth inhibition of human SF295 cells after 48 hrs by SRB assay	[PMID: 24387982]
SF-295	GI₅₀	3.87 nM Compound: CA4	Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SF-295	GI₅₀	0.004 μM Compound: CA4; NSC 613729	Cytotoxicity against human SF295 cells by SRB assay Cytotoxicity against human SF295 cells by SRB assay	[PMID: 26257861]
SF-295	GI₅₀	0.004 μM Compound: CA-4	Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
SF-539	GI₅₀	0.002 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SF539 cells after 48 hrs by SRB assay Growth inhibition of human SF539 cells after 48 hrs by SRB assay	[PMID: 22982122]
SF-539	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human SF539 cells after 48 hrs by SRB assay Growth inhibition of human SF539 cells after 48 hrs by SRB assay	[PMID: 24387982]
SF-539	GI₅₀	2.54 nM Compound: CA4	Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SF-539	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human SF539 cells by SRB assay Cytotoxicity against human SF539 cells by SRB assay	[PMID: 26257861]
SGC-7901	IC₅₀	0.028 μM Compound: 1a, CA-4	Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay	[PMID: 25233100]
SGC-7901	IC₅₀	0.028 μM Compound: 1a, CA-4	Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25529737]
SGC-7901	IC₅₀	0.026 μM Compound: CA-4	Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay	[PMID: 27428395]
SGC-7901	IC₅₀	0.012 μM Compound: 1; CA-4	Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 27994764]
SGC-7901	IC₅₀	0.012 μM Compound: 2; CA-4	Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay	[PMID: 30245397]
SGC-7901	IC₅₀	0.13 μM Compound: 1; CA-4	Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells measured after 72 hrs by MTT assay	[PMID: 30901597]
SGC-7901	IC₅₀	0.024 μM Compound: CA-4	Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay	[PMID: 31787361]
SGC-7901	IC₅₀	0.024 μM Compound: 1a; CA-4	Anti-proliferative activity against human SGC7901 cells after 72 hrs by MTT assay Anti-proliferative activity against human SGC7901 cells after 72 hrs by MTT assay	10.1039/C5MD00028A
SGC-7901	IC₅₀	0.024 μM Compound: 2; CA-4	Antiproliferative activity against human SGC7901 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00150A
SH-SY5Y	IC₅₀	5.8 nM Compound: 1	Cytotoxicity against SH-SY5Y human neuroblastoma cell line was determined Cytotoxicity against SH-SY5Y human neuroblastoma cell line was determined	[PMID: 15857132]
SH-SY5Y	IC₅₀	1.5 nM Compound: 1	Inhibitory concentration against Human SH-SY5Y neuroblastoma cells Inhibitory concentration against Human SH-SY5Y neuroblastoma cells	[PMID: 15963722]
SH-SY5Y	IC₅₀	1.6 nM Compound: 1, CA-4	Cytotoxicity against SHSY5Y cell line by MTT assay Cytotoxicity against SHSY5Y cell line by MTT assay	[PMID: 16913727]
SH-SY5Y	IC₅₀	2.3 nM Compound: 1, CA-4	Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21696175]
SH-SY5Y	IC₅₀	2.7 nM Compound: 1, CA-4	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25584687]
SiHa	IC₅₀	0.029 μM Compound: 2; CA-4	Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay	[PMID: 35339837]
SiHa	IC₅₀	0.029 μM Compound: 2; CA-4	Antiproliferative activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay Antiproliferative activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay	[PMID: 35339837]
SiHa	IC₅₀	>100 μM Compound: CA-4	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	10.1039/C3MD00372H
SK-BR-3	IC₅₀	5.1 nM Compound: 1, CA-4	Cytotoxicity against human SK-BR3 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter Cytotoxicity against human SK-BR3 cells assessed as [3H]thymidine incorporation after 72 hrs by microplate scintillation counter	[PMID: 18396050]
SK-BR-3	IC₅₀	0.008 μM Compound: CA4	Cytotoxicity against human SKBR3 cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human SKBR3 cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
SK-MEL-2	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay	[PMID: 22982122]
SK-MEL-2	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay	[PMID: 24387982]
SK-MEL-2	GI₅₀	4.37 nM Compound: CA4	Growth inhibition of human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SK-MEL-2	GI₅₀	0.004 μM Compound: CA4; NSC 613729	Cytotoxicity against human SK-MEL-2 cells by SRB assay Cytotoxicity against human SK-MEL-2 cells by SRB assay	[PMID: 26257861]
SK-MEL-28	GI₅₀	0.007 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay	[PMID: 22982122]
SK-MEL-28	GI₅₀	0.008 μM Compound: CA4, NSC 613729	Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay	[PMID: 24387982]
SK-MEL-28	GI₅₀	8.07 nM Compound: CA4	Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SK-MEL-28	GI₅₀	0.008 μM Compound: CA4; NSC 613729	Cytotoxicity against human SK-MEL-28 cells by SRB assay Cytotoxicity against human SK-MEL-28 cells by SRB assay	[PMID: 26257861]
SK-MEL-5	GI₅₀	2 μg/mL Compound: 1c	Compound was evaluated against Human cell line melanoma SK-MEL-5 Compound was evaluated against Human cell line melanoma SK-MEL-5	[PMID: 10212132]
SK-MEL-5	ED₅₀	1.4 μM Compound: 2	Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line. Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line.	[PMID: 1613753]
SK-MEL-5	ED₅₀	uM μM Compound: 1a	Cytotoxic concentration required to inhibit 50% cell growth in SKMEL-5 melanoma cell lines Cytotoxic concentration required to inhibit 50% cell growth in SKMEL-5 melanoma cell lines	[PMID: 1875350]
SK-MEL-5	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay	[PMID: 22982122]
SK-MEL-5	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay	[PMID: 24387982]
SK-MEL-5	GI₅₀	3.54 nM Compound: CA4	Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SK-MEL-5	GI₅₀	0.004 μM Compound: CA4; NSC 613729	Cytotoxicity against human SK-MEL-5 cells by SRB assay Cytotoxicity against human SK-MEL-5 cells by SRB assay	[PMID: 26257861]
SK-MEL-5	GI₅₀	0.003 μM Compound: CA-4	Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
SK-MES-1	IC₅₀	0.007 μM Compound: CA-4	Cytotoxicity against human SK-MES-1 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human SK-MES-1 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 38759453]
SK-N-SH	GI₅₀	2.6 μg/mL Compound: 1c	Compound was evaluated against Human cell line neuroblast SK-N-SH Compound was evaluated against Human cell line neuroblast SK-N-SH	[PMID: 10212132]
SK-N-SH	GI₅₀	0.00026 μg/mL Compound: 1a (Combretastatin A-4)	Growth inhibition against human neuroblastoma cell line (SK-N-SH) Growth inhibition against human neuroblastoma cell line (SK-N-SH)	[PMID: 15943482]
SK-OV-3	GI₅₀	<0.0001 μM Compound: CA-4	In vitro cytotoxic activity tested against human ovarian cancer (SK-OV3) cell line In vitro cytotoxic activity tested against human ovarian cancer (SK-OV3) cell line	[PMID: 12729640]
SK-OV-3	GI₅₀	0.00013 μM Compound: CA4	Growth inhibition of human SK-OV-3 after 48 hrs by SRB assay Growth inhibition of human SK-OV-3 after 48 hrs by SRB assay	[PMID: 18722127]
SK-OV-3	IC₅₀	0.0033 μM Compound: 1, CA-4	Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 19894742]
SK-OV-3	IC₅₀	0.0035 μM Compound: 1, CA-4	Antiproliferative activity against human SKOV3 cells expressing adenoviral MDR1 after 48 hrs by SRB assay Antiproliferative activity against human SKOV3 cells expressing adenoviral MDR1 after 48 hrs by SRB assay	[PMID: 19894742]
SK-OV-3	IC₅₀	1.8 μM Compound: 1, CA-4	Relative resistance, ratio of IC50 for human SKOV3 expressing adenoviral MDR1 cells to IC50 for human SKOV3 cells Relative resistance, ratio of IC50 for human SKOV3 expressing adenoviral MDR1 cells to IC50 for human SKOV3 cells	[PMID: 19894742]
SK-OV-3	IC₅₀	5.5 nM Compound: 4, CA4	Antiproliferative activity against human SKOV3 after 48 hrs by spectrophotometry Antiproliferative activity against human SKOV3 after 48 hrs by spectrophotometry	[PMID: 21774499]
SK-OV-3	IC₅₀	22 nM Compound: CA4	Antiproliferative activity against MDR-1-6/6 overexpressing human SKOV3 cells Antiproliferative activity against MDR-1-6/6 overexpressing human SKOV3 cells	[PMID: 21786793]
SK-OV-3	IC₅₀	6.05 nM Compound: CA4	Antiproliferative activity against human SKOV3 cells Antiproliferative activity against human SKOV3 cells	[PMID: 21786793]
SK-OV-3	IC₅₀	1.7 nM Compound: 1, CA-4, combretastatin	Cytotoxicity against human SKOV3 cells after 48 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 48 hrs by MTS assay	[PMID: 22304851]
SK-OV-3	GI₅₀	0.063 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay	[PMID: 22982122]
SK-OV-3	IC₅₀	11.5 nM Compound: CA-4	Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23332369]
SK-OV-3	IC₅₀	9.7 nM Compound: CA-4	Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23332369]
SK-OV-3	GI₅₀	0.00042 μM Compound: CA4	Growth inhibition of human SKOV3 cells by sulforhodamine B assay Growth inhibition of human SKOV3 cells by sulforhodamine B assay	[PMID: 23772309]
SK-OV-3	IC₅₀	4.5 nM Compound: CA-4	Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay Antiproliferative activity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 23895532]
SK-OV-3	GI₅₀	0.00533 μM Compound: CA4	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 23993969]
SK-OV-3	GI₅₀	0.00042 μM Compound: 2, CA4	Cytotoxicity against human SKOV3 cells by SRB assay Cytotoxicity against human SKOV3 cells by SRB assay	[PMID: 24016002]
SK-OV-3	IC₅₀	22 nM Compound: CA-4	Cytotoxicity against human SKOV3 cells expressing MDR1 after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells expressing MDR1 after 72 hrs by MTS assay	[PMID: 24087857]
SK-OV-3	IC₅₀	6.1 nM Compound: CA-4	Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay	[PMID: 24087857]
SK-OV-3	GI₅₀	0.00455 μM Compound: CA4, CA4P	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 24183586]
SK-OV-3	GI₅₀	0.059 μM Compound: CA4, NSC 613729	Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay	[PMID: 24387982]
SK-OV-3	GI₅₀	58.88 nM Compound: CA4	Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SK-OV-3	IC₅₀	1.7 nM Compound: 1, CA-4	Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay	[PMID: 24900453]
SK-OV-3	IC₅₀	4.2 nM Compound: 1, CA-4	Growth inhibition of paclitaxel-resistant human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of paclitaxel-resistant human SKOV3 cells after 48 hrs by SRB assay	[PMID: 24900453]
SK-OV-3	IC₅₀	0.001 μM Compound: CA-4	Growth inhibition of human SKOV3 cells by MTT assay Growth inhibition of human SKOV3 cells by MTT assay	[PMID: 25689111]
SK-OV-3	IC₅₀	6.9 nM Compound: CA-4	Antiproliferative activity against human SKOV3 cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay	[PMID: 25882519]
SK-OV-3	GI₅₀	0.059 μM Compound: CA4; NSC 613729	Cytotoxicity against human SKOV3 cells by SRB assay Cytotoxicity against human SKOV3 cells by SRB assay	[PMID: 26257861]
SK-OV-3	GI₅₀	5.06 nM Compound: CA4	Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26852340]
SK-OV-3	GI₅₀	31.6 μM Compound: 1; CA-4	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay	[PMID: 27161282]
SK-OV-3	IC₅₀	5.5 nM Compound: CA-4	Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27213719]
SK-OV-3	IC₅₀	7.2 nM Compound: CA-4	Antiproliferative activity against multidrug resistant human SKOV3 cells expressing MDR1-M6/6 after 48 hrs by SRB assay Antiproliferative activity against multidrug resistant human SKOV3 cells expressing MDR1-M6/6 after 48 hrs by SRB assay	[PMID: 27213719]
SK-OV-3	IC₅₀	0.012 μM Compound: CA-4	Growth inhibition of human SK-OV-3 cells Growth inhibition of human SK-OV-3 cells	[PMID: 27805821]
SK-OV-3	IC₅₀	0.38 μM Compound: 1a; CA-4	Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 29291446]
SK-OV-3	IC₅₀	0.012 μM Compound: 1; CA-4	Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 29306206]
SK-OV-3	IC₅₀	4.5 nM Compound: CA-4	Antiproliferative activity against human SKOV3 cells by SRB assay Antiproliferative activity against human SKOV3 cells by SRB assay	[PMID: 29655610]
SK-OV-3	IC₅₀	0.0059 μM Compound: CA-4	Antiproliferative activity against human SKOV3 cells after 72 hrs by CCK8 assay Antiproliferative activity against human SKOV3 cells after 72 hrs by CCK8 assay	[PMID: 30006162]
SK-OV-3	IC₅₀	5.5 nM Compound: CA-4	Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay	[PMID: 30098869]
SK-OV-3	IC₅₀	5.5 nM Compound: CA-4	Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 30297118]
SK-OV-3	GI₅₀	0.00455 μM Compound: CA4	Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay	[PMID: 31059248]
SK-OV-3	GI₅₀	0.00506 μM Compound: CA4	Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay	[PMID: 31534659]
SK-OV-3	IC₅₀	4.5 nM Compound: CA-4	Antiproliferative activity against human SK-OV-3 cells assessed as decrease in cell growth measured after 48 hrs by SRB method Antiproliferative activity against human SK-OV-3 cells assessed as decrease in cell growth measured after 48 hrs by SRB method	[PMID: 33310545]
SK-OV-3	IC₅₀	5.5 nM Compound: CA-4	Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SK-OV-3	IC₅₀	7.2 nM Compound: CA-4	Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SK-OV-3	IC₅₀	6 nM Compound: CA4	Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay	[PMID: 35797900]
SK-OV-3	IC₅₀	0.5 μM Compound: CA-4	Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36252396]
SK-OV-3	IC₅₀	5.5 nM Compound: CA-4	Antiproliferative activity against wild type human SK-OV-3 cells assessed as inhibition of cell growth by SRB assay Antiproliferative activity against wild type human SK-OV-3 cells assessed as inhibition of cell growth by SRB assay	[PMID: 36889150]
SK-OV-3	IC₅₀	7.2 nM Compound: CA-4	Antiproliferative activity against human SK-OV-3 cells overexpressing MDR-1-M6/6 assessed as inhibition of cell growth by SRB assay Antiproliferative activity against human SK-OV-3 cells overexpressing MDR-1-M6/6 assessed as inhibition of cell growth by SRB assay	[PMID: 36889150]
SK-OV-3	IC₅₀	1.42 nM Compound: CA-4	Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
SK-OV-3	EC₅₀	1.2 nM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Cytotoxicity against human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay Cytotoxicity against human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay	10.1039/C0MD00095G
SK-OV-3	EC₅₀	3.1 nM Compound: 5, (Z)-5, CA-4, Combretastatin A-4	Cytotoxicity against taxol-resistant human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay Cytotoxicity against taxol-resistant human SKOV3 cells assessed as cell viability after 48 hrs by MTS assay	10.1039/C0MD00095G
SMMC-7721	IC₅₀	3.22 μM Compound: CA-4	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 19665898]
SMMC-7721	IC₅₀	0.29 μM Compound: CA-4	Anticancer activity against human SMMC7721 cells after 72 hrs Anticancer activity against human SMMC7721 cells after 72 hrs	[PMID: 19713108]
SMMC-7721	IC₅₀	0.289 μM Compound: CA4	Cytotoxicity against human SMMC7721 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SMMC7721 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
SMMC-7721	IC₅₀	1.92 μM Compound: CA-4	Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay	[PMID: 28622907]
SMMC-7721	IC₅₀	0.0038 μM Compound: CA-4	Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay	[PMID: 29172084]
SMMC-7721	IC₅₀	1.72 μM Compound: CA-4	Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay	[PMID: 29407949]
SN12C	GI₅₀	0.006 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SN12C cells after 48 hrs by SRB assay Growth inhibition of human SN12C cells after 48 hrs by SRB assay	[PMID: 22982122]
SN12C	GI₅₀	0.006 μM Compound: CA4, NSC 613729	Growth inhibition of human SN12C cells after 48 hrs by SRB assay Growth inhibition of human SN12C cells after 48 hrs by SRB assay	[PMID: 24387982]
SN12C	GI₅₀	5.98 nM Compound: CA4	Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SNB-19	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SNB19 cells after 48 hrs by SRB assay Growth inhibition of human SNB19 cells after 48 hrs by SRB assay	[PMID: 22982122]
SNB-19	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human SNB19 cells after 48 hrs by SRB assay Growth inhibition of human SNB19 cells after 48 hrs by SRB assay	[PMID: 24387982]
SNB-19	GI₅₀	3.85 nM Compound: CA4	Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SNB-19	GI₅₀	0.004 μM Compound: CA4; NSC 613729	Cytotoxicity against human SNB19 cells by SRB assay Cytotoxicity against human SNB19 cells by SRB assay	[PMID: 26257861]
SNB-75	GI₅₀	0.007 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SNB75 cells after 48 hrs by SRB assay Growth inhibition of human SNB75 cells after 48 hrs by SRB assay	[PMID: 22982122]
SNB-75	GI₅₀	0.008 μM Compound: CA4, NSC 613729	Growth inhibition of human SNB75 cells after 48 hrs by SRB assay Growth inhibition of human SNB75 cells after 48 hrs by SRB assay	[PMID: 24387982]
SNB-75	GI₅₀	7.91 nM Compound: CA4	Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SNB-75	GI₅₀	0.008 μM Compound: CA4; NSC 613729	Cytotoxicity against human SNB75 cells by SRB assay Cytotoxicity against human SNB75 cells by SRB assay	[PMID: 26257861]
SNB-75	GI₅₀	0.008 μM Compound: CA-4	Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
SNU-423	IC₅₀	6 nM Compound: CA-4	Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay	[PMID: 19117761]
SR	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SR cells after 48 hrs by SRB assay Growth inhibition of human SR cells after 48 hrs by SRB assay	[PMID: 22982122]
SR	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human SR cells after 48 hrs by SRB assay Growth inhibition of human SR cells after 48 hrs by SRB assay	[PMID: 24387982]
SR	GI₅₀	2.99 nM Compound: CA4	Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SR	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human SR cells by SRB assay Cytotoxicity against human SR cells by SRB assay	[PMID: 26257861]
SR	GI₅₀	0.003 μM Compound: CA-4	Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
SW-1736	GI₅₀	7.1 μg/mL Compound: 1c	Compound was evaluated against Human cell line thyroid SW1736 Compound was evaluated against Human cell line thyroid SW1736	[PMID: 10212132]
SW-1736	GI₅₀	0.00026 μg/mL Compound: 1a (Combretastatin A-4)	Growth inhibition against human thyroid cell line( SW 1736) Growth inhibition against human thyroid cell line( SW 1736)	[PMID: 15943482]
SW1990	IC₅₀	0.25 μM Compound: CA-4	Anticancer activity against human SW1990 cells after 72 hrs Anticancer activity against human SW1990 cells after 72 hrs	[PMID: 19713108]
SW1990	IC₅₀	0.25 μM Compound: CA4	Cytotoxicity against human SW1990 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SW1990 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708012]
SW48	IC₅₀	3.32 nM Compound: CA-4	Antiproliferative activity in human SW48 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity in human SW48 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 22329561]
SW480	IC₅₀	3.63 nM Compound: CA-4	Antiproliferative activity in human SW480 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity in human SW480 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 22329561]
SW480	IC₅₀	18.2 nM Compound: CA-4	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 23356786]
SW480	IC₅₀	39.99 μM Compound: CA-4	Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
SW480	IC₅₀	270 nM Compound: CA-4	Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay	[PMID: 37804769]
SW-620	GI₅₀	0.005 μM Compound: CA-4	In vitro cytotoxic activity tested against human colon cancer (SW620) cell line In vitro cytotoxic activity tested against human colon cancer (SW620) cell line	[PMID: 12729640]
SW-620	IC₅₀	0.023 μM Compound: CA-4, 1a	Cytotoxicity against human SW620 cells after 72 hrs by MTT assay Cytotoxicity against human SW620 cells after 72 hrs by MTT assay	[PMID: 20338766]
SW-620	IC₅₀	1.52 nM Compound: CA-4	Antiproliferative activity in human SW620 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity in human SW620 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 22329561]
SW-620	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human SW620 cells after 48 hrs by SRB assay Growth inhibition of human SW620 cells after 48 hrs by SRB assay	[PMID: 22982122]
SW-620	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human SW620 cells after 48 hrs by SRB assay Growth inhibition of human SW620 cells after 48 hrs by SRB assay	[PMID: 24387982]
SW-620	GI₅₀	3.04 nM Compound: CA4	Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
SW-620	GI₅₀	0.003 μM Compound: CA4; NSC 613729	Cytotoxicity against human SW620 cells by SRB assay Cytotoxicity against human SW620 cells by SRB assay	[PMID: 26257861]
SW-620	IC₅₀	0.003 μM Compound: CA-4	Antiproliferative activity against human SW620 cells measured after 48 hrs by MTT assay Antiproliferative activity against human SW620 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
T-24	IC₅₀	0.0087 μM Compound: CA-4, 1a	Cytotoxicity against human T24 cells after 72 hrs by MTT assay Cytotoxicity against human T24 cells after 72 hrs by MTT assay	[PMID: 20338766]
T-24	IC₅₀	0.009 μM Compound: CA-4	Antiproliferative activity against human T-24 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay Antiproliferative activity against human T-24 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay	[PMID: 37890199]
T47D	GI₅₀	10 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human T47D cells after 48 hrs by SRB assay Growth inhibition of human T47D cells after 48 hrs by SRB assay	[PMID: 22982122]
T47D	IC₅₀	1.89 nM Compound: CA-4	Cytotoxicity against human T47D cells after 72 hrs by MTT assay Cytotoxicity against human T47D cells after 72 hrs by MTT assay	[PMID: 30472600]
T47D	IC₅₀	14.6 nM Compound: CA-4	Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31610372]
T47D	IC₅₀	0.0019 μM Compound: CA-4	Antiproliferative activity against human T47D cells measured after 48 hrs by MTT assay Antiproliferative activity against human T47D cells measured after 48 hrs by MTT assay	[PMID: 32717486]
T47D	IC₅₀	0.027 μM Compound: CA-4	Antiproliferative activity against human T47D cells assessed as cell growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 33895499]
T47D	IC₅₀	0.021 μM Compound: 2; CA-4	Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36334455]
T47D	IC₅₀	407 nM Compound: CA-4	Antiproliferative activity against human T47D cells assessed as reduction in cell growth by SRB assay Antiproliferative activity against human T47D cells assessed as reduction in cell growth by SRB assay	[PMID: 37816266]
T84	IC₅₀	23.43 nM Compound: CA-4	Antiproliferative activity in human T84 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity in human T84 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 22329561]
T98G	IC₅₀	0.011 μM Compound: CA4	Cytotoxicity against human T98G cells assessed as cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human T98G cells assessed as cell viability after 72 hrs by resazurin reduction assay	[PMID: 26599530]
TK-10	GI₅₀	0.1 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human TK10 cells after 48 hrs by SRB assay Growth inhibition of human TK10 cells after 48 hrs by SRB assay	[PMID: 22982122]
TK-10	GI₅₀	0.1 μM Compound: CA4, NSC 613729	Growth inhibition of human TK10 cells after 48 hrs by SRB assay Growth inhibition of human TK10 cells after 48 hrs by SRB assay	[PMID: 24387982]
TK-10	GI₅₀	100 nM Compound: CA4	Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
TMD8	IC₅₀	0.66 nM Compound: CA-4	Antiproliferative activity against human TMD8 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human TMD8 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay	[PMID: 36502578]
TSGH	IC₅₀	45 nM Compound: CA-4	In vitro cytotoxic activity against human TSGH cell line of stomach carcinoma In vitro cytotoxic activity against human TSGH cell line of stomach carcinoma	[PMID: 15139768]
TSGH 9201	IC₅₀	38 nM Compound: 4	Antiproliferative activity against human TSGH stomach carcinoma cell line by methylene blue dye assay Antiproliferative activity against human TSGH stomach carcinoma cell line by methylene blue dye assay	[PMID: 17034147]
U-251	GI₅₀	0.006 μM Compound: CA-4	In vitro cytotoxic activity tested against human CNS (U251) cell line In vitro cytotoxic activity tested against human CNS (U251) cell line	[PMID: 12729640]
U-251	GI₅₀	0.007 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human U251cells after 48 hrs by SRB assay Growth inhibition of human U251cells after 48 hrs by SRB assay	[PMID: 22982122]
U-251	GI₅₀	0.004 μM Compound: CA4, NSC 613729	Growth inhibition of human U251 cells after 48 hrs by SRB assay Growth inhibition of human U251 cells after 48 hrs by SRB assay	[PMID: 24387982]
U-251	GI₅₀	4.03 nM Compound: CA4	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
U-251	IC₅₀	0.54 μM Compound: CA-4	Antiproliferative activity against human U251 cells after 24 to 48 hrs by CKK8 assay Antiproliferative activity against human U251 cells after 24 to 48 hrs by CKK8 assay	[PMID: 25105922]
U-251	GI₅₀	0.004 μM Compound: CA4; NSC 613729	Cytotoxicity against human U251 cells by SRB assay Cytotoxicity against human U251 cells by SRB assay	[PMID: 26257861]
U-251	GI₅₀	0.004 μM Compound: CA-4	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 27031215]
U-251	GI₅₀	0.17 μM Compound: CA-4	Antiproliferative activity against human U251 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human U251 cells incubated for 48 hrs by MTT assay	[PMID: 32832031]
U-251	IC₅₀	0.13 μM Compound: CA-4	Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay	[PMID: 34311158]
U-251	IC₅₀	0.03 μM Compound: CA-4	Antiproliferative activity against human U-251 cells measured after 48 hrs by MTT assay Antiproliferative activity against human U-251 cells measured after 48 hrs by MTT assay	[PMID: 36150341]
U-251	IC₅₀	0.002 μM Compound: CA-4	Cytotoxicity against human U-251 cells incubated for 72 hrs by MTT assay Cytotoxicity against human U-251 cells incubated for 72 hrs by MTT assay	[PMID: 38452727]
U2932	IC₅₀	0.89 nM Compound: CA-4	Antiproliferative activity against human U2932 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human U2932 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay	[PMID: 36502578]
U2OS	IC₅₀	0.0141 μM Compound: 3, CA4	Anticancer activity against human U2OS cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay Anticancer activity against human U2OS cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay	[PMID: 25466200]
U2OS	IC₅₀	0.766 nM Compound: 7; CA-4	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 31401010]
U-87MG ATCC	IC₅₀	2.6 nM Compound: 4, CA4	Antiproliferative activity against human U87MG after 48 hrs by spectrophotometry Antiproliferative activity against human U87MG after 48 hrs by spectrophotometry	[PMID: 21774499]
U-87MG ATCC	IC₅₀	9.75 μM Compound: CA-4; B	Antiproliferative activity against human U87 cells after 48 hrs by MTT assay Antiproliferative activity against human U87 cells after 48 hrs by MTT assay	[PMID: 28774575]
U-87MG ATCC	IC₅₀	3 nM Compound: CA-4	Antiproliferative activity against human U87 cells after 72 hrs by resazurin-based fluorescence assay Antiproliferative activity against human U87 cells after 72 hrs by resazurin-based fluorescence assay	[PMID: 29202409]
U-87MG ATCC	IC₅₀	4 nM Compound: CA-4	Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay	[PMID: 30525602]
U-87MG ATCC	IC₅₀	0.48 μM Compound: CA-4	Antiproliferative activity against human U87 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 31830637]
U-87MG ATCC	IC₅₀	0.011 μM Compound: CA-4	Antiproliferative activity against human U-87 MG cells measured after 48 hrs by MTT assay Antiproliferative activity against human U-87 MG cells measured after 48 hrs by MTT assay	[PMID: 36150341]
U-937	IC₅₀	>10 μM Compound: CA4	Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins	[PMID: 21955454]
U-937	IC₅₀	0.001 μM Compound: 8; CA-4	Antiproliferative activity against human U-937 cells assessed as cell growth inhibition after 72 hrs by CCK8 assay Antiproliferative activity against human U-937 cells assessed as cell growth inhibition after 72 hrs by CCK8 assay	[PMID: 34454126]
U-937	IC₅₀	0.3 nM Compound: CA-4	Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 36162214]
U-937	IC₅₀	0.001 μM Compound: CA-4	Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth	[PMID: 36828299]
U-937	IC₅₀	0.0003 μM Compound: CA-4	Antiproliferative activity against human U-937 cells incubated for 72 hrs Antiproliferative activity against human U-937 cells incubated for 72 hrs	[PMID: 38171146]
UACC-257	GI₅₀	0.003 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human UACC257 cells after 48 hrs by SRB assay Growth inhibition of human UACC257 cells after 48 hrs by SRB assay	[PMID: 22982122]
UACC-257	GI₅₀	0.003 μM Compound: CA4, NSC 613729	Growth inhibition of human UACC257 cells after 48 hrs by SRB assay Growth inhibition of human UACC257 cells after 48 hrs by SRB assay	[PMID: 24387982]
UACC-257	GI₅₀	3.02 nM Compound: CA4	Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
UACC-62	GI₅₀	0.005 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human UACC62 cells after 48 hrs by SRB assay Growth inhibition of human UACC62 cells after 48 hrs by SRB assay	[PMID: 22982122]
UACC-62	GI₅₀	0.006 μM Compound: CA4, NSC 613729	Growth inhibition of human UACC62 cells after 48 hrs by SRB assay Growth inhibition of human UACC62 cells after 48 hrs by SRB assay	[PMID: 24387982]
UACC-62	GI₅₀	5.51 nM Compound: CA4	Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
UACC-62	GI₅₀	0.006 μM Compound: CA4; NSC 613729	Cytotoxicity against human UACC62 cells by SRB assay Cytotoxicity against human UACC62 cells by SRB assay	[PMID: 26257861]
UO-31	GI₅₀	0.019 μM Compound: 2, combretastatin A-4, CA-4, NSC 613729	Growth inhibition of human UO31 cells after 48 hrs by SRB assay Growth inhibition of human UO31 cells after 48 hrs by SRB assay	[PMID: 22982122]
UO-31	GI₅₀	0.019 μM Compound: CA4, NSC 613729	Growth inhibition of human UO31 cells after 48 hrs by SRB assay Growth inhibition of human UO31 cells after 48 hrs by SRB assay	[PMID: 24387982]
UO-31	GI₅₀	19.41 nM Compound: CA4	Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay	[PMID: 24388833]
UO-31	GI₅₀	0.019 μM Compound: CA4; NSC 613729	Cytotoxicity against human UO31 cells by SRB assay Cytotoxicity against human UO31 cells by SRB assay	[PMID: 26257861]
Vero	IC₅₀	2.56 μM Compound: Combretastatin A-4	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 32992133]
WI-38	IC₅₀	31.57 μM Compound: 1; CA-4	Cytotoxicity against human WI-38 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human WI-38 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 33421913]
Z-138	IC₅₀	0.78 nM Compound: CA-4	Antiproliferative activity against human Z138 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human Z138 cells assessed as inhibition of cell growth measured for 72 hrs by MTT assay	[PMID: 36502578]
ZR-75-1	IC₅₀	0.24 nM Compound: CA-4	Cytotoxicity against ZR-75-1 cell line Cytotoxicity against ZR-75-1 cell line	[PMID: 17249649]

In Vitro

Combretastatin A4 phosphate (≥ 50 μM) significantly increases the percentage of annexin-V-binding cells and significantly decreases forward scatter. Combretastatin A4 phosphate does not appreciably increase hemolysis. Hundred μM Combretastatin A4 phosphate significantly increases Fluo3-fluorescence. The effect of Combretastatin A4 phosphate (100 μM) on annexin-V-binding is significantly blunted, but not abolished, by removal of extracellular Ca²⁺. Combretastatin A4 phosphate (≥ 50 μM) significantly decreases GSH abundance and ATP levels but does not significantly increase ROS or ceramide^[2]. Polymersomes co-encapsulating doxorubicin-combretastatin-A4 phosphate (1:10) shows strong synergistic cytotoxicity against human nasopharyngeal epidermal carcinoma (KB) cells^[3]. Pretreatment with Combretastatin A4 phosphate does not influence the amount of VM in 3-D culture as well as the expression of these key molecules^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DBP and MBP at 30 minutes after administration are higher in rats treated with Combretastatin A4 disodium phosphate 120 mg/10 mL/kg. The toxicokinetic parameters of Combretastatin A4 phosphate and Combretastatin A4 in rats treated with Combretastatin A4 disodium phosphate 120 mg/10 mL/kg are indicated, and the values of Cmax, T1/2, and AUC0-inf for Combretastatin A4 are 156±13 μM, 5.87±1.69 h, and 89.4±10.1 h·μM, respectively^[1]. In vivo, W256 tumors show marked intratumoral hypoxia after Combretastatin A4 phosphate treatment, accompanied by increased VM formation. Combretastatin A4 phosphate exhibits only a delay in tumor growth within 2 days but rapid tumor regrowth afterward. VM density is positively related to tumor volume and tumor weight at day 8. Combretastatin A4 phosphate causes hypoxia which induces VM formation in W256 tumors through HIF-1α/EphA2/PI3K/matrix metalloproteinase (MMP) signaling pathway, resulting in the consequent regrowth of the damaged tumor^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 117048-59-6
Appearance Solid
Molecular Weight 316.35
Formula C₁₈H₂₀O₅
Color White to off-white
SMILES

OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
Synonyms

CRC 87-09
Structure Classification
- Phenols
- Monophenols
- Stilbenes
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

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Cancer Immunol Res

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]

2023 May 3;11(5):583-599. PMID: 36921097
ACS Appl Mater Interfaces

Nanogel-Incorporated Injectable Hydrogel for Synergistic Therapy Based on Sequential Local Delivery of Combretastatin-A4 Phosphate (CA4P) and Doxorubicin (DOX). [Abstract]

2018 Jun 6;10(22):18560-18573. PMID: 29767951
Biomater Adv

Near-infrared photoactivatable three-in-one nanoagents to aggravate hypoxia and enable amplified photo-chemotherapy. [Abstract]

2024 Jul 19:163:213962. PMID: 39032435
bioRxiv

Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells. [Abstract]

2025 Jan 24:2025.01.22.632572. PMID: 39896568

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (316.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1611 mL

15.8053 mL

31.6106 mL

5 mM

0.6322 mL

3.1611 mL

6.3221 mL

10 mM

0.3161 mL

1.5805 mL

3.1611 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 3 mg/mL (9.48 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 3 mg/mL (9.48 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocol

Animal Administration^[1]

Rats: Rats are administered a single intravenous dose of Combretastatin A4 disodium phosphate at 120 mg/10 mL/kg by bolus infusion (n=3). Blood is taken via the jugular vein and collected in heparin-coated tubes at 10 minutes and 1, 3, 6, and 24 hours after administration. Plasma is separated by centrifugation immediately after sampling. After centrifugation, an aliquot of plasma is mixed with the equivalent volume of 1% formic acid and stored at −20°C. The thawed plasma samples are purified by solid-phase extraction, and the plasma concentrations of combretastatin A4 phosphate (free base of Combretastatin A4 disodium phosphate; Combretastatin A4 phosphate) and combretastatin A4 (the metabolite of Combretastatin A4 disodium phosphate; Combretastatin A4 ) are determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Toxicokinetic parameters [maximum concentration (Cmax), terminal half-life (T1/2), and area under the concentration-time curve from time zero to infinity (AUC0-inf)] are obtained by non-compartmental analysis using Phoenix WinNonlin 6.3.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (311 KB)
SDS (641 KB)
- English - EN (641 KB)
- Français - FR (641 KB)
- Deutsch - DE (641 KB)
- Norwegian - NO (641 KB)
- Español - ES (641 KB)
- Swedish - SV (641 KB)
- Italian - IT (641 KB)
- Korean - KR (641 KB)
- Portuguese - PT (641 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tochinai R, et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71. [Content Brief]

[2]. Signoretto E, et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P). Cell Physiol Biochem. 2016;38(3):969-8 [Content Brief]

[3]. Zhu J, et al. Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma. J Biomed Nanotechnol. 2015 Jun;11(6):997-1006. [Content Brief]

[4]. Yao N, et al. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. Tumour Biol. 2015 Nov;36(11):8499-510 [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1611 mL	15.8053 mL	31.6106 mL	79.0264 mL
	5 mM	0.6322 mL	3.1611 mL	6.3221 mL	15.8053 mL
	10 mM	0.3161 mL	1.5805 mL	3.1611 mL	7.9026 mL
	15 mM	0.2107 mL	1.0537 mL	2.1074 mL	5.2684 mL
	20 mM	0.1581 mL	0.7903 mL	1.5805 mL	3.9513 mL
	25 mM	0.1264 mL	0.6322 mL	1.2644 mL	3.1611 mL
	30 mM	0.1054 mL	0.5268 mL	1.0537 mL	2.6342 mL
	40 mM	0.0790 mL	0.3951 mL	0.7903 mL	1.9757 mL
	50 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5805 mL
	60 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3171 mL
	80 mM	0.0395 mL	0.1976 mL	0.3951 mL	0.9878 mL
	100 mM	0.0316 mL	0.1581 mL	0.3161 mL	0.7903 mL

Keywords

Combretastatin A4

4 Cited Publications

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Combretastatin A4

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Publications Citing Use of MedChemExpress (MCE) Combretastatin A4

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Combretastatin A4

Cell Cycle/DNA Damage Compound Library

Natural Product Library

Anti-Cancer Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Phenols Library

Cytoskeleton Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Lung Cancer Compound Library

Anti-Cancer Natural Product Library

Protein-protein Interaction Inhibitor Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

High-Efficiency Gene Editing Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Combretastatin A4

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Combretastatin A4 Related Classifications

Cat. No.: HY-N2146