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Signaling Pathway

ABT-751

HY-13270

(ABT751; ABT 751; E7010; E-7010; E 7010)

ABT-751

ABT-751 Chemical Structure

ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $112 In-stock
10 mg $102 In-stock
50 mg $399 In-stock
100 mg $785 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €110 In-stock
10 mg €100 In-stock
50 mg €391 In-stock
100 mg €769 In-stock
200 mg Get quote
500 mg Get quote

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Product name: ABT-751
Cat. No.: HY-13270

ABT-751 Data Sheet

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    Purity: 98.88%

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    DataSheet

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    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of ABT-751

ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.
IC50 Value: 1.5 μM(neuroblastoma); 3.4 μM(non-neuroblastoma)
Target: Microtubule/Tubulin
in vitro: ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules and spares stable microtubules, accounting for the persistence of acetylated and detyrosinated α-tubulin positive polymerized tubules at the IC90 concentration of ABT-751.
in vivo: In Calu-6 xenograft model, ABT-751 as a single agent at 100 and 75 mg/kg/day shows significant antitumor activity, while in combination with cisplatin, ABT-751 shows a dose-dependent enhancement in growth delay. In the HT-29 colon xenograft model, ABT-751 also shows significant antitumor activity as a single agent and produced a dose-dependent enhancement in growth delay In combination with 5-FU. In dogs with lymphoma, ABT-751 exhibits the dose-limiting toxicities that included vomiting, diarrhea, anorexia, or some combination of these with a maximum tolerated dose (MTD) of 350 mg/m2 PO q24h. Furthermore, the mean AUC and Cmax for ABT-751 at the MTD of 350 mg/m2 is 5.55 μg-hour/mL and 0.9 μg/mL, respectively.
 

Chemical Information

M.Wt 371.41 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₁₈H₁₇N₃O₄S
CAS No 141430-65-1
Solvent & Solubility

DMSO: ≥ 48 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.6924 mL 13.4622 mL 26.9244 mL
5 mM 0.5385 mL 2.6924 mL 5.3849 mL
10 mM 0.2692 mL 1.3462 mL 2.6924 mL

References on ABT-751

Inhibitor Kit

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