Novel sulfonate derivatives: potent antimitotic agents

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1671-3. doi: 10.1016/s0960-894x(01)00279-7.
S L Gwaltney 2nd  1 ,  H M Imade ,  Q Li ,  L Gehrke ,  R B Credo ,  R B Warner ,  J Y Lee ,  P Kovar ,  D Frost ,  S C Ng ,  H L Sham
Affiliations
  • 1. Cancer Research, D47B, Building AP-10, Abbott Laboratories, 60064-6101, Abbott Park, IL, USA
PMID: 11425534 DOI: 10.1016/s0960-894x(01)00279-7
Abstract

The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) Cancer cells, which are resistant to many other antitumor agents.