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Signaling Pathway

Epothilone B

HY-17029

(EPO 906; Patupilone)

Epothilone B

Epothilone B Chemical Structure

Epothilone B (EPO906, Patupilone) is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $78 In-stock
2 mg $50 In-stock
5 mg $70 In-stock
10 mg $116 In-stock
50 mg $415 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €76 In-stock
2 mg €49 In-stock
5 mg €69 In-stock
10 mg €114 In-stock
50 mg €407 In-stock
100 mg Get quote
200 mg Get quote

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Product name: Epothilone B
Cat. No.: HY-17029

Epothilone B Data Sheet

  • View current batch:

    Purity: 99.78%

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    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of Epothilone B

Epothilone B (EPO906, Patupilone) is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.
IC50 Value: 1.8 μM(EC0.01)
Target: Microtubule/Tubulin
in vitro: Epothilone B shows better activity than Epothilone A. The EC0.01 of Epothilone B is 1.8 μM. Epothilone B potently inhibits cell proliferation in HCT116 cells, with IC50 of 0.8 nM. Epothilone B induces mitotic arrest and displays cytotoxicity in KB3-1, KBV-1, Hela, and Hs578T cells, with IC50 of 3 nM to 92 nM. Epothilone B competes with Taxol in binding to microtubules, with IC50 of 3.3 μM. In MCF-7 cells overexpressing GFP-α-tubulin, Epothilone B (3.5 nM) efficiently blocks microtubule dynamics. Meanwhile, Epothilone B induces mitotic arrest with IC50 of 3.5 nM. In multiple myeloma (MM) cells, including RPMI 8226, U266, MM.1S, LR5, and MR20, Epothilone B directly suppresses proliferation with IC50 of 1 nM to 10 nM. Similarly, Epothilone B (10 nM) also induces cell cycle arrest and apoptosis.
in vivo: In a mouse xenograft model of RPMI 8226 cells, Epothilone B (2.5 mg/kg–4 mg/kg) prolongs survival and suppresses tumor growth. Similarly, in mouse xenograft models of prostate cancer cells, including DU145 and PC3, Epothilone B at the same dose also inhibits tumor growth.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 507.68 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₇H₄₁NO₆S
CAS No 152044-54-7
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.9697 mL 9.8487 mL 19.6974 mL
5 mM 0.3939 mL 1.9697 mL 3.9395 mL
10 mM 0.1970 mL 0.9849 mL 1.9697 mL

References on Epothilone B

Inhibitor Kit

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