2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Glutaminase
  4. PROTAC TG2 degrader-2

PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study.

For research use only. We do not sell to patients.

PROTAC TG2 degrader-2 Chemical Structure

PROTAC TG2 degrader-2 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PROTAC TG2 degrader-2 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].

IC50 & Target

> 100 μM (TG2)
In Vitro

PROTAC TG2 degrader-2 (Compound 7) (10 μΜ, up to 24h) inhibits the migration of OVCAR5 and SKOV3 cell lines in both wound-healing assays and transwell migration assays[1].
PROTAC TG2 degrader-2 (10 μΜ) reduces the adhesion of OVCAR5 and SKOV3 cells to fibronectin[1].
PROTAC TG2 degrader-2 (up to 10 μΜ, 6 h) reduces the level of Transglutaminase 2(TG2) within 6 h in a concentration-dependent manner in both OVCAR5 and SKOV3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC TG2 degrader-2 Related Antibodies

Cell Migration Assay [1]

Cell Line: OVCAR5 and SKOV3 cells
Concentration: 10 μΜ
Incubation Time: Wound-healing assay: 24 h (OVCAR5 cells) and 12 h (OVCAR5 cells) (SKOV3 cells)
Result: Inhibited the migration.

Western Blot Analysis[1]

Cell Line: OVCAR5 and SKOV3 cells
Concentration: 0.1, 1 and 10 μΜ (OVCAR5 cells), 1 and 10 μΜ (OVCAR5 cells) (SKOV3 cells)
Incubation Time: 6 h and 24 h
Result: Reduced the level of TG2.
Molecular Weight

876.08

Formula

C47H57N9O6S
SMILES

O=C(CCOCCN(C1=CC(C)=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=N1)C)N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PROTAC TG2 degrader-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TG2 degrader-2PROTACsGlutaminaseOVCAR5SKOV3Ovarian cancerTransglutaminase 2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC TG2 degrader-2
Cat. No.:
HY-155102
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.