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Teriflunomide (Synonyms: A77 1726)

Cat. No.: HY-15405 Purity: 99.92%
Handling Instructions

Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation.

For research use only. We do not sell to patients.

Teriflunomide Chemical Structure

Teriflunomide Chemical Structure

CAS No. : 163451-81-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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50 mg USD 70 In-stock
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100 mg USD 108 In-stock
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500 mg USD 180 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation.

In Vitro

Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes[1].

In Vivo

Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity[1].

Clinical Trial
Molecular Weight

270.21

Formula

C₁₂H₉F₃N₂O₂

CAS No.

163451-81-8

SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O.[(Z)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 26 mg/mL (96.22 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7008 mL 18.5041 mL 37.0083 mL
5 mM 0.7402 mL 3.7008 mL 7.4017 mL
10 mM 0.3701 mL 1.8504 mL 3.7008 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

TeriflunomideA77 1726OthersInhibitorinhibitorinhibit

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Product Name:
Teriflunomide
Cat. No.:
HY-15405
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