Teriflunomide-d4
Based on 1 Customer Validation
Teriflunomide-d4 is deuterium labeled Teriflunomide.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 1185240-22-5
- Formula: C12H5D4F3N2O2
- Molecular Weight:274.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185240-22-5
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Unlabeled Cas 163451-81-8
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Appearance Solid
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Molecular Weight 274.23
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Formula C12H5D4F3N2O2
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Color White to yellow
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SMILES
FC(F)(C1=C([2H])C([2H])=C(C([2H])=C1[2H])NC(/C(C#N)=C(O)/C)=O)F
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Synonyms
A77 1726-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (91.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6466 mL | 18.2329 mL | 36.4657 mL | 91.1643 mL |
| 5 mM | 0.7293 mL | 3.6466 mL | 7.2931 mL | 18.2329 mL | |
| 10 mM | 0.3647 mL | 1.8233 mL | 3.6466 mL | 9.1164 mL | |
| 15 mM | 0.2431 mL | 1.2155 mL | 2.4310 mL | 6.0776 mL | |
| 20 mM | 0.1823 mL | 0.9116 mL | 1.8233 mL | 4.5582 mL | |
| 25 mM | 0.1459 mL | 0.7293 mL | 1.4586 mL | 3.6466 mL | |
| 30 mM | 0.1216 mL | 0.6078 mL | 1.2155 mL | 3.0388 mL | |
| 40 mM | 0.0912 mL | 0.4558 mL | 0.9116 mL | 2.2791 mL | |
| 50 mM | 0.0729 mL | 0.3647 mL | 0.7293 mL | 1.8233 mL | |
| 60 mM | 0.0608 mL | 0.3039 mL | 0.6078 mL | 1.5194 mL | |
| 80 mM | 0.0456 mL | 0.2279 mL | 0.4558 mL | 1.1396 mL |
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