2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Tyrosinase-IN-11

Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.

For research use only. We do not sell to patients.

Tyrosinase-IN-11 Chemical Structure

Tyrosinase-IN-11 Chemical Structure

CAS No. : 240797-64-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Tyrosinase-IN-11 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1].

In Vitro

Tyrosinase-IN-11 (compound 11c; 0.1-2 μM; 72 小时) decreases the protein levels of both TYR and MiTF in a dose-dependent manner[1].
Tyrosinase-IN-11 (50 μM) is slightly cytotoxic in the human malignant melanoma cells A375 and B16F10 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrosinase-IN-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: B16F10 cells
Concentration: 0.1, 0.5, 1, 2 μM
Incubation Time: 72 hours
Result: Decreased the protein levels of both TYR and MiTF in a dose-dependent manner.
In Vivo

Tyrosinase-IN-11 (compound 11c; 0.5, 1 mM; topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks) exhibits powerful antimelanogenesis ability in a guinea pig model in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp[1]
Dosage: 0.5, 1 mM
Administration: Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks
Result: Inhibited the production of melanin in a dose-dependent manner.
Molecular Weight

274.27

Formula

C15H14O5
CAS No.
SMILES

O=C(C1=C(C=C(C=C1)O)O)CCC2=CC=C(C=C2O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Tyrosinase-IN-11 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosinase-IN-11240797-64-2TyrosinaseL-tyrosinaseL-dopaantioxidantskin hyperpigmentationA375B16F10Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tyrosinase-IN-11
Cat. No.:
HY-149207
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.