Tyrosinase-IN-11
Based on 1 Customer Validation
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.
For research use only. We do not sell to patients.
- Purity: 98.12%
- CAS No.: 240797-64-2
- Formula: C15H14O5
- Molecular Weight:274.27
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Antioxidant Compound Library
HY-L037
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Metabolic Enzyme Compound Library
HY-L146
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Radioprotector Library
HY-L178
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MCE Bioactive Compound Library
HY-L001V
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Anti-Fibrosis Compound Library
HY-L185
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Tyrosinase-IN-11 (compound 11c; 0.1-2 μM; 72 h) decreases the protein levels of both TYR and MiTF in a dose-dependent manner[1].
Tyrosinase-IN-11 (50 μM) is slightly cytotoxic in the human malignant melanoma cells A375 and B16F10 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16F10 cells
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Concentration:0.1, 0.5, 1, 2 μM
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Incubation Time:72 hours
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Result:Decreased the protein levels of both TYR and MiTF in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp[1]
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Dosage:0.5, 1 mM
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Administration:Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks
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Result:Inhibited the production of melanin in a dose-dependent manner.
Chemical Information
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CAS No. 240797-64-2
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Appearance Solid
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Molecular Weight 274.27
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Formula C15H14O5
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Color Pink to orange
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SMILES
O=C(C1=C(C=C(C=C1)O)O)CCC2=CC=C(C=C2O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (455.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6460 mL | 18.2302 mL | 36.4604 mL | 91.1511 mL |
| 5 mM | 0.7292 mL | 3.6460 mL | 7.2921 mL | 18.2302 mL | |
| 10 mM | 0.3646 mL | 1.8230 mL | 3.6460 mL | 9.1151 mL | |
| 15 mM | 0.2431 mL | 1.2153 mL | 2.4307 mL | 6.0767 mL | |
| 20 mM | 0.1823 mL | 0.9115 mL | 1.8230 mL | 4.5576 mL | |
| 25 mM | 0.1458 mL | 0.7292 mL | 1.4584 mL | 3.6460 mL | |
| 30 mM | 0.1215 mL | 0.6077 mL | 1.2153 mL | 3.0384 mL | |
| 40 mM | 0.0912 mL | 0.4558 mL | 0.9115 mL | 2.2788 mL | |
| 50 mM | 0.0729 mL | 0.3646 mL | 0.7292 mL | 1.8230 mL | |
| 60 mM | 0.0608 mL | 0.3038 mL | 0.6077 mL | 1.5192 mL | |
| 80 mM | 0.0456 mL | 0.2279 mL | 0.4558 mL | 1.1394 mL | |
| 100 mM | 0.0365 mL | 0.1823 mL | 0.3646 mL | 0.9115 mL |
Tyrosinase-IN-11 Related Classifications
HY-149207 Related Classifications
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