AJUBA - ajuba LIM protein Gene

Also Known as JUB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84962

About AJUBA

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,971,177-22,982,551 (from NCBI)

This gene has 8 transcripts (splice variants), 171 orthologues and 2 paralogues. Broad expression in skin (RPKM 17.2), liver (RPKM 8.4) and 15 other tissues.

Summary

Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and regulation of cellular response to hypoxia. Acts upstream of or within gene silencing by miRNA and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AJUBA Products (3)

mRNA	Protein	Name
NM_001289097.2	NP_001276026.1	LIM domain-containing protein ajuba isoform 3
NM_032876.6	NP_116265.1	LIM domain-containing protein ajuba isoform 1
NM_198086.3	NP_932352.1	LIM domain-containing protein ajuba isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-catenin binding	IDA IDA: Inferred from direct assay	12417594	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15778465	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18805794	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IMP IMP: Inferred from mutant phenotype	20616046	GOA
acts upstream of or within miRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	20616046	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	20303269	GOA
acts upstream of or within positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	15870274	GOA
involved in regulation of cellular response to hypoxia	IDA IDA: Inferred from direct assay	22286099	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	22286099	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	20616046	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	12417594	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18805794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AJUBA Protein Structure

LIM

0
100
200
300
400
500
538 a.a.

Protein Preferred Names	Protein Names
LIM domain-containing protein ajuba	jub, ajuba homolog

AJUBA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AJUBA	Q96IF1	ZNF512B	Homo sapiens	Q96KM6	Validated Y2H	32296183
Intra	AJUBA	Q96IF1	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	AJUBA	Q96IF1	LATS2	Homo sapiens	Q9NRM7	Anti Tag CoIP	33961781
Intra	AJUBA	Q96IF1	LATS2	Homo sapiens	Q9NRM7	Y2H	16413547
Intra	AJUBA	Q96IF1	LATS2	Homo sapiens	Q9NRM7	Anti Bait CoIP	16413547
Intra	AJUBA	Q96IF1	LATS2	Homo sapiens	Q9NRM7	Pull Down	16413547
Intra	AJUBA	Q96IF1	ZNF541	Homo sapiens	Q9H0D2	Validated Y2H	32296183
Intra	AJUBA	Q96IF1	TEKT3	Homo sapiens	Q9BXF9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00504	AJUBA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AJUBA	RGD	RGD:620407
Mus musculus	AJUBA	MGD	MGI:1341886
Felis catus	AJUBA	VGNC	VGNC:80777
Bos taurus	AJUBA	VGNC	VGNC:25769
Macaca mulatta	AJUBA	VGNC	VGNC:69645
Others	AJUBA	NCBI