NDUFAB1 - NADH:ubiquinone oxidoreductase subunit AB1 Gene

Also Known as ACP; ACP1; SDAP; FASN2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4706

About NDUFAB1

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,581,014-23,596,316 (from NCBI)

This gene has 5 transcripts (splice variants), 236 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 68.8), colon (RPKM 46.1) and 25 other tissues.

Summary

Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]

NDUFAB1 Products (1)

mRNA Protein Name
NM_005003.3 NP_004994.1 acyl carrier protein, mitochondrial precursor
Molecular Function GO Annotation Evidence References Source
enables mitochondrial large ribosomal subunit binding IDA
IDA: Inferred from direct assay
28892042 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23157686 GOA
Biological Process GO Annotation Evidence References Source
involved in [2Fe-2S] cluster assembly IDA
IDA: Inferred from direct assay
31664822 GOA
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27626371 GOA
involved in protein lipoylation IMP
IMP: Inferred from mutant phenotype
21846720 GOA
Cellular Component GO Annotation Evidence References Source
part of mitochondrial [2Fe-2S] assembly complex IDA
IDA: Inferred from direct assay
31101807 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFAB1 Protein Structure

PP-binding

PP-binding: Phosphopantetheine attachment site (92 - 148)

  • 0
  • 100
  • 156 a.a.
Protein Preferred Names Protein Names

acyl carrier protein, mitochondrial

  • CI-SDAP

NDUFAB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDUFAB1 O14561 FNDC3B Homo sapiens Q53EP0-3 32296183
Intra
NDUFAB1 O14561 BEX5 Homo sapiens Q5H9J7 32296183
Intra
NDUFAB1 O14561 BEX5 Homo sapiens Q5H9J7 32296183
Intra
NDUFAB1 O14561 BEX5 Homo sapiens Q5H9J7 32296183
Intra
NDUFAB1 O14561 SLIRP Homo sapiens Q9GZT3 32296183
Intra
NDUFAB1 O14561 SLIRP Homo sapiens Q9GZT3
GMS
28892042
Intra
NDUFAB1 O14561 CNTF Homo sapiens P26441 32296183
Intra
NDUFAB1 O14561 CNTF Homo sapiens P26441 32296183
Intra
NDUFAB1 O14561 CCDC24 Homo sapiens Q8N4L8 32296183
Intra
NDUFAB1 O14561 ZNF410 Homo sapiens Q86VK4-3 32296183
Intra
NDUFAB1 O14561 NRF1 Homo sapiens Q16656-4 32296183
Intra
NDUFAB1 O14561 LMO2 Homo sapiens P25791-3 32296183
Intra
NDUFAB1 O14561 NOXA1 Homo sapiens Q86UR1-2 32296183
Intra
NDUFAB1 O14561 TOX2 Homo sapiens Q96NM4-3 32296183
Intra
NDUFAB1 O14561 TOX2 Homo sapiens Q96NM4-3 32296183
Intra
NDUFAB1 O14561 TOX2 Homo sapiens Q96NM4-3 32296183
Intra
NDUFAB1 O14561 ZNF19 Homo sapiens P17023 32296183
Intra
NDUFAB1 O14561 ZNF19 Homo sapiens P17023 32296183
Intra
NDUFAB1 O14561 ZNF19 Homo sapiens P17023 32296183
Intra
NDUFAB1 O14561 BBC3 Homo sapiens Q96PG8 32296183
Intra
NDUFAB1 O14561 ZNF829 Homo sapiens Q3KNS6-3 32296183
Intra
NDUFAB1 O14561 ZNF829 Homo sapiens Q3KNS6-3 32296183
Intra
NDUFAB1 O14561 ZNF829 Homo sapiens Q3KNS6-3 32296183
Intra
NDUFAB1 O14561 VAC14 Homo sapiens Q08AM6 32296183
Intra
NDUFAB1 O14561 VAC14 Homo sapiens Q08AM6 32296183
Intra
NDUFAB1 O14561 VAC14 Homo sapiens Q08AM6 32296183
Intra
NDUFAB1 O14561 FEM1A Homo sapiens Q9BSK4 32296183
Intra
NDUFAB1 O14561 ACTN3 Homo sapiens Q08043 32296183
Intra
NDUFAB1 O14561 PSMC3 Homo sapiens P17980 32296183
Intra
NDUFAB1 O14561 PSMC3 Homo sapiens P17980 32296183
Intra
NDUFAB1 O14561 PSMC3 Homo sapiens P17980 32296183
Intra
NDUFAB1 O14561 POP5 Homo sapiens Q969H6 32296183
Intra
NDUFAB1 O14561 TLX3 Homo sapiens O43711 32296183
Intra
NDUFAB1 O14561 KCTD9 Homo sapiens Q7L273 32296183
Intra
NDUFAB1 O14561 OIP5 Homo sapiens O43482 32296183
Intra
NDUFAB1 O14561 PPP1R16A Homo sapiens Q96I34 32296183
Intra
NDUFAB1 O14561 LNX1 Homo sapiens Q8TBB1 32296183
Intra
NDUFAB1 O14561 FHL3 Homo sapiens Q13643 32296183
Intra
NDUFAB1 O14561 FHL3 Homo sapiens Q13643 32296183
Intra
NDUFAB1 O14561 FHL3 Homo sapiens Q13643 32296183
Intra
NDUFAB1 O14561 NTAQ1 Homo sapiens Q96HA8 32296183
Intra
NDUFAB1 O14561 THAP1 Homo sapiens Q9NVV9 32296183
Intra
NDUFAB1 O14561 HINFP Homo sapiens Q9BQA5 32296183
Intra
NDUFAB1 O14561 HINFP Homo sapiens Q9BQA5 32296183
Intra
NDUFAB1 O14561 HINFP Homo sapiens Q9BQA5 32296183
Intra
NDUFAB1 O14561 MORN3 Homo sapiens Q6PF18 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NDUFAB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86983 NDUFAB1 Antibody (YA6676) WB, IHC-P, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Acute Gonococcal Prostatitis
  • Gonococcal Prostatitis

Mitochondrial Complex I Deficiency, Nuclear Type 1
  • Mitochondrial Complex I Deficiency

  • Nadh:Q(1) Oxidoreductase Deficiency

  • MC1DN1

  • Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Mitochondrial Respiratory Chain Complex I Deficiency

  • Isolated Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Nadh-Coq Reductase Deficiency

  • Isolated Nadh-Ubiquinone Reductase Deficiency

  • Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

  • Nuclear Type Mitochondrial Complex I Deficiency 1

  • Isolated Complex I Deficiency

  • Complex 1 Mitochondrial Respiratory Chain Deficiency

  • Nadh Coenzyme Q Reductase Deficiency

  • Complex I Mitochondrial Respiratory Chain Deficiency

  • Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

  • Nadh:Ubiquinone Oxidoreductase Deficiency

  • Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Leigh Syndrome
  • Leigh Disease

  • Infantile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

  • LS

  • Sne

  • Leigh'S Disease

  • Leigh Syndrome Due To Mitochondrial Complex I Deficiency

  • Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

  • Subacute Necrotizing Encephalomyelopathy

  • Necrotizing Encephalopathy Infantile Subacute Of Leigh

  • Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

  • Infantile Necrotizing Encephalomyelopathy

  • Juvenile Subacute Necrotizing Encephalomyelopathy

  • Leigh'S Necrotizing Encephalopathy

  • Subacute Necrotizing Encephalopathy

  • Juvenile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

  • Leigh Syndrome Due To Mitochondrial Complex V Deficiency

  • Encephalopathy, Subacute Necrotizing, Infantile

  • Encephalopathy, Subacute Necrotizing, Juvenile

  • Maternally Inherited Leigh Syndrome

  • Subacute Necrotising Encephalomyelopathy

  • Subacute Necrotising Encephalopathy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus NDUFAB1 VGNC VGNC:31952
Rattus norvegicus NDUFAB1 RGD RGD:1305619
Mus musculus NDUFAB1 MGD MGI:1917566
Others NDUFAB1 NCBI