FEM1A - fem-1 homolog A Gene

Also Known as EPRAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55527

About FEM1A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,791,734-4,801,273 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 4 paralogues.

Summary

Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin Ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FEM1A Products (1)

mRNA Protein Name
NM_018708.3 NP_061178.1 protein fem-1 homolog A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables EP4 subtype prostaglandin E2 receptor binding IPI
IPI: Inferred from physical interaction
16424369 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
16424369 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
29779948 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
16424369 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
29779948 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29779948 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
16424369 GOA
is active in mitochondrion IDA
IDA: Inferred from direct assay
19406122 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEM1A Protein Structure

Ank

Ank: Ankyrin repeat (42 - 70)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (88 - 179)

Ank_4

Ank_4: Ankyrin repeats (many copies) (188 - 235)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (561 - 617)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

protein fem-1 homolog A

  • FEM1-alpha

FEM1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FEM1A Q9BSK4 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
FEM1A Q9BSK4 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
FEM1A Q9BSK4 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
FEM1A Q9BSK4 MALT1 Homo sapiens Q9UDY8-2
Y2H Prey Pooling
32296183
Intra
FEM1A Q9BSK4 MALT1 Homo sapiens Q9UDY8-2
Validated Y2H
32296183
Intra
FEM1A Q9BSK4 MALT1 Homo sapiens Q9UDY8-2
Y2H Array
32296183
Intra
FEM1A Q9BSK4 NDUFAB1 Homo sapiens O14561
Y2H Prey Pooling
32296183
Intra
FEM1A Q9BSK4 NDUFAB1 Homo sapiens O14561
Y2H Array
32296183
Intra
FEM1A Q9BSK4 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
FEM1A Q9BSK4 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
FEM1A Q9BSK4 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
FEM1A Q9BSK4 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
FEM1A Q9BSK4 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
FEM1A Q9BSK4 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
FEM1A Q9BSK4 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rhabdomyosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04860 FEM1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04858 FEM1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FEM1A VGNC VGNC:108244
Mus musculus FEM1A MGD MGI:1335089
Felis catus FEM1A VGNC VGNC:62224
Rattus norvegicus FEM1A RGD RGD:1561112
Bos taurus FEM1A VGNC VGNC:28944
Others FEM1A NCBI