FEM1A - fem-1 homolog A Gene

Homo sapiens

Also known as EPRAP

Gene ID: 55527 | Gene type: protein coding

About FEM1A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,791,734-4,801,273 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 4 paralogues.

Summary

Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FEM1A Products(1)

mRNA	Protein	Name
NM_018708.3	NP_061178.1	protein fem-1 homolog A

FEM1A Protein Structure

Ank

Ank_2

Ank_4

Ank_2

0
200
400
600
669 a.a.

Protein Preferred Names

Protein Names

protein fem-1 homolog A

FEM1-alpha

Related Diseases

Diseases

Alias

Rhabdomyosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04858	FEM1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FEM1A	VGNC	VGNC:108244
Mus musculus	FEM1A	MGD	MGI:1335089
Felis catus	FEM1A	VGNC	VGNC:62224
Rattus norvegicus	FEM1A	RGD	RGD:1561112
Bos taurus	FEM1A	VGNC	VGNC:28944

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