POP5 - POP5 homolog, ribonuclease P/MRP subunit Gene

Also Known as RPP2; RPP20; hPop5; HSPC004

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51367

About POP5

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,578,764-120,581,402 (from NCBI)

This gene has 9 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in adrenal (RPKM 15.3), fat (RPKM 13.2) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

POP5 Products (2)

mRNA Protein Name
NM_015918.4 NP_057002.2 ribonuclease P/MRP protein subunit POP5 isoform a
NM_198202.2 NP_937845.1 ribonuclease P/MRP protein subunit POP5 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: Inferred from direct assay
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: Inferred from direct assay
30454648 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA 5'-leader removal IDA
IDA: Inferred from direct assay
16723659 GOA
Cellular Component GO Annotation Evidence References Source
part of multimeric ribonuclease P complex IDA
IDA: Inferred from direct assay
16723659 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
11413139 GOA
part of ribonuclease MRP complex IDA
IDA: Inferred from direct assay
16723659 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POP5 Protein Structure

RNase_P_Rpp14

RNase_P_Rpp14: Rpp14/Pop5 family (7 - 117)

  • 0
  • 100
  • 163 a.a.
Protein Preferred Names Protein Names

ribonuclease P/MRP protein subunit POP5

  • processing of precursor 5, ribonuclease P/MRP subunit

POP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POP5 Q969H6 CCDC102B Homo sapiens Q68D86
Validated Y2H
25416956
Intra
POP5 Q969H6 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra
POP5 Q969H6 CCDC102B Homo sapiens Q68D86
Y2H Array
32296183
Intra
POP5 Q969H6 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
POP5 Q969H6 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
POP5 Q969H6 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
POP5 Q969H6 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
POP5 Q969H6 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
POP5 Q969H6 CAMK2B Homo sapiens Q13554
Validated Y2H
25416956
Intra
POP5 Q969H6 CAMK2B Homo sapiens Q13554
Y2H Array
25416956
Intra
POP5 Q969H6 NDUFAB1 Homo sapiens O14561
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 NDUFAB1 Homo sapiens O14561
Y2H Array
32296183
Intra
POP5 Q969H6 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
POP5 Q969H6 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
POP5 Q969H6 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
POP5 Q969H6 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 POP4 Homo sapiens O95707
Anti Tag CoIP
33961781
Intra
POP5 Q969H6 POP4 Homo sapiens O95707
Pull Down
15096576
Intra
POP5 Q969H6 RPP30 Homo sapiens P78346
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 RPP30 Homo sapiens P78346
Anti Tag CoIP
33961781
Intra
POP5 Q969H6 RPP30 Homo sapiens P78346
Y2H Array
32296183
Intra
POP5 Q969H6 RPP25 Homo sapiens Q9BUL9
Anti Tag CoIP
33961781
Intra
POP5 Q969H6 POP1 Homo sapiens Q99575
Anti Tag CoIP
33961781
Intra
POP5 Q969H6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
POP5 Q969H6 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
POP5 Q969H6 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
POP5 Q969H6 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
Intra
POP5 Q969H6 CEP44 Homo sapiens Q9C0F1
Validated Y2H
32296183
Intra
POP5 Q969H6 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra
POP5 Q969H6 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra
POP5 Q969H6 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra
POP5 Q969H6 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Cross
POP5 Q969H6 tax Human T-cell leukemia virus 1 P14079
Y2H Pooling
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Anauxetic Dysplasia 2

  • ANXD2
Anauxetic Dysplasia 1

  • Anauxetic Dysplasia

  • Spondylometaepiphyseal Dysplasia, Menger Type

  • Spondylometaepiphyseal Dysplasia, Anauxetic Type

  • Spondyloepimetaphyseal Dysplasia, Anauxetic Type

  • ANXD1

  • Anxd

  • Spondylometaepiphyseal Dysplasia Anauxetic Type

  • Spondylometaepiphyseal Dysplasia Menger Type

  • Ad

  • Spondyloepimetaphyseal Dysplasia, Menger Type

  • Dysplasia, Anauxetic, Type 1
Enterocele

  • Vaginal Enterocele

  • Hernia

  • Hernias
Prolapse Of Female Genital Organ
Cholestasis, Intrahepatic, Of Pregnancy, 1

  • ICP1

  • Intrahepatic Cholestasis Of Pregnancy 1

  • Cholestasis, Pregnancy-Related, 1

  • Pregnancy Related Cholestasis 1

  • Cholestasis Of Pregnancy, Intrahepatic 1

  • Obstetric Cholestasis

  • Pregnancy-Related Cholestasis

  • Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Cholestasis, Intrahepatic, Of Pregnancy, Type 1

  • Cholestasis Of Pregnancy
Anismus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10877 POP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POP5 MGD MGI:2151221
Felis catus POP5 VGNC VGNC:107718
Bos taurus POP5 VGNC VGNC:33165
Canis familiaris POP5 VGNC VGNC:44817
Rattus norvegicus POP5 RGD RGD:1311819
Others POP5 NCBI