RPP30 - ribonuclease P/MRP subunit p30 Gene

Also Known as TSG15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10556

About RPP30

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,871,974-90,908,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in testis (RPKM 4.1), lymph node (RPKM 2.7) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

RPP30 Products (2)

mRNA Protein Name
NM_001104546.2 NP_001098016.1 ribonuclease P protein subunit p30 isoform a
NM_006413.5 NP_006404.1 ribonuclease P protein subunit p30 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: Inferred from direct assay
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: Inferred from direct assay
30454648 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA 5'-leader removal IDA
IDA: Inferred from direct assay
16723659 GOA
Cellular Component GO Annotation Evidence References Source
part of multimeric ribonuclease P complex IDA
IDA: Inferred from direct assay
16723659 GOA
part of ribonuclease MRP complex IDA
IDA: Inferred from direct assay
16723659 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP30 Protein Structure

RNase_P_p30

RNase_P_p30: RNase P subunit p30 (74 - 224)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

ribonuclease P protein subunit p30

  • RNase P subunit 2

RPP30 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPP30 P78346 POP5 Homo sapiens Q969H6
Y2H Array
32296183
Intra
RPP30 P78346 POP5 Homo sapiens Q969H6
Validated Y2H
32296183
Intra
RPP30 P78346 POP5 Homo sapiens Q969H6
Anti Tag CoIP
28514442
Intra
RPP30 P78346 POP5 Homo sapiens Q969H6
Y2H Prey Pooling
32296183
Intra
RPP30 P78346 RPP14 Homo sapiens O95059
Anti Tag CoIP
28514442
Intra
RPP30 P78346 RPP14 Homo sapiens O95059
Anti Tag CoIP
35271311
Intra
RPP30 P78346 RPP14 Homo sapiens O95059
Pull Down
15096576
Intra
RPP30 P78346 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra
RPP30 P78346 HMG20A Homo sapiens Q9NP66
Y2H Array
25416956
Intra
RPP30 P78346 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra
RPP30 P78346 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12215 RPP30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPP30 VGNC VGNC:34123
Canis familiaris RPP30 VGNC VGNC:45723
Rattus norvegicus RPP30 RGD RGD:1595116
Felis catus RPP30 VGNC VGNC:64745
Mus musculus RPP30 MGD MGI:1859683
Macaca mulatta RPP30 VGNC VGNC:77040
Others RPP30 NCBI