RPP30 - ribonuclease P/MRP subunit p30 Gene

Homo sapiens

Also known as TSG15

Gene ID: 10556 | Gene type: protein coding

About RPP30

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,871,974-90,908,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in testis (RPKM 4.1), lymph node (RPKM 2.7) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

RPP30 Products(2)

mRNA	Protein	Name
NM_001104546.2	NP_001098016.1	ribonuclease P protein subunit p30 isoform a
NM_006413.5	NP_006404.1	ribonuclease P protein subunit p30 isoform b

RPP30 Protein Structure

RNase_P_p30

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

ribonuclease P protein subunit p30

RNase P subunit 2

Related Diseases

Diseases

Alias

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12215	RPP30 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPP30	VGNC	VGNC:34123
Canis familiaris	RPP30	VGNC	VGNC:45723
Rattus norvegicus	RPP30	RGD	RGD:1595116
Felis catus	RPP30	VGNC	VGNC:64745
Mus musculus	RPP30	MGD	MGI:1859683
Macaca mulatta	RPP30	VGNC	VGNC:77040

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