RPP25 - ribonuclease P and MRP subunit p25 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54913

About RPP25

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:74,954,418-74,956,772 (from NCBI)

This gene has 1 transcript (splice variant), 240 orthologues and 1 paralogue.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in centriolar satellite and nucleoplasm. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. Biomarker of autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]

RPP25 Products (1)

mRNA Protein Name
NM_017793.3 NP_060263.2 ribonuclease P protein subunit p25

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: Inferred from direct assay
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: Inferred from direct assay
30454648 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA 5'-leader removal IDA
IDA: Inferred from direct assay
16723659 GOA
Cellular Component GO Annotation Evidence References Source
part of multimeric ribonuclease P complex IDA
IDA: Inferred from direct assay
16723659 GOA
part of ribonuclease MRP complex IDA
IDA: Inferred from direct assay
16723659 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP25 Protein Structure

Alba

Alba: Alba (37 - 99)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

ribonuclease P protein subunit p25

  • RNase P protein subunit p25

RPP25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPP25 Q9BUL9 DNAJB6 Homo sapiens O75190
Y2H Array
32814053
Intra
RPP25 Q9BUL9 DNAJB6 Homo sapiens O75190
Validated Y2H
32814053
Intra
RPP25 Q9BUL9 DNAJB6 Homo sapiens O75190
Y2H Pooling
32814053
Intra
RPP25 Q9BUL9 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra
RPP25 Q9BUL9 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra
RPP25 Q9BUL9 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra
RPP25 Q9BUL9 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
RPP25 Q9BUL9 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
RPP25 Q9BUL9 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
RPP25 Q9BUL9 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
Intra
RPP25 Q9BUL9 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 LRRC73 Homo sapiens Q5JTD7
Y2H Array
32296183
Intra
RPP25 Q9BUL9 LRRC73 Homo sapiens Q5JTD7
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra
RPP25 Q9BUL9 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra
RPP25 Q9BUL9 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
RPP25 Q9BUL9 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 SF3B4 Homo sapiens Q15427
Y2H Array
32296183
Intra
RPP25 Q9BUL9 SF3B4 Homo sapiens Q15427
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 PDLIM7 Homo sapiens Q9NR12
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 PDLIM7 Homo sapiens Q9NR12
Validated Y2H
32296183
Intra
RPP25 Q9BUL9 PDLIM7 Homo sapiens Q9NR12
Y2H Array
32296183
Intra
RPP25 Q9BUL9 POP4 Homo sapiens O95707
Pull Down
15096576
Intra
RPP25 Q9BUL9 POP5 Homo sapiens Q969H6
Pull Down
15096576
Intra
RPP25 Q9BUL9 POP5 Homo sapiens Q969H6
Anti Tag CoIP
28514442
Intra
RPP25 Q9BUL9 POP5 Homo sapiens Q969H6
Anti Tag CoIP
33961781
Intra
RPP25 Q9BUL9 RPP14 Homo sapiens O95059
Pull Down
15096576
Intra
RPP25 Q9BUL9 RPP14 Homo sapiens O95059
Anti Tag CoIP
33961781
Intra
RPP25 Q9BUL9 RPP14 Homo sapiens O95059
Anti Tag CoIP
28514442
Intra
RPP25 Q9BUL9 POP7 Homo sapiens O75817
Anti Tag CoIP
28514442
Intra
RPP25 Q9BUL9 POP7 Homo sapiens O75817
Pull Down
15096576
Intra
RPP25 Q9BUL9 POP7 Homo sapiens O75817
Anti Tag CoIP
33961781
Intra
RPP25 Q9BUL9 POP1 Homo sapiens Q99575
Anti Tag CoIP
33961781
Intra
RPP25 Q9BUL9 POP1 Homo sapiens Q99575
Anti Tag CoIP
28514442
Intra
RPP25 Q9BUL9 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 SAT1 Homo sapiens P21673
Y2H Array
32296183
Intra
RPP25 Q9BUL9 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
RPP25 Q9BUL9 RBPMS Homo sapiens Q93062-3
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 RBPMS Homo sapiens Q93062-3
Y2H Array
32296183
Intra
RPP25 Q9BUL9 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra
RPP25 Q9BUL9 DDI1 Homo sapiens Q8WTU0
Y2H Array
32296183
Intra
RPP25 Q9BUL9 DDI1 Homo sapiens Q8WTU0
Y2H Prey Pooling
32296183
Intra
RPP25 Q9BUL9 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
RPP25 Q9BUL9 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
RPP25 Q9BUL9 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
RPP25 Q9BUL9 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
RPP25 Q9BUL9 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
RPP25 Q9BUL9 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
RPP25 Q9BUL9 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
RPP25 Q9BUL9 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anauxetic Dysplasia 2

  • ANXD2
Chromosome 15q24 Deletion Syndrome

  • 15q24 Microdeletion Syndrome

  • Del(15)(Q24)

  • Monosomy 15q24

  • 15q24 Microdeletion

  • 15q24 Deletion

  • Interstitial Deletion Of Chromosome 15q24
Diffuse Scleroderma

  • Diffuse Systemic Sclerosis

  • Systemic Sclerosis, Diffuse

  • Scleroderma, Diffuse

  • Systemic Scleroderma

  • Progressive System Sclerosis
Anauxetic Dysplasia 1

  • Anauxetic Dysplasia

  • Spondylometaepiphyseal Dysplasia, Menger Type

  • Spondylometaepiphyseal Dysplasia, Anauxetic Type

  • Spondyloepimetaphyseal Dysplasia, Anauxetic Type

  • ANXD1

  • Anxd

  • Spondylometaepiphyseal Dysplasia Anauxetic Type

  • Spondylometaepiphyseal Dysplasia Menger Type

  • Ad

  • Spondyloepimetaphyseal Dysplasia, Menger Type

  • Dysplasia, Anauxetic, Type 1
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12214 RPP25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RPP25 RGD RGD:1305290
Bos taurus RPP25 VGNC VGNC:34121
Macaca mulatta RPP25 VGNC VGNC:77132
Mus musculus RPP25 MGD MGI:2143151
Felis catus RPP25 VGNC VGNC:64743
Others RPP25 NCBI