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PDLIM7 - PDZ and LIM domain 7 Gene

Also Known as LMP1; LMP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9260

About PDLIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,483,394-177,497,604 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 61.1), prostate (RPKM 52.9) and 22 other tissues.

Summary

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of RET/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

PDLIM7 Products (3)

mRNA	Protein	Name
NM_005451.5	NP_005442.2	PDZ and LIM domain protein 7 isoform 1
NM_203352.3	NP_976227.1	PDZ and LIM domain protein 7 isoform 2
NM_213636.3	NP_998801.1	PDZ and LIM domain protein 7 isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM7 Protein Structure

PDZ

LIM

0
100
200
300
400
457 a.a.

Protein Preferred Names	Protein Names
PDZ and LIM domain protein 7	1110003B01Rik

PDLIM7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDLIM7	Q9NR12	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	28514442
Intra	PDLIM7	Q9NR12	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	PDLIM7	Q9NR12	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Cross	PDLIM7	Q9NR12	Hoxa1	Mus musculus	P09022	Y2H	23088713
Cross	PDLIM7	Q9NR12	Hoxa1	Mus musculus	P09022	BiFC	23088713
Intra	PDLIM7	Q9NR12	PHF1	Homo sapiens	O43189	Y2H Array	31515488
Intra	PDLIM7	Q9NR12	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	PDLIM7	Q9NR12	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Validated Y2H	25416956
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Y2H Array	29892012
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Y2H Pooling	16189514
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Y2H Array	31515488
Intra	PDLIM7	Q9NR12	ENKD1	Homo sapiens	Q9H0I2	Y2H Pooling	16189514
Intra	PDLIM7	Q9NR12	GEM	Homo sapiens	P55040	Y2H Array	31515488
Intra	PDLIM7	Q9NR12	BAG3	Homo sapiens	O95817	Anti Tag CoIP	33961781
Intra	PDLIM7	Q9NR12	BAG3	Homo sapiens	O95817	Anti Tag CoIP	28514442
Intra	PDLIM7	Q9NR12	HEY2	Homo sapiens	Q9UBP5	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	IQGAP1	Homo sapiens	A4QPB0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PDLIM7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81821	PDLIM7 Antibody (YA1566)	WB	Human
HY-P81821A	PDLIM7 Antibody (YA1566)(PBS only)	WB	Human
HY-P84821	PDLIM7 Antibody (YA4518)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84821A	PDLIM7 Antibody (YA4518)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Endobronchial Leiomyoma
Larynx Squamous Papilloma	Laryngeal Squamous Cell Papilloma
Lymphoepithelioma-Like Carcinoma	Lymphoepithelial Carcinoma Nasopharyngeal Type Undifferentiated Carcinoma
Lung Leiomyoma	Pulmonary Leiomyoma Leiomyoma Of Lung
Pleural Empyema	Empyema Pyothorax Empyema, Pleural Abscess Of Pleural Cavity Abscess Of Thorax Empyema Of Pleura Empyema Of Pleura Without Fistula Empyema With Fistula Empyema With No Fistula Empyema With Pleural Fistula Empyema Without Mention Of Fistula Empyema, Chest Lung Empyema Pleural Empyema With Fistula Pleural Empyema With No Fistula Purulent Pleurisy Purulent Pleuritis Thorax Abscess Pyopneumothorax
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10284	PDLIM7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDLIM7	MGD	MGI:1914649
Bos taurus	PDLIM7	VGNC	VGNC:32712
Felis catus	PDLIM7	VGNC	VGNC:64093
Macaca mulatta	PDLIM7	VGNC	VGNC:75848
Rattus norvegicus	PDLIM7	RGD	RGD:628769
Others	PDLIM7	NCBI