PDLIM7 Antibody (YA4518)

Cat. No.: HY-P84821: Data Sheet User Guide for Antibodies
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PDLIM7 Antibody (YA4518) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDLIM7.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

PDLIM7 Antibody (YA4518) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDLIM7.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 50 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9NR12

Gene ID

9260 [NCBI]

Immunogen

Purified recombinant fragment of human PDLIM7 (AA: 86-280) expressed in HEK293-6e cells supernatant.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:20-1:100
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)

Subcellular Localization：Cytoplasm; Cytoplasm, cytoskeleton

Expression：
Tissue_specificity:Isomer 1 and isomer 2 are widely expressed, but isomer 2 is predominant in skeletal muscle, while isomer 1 is more abundant in the lungs, spleen, leukocytes, and fetal liver.

Isoforms & Post-Translational Modification：Q9NR12 has 6 isomers: Q9NR12-1: 49845 Da (predicted); Q9NR12-2: 46510 Da (predicted); Q9NR12-3: 16034 Da (predicted); Q9NR12-4: 30411 Da (predicted); Q9NR12-5: 20514 Da (predicted); Q9NR12-6: 24413 Da (predicted).

Subunit：Binds via its LIM zinc-binding 3 domain (LIM 3) to endocytic codes of INSR, but not with those of IGF1R, LDLR, TFRC, or EGFR. Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in a phosphorylation-independent manner via its LIM zinc-binding domain 2 (LIM 2). Probably part of a complex with SHC and the RET dimer. Interacts with TPM2. Interacts with TBX4 and TBX5 (By similarity)

Synonyms

LMP1; LMP3

Documentation

User Guide for Antibodies (1077 KB)