PDLIM7 Antibody (YA4518)(PBS only)
(Synonyms: LMP1; LMP3)PDLIM7 Antibody (YA4518) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDLIM7.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:20-1:100 | 1:200-1:400 | 1:10000 |
Product Details
PDLIM7 Antibody (YA4518) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDLIM7.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50 kDa
Purified recombinant fragment of human PDLIM7 (AA: 86-280) expressed in HEK293-6e cells supernatant.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PDLIM7 may function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:Isomer 1 and isomer 2 are widely expressed, but isomer 2 is predominant in skeletal muscle, while isomer 1 is more abundant in the lungs, spleen, leukocytes, and fetal liver. -
Isoforms & Post-Translational Modification
Q9NR12 has 6 isomers: Q9NR12-1: 49845 Da (predicted); Q9NR12-2: 46510 Da (predicted); Q9NR12-3: 16034 Da (predicted); Q9NR12-4: 30411 Da (predicted); Q9NR12-5: 20514 Da (predicted); Q9NR12-6: 24413 Da (predicted).
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Subunit
Binds via its LIM zinc-binding 3 domain (LIM 3) to endocytic codes of INSR, but not with those of IGF1R, LDLR, TFRC, or EGFR. Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in a phosphorylation-independent manner via its LIM zinc-binding domain 2 (LIM 2). Probably part of a complex with SHC and the RET dimer. Interacts with TPM2. Interacts with TBX4 and TBX5 (By similarity)
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SwissProt ID
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Synonyms
LMP1; LMP3
Documentation
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