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BBC3 - BCL2 binding component 3 Gene

Also Known as JFY1; PUMA; JFY-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27113

About BBC3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,220,824-47,232,860 (from NCBI)

This gene has 6 transcripts (splice variants) and 56 orthologues. Ubiquitous expression in colon (RPKM 3.5), stomach (RPKM 1.4) and 24 other tissues.

Summary

This gene encodes a member of the Bcl-2 Family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and Apoptosis. It can bind to anti-apoptotic Bcl-2 Family members to induce mitochondrial dysfunction and Caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for Cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

BBC3 Products (4)

mRNA	Protein	Name
NM_001127240.3	NP_001120712.1	bcl-2-binding component 3 isoform 1
NM_001127241.3	NP_001120713.1	bcl-2-binding component 3 isoform 2
NM_001127242.3	NP_001120714.1	bcl-2-binding component 3 isoform 3
NM_014417.5	NP_055232.1	bcl-2-binding component 3 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	26212789	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11463391	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11463392	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	26212789	GOA
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11463392	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20810912	GOA
involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	11463391	GOA
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17024184	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	16407291	GOA
involved in negative regulation of growth	IMP IMP: Inferred from mutant phenotype	11463392	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	21041309	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	21041309	GOA
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	11463392	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	22761832	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with lysosome	IDA IDA: Inferred from direct assay	26212789	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	11463391	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
bcl-2-binding component 3	p53 up-regulated modulator of apoptosis

BBC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BBC3	Q96PG8	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	BBC3	Q96PG8	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	BBC3	Q96PG8	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	BBC3	Q96PG8	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	BBC3	Q96PG8	UBASH3B	Homo sapiens	Q8TF42	Y2H Array	32296183
Intra	BBC3	Q96PG8	UBASH3B	Homo sapiens	Q8TF42	Y2H Prey Pooling	32296183
Intra	BBC3	Q96PG8	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	BBC3	Q96PG8	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	BBC3	Q96PG8	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	BBC3	Q96PG8	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	BBC3	Q9BXH1	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	26431330
Intra	BBC3	Q9BXH1	MCL1	Homo sapiens	Q07820	FPS	16697956
Intra	BBC3	Q9BXH1	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	15694340
Intra	BBC3	Q9BXH1	BCL2L1	Homo sapiens	Q07817-1	SPR	16151013
Intra	BBC3	Q9BXH1	EGFR	Homo sapiens	P00533	Anti Bait CoIP	20153921
Cross	BBC3	Q9BXH1	Mcl1	Mus musculus	P97287	Anti Bait CoIP	20627101
Cross	BBC3	Q9BXH1	Mcl1	Mus musculus	P97287	Anti Tag CoIP	15694340
Cross	BBC3	Q9BXH1	Mcl1	Mus musculus	P97287	Anti Tag CoIP	20627101
Intra	BBC3	Q9BXH1	BCL2L2	Homo sapiens	Q92843	SPR	15694340
Intra	BBC3	Q9BXH1	BCL2L2	Homo sapiens	Q92843	FPS	16697956
Intra	BBC3	Q9BXH1	BCL2	Homo sapiens	P10415	Anti Tag CoIP	17289999
Intra	BBC3	Q9BXH1	BCL2	Homo sapiens	P10415	Anti Bait CoIP	26431330
Intra	BBC3	Q9BXH1	BCL2	Homo sapiens	P10415	Anti Tag CoIP	15694340
Intra	BBC3	Q9BXH1	BCL2	Homo sapiens	P10415	FPS	16697956

Cross: Cross-species interaction Intra: Intraspecies interaction

BBC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80289	PUMA Antibody (YA116)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P86329	PUMA Antibody (YA6021)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2035	Pretilachlor		99.25%	Unkown
HY-RS01381	BBC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179507	p53 Activator 17		/	Unkown
HY-B2035R	Pretilachlor (Standard)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BBC3	MGD	MGI:2181667
Rattus norvegicus	BBC3	RGD	RGD:631434
Others	BBC3	NCBI