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Cat. No.: HY-184518

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P53/BET TCIP-1

P53/BET TCIP-1 (Compound 47) is a dual-functional hybrid molecule that possesses both reactivation of p53 Y220C (EC₅₀ ≤ 100 nM) and inhibition of BRD4/BET (EC₅₀ ≤ 500 nM) dual activities. P53/BET TCIP-1 exhibits significant inhibitory proliferation activity in p53 Y220C mutant tumor cells. P53/BET TCIP-1 can be used to study p53 Y220C mutation-related cancers (such as ovarian cancer, pancreatic cancer, gastric cancer, etc.).

For research use only. We do not sell to patients.

Formula: C₅₆H₆₁ClF₄N₁₀O₅
Molecular Weight:1065.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

P53/BET TCIP-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

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Chemical Information

Molecular Weight 1065.59
Formula C₅₆H₆₁ClF₄N₁₀O₅
SMILES

COC1=CC2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCCO[C@H]5CC[C@@H](CC5)NC(C6=CC(OC)=C(C=C6)NCC#CC7=CC8=C(N7CC(F)(F)F)C=CC=C8N[C@@H]9CCN(C[C@@H]9F)C)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lantermann, et al. Preparation of thienotriazolodiazepine derivatives and analogs as bifunctional p53-BET binding compounds and uses thereof. WO2026122577 A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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P53/BET TCIP-1

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